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The implications of epidemiological studies for the pathogenesis of contact lens related keratitis
Monday, Sep 21, 1992 Des Iles Borromees
X ICER Abstracts CODE C-l
tx3RNBAAND coNNl3cMvETlssuE
SEPTEMBER
THE IMPLICATIONS OF EPIDEMIOLOGICAL STUDIJ!.S FOR THE PATHCGENESIS OF CONTACT LENS RELATED KERATITIS
KENNETH
CHAIRPERSON:
2
9:18
F.&tow Involved in lnflammatlon B. Holden (Australia)
3
9:36
Contact M. Guillon
954 to:12
L2iiQIhhPaSS G.S. Wilson
In Viva
D. Minassian
and
Contact
Ww
(UK) and M.V.
F.,
Minassian,
D. l,*9
Road, London and London University.
Epidemiological studies of risk factors for keratitis in contact lens (CL) users have identified mechanisms that may be important in its pathogenesis. our case control studies of a population of CL users (n=1611) have shown extended wear soft contact lens (EWSCL) users to have an increased risk for both keratitis and metabolic complications compared to daily wear soft ien.5 (DWSCL) and gas-permeable hard iens (GPHCL) Users (p= 0.05). Multivariable analysis of this data has shown that lens hygiene and compliance were not significant factors in EWSCL users. Microbial contamination of the lens cases was associated with keratitis in a subgroup of 11/16 Pseudomonas keratitis cases compared to lb/44 controls (p=O.O14). In 4116 Pseudomonas cases no source of the organisms, either environmental or personal, could be identified. These observations support the hypothesis that the adverse metabolic effects of lens vear combined the potential for colonisation of the lens, both in the lens case and in the eye, probably accounts for the observed differences in risk associated with different lens types.
0 f Contact
&I&d Keratith J.K.G. Dart, F. Stapleton. M. Matheson (UK)
5
POLSE (USA)
9:oo
fslrthc1s
4
Dart, J.K.G. 1, 27 Stapleton **2, Matheson, M 1. 1. Moorfields Eye Hospital, City 2. The Institute of Ophthalmology,
PRESENTATION
NUMBER=
1
12
1
21/MONDAY
the fa2nlm? Riley (USA)
with
Effect of uH on Comeal Function K. Poke, R. Brand. S. Cohen and I. Bonanno (USA)
13
2 FACTORY INVOLVED INFLAMMATION B. Holden (Australia)
Abstract
IN
CONTACT
LENS
Not Available
14
3 CONTACT CORNEAL M. Guillon
Abstract
S.5
INDUCED
LENS IN VIVO WETTABILITY STAINING NIQ
Not Available
AND
X ICER Abstracts CODE C-l
tx3RNBAAND coNNl3cMvETlssuE
SEPTEMBER
THE IMPLICATIONS OF EPIDEMIOLOGICAL STUDIJ!.S FOR THE PATHCGENESIS OF CONTACT LENS RELATED KERATITIS
KENNETH
CHAIRPERSON:
2
9:18
F.&tow Involved in lnflammatlon B. Holden (Australia)
3
9:36
Contact M. Guillon
954 to:12
L2iiQIhhPaSS G.S. Wilson
In Viva
D. Minassian
and
Contact
Ww
(UK) and M.V.
F.,
Minassian,
D. l,*9
Road, London and London University.
Epidemiological studies of risk factors for keratitis in contact lens (CL) users have identified mechanisms that may be important in its pathogenesis. our case control studies of a population of CL users (n=1611) have shown extended wear soft contact lens (EWSCL) users to have an increased risk for both keratitis and metabolic complications compared to daily wear soft ien.5 (DWSCL) and gas-permeable hard iens (GPHCL) Users (p= 0.05). Multivariable analysis of this data has shown that lens hygiene and compliance were not significant factors in EWSCL users. Microbial contamination of the lens cases was associated with keratitis in a subgroup of 11/16 Pseudomonas keratitis cases compared to lb/44 controls (p=O.O14). In 4116 Pseudomonas cases no source of the organisms, either environmental or personal, could be identified. These observations support the hypothesis that the adverse metabolic effects of lens vear combined the potential for colonisation of the lens, both in the lens case and in the eye, probably accounts for the observed differences in risk associated with different lens types.
0 f Contact
&I&d Keratith J.K.G. Dart, F. Stapleton. M. Matheson (UK)
5
POLSE (USA)
9:oo
fslrthc1s
4
Dart, J.K.G. 1, 27 Stapleton **2, Matheson, M 1. 1. Moorfields Eye Hospital, City 2. The Institute of Ophthalmology,
PRESENTATION
NUMBER=
1
12
1
21/MONDAY
the fa2nlm? Riley (USA)
with
Effect of uH on Comeal Function K. Poke, R. Brand. S. Cohen and I. Bonanno (USA)
13
2 FACTORY INVOLVED INFLAMMATION B. Holden (Australia)
Abstract
IN
CONTACT
LENS
Not Available
14
3 CONTACT CORNEAL M. Guillon
Abstract
S.5
INDUCED
LENS IN VIVO WETTABILITY STAINING NIQ
Not Available
AND