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The effect of roentgen irradiation on the anterior lobe of the pituitary gland
913
ABSTRACYPS
the testis, the changes in the anterior lobe of the pituitary, and the hyperplasia and secretory activity of the mamma produced by estrinization. The result is the same as that produced by a continuous supply of thyrotropic hormone of the anterior lobe of the pituitary. In 3 of 5 adrenalectomized male mammary carcinoma after estrinization, two its development was delayed.
mice of a strain which regularly carcinoma did not develop. In
develops the other
CARL P. KUBER. Shapiro,
B. G.:
2: 1457,
Control
of Urinary
Secretion
by the Anterior
Pituitary,
Lancet
1938.
Investigation of the part played by the anterior pituitary in the control of urinary secretion was carried out by the administration of estrin in order to depress the pituitary activity and by the administration of anterior lobe extracts. Doses of 10 mg. of estradiol benzoate given to 16 patients for five or more days resulted in a significant decrease in urine output in 12. Subsequently an increased output was recorded which was greater than could be accounted for due to stored fluid. In 2 patients with diabetes insipidus a decrease in output was pro-
duced. Pregnancy urine extracts had no effect on the urine output. Antuitrin and antuitrin-G (Parke, Davis & Co.) both resulted in varying degrees of increased output, reaching as high as 280 per cent of the preinjection level on one occasion. The author suggests that the polyuria of Gushing’s syndrome may be a manifestation of anterior pituitary hyperactivity. He feels that experimentally he has corroborated the pathologic findings of von Hann that the presence of functioning anterior lobe tissue is necessary for the production of diabetes insipidus.
CARL P. HUBEFL Effkemann and Mueller-Jaeger: Anterior Severe Post Partum Hemorrhage, Arch.
Pituitary
Lobe Insutliciency
f. GynLk.
168:
Following
867,193Q.
The author followed up 86 women who had suffered severe postpartum hemorrhage seven to ten years previously. This was done to determine the accuracy of recent reports which claim that such postpartum hemorrhage leads to anterior pituitary ischemia and necro,sis, resulting in slowly developing endocrinopathies. The group studied showed a high incidence of subsequent genital atrophy with hypomenorrhea, sterility, and adiposity. Such findings can be linked definitely to the postpartum hemorrhage. These women also showed deficiency of lactation and anomalies of menstruation. The authors believe that such findings prove that postpartum hemorrhage is frequent in endocrinopathies rather than that endocrinopathies result from postpartum hemorrhage. In other words, pathology of the pituitary gland predisposes to postpartum hemorrhage.
RALPH A, REIS. Gumbrecht, Anterior
Keller and Loeser: Lobe of the Pituitary
The Effect of Roentgen Irradiation Gland, Klin. Wchnschr. 17: 801, 1938.
on the
The authors investigated the effect of roentgen irradiation on the anterior lobe of the pituitary gland of various laboratory animals, such as white mice, rats, and rabbits. They were unable to produce any type of structural change even when the animals were subjected to intensive irradiation. Unilateral irradiation of the hypophysis produced no changes in the quantity of thyrotropie or gonadotropie hormone. When both normal and castrated animals were subjected to repeated irradiation of the entire skull, a fatal cachexia was produced in each instance. This was probably due to a failure to secrete both the thyrotropic and gonadotropic hormones although no structural changes could be found.
RALPH A. REIS.
ABSTRACYPS
the testis, the changes in the anterior lobe of the pituitary, and the hyperplasia and secretory activity of the mamma produced by estrinization. The result is the same as that produced by a continuous supply of thyrotropic hormone of the anterior lobe of the pituitary. In 3 of 5 adrenalectomized male mammary carcinoma after estrinization, two its development was delayed.
mice of a strain which regularly carcinoma did not develop. In
develops the other
CARL P. KUBER. Shapiro,
B. G.:
2: 1457,
Control
of Urinary
Secretion
by the Anterior
Pituitary,
Lancet
1938.
Investigation of the part played by the anterior pituitary in the control of urinary secretion was carried out by the administration of estrin in order to depress the pituitary activity and by the administration of anterior lobe extracts. Doses of 10 mg. of estradiol benzoate given to 16 patients for five or more days resulted in a significant decrease in urine output in 12. Subsequently an increased output was recorded which was greater than could be accounted for due to stored fluid. In 2 patients with diabetes insipidus a decrease in output was pro-
duced. Pregnancy urine extracts had no effect on the urine output. Antuitrin and antuitrin-G (Parke, Davis & Co.) both resulted in varying degrees of increased output, reaching as high as 280 per cent of the preinjection level on one occasion. The author suggests that the polyuria of Gushing’s syndrome may be a manifestation of anterior pituitary hyperactivity. He feels that experimentally he has corroborated the pathologic findings of von Hann that the presence of functioning anterior lobe tissue is necessary for the production of diabetes insipidus.
CARL P. HUBEFL Effkemann and Mueller-Jaeger: Anterior Severe Post Partum Hemorrhage, Arch.
Pituitary
Lobe Insutliciency
f. GynLk.
168:
Following
867,193Q.
The author followed up 86 women who had suffered severe postpartum hemorrhage seven to ten years previously. This was done to determine the accuracy of recent reports which claim that such postpartum hemorrhage leads to anterior pituitary ischemia and necro,sis, resulting in slowly developing endocrinopathies. The group studied showed a high incidence of subsequent genital atrophy with hypomenorrhea, sterility, and adiposity. Such findings can be linked definitely to the postpartum hemorrhage. These women also showed deficiency of lactation and anomalies of menstruation. The authors believe that such findings prove that postpartum hemorrhage is frequent in endocrinopathies rather than that endocrinopathies result from postpartum hemorrhage. In other words, pathology of the pituitary gland predisposes to postpartum hemorrhage.
RALPH A, REIS. Gumbrecht, Anterior
Keller and Loeser: Lobe of the Pituitary
The Effect of Roentgen Irradiation Gland, Klin. Wchnschr. 17: 801, 1938.
on the
The authors investigated the effect of roentgen irradiation on the anterior lobe of the pituitary gland of various laboratory animals, such as white mice, rats, and rabbits. They were unable to produce any type of structural change even when the animals were subjected to intensive irradiation. Unilateral irradiation of the hypophysis produced no changes in the quantity of thyrotropie or gonadotropie hormone. When both normal and castrated animals were subjected to repeated irradiation of the entire skull, a fatal cachexia was produced in each instance. This was probably due to a failure to secrete both the thyrotropic and gonadotropic hormones although no structural changes could be found.
RALPH A. REIS.