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The effect of quinidine sulphate on ventricular tachycardia
Levine, Samuel A. and Fulton., Marshall N.: The Effect of Q.uinidine Ventricular Tachycardia. J. 1. M. A. 92: 1163, 19%.
Snlphate
on
Clinical experiments in ten cases showing paroxysmal or persistant tael~gca~tlia of ventricular origin indica,tes that quinidine sulphate has iu most insta,nces :I specific effect on restoring a normal rhythm. Ventricular tachycardia occurs occasionally in patients who have no urganic heart disease but more commonly in those with coronnrp thrombosis. Although quinidine does not have any effect on the other complications of coronary thrombosis such as rupture of the heart or production of emboli, its beneficial influence on ventricular taehyea~dia is most dramatic and may be life saving. It is highly probable that ventricular taehycardia is of the nature of a circus movement like that of auriculnr flutter and auricular fibrillation and that the effect of quinidine is similar in all these conditions.
Moore, Dec.,
Henry:
Paroxysmal
Ventricular
Tachycardia.
Irish
J.
Med.
Sci.,
754,
1938.
A case of paroxysmal tachy-eardia in a bog 12 years old, probably arising in the ventricular muscle is described. The patient has been under observation foi more than .56 months. The attacks have become less frequent and of shorter duration. Electrocardiograms are presented showing the character of the waves during the attacks and intervals of regular sinus rhythm. The attacks occurred spontaneously, were readily induced by the administration of atropine and whether spontaneous or induced by atropine lver’e readily terminated by giving quinidine orally. They usually stu.rted n-311 an abrupt change in the form of the QRS complex and approsimatclp a normal heart rate. The ventricular rate during the attack rose to about 170 per minute. The T wave in the slow atropine peroxysm was upright lvhenever recorded, whereas it was inverted in the slow spontaneous attacks.
Coombs, Carey F.: The Distal Phenomena Bristol
Medico-Chirurgical
J.
46:
35,
that Accompany
High Arterial
Tension.
1929.
In this address the author described the effects to be noted in the body as :L result of high arterial tension. He mentions the effect in the cerebral ciroulation He believes that all and the brain, in the peripheral muscles and other tissues. of these phenomena can be ascribed at least in part to gradual wearing down of He believes that the importance of obstructhe elasticity of the arterial tree. tion in the small vessels is not substantiated by examination of the tissues.
D. C. and Karn, M. Noel: An Investigation of Blood Pressure, Pulse Rate and the Response to Exercise During Normal Pregnancy, and S’ome Observations after Confinement. Quart. .J. Jlcd. 22: 381: 1X9.
Hare,
The object of this investigation of the circulation during the course vvere blood pressure and pulse rate rate
to
an
exercise test.
been to study of normal pregnancy. measurements and
has
One hundred and six individuals
the
lmysiological The methods the response of
reactions employed the pulse
are included in the study,
three-fourths of whom were seen several times at intervals of four weeks or more. A suitable group of nonpregnaut women wcrc exnmiuerl as ccntvols using the same methods under the same conditions. It was found that the average systolic blood pressure of healthy women during also the average of nonpregnant women; pregnancy is lower than the average deviation during pregnancy is less and the range is consequently slightly smaller.
Snlphate
on
Clinical experiments in ten cases showing paroxysmal or persistant tael~gca~tlia of ventricular origin indica,tes that quinidine sulphate has iu most insta,nces :I specific effect on restoring a normal rhythm. Ventricular tachycardia occurs occasionally in patients who have no urganic heart disease but more commonly in those with coronnrp thrombosis. Although quinidine does not have any effect on the other complications of coronary thrombosis such as rupture of the heart or production of emboli, its beneficial influence on ventricular taehyea~dia is most dramatic and may be life saving. It is highly probable that ventricular taehycardia is of the nature of a circus movement like that of auriculnr flutter and auricular fibrillation and that the effect of quinidine is similar in all these conditions.
Moore, Dec.,
Henry:
Paroxysmal
Ventricular
Tachycardia.
Irish
J.
Med.
Sci.,
754,
1938.
A case of paroxysmal tachy-eardia in a bog 12 years old, probably arising in the ventricular muscle is described. The patient has been under observation foi more than .56 months. The attacks have become less frequent and of shorter duration. Electrocardiograms are presented showing the character of the waves during the attacks and intervals of regular sinus rhythm. The attacks occurred spontaneously, were readily induced by the administration of atropine and whether spontaneous or induced by atropine lver’e readily terminated by giving quinidine orally. They usually stu.rted n-311 an abrupt change in the form of the QRS complex and approsimatclp a normal heart rate. The ventricular rate during the attack rose to about 170 per minute. The T wave in the slow atropine peroxysm was upright lvhenever recorded, whereas it was inverted in the slow spontaneous attacks.
Coombs, Carey F.: The Distal Phenomena Bristol
Medico-Chirurgical
J.
46:
35,
that Accompany
High Arterial
Tension.
1929.
In this address the author described the effects to be noted in the body as :L result of high arterial tension. He mentions the effect in the cerebral ciroulation He believes that all and the brain, in the peripheral muscles and other tissues. of these phenomena can be ascribed at least in part to gradual wearing down of He believes that the importance of obstructhe elasticity of the arterial tree. tion in the small vessels is not substantiated by examination of the tissues.
D. C. and Karn, M. Noel: An Investigation of Blood Pressure, Pulse Rate and the Response to Exercise During Normal Pregnancy, and S’ome Observations after Confinement. Quart. .J. Jlcd. 22: 381: 1X9.
Hare,
The object of this investigation of the circulation during the course vvere blood pressure and pulse rate rate
to
an
exercise test.
been to study of normal pregnancy. measurements and
has
One hundred and six individuals
the
lmysiological The methods the response of
reactions employed the pulse
are included in the study,
three-fourths of whom were seen several times at intervals of four weeks or more. A suitable group of nonpregnaut women wcrc exnmiuerl as ccntvols using the same methods under the same conditions. It was found that the average systolic blood pressure of healthy women during also the average of nonpregnant women; pregnancy is lower than the average deviation during pregnancy is less and the range is consequently slightly smaller.