P127
377
THE EFFECTS LIVER
OF PERFLUOROCHEMICALS
V.Obraztsov,
1
2
, A.Saprin
V.Mishin
ON DETOXIFICATION
3
SYSTEMS
OF RAT
4
and G.Mikhailov
Institute of Biological Physics, Academy of Sciences, Pushchino, Moscow Region 1, Institute of Clinical and Experimental Medicine, Academy of Medical Sciences, Siberian Department, Novosibirsk 2, All-Union Scientific Institute of Biotechnology, Moscow 3 and Institute of Hygiene, Toxicology and Professional Pathology, Volgograd 4 (USSR)
Though
perfluorochemicals
organism,
(PFSs)
they
nonetheless
connected
with
induction
instance
intravenous
resulted
in
monooxigenase
the
microsomal
cytochromes[2]
induction
of
detoxification glutathione reactions of
account on
PFC
enzymes
to
animals.
considering emulsion.
activation
A
the
l.V.Obraztsov,
PFCs
Obviously
rats
P-450-dependent characteristics of
activated
the
found
that
could
this
of
data of
A.Sklifas
A.Grishanova,
some be
with
phase
other
be
systems by
taken
substitutes PFCs
systems
as
a
PFC into
based
drug
for
is discussed.
and K.Makarov,
N.Gutkina,
II and
conjugation
activated
must
blood
applying
detoxification
the
of
induced
Simultaneously
catalize
application
and V.Lyakhovich,
For
to
UDP-glucuroniltransferase
which also
systems.
composition
studied.
protection
D.Shekhtman,
USSR 53, 613 (1988). -I 2.V.Mishin, V.Obraztsov, O.Khatsenko
been
possibility
of the liver
isoform
living
activity
emulsion
Physico-chemical an
P-450
It was
PFC
cytochrome
(microsomal
biochemical
of
in
biological
detoxification
of
have
cytochrome
in liver.
(1989).
and
S-transferase)
organism
injection
of liver
enzymes.
inducers[l]
metabolized
a certain
administration induction
system
fluorocarbon
aren't
show
Biochemistry
D.Shekhtman,
Chem.-Biol.Interactions,
72,143