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THE HIGH CVD MORTALITY PREVALENCE IN NOVOSIBIRSK POPULATION
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T-lymphocytes as well as on high sensitive C-reactive) protein (hs-CRP) known to be associated with EH. Method: 98 hypercholesterolemic patients with EH, aged from 47 to 68 years have been examined. Physiotens was given in a daily dose 0.4-0.8 mg for 6 months. Interleukin-2 (IL-2), IFN-gamma producing T helper (CD4+) and T suppressor (CD8+) lymphocytes from whole blood samples were determined by FACS-analysis. Plasma CRP levels were measured by high sensitivity method. Conclusion: The reduction of LDL cholesterol and hs-CRP may reflect atheroprotective effect of Physiotens. The global T-cell repertoire perturbation in EH is not affected by Physiotens treatment, which perhaps contributes to the safety profile of this drug. Results: hs-CRP levels as well as CD4+/IL-2+ and CD8+/IL-2+ lymphocytes were increased in EH patients (p < 0.01). After Physiotens therapy LDL cholesterol was reduced by 36.8± 15.9% (p < 0.001). The hs-CRP levels were significantly reduced after therapy from 2.26±1.8 to 1.04±0.3 mg/l; p < 0.001).CD4+/IL-2+ and CD8+/IL-2+ cells did not change after Physiotens therapy. 191
CORRELATIONS BETWEEN BLOOD PRESSURE AND LIPIDS
A. Lejnieks, A. Kalvelis, G. Bahs, I. Stukena, U. Teibe. Department of Internal Diseases,Riga Stradins University, Riga, Latvia Background: Elevated blood pressure (BP) and dyslipidemia are the most significant risk factors. In spite of their high prevalence, inter-correlations between these two risk factors have not been studied deeply enough, especially in relation to both sexes. Aim: Aim of study is to detect correlations between BP and lipids. Methods: We detected systolic blood pressure (SBP), diastolic blood pressure (DBP) and lipid profile in 773 outpatients (73% of which were women) and correlations of factors by using Pearson’s correlation coefficient (PCC). Results: Average age of patients was 55.6±14.4 years. Following mean values were obtained: SBP was 136,3±19,7 mmHg, DBP was 82.3±9,6 mmHg, total cholesterol (TC) 5.72±1.22 mmol/L, low-density lipoprotein cholesterol (LDLC) 3.58±1.03 mmol/L, high-density lipoprotein cholesterol (HDLC) 1.38±0.38 mmol/L and triglycerides (TG) 1.69±1.15 mmol/L. Inter-correlations among SBP, DBP and lipids (as of PCC) showed a positive significant correlation of TC, LDLC and TG with both SBP and DBP in the whole studied group, especially in women. There was a negative correlation of HDLC only with SBP. LDLC correlated with both BPs only in women, but not in men. TC in men correlated only with SBP. Only in women there was a negative correlation of HDLC with both SBP and DBP. Conclusion: There are significant correlations between BP and lipids, including differences among both sexes. Correlations between BP and lipids were more evident in women. Besides, only in women HDLC negatively correlated with BP and LDLC positively correlated with BP. 192
THE HIGH CVD MORTALITY PREVALENCE IN NOVOSIBIRSK POPULATION
Yu. Nikitin, G.I. Simonova, O.M. Glushanina, L.V. Sherbakova. Institute of Internal Medicine SB RAMN, Novosibirsk, Russia Aim: To estimate the dynamics of high risk of fatal CVD in Novosibirsk population during the period 1985-2005 years. Methods and materials: Risk of fatal CVD was estimated according the SCORE scale on the basis of data of three periods: 1984-1985– 1421 subjects, 1994-1995 – 1572 subjects, 2003-2005 – 6562 subjects (age group 45-64 years old). We marked out three risk levels: low - <1%, medium 2-4%, high - >5%. Subjects with previous CVD and diabetes of I or II type (CPGTE, 2003) were considered to have high risk of CVD mortality. Results: The prevalence of high risk in men prevailed compared with other gradations; significant part of women had low risk in all periods of the study. The prevalence of high and medium risks gradations in men were higher then in women. During the period 2003-2005 y the prevalence of high risk in men significantly increased ompared to the period of mid-80s and mid-90s (51%, 36%, 38%, accordingly, p<0,001). The revalence of high risk in women wasn’t higher 10% during all periods and didn’t change for 20 years. During the whole period (20 years) increased the part of women with medium risk (23%- in 1985 and 29% - in 2005).
Conclusion: Thus, during the period of 20 years increased the prevalence of high risk gradations of CVD mortality in men, and medium risk in women. 193
THE RELATIONSHIP BETWEEN MEAN PLATELET VOLUME AND SERUM IL-6 LEVELS IN TYPE 2 DIABETIC PATIENTS AFTER SURGICAL OPERATION
H. Terekeci 1 , C. Top 1 , B. Sahan 1 , M.E. Onde 2 , A.K. Gurbuz 1 . 1 Internal Medicine, GATA Haydarpasa Training Hospital, Istanbul, Turkey; 2 Endocrinology and Metabolism, GATA Haydarpasa Training Hospital, Istanbul, Turkey Background and aims: To evaluate the relationship between mean platelet volume (MPV) and serum IL-6 levels in type 2 diabetic patients after surgical operation. Methods: Twenty-five type 2 diabetic patients (aged 60.2±12.4 years) and 14 non-diabetic controls (aged 51.4±16.8 years) with gall-bladder disease who are operated were enrolled in the study. Before and after the operation, all subjects underwent a diagnostic protocol including serum IL-6 and platelets index analysis. Results: The study results showed that there were statistically significant difference between study patients (type 2 diabetic patients) and healthy control subjects in accordance to HOMA scores (4.5±3.0 vs 1.3±0.6, p<0.001), QUICKI scores (0.55±0.3 vs 0.69± 0.1, p<0.001), post-operative IL-6 levels (122.1±148.7 ng/dl vs 38.4±41.8 ng/dl, p<0.05). There were no statistically significant difference between study patients and control subjects in accordance to pre-op MPV (8.5±1.3 fL vs 8.6±0.9 fL, p>0.05), post-op MPV (8.8±1.3 fL vs 9.2±1.4 fL, p>0.05), pre-op IL-6 levels (9.6±12.4 ng/dl vs 6.7±6.9 ng/dl, p>0.05). There was a statistically significant correlation between post-op MPV and serum IL-6 levels (r=0,42, p<0,01). There was no statistically significant correlation between pre-op MPV and serum IL-6 levels (r=-0,12, p>0,05). Conclusions: These results have shown that there was a relationship between platelet morphology changes and pro-inflammatory state due to surgical operation. This relationship may be important for developing vascular complications after surgery in diabetic patients. 194
EFFECT OF RIMONABANT ON WEIGHT LOSS IN OVERWEIGHT PATIENTS WITH SLEEP APNEA SYNDROME
A. Vasiliou, E. Daskalopoulou, D. Kosmidis, C. Magnis, N. Michailidis, T. Hainopoulou, E. Vlachogiannis. Sleep Laboratory, Department of Internal Medicine, “St Paul” General Hospital, Thessaloniki, Greece Objectives: Obesity is one of the reasons for obstructive sleep apnea syndrome (OSAS). Treatment with continuous positive airway pressure (CPAP) may be associated with changes in leptin and BMI levels. However in many patients severe or very obesity, is not regulated by CPAP therapy. Among drugs, rimonabant has been increasingly used in the management of obesity. We aimed to assess the action of rimonabant to overweight patients with OSAS. Subjects and Methods: Twenty-four overweight OSAS patients, 9 males and 15 females, aged 42 to 54 years with BMI 37 to 43 kg/m2 were investigated. OSAS was estimated by polysomnography with an apnea-hypopnea cut off- point index more than 10 apneas-hypopneas per hour. All of them were on CPAP therapy. Results: At three months after rimonabant granting, it was observed a reduction of weight, 102.98±15.97 vs 112.38±18.54, BMI, 37.44±5.11 vs 40.21±5.61, waist, 111.78±30.36 vs 124.80±12.42, and hip, 121.94±9.37 vs 128.22±10.18, p<0.05. However significant was the difference between the first and the last value of weight, p<0.000, BMI, p<0.000, waist, p<0.000 and hip, p<0.000. It was not observed adverse events with an incidence of 5%. Conclusions: According to these results, rimonabant guide to weight loss in severe or very severe overweight OSAS patients.
77th Congress of the European Atherosclerosis Society, April 26–29, 2008, Istanbul, Turkey
Publication Only
T-lymphocytes as well as on high sensitive C-reactive) protein (hs-CRP) known to be associated with EH. Method: 98 hypercholesterolemic patients with EH, aged from 47 to 68 years have been examined. Physiotens was given in a daily dose 0.4-0.8 mg for 6 months. Interleukin-2 (IL-2), IFN-gamma producing T helper (CD4+) and T suppressor (CD8+) lymphocytes from whole blood samples were determined by FACS-analysis. Plasma CRP levels were measured by high sensitivity method. Conclusion: The reduction of LDL cholesterol and hs-CRP may reflect atheroprotective effect of Physiotens. The global T-cell repertoire perturbation in EH is not affected by Physiotens treatment, which perhaps contributes to the safety profile of this drug. Results: hs-CRP levels as well as CD4+/IL-2+ and CD8+/IL-2+ lymphocytes were increased in EH patients (p < 0.01). After Physiotens therapy LDL cholesterol was reduced by 36.8± 15.9% (p < 0.001). The hs-CRP levels were significantly reduced after therapy from 2.26±1.8 to 1.04±0.3 mg/l; p < 0.001).CD4+/IL-2+ and CD8+/IL-2+ cells did not change after Physiotens therapy. 191
CORRELATIONS BETWEEN BLOOD PRESSURE AND LIPIDS
A. Lejnieks, A. Kalvelis, G. Bahs, I. Stukena, U. Teibe. Department of Internal Diseases,Riga Stradins University, Riga, Latvia Background: Elevated blood pressure (BP) and dyslipidemia are the most significant risk factors. In spite of their high prevalence, inter-correlations between these two risk factors have not been studied deeply enough, especially in relation to both sexes. Aim: Aim of study is to detect correlations between BP and lipids. Methods: We detected systolic blood pressure (SBP), diastolic blood pressure (DBP) and lipid profile in 773 outpatients (73% of which were women) and correlations of factors by using Pearson’s correlation coefficient (PCC). Results: Average age of patients was 55.6±14.4 years. Following mean values were obtained: SBP was 136,3±19,7 mmHg, DBP was 82.3±9,6 mmHg, total cholesterol (TC) 5.72±1.22 mmol/L, low-density lipoprotein cholesterol (LDLC) 3.58±1.03 mmol/L, high-density lipoprotein cholesterol (HDLC) 1.38±0.38 mmol/L and triglycerides (TG) 1.69±1.15 mmol/L. Inter-correlations among SBP, DBP and lipids (as of PCC) showed a positive significant correlation of TC, LDLC and TG with both SBP and DBP in the whole studied group, especially in women. There was a negative correlation of HDLC only with SBP. LDLC correlated with both BPs only in women, but not in men. TC in men correlated only with SBP. Only in women there was a negative correlation of HDLC with both SBP and DBP. Conclusion: There are significant correlations between BP and lipids, including differences among both sexes. Correlations between BP and lipids were more evident in women. Besides, only in women HDLC negatively correlated with BP and LDLC positively correlated with BP. 192
THE HIGH CVD MORTALITY PREVALENCE IN NOVOSIBIRSK POPULATION
Yu. Nikitin, G.I. Simonova, O.M. Glushanina, L.V. Sherbakova. Institute of Internal Medicine SB RAMN, Novosibirsk, Russia Aim: To estimate the dynamics of high risk of fatal CVD in Novosibirsk population during the period 1985-2005 years. Methods and materials: Risk of fatal CVD was estimated according the SCORE scale on the basis of data of three periods: 1984-1985– 1421 subjects, 1994-1995 – 1572 subjects, 2003-2005 – 6562 subjects (age group 45-64 years old). We marked out three risk levels: low - <1%, medium 2-4%, high - >5%. Subjects with previous CVD and diabetes of I or II type (CPGTE, 2003) were considered to have high risk of CVD mortality. Results: The prevalence of high risk in men prevailed compared with other gradations; significant part of women had low risk in all periods of the study. The prevalence of high and medium risks gradations in men were higher then in women. During the period 2003-2005 y the prevalence of high risk in men significantly increased ompared to the period of mid-80s and mid-90s (51%, 36%, 38%, accordingly, p<0,001). The revalence of high risk in women wasn’t higher 10% during all periods and didn’t change for 20 years. During the whole period (20 years) increased the part of women with medium risk (23%- in 1985 and 29% - in 2005).
Conclusion: Thus, during the period of 20 years increased the prevalence of high risk gradations of CVD mortality in men, and medium risk in women. 193
THE RELATIONSHIP BETWEEN MEAN PLATELET VOLUME AND SERUM IL-6 LEVELS IN TYPE 2 DIABETIC PATIENTS AFTER SURGICAL OPERATION
H. Terekeci 1 , C. Top 1 , B. Sahan 1 , M.E. Onde 2 , A.K. Gurbuz 1 . 1 Internal Medicine, GATA Haydarpasa Training Hospital, Istanbul, Turkey; 2 Endocrinology and Metabolism, GATA Haydarpasa Training Hospital, Istanbul, Turkey Background and aims: To evaluate the relationship between mean platelet volume (MPV) and serum IL-6 levels in type 2 diabetic patients after surgical operation. Methods: Twenty-five type 2 diabetic patients (aged 60.2±12.4 years) and 14 non-diabetic controls (aged 51.4±16.8 years) with gall-bladder disease who are operated were enrolled in the study. Before and after the operation, all subjects underwent a diagnostic protocol including serum IL-6 and platelets index analysis. Results: The study results showed that there were statistically significant difference between study patients (type 2 diabetic patients) and healthy control subjects in accordance to HOMA scores (4.5±3.0 vs 1.3±0.6, p<0.001), QUICKI scores (0.55±0.3 vs 0.69± 0.1, p<0.001), post-operative IL-6 levels (122.1±148.7 ng/dl vs 38.4±41.8 ng/dl, p<0.05). There were no statistically significant difference between study patients and control subjects in accordance to pre-op MPV (8.5±1.3 fL vs 8.6±0.9 fL, p>0.05), post-op MPV (8.8±1.3 fL vs 9.2±1.4 fL, p>0.05), pre-op IL-6 levels (9.6±12.4 ng/dl vs 6.7±6.9 ng/dl, p>0.05). There was a statistically significant correlation between post-op MPV and serum IL-6 levels (r=0,42, p<0,01). There was no statistically significant correlation between pre-op MPV and serum IL-6 levels (r=-0,12, p>0,05). Conclusions: These results have shown that there was a relationship between platelet morphology changes and pro-inflammatory state due to surgical operation. This relationship may be important for developing vascular complications after surgery in diabetic patients. 194
EFFECT OF RIMONABANT ON WEIGHT LOSS IN OVERWEIGHT PATIENTS WITH SLEEP APNEA SYNDROME
A. Vasiliou, E. Daskalopoulou, D. Kosmidis, C. Magnis, N. Michailidis, T. Hainopoulou, E. Vlachogiannis. Sleep Laboratory, Department of Internal Medicine, “St Paul” General Hospital, Thessaloniki, Greece Objectives: Obesity is one of the reasons for obstructive sleep apnea syndrome (OSAS). Treatment with continuous positive airway pressure (CPAP) may be associated with changes in leptin and BMI levels. However in many patients severe or very obesity, is not regulated by CPAP therapy. Among drugs, rimonabant has been increasingly used in the management of obesity. We aimed to assess the action of rimonabant to overweight patients with OSAS. Subjects and Methods: Twenty-four overweight OSAS patients, 9 males and 15 females, aged 42 to 54 years with BMI 37 to 43 kg/m2 were investigated. OSAS was estimated by polysomnography with an apnea-hypopnea cut off- point index more than 10 apneas-hypopneas per hour. All of them were on CPAP therapy. Results: At three months after rimonabant granting, it was observed a reduction of weight, 102.98±15.97 vs 112.38±18.54, BMI, 37.44±5.11 vs 40.21±5.61, waist, 111.78±30.36 vs 124.80±12.42, and hip, 121.94±9.37 vs 128.22±10.18, p<0.05. However significant was the difference between the first and the last value of weight, p<0.000, BMI, p<0.000, waist, p<0.000 and hip, p<0.000. It was not observed adverse events with an incidence of 5%. Conclusions: According to these results, rimonabant guide to weight loss in severe or very severe overweight OSAS patients.
77th Congress of the European Atherosclerosis Society, April 26–29, 2008, Istanbul, Turkey