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THE EFFECTS OF ESTROGEN REPLACEMENT THERAPY ON SERUM LIPID PROFILE IN SURGICALLY MENOPAUSED WOMEN
8th European Congress on Menopause (EMAS) / Maturitas 63, Supplement 1 (2009) S1–S136
Keywords: Menopause, familial hypercholesterolaemia, nonfasting triglycerides.
221 THE EFFECTS OF ESTROGEN REPLACEMENT THERAPY ON SERUM LIPID PROFILE IN SURGICALLY MENOPAUSED WOMEN K.H. Kim, K.S. Lee, D.H. Lee, S.C. Kim, J.K. Joo. Pusan National University, Obstetrics & Gynecology, Busan, Korea, Republic of Objectives: To evaluate short-term and long-term effects of estrogen replacement therapy (ERT) on lipid profile in surgically menopaused women. Methods: In this cross-sectional study, 120 surgically menopaused women after total hysterectomy and bilateral oophorectomy and 107 natural postmenopausal women were enrolled. After surgical menopause, 28 women received 0.625 mg conjugated equine estrogen (CEE) and 32 women did not for 3 months, 28 women received and 32 women were did not for 1 year. Natural postmenopausal women received 0.625 mg conjugated equine estrogen (CEE) and 5 mg medroxyprogesterone acetate (MPA). The effects of Hormone therapy on plasma levels of lipids were investigated. Results: During hormone therapy, total cholesterol and LDL cholesterol level decreased significantly for 3 months and 1 year in surgically menopaused women (p<0.05). HDL cholesterol level raised at 3 months but there was not significant statistical difference (p>0.05). Triglyceride level decreased in surgically menopaused women not received ERT but there was no significant statistical difference (p>0.05). Conclusions: The results of our study results suggest that ERT had more beneficial effects on lipid profile in surgically menopaused women. Keywords: Estrogen, lipid profile, menopause.
222 EFFECTS OF HORMONE THERAPY ON SERUM HS-CRP LEVELS IN SURGICALLY MENOPAUSED WOMEN K.S. Lee, K.H. Kim, D.H. Lee, S.C. Kim, J.K. Joo. Pusan National University, Obstetrics & Gynecology, Busan, Korea, Republic of Objectives: To investigate the effects of hormone therapy (HT) on highsensitivity C-reactive protein (hs-CRP) in surgically menopaused women. Methods: In this study, 156 healthy women were enrolled. After surgical menopause, 28 women were receiving HT and 32 women were not for 3 months, 28 women were receiving and 32 women were not for 1 year. Control group included 36 healthy premenopausal women not receiving HT. The effect of HT on plasma levels of hs-CRP and lipids were investigated. Results: Mean hs-CRP concentrations were significantly higher in surgically menopaused women receiving HT than premenopausal women. Mean hs-CRP concentrations were also higher in surgically menopaused women not receiving HT than premenopausal women (premenopausal: 0.069±0.080, 3 months after surgical menopause: 0.108±0.215, 1 year after surgical menopause: 0.081±0.146 mg/dL, p>0.05). Total cholesterol and LDL cholesterol were significantly lower in surgically menopaused women receiving HT than not receiving HT for 3 months and 1 year (total cholesterol; 191.3±44.7 in HT group, 227.1±24.5 in no HT group for 3 months after surgical menopause: 191.9±29.4 in HT group, 218.2±34.4 in no HT group for 1 year after surgical menopause, LDL cholesterol; 117.5±25.7 in HT group, 129.1±22.5 in no HT group for 3 months after surgical menopause: 120.6±26.2 in HT group, 136.6±32.1 in no HT group for 1 year after menopause). Conclusions: hs-CRP was increased in surgically menopaused women than premenopausal women, however, there was no significant changes in hs-CRP between HT group and no HT group for 3 months and 1 year. Keywords: hs-CRP, Hormone therapy, Menopause, Lipid.
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in women, in Brazil is less estimated even when the statistics show that it is increasing. CAD is a multifactor disease and many of the biological and psychological risk factors are well known studied and measured. However, the social determinants of this disease were insufficient studied and neglected. Objective: To identify the relationship between the profile of social exclusion and the perception of quality of life in CAD. Methods: A cross-sectional survey of 159 women with CAD, in menopausal period (aged 39-64 years) attended of outpatient ambulatory were invited to answer questions on social-economic and cultural items and quality of life (Flanagan Scale). Were selected also, 20 to a focal group (qualitative research). Data was analyzed by SPSS statistics program. Results: Predominant white (58%), married (43%), catholic (61%), incomplete school instruction (47%), housewives (37%); living in own residences (69%) in the south zone of the capital, witch means violent neighborhood (42%), personal income from 1 to 6 minimum salary (75%). Flanagan Scale showed that they feel unsatisfied in: Material well being (58%); Health (57%); Family relationship (68%); Children (52%), Intimacy (66%); Social activities (57%); Personal development (65%); Work (68%), Communication (46%); Recreation: socialization (68%), entertainment (74%), active recreation (81%); Solitude (69%). Conclusions: Low income, low instruction, absence of work qualification, social participation, leisure and low social support were strongest represented in the women’s interviewees but they don’t notice clearly the relationship with CAD and their poor quality of life. Keywords: CAD, QoL.
224 REDUCED LEFT VENTRICULAR DIASTOLIC FUNCTION AND ELEVATED EPICARDIAL ADIPOSE TISSUE: EFFECTS OF AGE & MENOPAUSAL STATUS K. Moreau, C. Bergman, L. Tobin, W. Kohrt, W. Gozansky. University of Colorado Denver, Medicine, Aurora, United States Objectives: Left ventricular (LV) diastolic dysfunction is associated with cardiovascular disease (CVD) morbidity and mortality. Epicardial adipose tissue (EAT), a visceral thoracic fat depot, is associated with increased CVD risk. We determined whether reduced LV diastolic function was related to elevated EAT in women and whether age and menopausal status impacted these relations. Methods: EAT thickness and LV diastolic function were assessed by transthoracic echocardiography in 43 healthy women who were not taking hormone supplements: 6 premenopausal (30±2 yr; Mean±SEM), 17 perimenopausal (51±1 yr), and 20 postmenopausal (58±1 yr). We acquired E/A ratio (peak early diastolic transmitral velocity (E)/late diastolic transmitral velocity (A); low values=dysfunction) and E/E ratio (E =peak early diastolic tissue velocity). The latter is a more robust measure of diastolic function (high values=dysfunction) that is not influenced by pseudonormalization. Results: E/E and E/A were correlated with EAT thickness (r=0.68, P<0.001 and r=-0.47, P=0.006, respectively). E/E and EAT remained correlated (r=0.58, P=0.001) after age-adjustment but not E/A and EAT (r=-0.12, P=0.53). E/E ratio (P=0.03) and EAT thickness (P=0.001) were elevated across menopausal status (premenopausal < perimenopausal < postmenopausal). However, these associations were no longer significant after age-adjustment (all P>0.05). Conclusion: These preliminary findings suggest that aging is associated with adverse changes in LV diastolic function and EAT thickness, even among healthy women. Moreover, the decline in LV diastolic function is related to elevations in EAT. It remains unclear whether the accumulation of EAT is mechanistically involved in the development of diastolic dysfunction with aging in menopausal women. Keywords: Aging, Menopause, Adiposity
225 223 MENOPAUSE AND CORONARY ARTERY DISEASE: CONNECTIONS TO SOCIAL EXCLUSION PROFILE AND POOR QUALITY OF LIFE S.L. Medeiros 1 , E.R.G. Alexandre 2 . 1 Institute Dante Pazzanese of Cardiology, Research Department, Sao Paulo, Brazil; 2 Institute Dante Pazzanese of Cardiology, Women’s Departament, Sao Paulo, Brazil Introduction: The dimension of Coronary Artery Disease (CAD) especially
ASSOCIATION BETWEEN ANTHROPOMETRIC INDICATORS OF BODY FAT AND METABOLIC RISK IN POSTMENOPAUSAL WOMEN E.A.P. Nahas, F. Orsatti, J. Nahas-Neto, N. Maesta, A.P. Tardivo, P. Traiman. Botucatu Medical School - Sao Paulo State University - UNESP, Gynecology and Obstetrics, Botucatu, Brazil Objectives: To evaluate anthropometric indicators of body fat and their association with metabolic risk markers in postmenopausal women.
Keywords: Menopause, familial hypercholesterolaemia, nonfasting triglycerides.
221 THE EFFECTS OF ESTROGEN REPLACEMENT THERAPY ON SERUM LIPID PROFILE IN SURGICALLY MENOPAUSED WOMEN K.H. Kim, K.S. Lee, D.H. Lee, S.C. Kim, J.K. Joo. Pusan National University, Obstetrics & Gynecology, Busan, Korea, Republic of Objectives: To evaluate short-term and long-term effects of estrogen replacement therapy (ERT) on lipid profile in surgically menopaused women. Methods: In this cross-sectional study, 120 surgically menopaused women after total hysterectomy and bilateral oophorectomy and 107 natural postmenopausal women were enrolled. After surgical menopause, 28 women received 0.625 mg conjugated equine estrogen (CEE) and 32 women did not for 3 months, 28 women received and 32 women were did not for 1 year. Natural postmenopausal women received 0.625 mg conjugated equine estrogen (CEE) and 5 mg medroxyprogesterone acetate (MPA). The effects of Hormone therapy on plasma levels of lipids were investigated. Results: During hormone therapy, total cholesterol and LDL cholesterol level decreased significantly for 3 months and 1 year in surgically menopaused women (p<0.05). HDL cholesterol level raised at 3 months but there was not significant statistical difference (p>0.05). Triglyceride level decreased in surgically menopaused women not received ERT but there was no significant statistical difference (p>0.05). Conclusions: The results of our study results suggest that ERT had more beneficial effects on lipid profile in surgically menopaused women. Keywords: Estrogen, lipid profile, menopause.
222 EFFECTS OF HORMONE THERAPY ON SERUM HS-CRP LEVELS IN SURGICALLY MENOPAUSED WOMEN K.S. Lee, K.H. Kim, D.H. Lee, S.C. Kim, J.K. Joo. Pusan National University, Obstetrics & Gynecology, Busan, Korea, Republic of Objectives: To investigate the effects of hormone therapy (HT) on highsensitivity C-reactive protein (hs-CRP) in surgically menopaused women. Methods: In this study, 156 healthy women were enrolled. After surgical menopause, 28 women were receiving HT and 32 women were not for 3 months, 28 women were receiving and 32 women were not for 1 year. Control group included 36 healthy premenopausal women not receiving HT. The effect of HT on plasma levels of hs-CRP and lipids were investigated. Results: Mean hs-CRP concentrations were significantly higher in surgically menopaused women receiving HT than premenopausal women. Mean hs-CRP concentrations were also higher in surgically menopaused women not receiving HT than premenopausal women (premenopausal: 0.069±0.080, 3 months after surgical menopause: 0.108±0.215, 1 year after surgical menopause: 0.081±0.146 mg/dL, p>0.05). Total cholesterol and LDL cholesterol were significantly lower in surgically menopaused women receiving HT than not receiving HT for 3 months and 1 year (total cholesterol; 191.3±44.7 in HT group, 227.1±24.5 in no HT group for 3 months after surgical menopause: 191.9±29.4 in HT group, 218.2±34.4 in no HT group for 1 year after surgical menopause, LDL cholesterol; 117.5±25.7 in HT group, 129.1±22.5 in no HT group for 3 months after surgical menopause: 120.6±26.2 in HT group, 136.6±32.1 in no HT group for 1 year after menopause). Conclusions: hs-CRP was increased in surgically menopaused women than premenopausal women, however, there was no significant changes in hs-CRP between HT group and no HT group for 3 months and 1 year. Keywords: hs-CRP, Hormone therapy, Menopause, Lipid.
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in women, in Brazil is less estimated even when the statistics show that it is increasing. CAD is a multifactor disease and many of the biological and psychological risk factors are well known studied and measured. However, the social determinants of this disease were insufficient studied and neglected. Objective: To identify the relationship between the profile of social exclusion and the perception of quality of life in CAD. Methods: A cross-sectional survey of 159 women with CAD, in menopausal period (aged 39-64 years) attended of outpatient ambulatory were invited to answer questions on social-economic and cultural items and quality of life (Flanagan Scale). Were selected also, 20 to a focal group (qualitative research). Data was analyzed by SPSS statistics program. Results: Predominant white (58%), married (43%), catholic (61%), incomplete school instruction (47%), housewives (37%); living in own residences (69%) in the south zone of the capital, witch means violent neighborhood (42%), personal income from 1 to 6 minimum salary (75%). Flanagan Scale showed that they feel unsatisfied in: Material well being (58%); Health (57%); Family relationship (68%); Children (52%), Intimacy (66%); Social activities (57%); Personal development (65%); Work (68%), Communication (46%); Recreation: socialization (68%), entertainment (74%), active recreation (81%); Solitude (69%). Conclusions: Low income, low instruction, absence of work qualification, social participation, leisure and low social support were strongest represented in the women’s interviewees but they don’t notice clearly the relationship with CAD and their poor quality of life. Keywords: CAD, QoL.
224 REDUCED LEFT VENTRICULAR DIASTOLIC FUNCTION AND ELEVATED EPICARDIAL ADIPOSE TISSUE: EFFECTS OF AGE & MENOPAUSAL STATUS K. Moreau, C. Bergman, L. Tobin, W. Kohrt, W. Gozansky. University of Colorado Denver, Medicine, Aurora, United States Objectives: Left ventricular (LV) diastolic dysfunction is associated with cardiovascular disease (CVD) morbidity and mortality. Epicardial adipose tissue (EAT), a visceral thoracic fat depot, is associated with increased CVD risk. We determined whether reduced LV diastolic function was related to elevated EAT in women and whether age and menopausal status impacted these relations. Methods: EAT thickness and LV diastolic function were assessed by transthoracic echocardiography in 43 healthy women who were not taking hormone supplements: 6 premenopausal (30±2 yr; Mean±SEM), 17 perimenopausal (51±1 yr), and 20 postmenopausal (58±1 yr). We acquired E/A ratio (peak early diastolic transmitral velocity (E)/late diastolic transmitral velocity (A); low values=dysfunction) and E/E ratio (E =peak early diastolic tissue velocity). The latter is a more robust measure of diastolic function (high values=dysfunction) that is not influenced by pseudonormalization. Results: E/E and E/A were correlated with EAT thickness (r=0.68, P<0.001 and r=-0.47, P=0.006, respectively). E/E and EAT remained correlated (r=0.58, P=0.001) after age-adjustment but not E/A and EAT (r=-0.12, P=0.53). E/E ratio (P=0.03) and EAT thickness (P=0.001) were elevated across menopausal status (premenopausal < perimenopausal < postmenopausal). However, these associations were no longer significant after age-adjustment (all P>0.05). Conclusion: These preliminary findings suggest that aging is associated with adverse changes in LV diastolic function and EAT thickness, even among healthy women. Moreover, the decline in LV diastolic function is related to elevations in EAT. It remains unclear whether the accumulation of EAT is mechanistically involved in the development of diastolic dysfunction with aging in menopausal women. Keywords: Aging, Menopause, Adiposity
225 223 MENOPAUSE AND CORONARY ARTERY DISEASE: CONNECTIONS TO SOCIAL EXCLUSION PROFILE AND POOR QUALITY OF LIFE S.L. Medeiros 1 , E.R.G. Alexandre 2 . 1 Institute Dante Pazzanese of Cardiology, Research Department, Sao Paulo, Brazil; 2 Institute Dante Pazzanese of Cardiology, Women’s Departament, Sao Paulo, Brazil Introduction: The dimension of Coronary Artery Disease (CAD) especially
ASSOCIATION BETWEEN ANTHROPOMETRIC INDICATORS OF BODY FAT AND METABOLIC RISK IN POSTMENOPAUSAL WOMEN E.A.P. Nahas, F. Orsatti, J. Nahas-Neto, N. Maesta, A.P. Tardivo, P. Traiman. Botucatu Medical School - Sao Paulo State University - UNESP, Gynecology and Obstetrics, Botucatu, Brazil Objectives: To evaluate anthropometric indicators of body fat and their association with metabolic risk markers in postmenopausal women.