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The epidemiologyic study of suicide in north west of Iran
Abstracts / Toxicology Letters 196S (2010) S37–S351
P105-011 Analysis of Y chromosome microdeletion and altered sperm quality in subjects exposed to hexachlorocyclohexane (HCH) F.H. Khan, P. Ganesan, S. Kumar University of Lucknow, India Over the past few decades with the increasing effects of environmental factors, a remarkable drop in fertility rate of men has been observed all over the world. Therefore, we undertook a study to examine the relationship between environmental hexachlorocyclohexane (HCH) exposure and its reproductive potential. The study population was composed of 25 men with moderate exposure to HCH (farmers), 7 men highly exposed to HCH (living at dumping site of HCH) and 25 comparable controls with no such exposure history. The study parameters included recording of demographic characteristics, oxidative stress (GSH and MDA), Y chromosome deletions and semen quality. The mean blood HCH level was observed ∼3 times higher in exposed groups and ∼2 times higher in farmers as compared to the control. Malondialdehyde (MDA) levels, an endproduct of lipid peroxidation, were significantly higher while the antioxidant glutathione (GSH) levels were significantly lower in the exposed group as compared to the control group. We found three men with Yq deletion in AZFa and AZFc regions (5.55%) in exposed group. All subjects have normal semen quality except subject-F25 (Farmer) with 40% sperm motility (asthenospermic) without any Yq deletion and Ex7 (exposed group) with 20% sperm motility (severe asthenospermic), showing deletion of sY95, sY1161, sY1191 and sY1206 while Ex3 with normal semen quality, showing deletion of sY1161. The subject Ex4 is suffering from idiopathic infertility, showing deletion of sY95. The findings of this study indicated that the exposure of HCH may cause Yq deletions, possibly mediated through oxidative stress, resulting impaired human male reproductive functions. doi:10.1016/j.toxlet.2010.03.305
P105-012 National Poison Control Centre in Serbia: Current activities and challenges J. Jovic-Stosic, S. Vucinic, G. Babic, T. Rezic, O. Potrebic National Poison Control Centre, Military Medical Academy, Belgrade, Serbia The objective of this paper is to review the activities and challenges of Poison Control Centre in developing country, in order to exchange the experience and discuss major problems. National Poison Control Centre in Serbia exists for 12 years, and is consisted of informational, treatment, analytical, and experimental departments. It is covering the treatment of acute poisonings within the metropolitan area of about 2 million inhabitants, but is also opened for transfer of severe poisonings from the country and neighboring states (about 8 million inhabitants). The number of poisoning treated in the Centre increased within the last decade, from 2557 in 1999 to 4084 in 2008. Centre has an emergency room and the hospital part with intensive care unit. The vast majority of poisonings, mainly by alcohol and narcotics could be managed in the emergency room, and 25-30% of patients were admitted for hospital treatment. For the same area, Centre provides informational service. About 86% of calls were from medical doctors (more than 1/3 from pediatricians). The number of calls is small but is increasing constantly, as well as the ratio between the number of
S83
calls and the number persons transported to the Centre and, starting form 3% in 1999 to the 12% in 2008. It is the opposite situation comparing with western Poison Control Centres which report that about 10% of reported exposures need medical care. The reason for such low incidence of calls to our centre is probably not the lack of need for the advice, but rather lack of information on benefit from poison centre consultation. System of treatment of poisoning in our country needs improvements. To get maximum benefit from the system, more funding and efforts must be directed to the development, implementation and refinement of system of consultation and poisoning management on site. doi:10.1016/j.toxlet.2010.03.306
P105-013 The epidemiologyic study of suicide in north west of Iran E. Farzaneh 1 , I. Sayadrezai 1 , F. Nasl Seraji 1 , B. Mostafazadeh 2 Ardabil University of Medical Sciences, Ardabil, Iran, 2 Logman Poison Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
1
Objective: Suicide is an important problem for social safety and health. Recognizing some factors of risk forecasting after epidemiologic studies on people whom attempted to suicide could prepare and present outlines and proper guides for preventing by health and social planners. This research is purposed on suicide epidemiologic study to obtain full and enough data about deceased people by suicide has been accomplished in Ardebil province. Methods: The accomplished research is a descriptive and analytic sectional research which is based on all deceased people by suicide during 6 years, which their statistics have been registered in Bualy, Fatemi & Alavy hospitals and forensic medicine of Ardebil province. The used tool was created researcher form that included epidemiologic particular of deceased people. The data were analyzed using SPSS software version 13. Results: The highest rate of suicide had been belonged to age rank of 15–24 years (43.8%) and had occurred in female (62.5, %), married people (57.8%) urban society (65.6%) and patient without past chronic physical illness or psychiatric history and without preattempt suicide. Self-poisoning by drugs and toxins was the most common used method in this case (90.6%). Orderly among drugs and toxins organo-phosphorate toxin, tricyclic antidepressants and aluminum phosphid had been most used. Conclusion: This research is indicating various risk factors such as sex, age, marriage status, residing place of society and easy access to drugs and toxins. According to obtained results, it is better or proper to accomplished related education and training of preventation and interference of mental health in second and third decades of life with allocation of much time for females (especially the married people of this group). It is suggested that must be considered more attention to education, preventation, diagnosis and treatment of poisoning especially poisoning by most common drugs and toxins. doi:10.1016/j.toxlet.2010.03.307
P105-011 Analysis of Y chromosome microdeletion and altered sperm quality in subjects exposed to hexachlorocyclohexane (HCH) F.H. Khan, P. Ganesan, S. Kumar University of Lucknow, India Over the past few decades with the increasing effects of environmental factors, a remarkable drop in fertility rate of men has been observed all over the world. Therefore, we undertook a study to examine the relationship between environmental hexachlorocyclohexane (HCH) exposure and its reproductive potential. The study population was composed of 25 men with moderate exposure to HCH (farmers), 7 men highly exposed to HCH (living at dumping site of HCH) and 25 comparable controls with no such exposure history. The study parameters included recording of demographic characteristics, oxidative stress (GSH and MDA), Y chromosome deletions and semen quality. The mean blood HCH level was observed ∼3 times higher in exposed groups and ∼2 times higher in farmers as compared to the control. Malondialdehyde (MDA) levels, an endproduct of lipid peroxidation, were significantly higher while the antioxidant glutathione (GSH) levels were significantly lower in the exposed group as compared to the control group. We found three men with Yq deletion in AZFa and AZFc regions (5.55%) in exposed group. All subjects have normal semen quality except subject-F25 (Farmer) with 40% sperm motility (asthenospermic) without any Yq deletion and Ex7 (exposed group) with 20% sperm motility (severe asthenospermic), showing deletion of sY95, sY1161, sY1191 and sY1206 while Ex3 with normal semen quality, showing deletion of sY1161. The subject Ex4 is suffering from idiopathic infertility, showing deletion of sY95. The findings of this study indicated that the exposure of HCH may cause Yq deletions, possibly mediated through oxidative stress, resulting impaired human male reproductive functions. doi:10.1016/j.toxlet.2010.03.305
P105-012 National Poison Control Centre in Serbia: Current activities and challenges J. Jovic-Stosic, S. Vucinic, G. Babic, T. Rezic, O. Potrebic National Poison Control Centre, Military Medical Academy, Belgrade, Serbia The objective of this paper is to review the activities and challenges of Poison Control Centre in developing country, in order to exchange the experience and discuss major problems. National Poison Control Centre in Serbia exists for 12 years, and is consisted of informational, treatment, analytical, and experimental departments. It is covering the treatment of acute poisonings within the metropolitan area of about 2 million inhabitants, but is also opened for transfer of severe poisonings from the country and neighboring states (about 8 million inhabitants). The number of poisoning treated in the Centre increased within the last decade, from 2557 in 1999 to 4084 in 2008. Centre has an emergency room and the hospital part with intensive care unit. The vast majority of poisonings, mainly by alcohol and narcotics could be managed in the emergency room, and 25-30% of patients were admitted for hospital treatment. For the same area, Centre provides informational service. About 86% of calls were from medical doctors (more than 1/3 from pediatricians). The number of calls is small but is increasing constantly, as well as the ratio between the number of
S83
calls and the number persons transported to the Centre and, starting form 3% in 1999 to the 12% in 2008. It is the opposite situation comparing with western Poison Control Centres which report that about 10% of reported exposures need medical care. The reason for such low incidence of calls to our centre is probably not the lack of need for the advice, but rather lack of information on benefit from poison centre consultation. System of treatment of poisoning in our country needs improvements. To get maximum benefit from the system, more funding and efforts must be directed to the development, implementation and refinement of system of consultation and poisoning management on site. doi:10.1016/j.toxlet.2010.03.306
P105-013 The epidemiologyic study of suicide in north west of Iran E. Farzaneh 1 , I. Sayadrezai 1 , F. Nasl Seraji 1 , B. Mostafazadeh 2 Ardabil University of Medical Sciences, Ardabil, Iran, 2 Logman Poison Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
1
Objective: Suicide is an important problem for social safety and health. Recognizing some factors of risk forecasting after epidemiologic studies on people whom attempted to suicide could prepare and present outlines and proper guides for preventing by health and social planners. This research is purposed on suicide epidemiologic study to obtain full and enough data about deceased people by suicide has been accomplished in Ardebil province. Methods: The accomplished research is a descriptive and analytic sectional research which is based on all deceased people by suicide during 6 years, which their statistics have been registered in Bualy, Fatemi & Alavy hospitals and forensic medicine of Ardebil province. The used tool was created researcher form that included epidemiologic particular of deceased people. The data were analyzed using SPSS software version 13. Results: The highest rate of suicide had been belonged to age rank of 15–24 years (43.8%) and had occurred in female (62.5, %), married people (57.8%) urban society (65.6%) and patient without past chronic physical illness or psychiatric history and without preattempt suicide. Self-poisoning by drugs and toxins was the most common used method in this case (90.6%). Orderly among drugs and toxins organo-phosphorate toxin, tricyclic antidepressants and aluminum phosphid had been most used. Conclusion: This research is indicating various risk factors such as sex, age, marriage status, residing place of society and easy access to drugs and toxins. According to obtained results, it is better or proper to accomplished related education and training of preventation and interference of mental health in second and third decades of life with allocation of much time for females (especially the married people of this group). It is suggested that must be considered more attention to education, preventation, diagnosis and treatment of poisoning especially poisoning by most common drugs and toxins. doi:10.1016/j.toxlet.2010.03.307