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The impact of 12-week aquatic exercise on lipid and renal parameters in chronic renal failure patients
Pedro
RPSA > 0.I7
RPSA <0.I7
p
from 4,17 to 3,89 and triglycerides from 2.34 to 2.25. OxS parameters remained almost unchanged. We conclude that regular low-intensity aquatic exercise can due to abovementioned beneficial effects be included into the rehabilitation programs for CRY pts.
II9±46 mg/dl I84±62 mg/dl
I07±28 mg/dl I62±28 mg/dl
p 0.0I p 0.0I
~-~
either group. Patients with acute bacterial prostatitis excepted. All results were analyzed in the same laboratory before transfusion therapy. Results:
LDL-C: TC
183
Conclusion: The aim of this study was that the TC and LDL-C levels in patients with cancer prostate (RPSA <0.17) are decreased statistically significantly.
ECHOTOMOGRAPHIC CAROTID B-MODE ULTRASOUND (ECBUS) IN ASSESSMENT OF CAROTID ATHEROSCLEROSIS IN PATIENTS W I T H CORONARY ARTERY DISEASE (CAD)
E. Pedro, J. Baptista, I. Tareco, J. Ferreira, S. Comes. Instituto do Coracao,
H. Santa Cruz, Carnaxide, Portugal ~-~THE LIPID PROFILE OF PATIENTS W I T H LATTER HAEMORRHAGE FROM THE UPPER GASTROINTESTINAL TRACT S. Paximadas, S. Pagoni, A. Efstratopoulos, N. Sakarelou, E. Liatzoura, A. Chantzis. General Hospital of Athens 'Elpis" , Athens, Greece Purpose: The study of lipid profile in patients with latter haemorrhage from esophagus, stomach or duodenum. M a t e r i a l a n d M e t h o d s : 114 inpatients with latter acute haemorrhage from the upper gastrointestinal tract (46 females and 68 males) aged 69±11 years (45 90 years) were studied. Total Cholesterol (TC), Triglycerides (TG), HDL Cholesterol (HDL-C), LDL Cholesterol (LDL-C), Haemoglobin (Hb), Haematocrit (Ht) and Platelets (PLT) levels from all patients were measured. The most common causes of upper gastrointestinal tract haemorrhage due to erosive/haemorrhage gastric disease from nonsteroidal anti-inflammatory agents and gastric or duodenal ulcer disease. Endoscopy in used in all patients. Patients with chronic active liver disease, haematemesis from esophageal varices, stomach malignancy or telangiectasias and anticoagulated drugs excluded. Serum lipid levels from all patients (Group A) compared to 104 random controls (Group B). All results were analyzed in the same laboratory before transfusion therapy. Results: Group A TC 154±40 (81 277), TG 117±69 (42 334), HDL-C 38±20 (21~62), LDL-C 98±31 (39 192) (mg/dl), Group B TC 219±15 (180240), TG 117±22 (65 147), HDL-C 46±7 (36 59), LDL-C 150±11 (116 160) (mg/dl), TC p-0.0001, TG p-0.3, HDL-C p-0.0001, LDL-C p-0.0001. From Group A the effects were: Ht-31,5±6 (19M4)%, Hb-10,3±2 (5,3 14,3) g/dl, INR-1,2±0,13 (1,06 1,66), Fibrinogen-287±92 (143 576) mg/dl and Protein C-91,1±25,4 (29,6 144,3) %. Conclusion: The study shows that the TC, HDL-C and LDL-C levels in patients with latter haemorrhage from upper gastrointestinal tract are decreased statistically significant compared to the general population.
~4--~ THE IMPACT OF 12-WEEK AQUATIC EXERCISE ON LIPID AND RENAL PARAMETERS IN CHRONIC RENAL FAILURE PATIENTS Y. Pechter 1, J. Maaroos 1, S. Mesikepp 2, A. Veraksits 1, M. Ots 2.
JDepartment of Sports Medicine and Rehabilitation, 2Department of Internal Medicine, Tartu University, Estonia Regular exercise is often recommended as an important part of the rehabilitation therapy. We presumed that individually dosed aquatic exercise training could be an effective method for CRY patients retarding the progression of premature athero- and glomerulosclerosis. Therefore, we investigated lipid, oxidative stress (OxS), cardiorespiratory and renal parameters in exercising CRY pts group. 9 pts exercised vertically in water pool 2 times per week 30 minutes involving rhythmic movements with joints and body during 12 weeks. Serum creatinine, urea, Cystatin C, cholesterol, HDL/LDL-cholesterol, triglycerides, oxidative stress parameters, cardiorespiratory parameters and urinary protein excretion were measured before and after the program. Products of LPO were detected together with markers of antioxidant status (concentrations of total glutathione incl. reduced and oxidized forms: tGSH-GSH+GSSG). Overall exercise capacity measured as peak oxygen uptake ml/kg/min (VO2 max). Results showed that six of nine pts improved their cardiorespiratory functional capacity. Renal functional parameters showed also an improvement: 24 h proteinuria (g/24h) diminished significantly: from 0.76 before to 0,125 after the study (p-0,002) and mean Cystatin C (mg/1) level decreased from 3,89 1.69 to 1.36 (p<0,05). Tendency of the improvement of lipid parameters (mmol/1) was noticed as well: serum cholesterol from 6.55 before to 6.16after the program, LDL-cholesterol
Atherosclerosis is a systemic disease evolved different arteries. A i m of Study: Using ECBUS in patients with CAD by coronary angiographic exam to screen carotid artery disease. M e t h o d s : Between May 2000 and November 2000, 38 patients with CAD were enrolled, 79% male with an average age of 65 years old. 74% were hypercholesterolemia, 61% had arterial hypertension, 26% had smoking habits, 21% were diabetic, 29% had familial history of atherosclerosis, 13% had risk levels HI)L- cholesterol and 8% were hypertriglyceridemic. The Body Mass Index (B.M.I.) was 27.6 Kg/m2 and 18% of the patients had BMI greater than 30 kg/m2 and 66% had BMI greater than 25 and below 30 kg/m2. ECBUS were performed with transducer 10 MHz (Biosound). We studied: intima-media thickness (IMT) measured in common carotid artery, the screen and the echogenic pattern study and the maximum thickness of atheroma plaques (MT). Results: IMT was 0.86 mm in fight carotid artery and 0.85 mm in left carotid artery. 82% had atheroma plaques (2.45 plaques per patient). MT was 2.38 mm in left carotid artery and 2.38 mm in right carotid artery. Echogenic pattern showed: 17% of patients had not fibrous plaques, 33% had fibrous plaques, 13% had mixtes plaques and 37% had plaques with calcifications. Conclusions: 1. Patients with CAD had higher prevalence of carotid artery disease. 2.2/3 of patients had carotid atheroma plaques with characteristic pattern to develop thrombotic complications. 3. Patients with CAD must make ECBUS.
•
RESULTS OF LONG-TERM TREATMENT OF HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA (FH) CHILD W I T H DEXTRAN SULPHATE ADSORPTION. PORTUGUESE EXPERIENCE
E. Pedro 1, G. Ribeiro 1, P. Ramos 1, Z. Costa 1, A. Gaddi 2, R. Fellin3, M. Pals 1, S. Gomes 1. Jlnstituto do Coracao, H. Santa Cruz, Carnaxide,
Portugal," 2Universita Degli Studi di Bologna," 3Universit~ Degli Studi di Ferrara, Italy FH is a rare form of altered lipoprotein metabolism with a high risk of myocardial infarction and other severe manifestation of cerebral and peripheral vascular atherosclerosis. Mabuchi et al. described the use of the twin small dextran sulphate cellulose columns (DSC/LDL-A). Patient: D.R. 13 years old boy, exuberant xathomas, total cholesterol (T-chol) between 1000 1300 mg/dl. Patient' s skin fibroblasts were 0% LDLreceptor activity. M e t h o d s : The patient was treated with DSC/LDL-A (Liposorber LA-15) twice every month since July 96 until July 01 (125 treatments). Each year of treatment Cardiac Eco-Doppler (CED) and Echotomographic Carotid B-Mode Ultrasound (ECBUS) were performed. Coronary angiography was performed before and after to years of treatment. Results: We observed a reduction of 69.6% T-Chol, 65.5% TG, 23.2% T-HDL, 23.3% Apo A1, 67.5% Apo B, 68.1% Lp (a), and 41.8% FB. Coronary angiography showed no coronary artery disease. After 5 years of CED showed aortic gradient <20 mm Hg but with insufficiency aortic grade I ~ I and a significant reduction of aortic walls thickness and the ECBUS shoed no evidence of a significant progression of a little fatty plaque which was observed in bifurcation of left common carotid artery after 2 years of treatment the xanthomata skin and tendons were resolved. Conclusions: 1. DSC/LDL-A was confirmed to be an effective and safe treatment for homozygous FH. 2. The regression of skin and tendons xanthomas was observed after a short-term treatment. 3. In a homozygous FH child no significant progression of atheriosclerosis was observed after a long-term of DSC/LDL-A.
73rd EAS Congress
RPSA > 0.I7
RPSA <0.I7
p
from 4,17 to 3,89 and triglycerides from 2.34 to 2.25. OxS parameters remained almost unchanged. We conclude that regular low-intensity aquatic exercise can due to abovementioned beneficial effects be included into the rehabilitation programs for CRY pts.
II9±46 mg/dl I84±62 mg/dl
I07±28 mg/dl I62±28 mg/dl
p 0.0I p 0.0I
~-~
either group. Patients with acute bacterial prostatitis excepted. All results were analyzed in the same laboratory before transfusion therapy. Results:
LDL-C: TC
183
Conclusion: The aim of this study was that the TC and LDL-C levels in patients with cancer prostate (RPSA <0.17) are decreased statistically significantly.
ECHOTOMOGRAPHIC CAROTID B-MODE ULTRASOUND (ECBUS) IN ASSESSMENT OF CAROTID ATHEROSCLEROSIS IN PATIENTS W I T H CORONARY ARTERY DISEASE (CAD)
E. Pedro, J. Baptista, I. Tareco, J. Ferreira, S. Comes. Instituto do Coracao,
H. Santa Cruz, Carnaxide, Portugal ~-~THE LIPID PROFILE OF PATIENTS W I T H LATTER HAEMORRHAGE FROM THE UPPER GASTROINTESTINAL TRACT S. Paximadas, S. Pagoni, A. Efstratopoulos, N. Sakarelou, E. Liatzoura, A. Chantzis. General Hospital of Athens 'Elpis" , Athens, Greece Purpose: The study of lipid profile in patients with latter haemorrhage from esophagus, stomach or duodenum. M a t e r i a l a n d M e t h o d s : 114 inpatients with latter acute haemorrhage from the upper gastrointestinal tract (46 females and 68 males) aged 69±11 years (45 90 years) were studied. Total Cholesterol (TC), Triglycerides (TG), HDL Cholesterol (HDL-C), LDL Cholesterol (LDL-C), Haemoglobin (Hb), Haematocrit (Ht) and Platelets (PLT) levels from all patients were measured. The most common causes of upper gastrointestinal tract haemorrhage due to erosive/haemorrhage gastric disease from nonsteroidal anti-inflammatory agents and gastric or duodenal ulcer disease. Endoscopy in used in all patients. Patients with chronic active liver disease, haematemesis from esophageal varices, stomach malignancy or telangiectasias and anticoagulated drugs excluded. Serum lipid levels from all patients (Group A) compared to 104 random controls (Group B). All results were analyzed in the same laboratory before transfusion therapy. Results: Group A TC 154±40 (81 277), TG 117±69 (42 334), HDL-C 38±20 (21~62), LDL-C 98±31 (39 192) (mg/dl), Group B TC 219±15 (180240), TG 117±22 (65 147), HDL-C 46±7 (36 59), LDL-C 150±11 (116 160) (mg/dl), TC p-0.0001, TG p-0.3, HDL-C p-0.0001, LDL-C p-0.0001. From Group A the effects were: Ht-31,5±6 (19M4)%, Hb-10,3±2 (5,3 14,3) g/dl, INR-1,2±0,13 (1,06 1,66), Fibrinogen-287±92 (143 576) mg/dl and Protein C-91,1±25,4 (29,6 144,3) %. Conclusion: The study shows that the TC, HDL-C and LDL-C levels in patients with latter haemorrhage from upper gastrointestinal tract are decreased statistically significant compared to the general population.
~4--~ THE IMPACT OF 12-WEEK AQUATIC EXERCISE ON LIPID AND RENAL PARAMETERS IN CHRONIC RENAL FAILURE PATIENTS Y. Pechter 1, J. Maaroos 1, S. Mesikepp 2, A. Veraksits 1, M. Ots 2.
JDepartment of Sports Medicine and Rehabilitation, 2Department of Internal Medicine, Tartu University, Estonia Regular exercise is often recommended as an important part of the rehabilitation therapy. We presumed that individually dosed aquatic exercise training could be an effective method for CRY patients retarding the progression of premature athero- and glomerulosclerosis. Therefore, we investigated lipid, oxidative stress (OxS), cardiorespiratory and renal parameters in exercising CRY pts group. 9 pts exercised vertically in water pool 2 times per week 30 minutes involving rhythmic movements with joints and body during 12 weeks. Serum creatinine, urea, Cystatin C, cholesterol, HDL/LDL-cholesterol, triglycerides, oxidative stress parameters, cardiorespiratory parameters and urinary protein excretion were measured before and after the program. Products of LPO were detected together with markers of antioxidant status (concentrations of total glutathione incl. reduced and oxidized forms: tGSH-GSH+GSSG). Overall exercise capacity measured as peak oxygen uptake ml/kg/min (VO2 max). Results showed that six of nine pts improved their cardiorespiratory functional capacity. Renal functional parameters showed also an improvement: 24 h proteinuria (g/24h) diminished significantly: from 0.76 before to 0,125 after the study (p-0,002) and mean Cystatin C (mg/1) level decreased from 3,89 1.69 to 1.36 (p<0,05). Tendency of the improvement of lipid parameters (mmol/1) was noticed as well: serum cholesterol from 6.55 before to 6.16after the program, LDL-cholesterol
Atherosclerosis is a systemic disease evolved different arteries. A i m of Study: Using ECBUS in patients with CAD by coronary angiographic exam to screen carotid artery disease. M e t h o d s : Between May 2000 and November 2000, 38 patients with CAD were enrolled, 79% male with an average age of 65 years old. 74% were hypercholesterolemia, 61% had arterial hypertension, 26% had smoking habits, 21% were diabetic, 29% had familial history of atherosclerosis, 13% had risk levels HI)L- cholesterol and 8% were hypertriglyceridemic. The Body Mass Index (B.M.I.) was 27.6 Kg/m2 and 18% of the patients had BMI greater than 30 kg/m2 and 66% had BMI greater than 25 and below 30 kg/m2. ECBUS were performed with transducer 10 MHz (Biosound). We studied: intima-media thickness (IMT) measured in common carotid artery, the screen and the echogenic pattern study and the maximum thickness of atheroma plaques (MT). Results: IMT was 0.86 mm in fight carotid artery and 0.85 mm in left carotid artery. 82% had atheroma plaques (2.45 plaques per patient). MT was 2.38 mm in left carotid artery and 2.38 mm in right carotid artery. Echogenic pattern showed: 17% of patients had not fibrous plaques, 33% had fibrous plaques, 13% had mixtes plaques and 37% had plaques with calcifications. Conclusions: 1. Patients with CAD had higher prevalence of carotid artery disease. 2.2/3 of patients had carotid atheroma plaques with characteristic pattern to develop thrombotic complications. 3. Patients with CAD must make ECBUS.
•
RESULTS OF LONG-TERM TREATMENT OF HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA (FH) CHILD W I T H DEXTRAN SULPHATE ADSORPTION. PORTUGUESE EXPERIENCE
E. Pedro 1, G. Ribeiro 1, P. Ramos 1, Z. Costa 1, A. Gaddi 2, R. Fellin3, M. Pals 1, S. Gomes 1. Jlnstituto do Coracao, H. Santa Cruz, Carnaxide,
Portugal," 2Universita Degli Studi di Bologna," 3Universit~ Degli Studi di Ferrara, Italy FH is a rare form of altered lipoprotein metabolism with a high risk of myocardial infarction and other severe manifestation of cerebral and peripheral vascular atherosclerosis. Mabuchi et al. described the use of the twin small dextran sulphate cellulose columns (DSC/LDL-A). Patient: D.R. 13 years old boy, exuberant xathomas, total cholesterol (T-chol) between 1000 1300 mg/dl. Patient' s skin fibroblasts were 0% LDLreceptor activity. M e t h o d s : The patient was treated with DSC/LDL-A (Liposorber LA-15) twice every month since July 96 until July 01 (125 treatments). Each year of treatment Cardiac Eco-Doppler (CED) and Echotomographic Carotid B-Mode Ultrasound (ECBUS) were performed. Coronary angiography was performed before and after to years of treatment. Results: We observed a reduction of 69.6% T-Chol, 65.5% TG, 23.2% T-HDL, 23.3% Apo A1, 67.5% Apo B, 68.1% Lp (a), and 41.8% FB. Coronary angiography showed no coronary artery disease. After 5 years of CED showed aortic gradient <20 mm Hg but with insufficiency aortic grade I ~ I and a significant reduction of aortic walls thickness and the ECBUS shoed no evidence of a significant progression of a little fatty plaque which was observed in bifurcation of left common carotid artery after 2 years of treatment the xanthomata skin and tendons were resolved. Conclusions: 1. DSC/LDL-A was confirmed to be an effective and safe treatment for homozygous FH. 2. The regression of skin and tendons xanthomas was observed after a short-term treatment. 3. In a homozygous FH child no significant progression of atheriosclerosis was observed after a long-term of DSC/LDL-A.
73rd EAS Congress