The effects of perfluorochemicals on detoxification systems of rat liver

The effects of perfluorochemicals on detoxification systems of rat liver

P127 377 THE EFFECTS LIVER OF PERFLUOROCHEMICALS V.Obraztsov, 1 2 , A.Saprin V.Mishin ON DETOXIFICATION 3 SYSTEMS OF RAT 4 and G.Mikhail...

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P127

377

THE EFFECTS LIVER

OF PERFLUOROCHEMICALS

V.Obraztsov,

1

2

, A.Saprin

V.Mishin

ON DETOXIFICATION

3

SYSTEMS

OF RAT

4

and G.Mikhailov

Institute of Biological Physics, Academy of Sciences, Pushchino, Moscow Region 1, Institute of Clinical and Experimental Medicine, Academy of Medical Sciences, Siberian Department, Novosibirsk 2, All-Union Scientific Institute of Biotechnology, Moscow 3 and Institute of Hygiene, Toxicology and Professional Pathology, Volgograd 4 (USSR)

Though

perfluorochemicals

organism,

(PFSs)

they

nonetheless

connected

with

induction

instance

intravenous

resulted

in

monooxigenase

the

microsomal

cytochromes[2]

induction

of

detoxification glutathione reactions of

account on

PFC

enzymes

to

animals.

considering emulsion.

activation

A

the

l.V.Obraztsov,

PFCs

Obviously

rats

P-450-dependent characteristics of

activated

the

found

that

could

this

of

data of

A.Sklifas

A.Grishanova,

some be

with

phase

other

be

systems by

taken

substitutes PFCs

systems

as

a

PFC into

based

drug

for

is discussed.

and K.Makarov,

N.Gutkina,

II and

conjugation

activated

must

blood

applying

detoxification

the

of

induced

Simultaneously

catalize

application

and V.Lyakhovich,

For

to

UDP-glucuroniltransferase

which also

systems.

composition

studied.

protection

D.Shekhtman,

USSR 53, 613 (1988). -I 2.V.Mishin, V.Obraztsov, O.Khatsenko

been

possibility

of the liver

isoform

living

activity

emulsion

Physico-chemical an

P-450

It was

PFC

cytochrome

(microsomal

biochemical

of

in

biological

detoxification

of

have

cytochrome

in liver.

(1989).

and

S-transferase)

organism

injection

of liver

enzymes.

inducers[l]

metabolized

a certain

administration induction

system

fluorocarbon

aren't

show

Biochemistry

D.Shekhtman,

Chem.-Biol.Interactions,

72,143