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The induction of microscopic brain tumours in the rat
Fd Chem. Toxic. Vol. 24. No. 2, p. 75, 1986
Printed in Great Britain
THE INDUCTION
OF M I C R O S C O P I C IN T H E R A T
BRAIN TUMOURS
THE SIGNIFICANCE FOR MAN An International Workshop held on 19/20 July 1984 at the Robens Institute, University of Surrey CONTENTS Page
Preface. By L. Golberg Introduction. By P. Grasso Neurogenesis and gliogenesis in the human brain. By M. Berry Brain tumours in man. By R. O. Weller Epidemiology of brain tumours in man and their relationship with chemical agents. By R. D. Jones Brain tumours in mice, with particular reference to astrocytoma. By H. Fraser Spontaneous brain tumours in Sprague Dawley rats. By C. Gopinath The dewelopment of nitrosourea-induced brain tumours with a special note on changes occurring during latency. By P. L. Lantos Primary brain tumours in Fischer-344 rats chronically exposed to acrylonitrile in their drinkingwater. By D. D. Bigner, S. H. Bigner, P. C. Burger, J. D. Shelburne and H. S. Friedman The brain tumour issue in long-term toxicity studies in rats. By A. Koestner Frequency, size and location of brain tumours in F-344 rats chronically exposed to ethylene oxide. By R. H. Garman, W. M. Snellings and R. R. Maronpot Brain turnouts problems and perspectives. By J. A. Swenberg
77 78 79 91 99 105 113 121 129 139 145 155
The conference was chaired jointly by Professor Leon Golberg and Professor John Cavanagh. The organizers are grateful for the support of the following sponsors: Berol Kemi AB, BP Chemicals, Dow Chemicals (Europe), Ethylene Oxide Industry Council (USA), ICI (Central Toxicology Laboratory), Monsanto, Montedison and Shell International. The papers published here are based on the workshop presentations and were received for publication in August 1985. The comments noted in the "Points from Discussion" sections following individual papers are not necessarily views expressed by the author of the paper.
75 F ( 1 24 2
A
Printed in Great Britain
THE INDUCTION
OF M I C R O S C O P I C IN T H E R A T
BRAIN TUMOURS
THE SIGNIFICANCE FOR MAN An International Workshop held on 19/20 July 1984 at the Robens Institute, University of Surrey CONTENTS Page
Preface. By L. Golberg Introduction. By P. Grasso Neurogenesis and gliogenesis in the human brain. By M. Berry Brain tumours in man. By R. O. Weller Epidemiology of brain tumours in man and their relationship with chemical agents. By R. D. Jones Brain tumours in mice, with particular reference to astrocytoma. By H. Fraser Spontaneous brain tumours in Sprague Dawley rats. By C. Gopinath The dewelopment of nitrosourea-induced brain tumours with a special note on changes occurring during latency. By P. L. Lantos Primary brain tumours in Fischer-344 rats chronically exposed to acrylonitrile in their drinkingwater. By D. D. Bigner, S. H. Bigner, P. C. Burger, J. D. Shelburne and H. S. Friedman The brain tumour issue in long-term toxicity studies in rats. By A. Koestner Frequency, size and location of brain tumours in F-344 rats chronically exposed to ethylene oxide. By R. H. Garman, W. M. Snellings and R. R. Maronpot Brain turnouts problems and perspectives. By J. A. Swenberg
77 78 79 91 99 105 113 121 129 139 145 155
The conference was chaired jointly by Professor Leon Golberg and Professor John Cavanagh. The organizers are grateful for the support of the following sponsors: Berol Kemi AB, BP Chemicals, Dow Chemicals (Europe), Ethylene Oxide Industry Council (USA), ICI (Central Toxicology Laboratory), Monsanto, Montedison and Shell International. The papers published here are based on the workshop presentations and were received for publication in August 1985. The comments noted in the "Points from Discussion" sections following individual papers are not necessarily views expressed by the author of the paper.
75 F ( 1 24 2
A