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The hormonal functions of granulosa cell tumors
!Wi
ABSTRACTS
content in the blood and in two an inronstant prolan secretion in the vomitus. At the time the vomiting ceased there was a rise in the prolan content of the urinra in three cases aud a fall in the prolan coutent of the blood serum in two. Ill control cases the urine and blood serum of pregnant women showed normal proIan contents.
The Hormonal Dworzack and Poleschka: Arch. f. GynLk. 154: 441, 1933.
Functions
of Granulosa
Cell Tumors,
Hypertrophy of the endometrium and myometrium together with metrorrhagia Th! and breast hypertrophy are frequently found with granulosa cell turnore. endometrial change is usually a glandular cystic hyperplasia and is praVticallJ always present. Occasionally a deeitlua-like change is found. Such changes must be due to hormonal activity of these tumow. The aut.hors were unable to find any definite anterior hypophysis reaction but found that the elimination of the% follicular hormone jumped from 2 to 3 units per liter of urine during the intermenstrual period of 50 units per liter when grauulosa cell tumors were present. Such a byperhormonal state produces the uterine enlargement and the endometrial hyperplasia. The corpus luteum hormone is also prol~ahlp prc~duced, since, thcrcl is occasionally a decidua formation. The authors believe that it will soon be possible to diagnose granulosa cell tumors before operation. They believe that frozen sections should be made whenever this type of tumor is suspected or diagnosed during operation, in order that a radical operation may be performed if this type of tumor is diagnosrtl. l‘hc; question of recurrences following operation and postoperative irradiation ~:an bc determined by examination8 for the hormones p~~oduced lrp the tumor.
Bergstrand, Seandinav.
H. : The Nature
of Virilizing
Ovarian
Tumors, dcta
obst.
et gyut~.
13: 336, 193-L
The author describes ovarian tumors in 4 cases of hirsutism from his 0~1 serie!* and he also microscopically examined the two cases reported by Berner and Strass, mann. In two of his own cases he proved the growth to be a folliculoma or il especially as the strands of tumor cells form bodies re granulosa cell tumor, sembling atretic follicles. On the basis of these two cases, be made a histologic analysis of the four others, and came to the conclusion that the.y are fundamcntall~ of the same nature. In one of theni, hc found an unmistakable ovum in thts center of the large mass of malignant tumor tissue. Besides ovarian elements, grarmlosa and lutein cells, cysts lined with columnar epithelimn and containing mucus tl~curred in 3 c&see. In 3 cases these cysts were quite distinct from the ovari;ru elements of the tumor. He therefore considers these tumors to be a. combined malformation of the germinal epithelium of the mesone.pbros and of Wolff’s durt or Mueller’s duct. From t.he clinical point of view it is interesting tu note that, these tumors, which miscroscopically are shaped like ovaries, often show nlitosis and others signs of rapid growth, but nevertheless are as a rule clinically benigx if removed in time. In one of the author ‘S casts, howcvcsr, the patient d&1 ?‘J.III:I extensive metastases of the peritoneum. The microscopic examination gives ‘no clue wht~ther thp active hormone is lug*duced by the granulosa or the lutein cells of tbe tumor. The investigations of Steinach and Kun, who in 1931 were able to clemonstrate. the viriljzjng effect oa guinea pigs of corpus luteum extract, seem to indicate that this secaretion is :, func2. tion of the lutein V,ells.
ABSTRACTS
content in the blood and in two an inronstant prolan secretion in the vomitus. At the time the vomiting ceased there was a rise in the prolan content of the urinra in three cases aud a fall in the prolan coutent of the blood serum in two. Ill control cases the urine and blood serum of pregnant women showed normal proIan contents.
The Hormonal Dworzack and Poleschka: Arch. f. GynLk. 154: 441, 1933.
Functions
of Granulosa
Cell Tumors,
Hypertrophy of the endometrium and myometrium together with metrorrhagia Th! and breast hypertrophy are frequently found with granulosa cell turnore. endometrial change is usually a glandular cystic hyperplasia and is praVticallJ always present. Occasionally a deeitlua-like change is found. Such changes must be due to hormonal activity of these tumow. The aut.hors were unable to find any definite anterior hypophysis reaction but found that the elimination of the% follicular hormone jumped from 2 to 3 units per liter of urine during the intermenstrual period of 50 units per liter when grauulosa cell tumors were present. Such a byperhormonal state produces the uterine enlargement and the endometrial hyperplasia. The corpus luteum hormone is also prol~ahlp prc~duced, since, thcrcl is occasionally a decidua formation. The authors believe that it will soon be possible to diagnose granulosa cell tumors before operation. They believe that frozen sections should be made whenever this type of tumor is suspected or diagnosed during operation, in order that a radical operation may be performed if this type of tumor is diagnosrtl. l‘hc; question of recurrences following operation and postoperative irradiation ~:an bc determined by examination8 for the hormones p~~oduced lrp the tumor.
Bergstrand, Seandinav.
H. : The Nature
of Virilizing
Ovarian
Tumors, dcta
obst.
et gyut~.
13: 336, 193-L
The author describes ovarian tumors in 4 cases of hirsutism from his 0~1 serie!* and he also microscopically examined the two cases reported by Berner and Strass, mann. In two of his own cases he proved the growth to be a folliculoma or il especially as the strands of tumor cells form bodies re granulosa cell tumor, sembling atretic follicles. On the basis of these two cases, be made a histologic analysis of the four others, and came to the conclusion that the.y are fundamcntall~ of the same nature. In one of theni, hc found an unmistakable ovum in thts center of the large mass of malignant tumor tissue. Besides ovarian elements, grarmlosa and lutein cells, cysts lined with columnar epithelimn and containing mucus tl~curred in 3 c&see. In 3 cases these cysts were quite distinct from the ovari;ru elements of the tumor. He therefore considers these tumors to be a. combined malformation of the germinal epithelium of the mesone.pbros and of Wolff’s durt or Mueller’s duct. From t.he clinical point of view it is interesting tu note that, these tumors, which miscroscopically are shaped like ovaries, often show nlitosis and others signs of rapid growth, but nevertheless are as a rule clinically benigx if removed in time. In one of the author ‘S casts, howcvcsr, the patient d&1 ?‘J.III:I extensive metastases of the peritoneum. The microscopic examination gives ‘no clue wht~ther thp active hormone is lug*duced by the granulosa or the lutein cells of tbe tumor. The investigations of Steinach and Kun, who in 1931 were able to clemonstrate. the viriljzjng effect oa guinea pigs of corpus luteum extract, seem to indicate that this secaretion is :, func2. tion of the lutein V,ells.