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The Intravenous Administration of Oil of Chenopodium to Horse
OIL OF CHENOPODIUM FOR HORSES
Clinical
457
Jlrticl~s
The Intravenous Administration of Oil of Chenopodium to Horses. By MAJOR A. A. PRYER, D.S.O., R.A.V.C. , I nstructor and B acteriologist , R oyal Army Veterinary School, Aldershot.
Introduction. THE findings of Fernan-Nunez, recorded briefly on page 979, Tropical Diseases B ulletin , December, 1927, suggested further investigation of the intravenous administration of oil of chenopodium to horses. Enquiry was instituted with a view to obtaining information on t he following p oints:(a) Whether oil of chenopodium could be given conveniently in this ma nner. (b) If so, the maximum dose tha t could be employed safely. (c) The anthelminthic effi ciency of the drug given intravenously compared with its proved efficiency when administered per orem . It was hoped tha t if oil of chenopodium could be shown t o be a reliable anthelminthic, when administered intravenously, the undermentioned a dvantages would result :(a) A fi nancial saving in virtue of the smaller dose which it would b e n ecessary t o empl oy. This is a serious considera tion when u sing an expensive agent on a large number of anim als. (b) Definite an thelminthic action on la rva: encysted in the bowel wall or blood vessels, which appear to remain untouched hy the oral administration of the drug. (c) A bolition of the prolonged period of fas ting insisted upon commonly, before giving the drug by the mouth . Technique and Observations. Th ree horses, a b rown mare, a ch estnut mare and a chestnut gelding, of t he cavalry type were select ed as subjects. All appeared in satisfactory condition, but examination of the freces, by the sugar flo tation method, revealed the presence of ova of Strongylida:. SUBJ ECT No. r - BROWN MARE.-On r 6-r z- 27, ova of strongylidre were det ected in the fa:ces to the number of 50 per fi eld . On the same date and without an y prepara tion she received 5 c.c. of undiluted oil of ch enopodium intravenously.
4 58
THE VETERINARY JOURNAL
lo untoward sequela: resulted. Subsequent examjna tion of the fa:ces revealed the following coun ts:I 7- I 2- 27 I 8- I 2- 27 (8 a. m.) I 8-I 2- 27 (noon) 20- I 2- 27 2I- I2- 27 3- I - 28 5- I - 2 6- I - 28
70 ova of strongylida: per field. I4 I OO
I2 I2 I
3 IS
On the 6-r-28 a further 7t c.c. of oil of chenopodium were given int ravenously. Again no ill results were observed . Continued examination of the fa:ces showed : 7- 1- 28 8-I- 28 9-I- 28 I o--I - 28 II- I- 28 I 2- I - 28 'I 3- I - 28 IS- I- 28 I 6- I- 28 I 7- I- 28 I 8- I -28 I 9- I- 28 2o--I -28 2! - I-28 22-I - 28 23- 1- 28 24- I- 28 2S- I- 28 26-I- 28 27- 1- 28
22 ova of strongylida: per fi eld. go 25 ISO IS O
I 20 54 I6 6o 36 62 6 5
s
13
s 5 7 2
II
Counts were d iscontinued after 27- I - 28 and on 3I - I- 28 the subj ect was destroyed . Post-mortem examination revealed 34 A scaris equi, all located anterior to the ileo-ca:cal valve and 47 nemat odes which ap peared t o be S trongyli vulgaris. The majority were active. No na ked-eye appearances of trichonema or triodontophorous infections were detected . The anterior mesenteric a rtery and its b ranches were normal. SUBJ ECT No. 2- CHESTNUT MARE.-One hundred and ten ova of
OIL OF CHENOPODIUM FOR HORSES
459
strongylidce per field were counted on I 6- I- 28, but between 20- I - 28 and 27- I --28 the count dropped , without treatment to a daily average of 20 per field with a maximum of 39 and a minimum of seven. On 28- I- 28 the count rose suddenly to I 09 per field and IO c.c. of oil of chenopodium were given intravenously. Twenty seconds later violent excitement resulted and the followin g symptoms were observed:Eyeballs prominent and rolling, ears moved rapidly, animal kicked , struck wildly with the forelegs and fell to the floor of the stall ; it rose again immediately and, breaking away from the attendant, escaped from the stable in a state of delirium, but was captured within two minutes. The delirium passed off rapidly, but for the nex t half hour signs of nausea , dull colic and subdued excitement were exhibited . The bowels were evacuated five times in twelve minutes, the fceces becoming progressively softer. The writer has seen numerous cases of faintness and temporary collapse following intravenous medication , but never previously the train of symptoms described above. All the symptoms subsided slowly and at the expiration of one and a half hours the animal appeared normal. Subsequent examination of the fceces revealed:-29-I- 28 3o-I-28 3I- I- 28 I- 2- 28 2-2-28 3-2-28 4- 2- 28 5- 2-28 6- 2-28
29 ova of st rongylidce per fi eld. 6s IS O SO 87 4 44 I6 I3
SUBJECT No. 3-CHESTNUT GELDI NG .- Twenty-five ova of strongylidce per field were present on I6- I- 28. Between 20-I- 2 and 27-I-28 the average daily count was eight per fi eld with a maxi.mum of IS and a minimum of one. On 28-I- 28 the count stood at one per field and 7t c.c. of oil of chenopodium were given intravenously. Very slight transient restlessness, accompanied by two rapid defcecations followed, but vanished after five minutes. Otherwi se no local or ge neral disturbance occurred.
460
THE VETERINARY JOURNAL
Subsequent examinations of freces revealed : 29- I -28 I6 ova of strongylidre per field . 3o-I -28 I 3I-I-28 nil I-2- 28 2 2- 2- 28 I I 3- 2-28 I 4- 2- 28 5- 2-28 3 6- 2- 28 2
·Summary and Conclusion. (a) Undiluted oil of chenopodium may be introduced i-n to the jugular veins of horses without untoward sequelre. (b) A dose of 5 c.c. in one case and 7t c.c. in another failed to produce any constitutional disturbance when given to horses of approximately goo lbs. body weight. In the third case the administration of 7t c.c. to an animal of the same body weight produced transient restlessness. In a fourth case the administration of ro c.c. evoked delirium . (c) Judged by the following facts , the anthelminthic value of oil of chenopodium when administered intravenously to horses appears low if not actually negative. Ninety horses showing ova of strongylidre in their freces, to the average number of I6 per fi eld, but with a maximum of 40 and a minimum of two per field, were subjected to treatment by oil of chenopodium administered, in conjunction with laxatives, by the cesophageal tube. In every case re-examination of the freces after the cessation of purging showed a negative count, although in a number of the patients the count reappeared at a later date. One infers from this that oil of chenopodium given by the mouth is roo per cent. efficient in clearing helminths from the intestines. Its action on encysted larvre is another matter. In the three animals which are the subject of this report and to which oil of chenopodium was administered intravenously, a negative count resulted in one case only and then lasted but for a single day. In Subjects Nos. I and 2 increased egg counts occurred at !varying intervals between one and seven days after they had received the chenopodium, hut the results were too indefinite to attribute th em to the action of the drug. In any case the abundance of parasites recovered on post-mortem examination of Subject No. I suppor;ts the inference of low anthelminthic value when administered intravenously. The value of the daily egg counts of the freces as a standard by
I I TUSSUSCEPTION OF THE SMALL BOWEL 461 which to judge anthelminthic efficiency is open to objection, but the time and labour necessary for searching freces for the macroscopic forms of the para<:ites was not forthcoming. In any event the method sufficed to show the very different results obtained after the respective use of the oral and intravenous channels of administration . The wide daily fluctuations in the egg content of Subject os. r and 2 before they received treatment , varying as they did from seven to II O per field in the one case and from one t o 25 per field in the other, indicat e that any attempt to reconcile the egg count to the intensity of the infestation must be fallacious. Stevenson (Veterinary R ecord, Vol. 36, 1924, p . 520) suggests that horses in a debilitated condition exhibit with some degree of uniformity a higher count than those in good condition . The variation in the daily counts of individual animals, together with the fact that horses in good condition show freq u ently intermittent if not constant counts of 30 or more to the field, renders it difficult to formulat e any standard of this. description which may be accepted as a satisfactory basis for diagnosis a nd treatment. Author's Note. Daily examination of the freces , together with all treatment , was discontinued in the case of Subjects Nos. 2 and 3 on 6-2- 28. A random examin a tion , h owever , made on 29- 3- 28 showed counts of ro per field in the case of the chestnut mare and 2 · 4 per field in the case of the gelding. The mare is the better of th e two in general condition.
Intussusception of the Small Bowel. By S. DE M. WOODWARD, M.R.C.V.S., Birmingham. DATE.-May 13th, 1926. SUBJECT.-Brown cob , mare, seven years old , the property of Birmingham Co-operative Dairy. Brought into hospital from one of the depots with acute colic. Dose of chloral hydrate administered without effect. H ypodermic inj ections of morphia and atropine gave no relief, but pain increased, so much so, that it was impossible in later stages to get near the mare with safety to administer any d raught or hyp odermic inj ection. She rolled ove r from side to side with ex traordinary quickness, was up and down , sweating profusely. In fact , I have never seen an animal in such acute pain. She died during the night . · Post-mortem examination revealed intussusception of the small bowel. The actual invagination measured 6 feet and the bowel when
Clinical
457
Jlrticl~s
The Intravenous Administration of Oil of Chenopodium to Horses. By MAJOR A. A. PRYER, D.S.O., R.A.V.C. , I nstructor and B acteriologist , R oyal Army Veterinary School, Aldershot.
Introduction. THE findings of Fernan-Nunez, recorded briefly on page 979, Tropical Diseases B ulletin , December, 1927, suggested further investigation of the intravenous administration of oil of chenopodium to horses. Enquiry was instituted with a view to obtaining information on t he following p oints:(a) Whether oil of chenopodium could be given conveniently in this ma nner. (b) If so, the maximum dose tha t could be employed safely. (c) The anthelminthic effi ciency of the drug given intravenously compared with its proved efficiency when administered per orem . It was hoped tha t if oil of chenopodium could be shown t o be a reliable anthelminthic, when administered intravenously, the undermentioned a dvantages would result :(a) A fi nancial saving in virtue of the smaller dose which it would b e n ecessary t o empl oy. This is a serious considera tion when u sing an expensive agent on a large number of anim als. (b) Definite an thelminthic action on la rva: encysted in the bowel wall or blood vessels, which appear to remain untouched hy the oral administration of the drug. (c) A bolition of the prolonged period of fas ting insisted upon commonly, before giving the drug by the mouth . Technique and Observations. Th ree horses, a b rown mare, a ch estnut mare and a chestnut gelding, of t he cavalry type were select ed as subjects. All appeared in satisfactory condition, but examination of the freces, by the sugar flo tation method, revealed the presence of ova of Strongylida:. SUBJ ECT No. r - BROWN MARE.-On r 6-r z- 27, ova of strongylidre were det ected in the fa:ces to the number of 50 per fi eld . On the same date and without an y prepara tion she received 5 c.c. of undiluted oil of ch enopodium intravenously.
4 58
THE VETERINARY JOURNAL
lo untoward sequela: resulted. Subsequent examjna tion of the fa:ces revealed the following coun ts:I 7- I 2- 27 I 8- I 2- 27 (8 a. m.) I 8-I 2- 27 (noon) 20- I 2- 27 2I- I2- 27 3- I - 28 5- I - 2 6- I - 28
70 ova of strongylida: per field. I4 I OO
I2 I2 I
3 IS
On the 6-r-28 a further 7t c.c. of oil of chenopodium were given int ravenously. Again no ill results were observed . Continued examination of the fa:ces showed : 7- 1- 28 8-I- 28 9-I- 28 I o--I - 28 II- I- 28 I 2- I - 28 'I 3- I - 28 IS- I- 28 I 6- I- 28 I 7- I- 28 I 8- I -28 I 9- I- 28 2o--I -28 2! - I-28 22-I - 28 23- 1- 28 24- I- 28 2S- I- 28 26-I- 28 27- 1- 28
22 ova of strongylida: per fi eld. go 25 ISO IS O
I 20 54 I6 6o 36 62 6 5
s
13
s 5 7 2
II
Counts were d iscontinued after 27- I - 28 and on 3I - I- 28 the subj ect was destroyed . Post-mortem examination revealed 34 A scaris equi, all located anterior to the ileo-ca:cal valve and 47 nemat odes which ap peared t o be S trongyli vulgaris. The majority were active. No na ked-eye appearances of trichonema or triodontophorous infections were detected . The anterior mesenteric a rtery and its b ranches were normal. SUBJ ECT No. 2- CHESTNUT MARE.-One hundred and ten ova of
OIL OF CHENOPODIUM FOR HORSES
459
strongylidce per field were counted on I 6- I- 28, but between 20- I - 28 and 27- I --28 the count dropped , without treatment to a daily average of 20 per field with a maximum of 39 and a minimum of seven. On 28- I- 28 the count rose suddenly to I 09 per field and IO c.c. of oil of chenopodium were given intravenously. Twenty seconds later violent excitement resulted and the followin g symptoms were observed:Eyeballs prominent and rolling, ears moved rapidly, animal kicked , struck wildly with the forelegs and fell to the floor of the stall ; it rose again immediately and, breaking away from the attendant, escaped from the stable in a state of delirium, but was captured within two minutes. The delirium passed off rapidly, but for the nex t half hour signs of nausea , dull colic and subdued excitement were exhibited . The bowels were evacuated five times in twelve minutes, the fceces becoming progressively softer. The writer has seen numerous cases of faintness and temporary collapse following intravenous medication , but never previously the train of symptoms described above. All the symptoms subsided slowly and at the expiration of one and a half hours the animal appeared normal. Subsequent examination of the fceces revealed:-29-I- 28 3o-I-28 3I- I- 28 I- 2- 28 2-2-28 3-2-28 4- 2- 28 5- 2-28 6- 2-28
29 ova of st rongylidce per fi eld. 6s IS O SO 87 4 44 I6 I3
SUBJECT No. 3-CHESTNUT GELDI NG .- Twenty-five ova of strongylidce per field were present on I6- I- 28. Between 20-I- 2 and 27-I-28 the average daily count was eight per fi eld with a maxi.mum of IS and a minimum of one. On 28-I- 28 the count stood at one per field and 7t c.c. of oil of chenopodium were given intravenously. Very slight transient restlessness, accompanied by two rapid defcecations followed, but vanished after five minutes. Otherwi se no local or ge neral disturbance occurred.
460
THE VETERINARY JOURNAL
Subsequent examinations of freces revealed : 29- I -28 I6 ova of strongylidre per field . 3o-I -28 I 3I-I-28 nil I-2- 28 2 2- 2- 28 I I 3- 2-28 I 4- 2- 28 5- 2-28 3 6- 2- 28 2
·Summary and Conclusion. (a) Undiluted oil of chenopodium may be introduced i-n to the jugular veins of horses without untoward sequelre. (b) A dose of 5 c.c. in one case and 7t c.c. in another failed to produce any constitutional disturbance when given to horses of approximately goo lbs. body weight. In the third case the administration of 7t c.c. to an animal of the same body weight produced transient restlessness. In a fourth case the administration of ro c.c. evoked delirium . (c) Judged by the following facts , the anthelminthic value of oil of chenopodium when administered intravenously to horses appears low if not actually negative. Ninety horses showing ova of strongylidre in their freces, to the average number of I6 per fi eld, but with a maximum of 40 and a minimum of two per field, were subjected to treatment by oil of chenopodium administered, in conjunction with laxatives, by the cesophageal tube. In every case re-examination of the freces after the cessation of purging showed a negative count, although in a number of the patients the count reappeared at a later date. One infers from this that oil of chenopodium given by the mouth is roo per cent. efficient in clearing helminths from the intestines. Its action on encysted larvre is another matter. In the three animals which are the subject of this report and to which oil of chenopodium was administered intravenously, a negative count resulted in one case only and then lasted but for a single day. In Subjects Nos. I and 2 increased egg counts occurred at !varying intervals between one and seven days after they had received the chenopodium, hut the results were too indefinite to attribute th em to the action of the drug. In any case the abundance of parasites recovered on post-mortem examination of Subject No. I suppor;ts the inference of low anthelminthic value when administered intravenously. The value of the daily egg counts of the freces as a standard by
I I TUSSUSCEPTION OF THE SMALL BOWEL 461 which to judge anthelminthic efficiency is open to objection, but the time and labour necessary for searching freces for the macroscopic forms of the para<:ites was not forthcoming. In any event the method sufficed to show the very different results obtained after the respective use of the oral and intravenous channels of administration . The wide daily fluctuations in the egg content of Subject os. r and 2 before they received treatment , varying as they did from seven to II O per field in the one case and from one t o 25 per field in the other, indicat e that any attempt to reconcile the egg count to the intensity of the infestation must be fallacious. Stevenson (Veterinary R ecord, Vol. 36, 1924, p . 520) suggests that horses in a debilitated condition exhibit with some degree of uniformity a higher count than those in good condition . The variation in the daily counts of individual animals, together with the fact that horses in good condition show freq u ently intermittent if not constant counts of 30 or more to the field, renders it difficult to formulat e any standard of this. description which may be accepted as a satisfactory basis for diagnosis a nd treatment. Author's Note. Daily examination of the freces , together with all treatment , was discontinued in the case of Subjects Nos. 2 and 3 on 6-2- 28. A random examin a tion , h owever , made on 29- 3- 28 showed counts of ro per field in the case of the chestnut mare and 2 · 4 per field in the case of the gelding. The mare is the better of th e two in general condition.
Intussusception of the Small Bowel. By S. DE M. WOODWARD, M.R.C.V.S., Birmingham. DATE.-May 13th, 1926. SUBJECT.-Brown cob , mare, seven years old , the property of Birmingham Co-operative Dairy. Brought into hospital from one of the depots with acute colic. Dose of chloral hydrate administered without effect. H ypodermic inj ections of morphia and atropine gave no relief, but pain increased, so much so, that it was impossible in later stages to get near the mare with safety to administer any d raught or hyp odermic inj ection. She rolled ove r from side to side with ex traordinary quickness, was up and down , sweating profusely. In fact , I have never seen an animal in such acute pain. She died during the night . · Post-mortem examination revealed intussusception of the small bowel. The actual invagination measured 6 feet and the bowel when