- Email: [email protected]
The influencing factors on blood sugar and insulin levels in OGTT
Poster Session
S56
need to lose weight, eat ‘healthily’and take meals at regular intervals. Most patients thought regular carbohydrate intake was necessitated by their diabetes rather than their treatment. Patients found changing eating patterns and diet among the most difficult of the lifestyle changes demanded of them: 20% often or always skipped breakfast, 12% often or always skipped lunch, 27% regularly postponed lunch, 12% regularly skipped dinner, and 21% regularly postponed dinner. There was a consensus that strict mealtimes and dietary restrictions created lifestyle limitations and stigma. In conclusion, patients with Type 2 diabetes find dietary changes and compliance to strict meal patterns difficult, and are confused about the reasons for doing so.
P282 The Inlluencing Factors on Blood Sugar and Insulin Levels in OGTT N. SAITO ’ , S.Saito ’ , A. Yamaguchi 2, K. Sakai 2, M. Yamana3, E Ootsujis, T. Kannagi3, H. Sayama3. ’ Dept of Internal Medicine and Adult Disease Research, Miyazaki Aiwa Hospital, Miyazaki, Japan; ’ Cooking Science, Kyoto Women University; 3 Kyoto Prevention Medicial Center
This study aims to clarify the factors influencing on blood sugar and insulin levels in oral GTT(OG’lT). In this study 403 subjects of both sexes without drug administration were recruited, consisting of 116 ones aged below 39 years, 209 ones aged between 40 and 59 years and 78 ones aged over 60 years. OG’IT was measured using 75g of treran Cl at fasting in the early morning. Three types such as normal, borderline and diabetic types were diagnosed by the criteria of Japanese Diabetic Society. Diabetic type was over 126 mg/dl of FBS and over 200 mg/dl at 120 min in GG’IT, while normal type was below 110 mg/dl and below 140 mg/dl, respectively. The grades of glucose intolerance and aging influenced the blood sugar and insulin levels in OGTT. The peak values of blood sugar in OGTT were 30 min in normal type, 60 min in borderline type and 60 to 90 min in diabetic type. The peak values of insulin were 60 min, 60 to 120 min and 120 min, respectively. In the aged subjects over 60 years old blood sugar levels did not decrease remarkably after 90 min in OGTT. By obesity insulin levels increased as compared to normal weight, even when blood sugar levels were almost same in OGTT of the three types, indicating the presence of insulin resistance. Summary: The grades of glucose intolerance, aging and obesity influenced on the changing patterns of blood sugar and insulin in OGTT.
P283 The Effect of Methylcobalamin on the Secretion of Testosterone in STZ-Induced Diabetic Rats J.T. DOU, S.P. Zhang, C.Y. Pan, A.Y. Guo. Department of Endocrinology,
General Hospital of PLA, Beijing, China
Aim: To investigate the effect of methylcobalamin on the secretion of testosterone in diabetic rats. Methods: 30 male Wistar rats were randomly divided into 3 groups: normal group,diabetic rats treated with Methylcobalamin group and diabetic rats(DM) group. The diabetic rat model was induced by Streptozotocin(STZ). Methylcobalamin(5OO~g!kg)was injected intramuscularly in Methylcobalamin treated group and same volume of saline was injected in the other groups. At the end of 2 months triaLthe blood glucose, body weight,testoeterone and hCG binding site of testis were measured. Results: Body weight was significantly higher and blood glucose was lower in normal group than that of other groups. There were no significant differences in body weight and blood glucose between Methylcobalamin treated group and DM group. The level of testosterone and hCG binding site in normal group were significantly higher than those in other two groups (p
1
terone secretion and hCG binding site, both of them being reduced. Methylcobalamin may protect Leydig cells from damage of diabetes, but the mechanism is unclear. Moreover the Methylcobalamin has no effect on body weight and blood glucose of diabetic rats,
P284 How Precise Is Blood Pressure Measurement in the Wrist in Patients with a Long History of Diabetes Mellitus? S. ECKERT, N. Lotz, D. Horstkotte. Heart and Diabetes Center North Rhine-Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany Blood pressure self-measurement in the wrist is increasingly applied in patients (pts) with diabetes mellitus. Pts with a long history of diabetes mellitus often present endothelial dysfunction due to diffuse arteriosclerosis. We tested the accuracy of the blood pressure measuring device Omron R3 applied in the wrist in long-term diabetics in comparison to non-diabetics by simultaneous invasive comparative measurements according to DIN 58130. Following cardiac catheterization, we performed 5 subsequent invasive comparative measurements in 30 pts with sinus rhythm (n=150 measurements) according to protocol DIN 58 130. Group A: 15 non-diabetics without coronary artery diseases; group B: 15 diabetics with diabetes present for 23f6 years. Nine pts had severe, six moderate coronary disease. The systolic and diastolic reference values were determined from the highest and lowest invasive values during noninvasive measurements of blood pressure. The differences and the standard deviation between the arterial reference values and the noninvasive blood pressure measurements were calculated: systolic
A: non-diabetics 8: diabetics European standard
diastolic
(mm&)
CmHg)
-2.2+3.9 -3.4ztE.O
-0.2i2.7 +1.5*7.8
*5*s
f5fS
Group A. the device finished all of the measurements meaumnents in 4 pts.
started. Group B: the device aborted
17
The Omron R3 blood pressure self-measuring device for the use in the wrist fulfils the European Standard approvol requirements in terms of invasive validation method for both groups.
p285 Esophageal Motility in Patients with ‘Qpe-1 Diabetes Mellitus MONA SALEM, Eman Monir, Hesham Ezz El Din ’ , Heba El-Khashab. Pediatric and ’ Internal Medicine Departments, Faculty of Medicine, Ain Shams University
Gastrointestinal motility disorders are common in diabetic patients particularly those complicated by autonomic neuropathy. Thirty-one patients (20 males and 11 females) with type-l diabetes mellitus attending the Diabetes Clinic Children’s Hospital Ain Shams University were enrolled in this study. Their ages ranged from 10 to 20.5 years with a mean of 15.19f3.95 years. They were divided into two groups; group I, comprised 17 patients without autonomic neuropathy and group II, 14 patients complicated by autonomic neuropathy. Mean random blood glucose, mean glycosylated hemoglobin (HbAiC), microalbumin, autonomic cardiovascular reflexes and esophageal manometric studies were performed. The results revealed esophageal dysmotility in both groups in the form of decreased lower esophageal sphincter pressure, decreased amplitude, velocity and duration of esophageal contractions. Comparing the two groups all esophageal manometric parameters were more evident in the diabetic group complicated by autonomic neuropathy especially so in the amplitude of esophageal contractions (PcO.05) which was statistically significant.
S56
need to lose weight, eat ‘healthily’and take meals at regular intervals. Most patients thought regular carbohydrate intake was necessitated by their diabetes rather than their treatment. Patients found changing eating patterns and diet among the most difficult of the lifestyle changes demanded of them: 20% often or always skipped breakfast, 12% often or always skipped lunch, 27% regularly postponed lunch, 12% regularly skipped dinner, and 21% regularly postponed dinner. There was a consensus that strict mealtimes and dietary restrictions created lifestyle limitations and stigma. In conclusion, patients with Type 2 diabetes find dietary changes and compliance to strict meal patterns difficult, and are confused about the reasons for doing so.
P282 The Inlluencing Factors on Blood Sugar and Insulin Levels in OGTT N. SAITO ’ , S.Saito ’ , A. Yamaguchi 2, K. Sakai 2, M. Yamana3, E Ootsujis, T. Kannagi3, H. Sayama3. ’ Dept of Internal Medicine and Adult Disease Research, Miyazaki Aiwa Hospital, Miyazaki, Japan; ’ Cooking Science, Kyoto Women University; 3 Kyoto Prevention Medicial Center
This study aims to clarify the factors influencing on blood sugar and insulin levels in oral GTT(OG’lT). In this study 403 subjects of both sexes without drug administration were recruited, consisting of 116 ones aged below 39 years, 209 ones aged between 40 and 59 years and 78 ones aged over 60 years. OG’IT was measured using 75g of treran Cl at fasting in the early morning. Three types such as normal, borderline and diabetic types were diagnosed by the criteria of Japanese Diabetic Society. Diabetic type was over 126 mg/dl of FBS and over 200 mg/dl at 120 min in GG’IT, while normal type was below 110 mg/dl and below 140 mg/dl, respectively. The grades of glucose intolerance and aging influenced the blood sugar and insulin levels in OGTT. The peak values of blood sugar in OGTT were 30 min in normal type, 60 min in borderline type and 60 to 90 min in diabetic type. The peak values of insulin were 60 min, 60 to 120 min and 120 min, respectively. In the aged subjects over 60 years old blood sugar levels did not decrease remarkably after 90 min in OGTT. By obesity insulin levels increased as compared to normal weight, even when blood sugar levels were almost same in OGTT of the three types, indicating the presence of insulin resistance. Summary: The grades of glucose intolerance, aging and obesity influenced on the changing patterns of blood sugar and insulin in OGTT.
P283 The Effect of Methylcobalamin on the Secretion of Testosterone in STZ-Induced Diabetic Rats J.T. DOU, S.P. Zhang, C.Y. Pan, A.Y. Guo. Department of Endocrinology,
General Hospital of PLA, Beijing, China
Aim: To investigate the effect of methylcobalamin on the secretion of testosterone in diabetic rats. Methods: 30 male Wistar rats were randomly divided into 3 groups: normal group,diabetic rats treated with Methylcobalamin group and diabetic rats(DM) group. The diabetic rat model was induced by Streptozotocin(STZ). Methylcobalamin(5OO~g!kg)was injected intramuscularly in Methylcobalamin treated group and same volume of saline was injected in the other groups. At the end of 2 months triaLthe blood glucose, body weight,testoeterone and hCG binding site of testis were measured. Results: Body weight was significantly higher and blood glucose was lower in normal group than that of other groups. There were no significant differences in body weight and blood glucose between Methylcobalamin treated group and DM group. The level of testosterone and hCG binding site in normal group were significantly higher than those in other two groups (p
1
terone secretion and hCG binding site, both of them being reduced. Methylcobalamin may protect Leydig cells from damage of diabetes, but the mechanism is unclear. Moreover the Methylcobalamin has no effect on body weight and blood glucose of diabetic rats,
P284 How Precise Is Blood Pressure Measurement in the Wrist in Patients with a Long History of Diabetes Mellitus? S. ECKERT, N. Lotz, D. Horstkotte. Heart and Diabetes Center North Rhine-Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany Blood pressure self-measurement in the wrist is increasingly applied in patients (pts) with diabetes mellitus. Pts with a long history of diabetes mellitus often present endothelial dysfunction due to diffuse arteriosclerosis. We tested the accuracy of the blood pressure measuring device Omron R3 applied in the wrist in long-term diabetics in comparison to non-diabetics by simultaneous invasive comparative measurements according to DIN 58130. Following cardiac catheterization, we performed 5 subsequent invasive comparative measurements in 30 pts with sinus rhythm (n=150 measurements) according to protocol DIN 58 130. Group A: 15 non-diabetics without coronary artery diseases; group B: 15 diabetics with diabetes present for 23f6 years. Nine pts had severe, six moderate coronary disease. The systolic and diastolic reference values were determined from the highest and lowest invasive values during noninvasive measurements of blood pressure. The differences and the standard deviation between the arterial reference values and the noninvasive blood pressure measurements were calculated: systolic
A: non-diabetics 8: diabetics European standard
diastolic
(mm&)
CmHg)
-2.2+3.9 -3.4ztE.O
-0.2i2.7 +1.5*7.8
*5*s
f5fS
Group A. the device finished all of the measurements meaumnents in 4 pts.
started. Group B: the device aborted
17
The Omron R3 blood pressure self-measuring device for the use in the wrist fulfils the European Standard approvol requirements in terms of invasive validation method for both groups.
p285 Esophageal Motility in Patients with ‘Qpe-1 Diabetes Mellitus MONA SALEM, Eman Monir, Hesham Ezz El Din ’ , Heba El-Khashab. Pediatric and ’ Internal Medicine Departments, Faculty of Medicine, Ain Shams University
Gastrointestinal motility disorders are common in diabetic patients particularly those complicated by autonomic neuropathy. Thirty-one patients (20 males and 11 females) with type-l diabetes mellitus attending the Diabetes Clinic Children’s Hospital Ain Shams University were enrolled in this study. Their ages ranged from 10 to 20.5 years with a mean of 15.19f3.95 years. They were divided into two groups; group I, comprised 17 patients without autonomic neuropathy and group II, 14 patients complicated by autonomic neuropathy. Mean random blood glucose, mean glycosylated hemoglobin (HbAiC), microalbumin, autonomic cardiovascular reflexes and esophageal manometric studies were performed. The results revealed esophageal dysmotility in both groups in the form of decreased lower esophageal sphincter pressure, decreased amplitude, velocity and duration of esophageal contractions. Comparing the two groups all esophageal manometric parameters were more evident in the diabetic group complicated by autonomic neuropathy especially so in the amplitude of esophageal contractions (PcO.05) which was statistically significant.