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The international collaboration on cancer reporting (ICCR): development of evidence-based core data sets for pathology cancer reporting
ABSTRACTS
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behaviour. Multiple systems of nomenclature, classification, grading and staging have been proposed for these tumours, leading to confusion and inconsistency in their pathological assessment. In particular, predicting how a given tumour will behave can be difficult; however with increasing options for clinical management, pathologists are coming under increasing pressure to do so. This talk will canvas various proposals for classification and grading of gastroenteropancreatic neuroendocrine tumours (GEP-NETs) and outline some of the issues and challenges raised by these systems, as well as attempt to offer some practical advice on pathological reporting of GEP-NETs.
(RCC), acquired cystic disease associated RCC, clear cell tubulopapillary RCC, t(6;11) translocation carcinoma, and hereditary leiomyomatosis and RCC] and emerging entities [thyroid-like follicular RCC, succinate dehydrogenase B (SDHB) mutation associated RCC, and ALK-translocation associated RCC]. A summary of the entities accepted in these categories by consensus at the International Society of Urological Pathology meeting in Vancouver in March 2012 will be given. Discussion of important familial tumours involving the kidney will be included.
THE INTERNATIONAL COLLABORATION ON CANCER REPORTING (ICCR): DEVELOPMENT OF EVIDENCE-BASED CORE DATA SETS FOR PATHOLOGY CANCER REPORTING
Fiona Maclean Douglass Hanly Moir Pathology, Macquarie Park, Sydney, and University of Notre Dame, Sydney, NSW, Australia
D. Ellis1, J. Dvorak2, L. Hirschowitz3, M. Judge4, A. Kwiatkowski5, J. Srigley6, M. K. Washington7, M. Wells3 1Royal College of Pathologists of Australasia, Sydney, Australia, 2College of American Pathologists, Northfield, United Kingdom, 3Royal College of Pathologists, London, United Kingdom, 4Royal College of Pathologists of Australasia, Surry Hills, Australia, 5Canadian Partnership Against Cancer, Toronto, Canada, 6Canadian Association of Pathology, Toronto, Canada, 7College of American Pathologists, Nashville, United States
During this presentation there will be discussion of both macroscopic and microscopic features important to include in reports pertaining to renal tumours, and common difficulties and misconceptions such as the renal sinus will be considered and identified. Use of synoptic reports will be discussed, as will the consensus decisions coming out of the International Society of Urological Pathology meeting in Vancouver in 2012, including the change to grading of renal cell carcinomas.
Background: Global collaboration and standardisation of Cancer Pathology Datasets (CPDS) is essential for international benchmarking and epidemiological research in cancer and to reduce the burden of dataset production but has not been previously attempted. Design: The International Collaboration on Cancer Reporting (ICCR), including Pathology Colleges and Associations of the USA, UK, Canada and Australia, was established in 2011 to develop internationally agreed and evidence-based CPDS. The ICCR initially established four international review panels (RP) to develop CPDS for prostate, lung, endometrial carcinoma and melanoma, each comprising an ICCR pathology lead and two international experts from each country. Each chair facilitated an evidence-based review and harmonisation of the core (required) data elements, permitted responses, non-core (recommended) elements and terminology. Core elements included stage, tumour type and predictive or prognostic data for which there was Level III-2 evidence to support inclusion.1 Results: The RPs for each cancer successfully developed CPDS with fewer core elements than existing national datasets. Definitions and permitted responses for all data elements were agreed. Conclusion: This ICCR pilot study demonstrated that internationally standardised and evidence-based CPDS can be produced efficiently with significant improvements in content, including harmonised terminology, definitions and required responses. Reference 1. Merlin T, Weston A, Tooher R. Extending an evidence hierarchy to include topics other than treatment: revising the Australian ‘levels of evidence’. BMC Med Res Method 2009; 9: 34.
HOW TO REPORT RENAL TUMOURS
MYCETOMA OF THE MAXILLARY SINUS: REPORT OF TWO CASES O. Allsobrook, A. M. Rich Medlab Dental, Faculty of Dentistry, University of Otago, New Zealand The fungus Aspergillus may cause invasive or non-invasive infection, usually pulmonary, in immuno-compromised individuals. Less often Aspergillus infects the maxillary sinus causing a noninvasive mycetoma. These occur in immuno-competent individuals who often present with nasal obstruction, chronic sinusitis, or pain. The mass of fungal hyphae has a predisposition to calcify, leading to the formation of an antrolith in the maxillary sinus, usually unilaterally. The diagnosis is made based on the radiographic presentation of a non-invasive calcified mass in the sinus, along with the histological appearance of a collection of fungal hyphae (fruiting bodies along with acutely branching hyphae suggests Aspergillus infection). Treatment is based on the clinical signs and symptoms and the health of the patient. If untreated, the Aspergillus can progress to invasion of blood vessels, destruction of the surrounding tissues and bone, and spread to distant organs. The aim of this presentation is to discuss two cases of Aspergillus mycetoma occurring in two female patients in their sixties, who presented clinically with radio-opacities in the maxillary sinus. ULCERATED PALATAL TUMOUR IN ASSOCIATION WITH ELEVATED SERUM IgG4
Fiona Maclean Douglass Hanly Moir Pathology, Macquarie Park, Sydney, and University of Notre Dame, Sydney, NSW, Australia
T. M. Phillips1, D. Hyam3,4, K. L. Randall2,4, J. E. Dahlstrom1,4 Departments of 1Anatomical Pathology and 2Immunology, ACT Pathology, The Canberra Hospital, Woden, 3Department of Maxillofacial Surgery, The Canberra Hospital, Woden and 4ANU Medical School, ACT, Australia
This presentation will give an update on renal tumours encompassing new entities [including tubulocystic renal cell carcinoma
A generally healthy 66-year-old woman presented with a painless mass at the junction of the soft and hard palate, adjacent to the
UPDATE ON RENAL TUMOURS
Copyright © Royal College of pathologists of Australasia. Unauthorized reproduction of this article is prohibited.
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behaviour. Multiple systems of nomenclature, classification, grading and staging have been proposed for these tumours, leading to confusion and inconsistency in their pathological assessment. In particular, predicting how a given tumour will behave can be difficult; however with increasing options for clinical management, pathologists are coming under increasing pressure to do so. This talk will canvas various proposals for classification and grading of gastroenteropancreatic neuroendocrine tumours (GEP-NETs) and outline some of the issues and challenges raised by these systems, as well as attempt to offer some practical advice on pathological reporting of GEP-NETs.
(RCC), acquired cystic disease associated RCC, clear cell tubulopapillary RCC, t(6;11) translocation carcinoma, and hereditary leiomyomatosis and RCC] and emerging entities [thyroid-like follicular RCC, succinate dehydrogenase B (SDHB) mutation associated RCC, and ALK-translocation associated RCC]. A summary of the entities accepted in these categories by consensus at the International Society of Urological Pathology meeting in Vancouver in March 2012 will be given. Discussion of important familial tumours involving the kidney will be included.
THE INTERNATIONAL COLLABORATION ON CANCER REPORTING (ICCR): DEVELOPMENT OF EVIDENCE-BASED CORE DATA SETS FOR PATHOLOGY CANCER REPORTING
Fiona Maclean Douglass Hanly Moir Pathology, Macquarie Park, Sydney, and University of Notre Dame, Sydney, NSW, Australia
D. Ellis1, J. Dvorak2, L. Hirschowitz3, M. Judge4, A. Kwiatkowski5, J. Srigley6, M. K. Washington7, M. Wells3 1Royal College of Pathologists of Australasia, Sydney, Australia, 2College of American Pathologists, Northfield, United Kingdom, 3Royal College of Pathologists, London, United Kingdom, 4Royal College of Pathologists of Australasia, Surry Hills, Australia, 5Canadian Partnership Against Cancer, Toronto, Canada, 6Canadian Association of Pathology, Toronto, Canada, 7College of American Pathologists, Nashville, United States
During this presentation there will be discussion of both macroscopic and microscopic features important to include in reports pertaining to renal tumours, and common difficulties and misconceptions such as the renal sinus will be considered and identified. Use of synoptic reports will be discussed, as will the consensus decisions coming out of the International Society of Urological Pathology meeting in Vancouver in 2012, including the change to grading of renal cell carcinomas.
Background: Global collaboration and standardisation of Cancer Pathology Datasets (CPDS) is essential for international benchmarking and epidemiological research in cancer and to reduce the burden of dataset production but has not been previously attempted. Design: The International Collaboration on Cancer Reporting (ICCR), including Pathology Colleges and Associations of the USA, UK, Canada and Australia, was established in 2011 to develop internationally agreed and evidence-based CPDS. The ICCR initially established four international review panels (RP) to develop CPDS for prostate, lung, endometrial carcinoma and melanoma, each comprising an ICCR pathology lead and two international experts from each country. Each chair facilitated an evidence-based review and harmonisation of the core (required) data elements, permitted responses, non-core (recommended) elements and terminology. Core elements included stage, tumour type and predictive or prognostic data for which there was Level III-2 evidence to support inclusion.1 Results: The RPs for each cancer successfully developed CPDS with fewer core elements than existing national datasets. Definitions and permitted responses for all data elements were agreed. Conclusion: This ICCR pilot study demonstrated that internationally standardised and evidence-based CPDS can be produced efficiently with significant improvements in content, including harmonised terminology, definitions and required responses. Reference 1. Merlin T, Weston A, Tooher R. Extending an evidence hierarchy to include topics other than treatment: revising the Australian ‘levels of evidence’. BMC Med Res Method 2009; 9: 34.
HOW TO REPORT RENAL TUMOURS
MYCETOMA OF THE MAXILLARY SINUS: REPORT OF TWO CASES O. Allsobrook, A. M. Rich Medlab Dental, Faculty of Dentistry, University of Otago, New Zealand The fungus Aspergillus may cause invasive or non-invasive infection, usually pulmonary, in immuno-compromised individuals. Less often Aspergillus infects the maxillary sinus causing a noninvasive mycetoma. These occur in immuno-competent individuals who often present with nasal obstruction, chronic sinusitis, or pain. The mass of fungal hyphae has a predisposition to calcify, leading to the formation of an antrolith in the maxillary sinus, usually unilaterally. The diagnosis is made based on the radiographic presentation of a non-invasive calcified mass in the sinus, along with the histological appearance of a collection of fungal hyphae (fruiting bodies along with acutely branching hyphae suggests Aspergillus infection). Treatment is based on the clinical signs and symptoms and the health of the patient. If untreated, the Aspergillus can progress to invasion of blood vessels, destruction of the surrounding tissues and bone, and spread to distant organs. The aim of this presentation is to discuss two cases of Aspergillus mycetoma occurring in two female patients in their sixties, who presented clinically with radio-opacities in the maxillary sinus. ULCERATED PALATAL TUMOUR IN ASSOCIATION WITH ELEVATED SERUM IgG4
Fiona Maclean Douglass Hanly Moir Pathology, Macquarie Park, Sydney, and University of Notre Dame, Sydney, NSW, Australia
T. M. Phillips1, D. Hyam3,4, K. L. Randall2,4, J. E. Dahlstrom1,4 Departments of 1Anatomical Pathology and 2Immunology, ACT Pathology, The Canberra Hospital, Woden, 3Department of Maxillofacial Surgery, The Canberra Hospital, Woden and 4ANU Medical School, ACT, Australia
This presentation will give an update on renal tumours encompassing new entities [including tubulocystic renal cell carcinoma
A generally healthy 66-year-old woman presented with a painless mass at the junction of the soft and hard palate, adjacent to the
UPDATE ON RENAL TUMOURS
Copyright © Royal College of pathologists of Australasia. Unauthorized reproduction of this article is prohibited.