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The lipid profile in aids patients
Poster session abstracts/Atherosclerosis 115 (Suppl.) (1995) $45-$129 P18 Lipoproteins
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ULTRASOUND EVALUATION OF ASYMPTOMATIC ATHEROSCLEROSIS IN HIV INFECTION J. Coustans J.M. Marchand, P. Rispal, C. Lasseur, M. Seigneur, J.L. Pellegrin, B. Leng, C. Cortri CHRU, Bordeaux, France
APOLIPOPROTEIN B LEVEL CHANGES THROUGHOUT THE TERM-PERIOD IN A SELECTED OF NEWBORNS IN THE TOLEDO STUDY (SPAIN)" S. Bastida~, C. Cuesta ~, S. Perea2, F.J. Sfinchez-Muniz~ qnstituto de Nutrici6n y Bromatologfa (CSIC-UCM); Facultad de Farmacia; Universidad Complutense de Madrid (Spain); 2Servicio de Farmacia; Hospital Virgen de la Salud de Toledo (Spain).
Atherosclerosis has been reported in HIV-positive patients in 2 previous studies: one on the coronary arteries of 8 patients at autopsy, the other about athero-embolism of lower limb arteries in 4 patients. The objective of our study was to assess asymptomatic atherosclerosis in HIV-positive patients in vivo by ultasound. Patients, methods: 29 HIV-positive patients and 16 controls were matched for sex, age and tobacco consumption. All had a doppler/ echoduplex examination of carotid arteries, abdominal aorta and lower limb arteries, and a determination of plasma lipids. Results: 10 HIV-positive patients (34.5%) and 1 control (6.25%) had plaques (p=0.04). HIV+plq+ HlV+plq- all H1V+ controls Number of subiects I0 19 29 16 mean age years (SD) 38.4(8.2) 37.8(10.4) 38(9.7) 41(10) tobacco year-packs (SD) 25(18) 15(7) 19(14) 19(12) infection years(SD) 6.7(3.6) 5(3) 5.6(3.2) CD4 cells/mm3 (SD) 82(82) 220(202) 172(161) cholesterol mmol/I (SD) 4.2(1.4) 4.8(1.4) 4.6(1.4) 5.1(1.4) trigIycerides mmol/l (SD) 2(0.1) 1.9(0.9)* 1.9(1)* 1.1(0.3) HDL-chol mmol/l (SD) 0.7(0.2)* 0.9(0.4) 0.8(0.4)* 1.3(0.3) Lp(a) g/l median (SD) 0.34(0.3) 0.23(0.2) 0.27(0.3) 0.27(0.4) *significant difference (versus controls), plq+/plq-= with/without plaques
The Toledo Study was born in the Virgen de la Salud Hospital of Toledo (Spain), studying 705 neonates. Due to lipids and lipoproteins appear to be highly influence by the kind of delivery, gestational age, body weight, fetal distress, etc. the current communication describes the results of apolipoprotein (Apo) B in a total of 548 healthy, full-term, single born from eutocic delivery with cephalic presentation, without fetal distress, and appropriate body weight for gestational age-newborns. Male and female neonates were also studied separately. The concentration of Apo B in the total of newborns was 0.29 4- 0.09 g/L being no differences between male and female. Apo B increased significantly between wk 37 and 41 in both sex-neonates. No sex relate effect was found upon Apo B in any studied wk. Normality range were set to be employed in future work for follow-up and perhaps intervention in newborns with high concentration of Apo B ( > 0 . 4 7 g/L for male and female neonates). "Partially supported by Behring Institute.
Conclusion: Asymptomatic atherosclerosis occurs in one third of uuselected HIV-positive patients. Those patients with plaques have larger tobacco consumption and lower HDLcholesterol. HIV infection is characterized by an atherogenic lipidic profile. HIV might accelerate the development of atherosclerosis.
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THE LIPID PROFILE IN AIDS PATIENTS Sp. Paximadas, St. Pagoni, El. Vervesou, A. Armenaka, E. Chatzikonstantinos, S. Giannakidis Unit Lipid and 1st Dept Internal Medicin, General Hospital of Athens "ELPIS", Greece
ANTHROPOMETRY AND LIPOPROTEINS-RELATED CHARACTERISTICS OF YOUNG ADULT MALES IN TAIWAN Yu-An Ding, Nain-Feng Chu Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, R.O.C.
Purpose: To study the lipid profile in AIDS patients and a possible role in diagnosis. Material-Methods: 32 AIDS patients (25 males and 7 females), aged 20-68 years (mean age 34+:8 years) were studied (Group A). Serum lipid levels of Group A were compared to those of 80 randomly selected controls that came to the outpatient clinic for a checkup (Group B), aged 17-66 years (mean age 484-12 years). Results: Group A Group B TC(mg/dl) 158+38 229+424 TG(mg/dl) 178+:98 120+603 HDL(mg/dl) 32+: 12 44 4-113 LDL(mg/dl) 764-28 163+:374 Chylom(%) 11.74-11.3 0.74-1.54 g(%) 47.04-17.7 54.3_+9.42 pre-I~(%) 15.94-19.3 19.0+7.7 ~ ~(%) 25.44-14.0 26.0_+6.0NS apoAI(mg/dl) 83 5=45 134 +: 254 apoB(mg/dl) 56-+32 140-+324 (*p< .02, Zp< .03, 3p< .001, 4p< .00001, NS=Not Significant Conclusion: HIV infected patients have abnormal lipid metabolism. These lipidaemic parameters should be taken into consideration when evaluating these patients.
To investigate the prevalence of obesity and the lipoprotein-related characteristics among young male adults in Taiwan area. A crosssectional survey with total 936 males (mean age 20, 18-24) were enrolled. The prevalence of obesity was 9.6% by the criterion of body weight greater than 20% of ideal body weight, or 12.6% by the criterion of body mass index (BMI) greater than 25. The obese subjects had significantly higher serum total cholesterol (CHOL), triglyceride (TG) and apo-lipoprotein B (apo B) and lower high density lipoprotein-cholesterol (HDL-C) levels than the non-obese. Whereas, apo-A1 and the lipoprotein[a] (Lp[a]) levels were no difference between two groups. Pearson correlation coefficient of body weight, body height, BMI, waist circumference, hip circumference and waist-hip ratio (WHR) to lipoproteins variables showed that both BMI and WHR are positively correlated with CHOL, TG and apo B, but negatively correlated with HDL-C. Furthermore the lipoproteins variables seem to be more correlated with BMI than WHR in lean subjects (BMI < 25). However, this phenomena was quite different in obese (BM1 > 25) subjects, that the WHR is more correlated with lipoprotein variables than BMI does.
S121
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455
ULTRASOUND EVALUATION OF ASYMPTOMATIC ATHEROSCLEROSIS IN HIV INFECTION J. Coustans J.M. Marchand, P. Rispal, C. Lasseur, M. Seigneur, J.L. Pellegrin, B. Leng, C. Cortri CHRU, Bordeaux, France
APOLIPOPROTEIN B LEVEL CHANGES THROUGHOUT THE TERM-PERIOD IN A SELECTED OF NEWBORNS IN THE TOLEDO STUDY (SPAIN)" S. Bastida~, C. Cuesta ~, S. Perea2, F.J. Sfinchez-Muniz~ qnstituto de Nutrici6n y Bromatologfa (CSIC-UCM); Facultad de Farmacia; Universidad Complutense de Madrid (Spain); 2Servicio de Farmacia; Hospital Virgen de la Salud de Toledo (Spain).
Atherosclerosis has been reported in HIV-positive patients in 2 previous studies: one on the coronary arteries of 8 patients at autopsy, the other about athero-embolism of lower limb arteries in 4 patients. The objective of our study was to assess asymptomatic atherosclerosis in HIV-positive patients in vivo by ultasound. Patients, methods: 29 HIV-positive patients and 16 controls were matched for sex, age and tobacco consumption. All had a doppler/ echoduplex examination of carotid arteries, abdominal aorta and lower limb arteries, and a determination of plasma lipids. Results: 10 HIV-positive patients (34.5%) and 1 control (6.25%) had plaques (p=0.04). HIV+plq+ HlV+plq- all H1V+ controls Number of subiects I0 19 29 16 mean age years (SD) 38.4(8.2) 37.8(10.4) 38(9.7) 41(10) tobacco year-packs (SD) 25(18) 15(7) 19(14) 19(12) infection years(SD) 6.7(3.6) 5(3) 5.6(3.2) CD4 cells/mm3 (SD) 82(82) 220(202) 172(161) cholesterol mmol/I (SD) 4.2(1.4) 4.8(1.4) 4.6(1.4) 5.1(1.4) trigIycerides mmol/l (SD) 2(0.1) 1.9(0.9)* 1.9(1)* 1.1(0.3) HDL-chol mmol/l (SD) 0.7(0.2)* 0.9(0.4) 0.8(0.4)* 1.3(0.3) Lp(a) g/l median (SD) 0.34(0.3) 0.23(0.2) 0.27(0.3) 0.27(0.4) *significant difference (versus controls), plq+/plq-= with/without plaques
The Toledo Study was born in the Virgen de la Salud Hospital of Toledo (Spain), studying 705 neonates. Due to lipids and lipoproteins appear to be highly influence by the kind of delivery, gestational age, body weight, fetal distress, etc. the current communication describes the results of apolipoprotein (Apo) B in a total of 548 healthy, full-term, single born from eutocic delivery with cephalic presentation, without fetal distress, and appropriate body weight for gestational age-newborns. Male and female neonates were also studied separately. The concentration of Apo B in the total of newborns was 0.29 4- 0.09 g/L being no differences between male and female. Apo B increased significantly between wk 37 and 41 in both sex-neonates. No sex relate effect was found upon Apo B in any studied wk. Normality range were set to be employed in future work for follow-up and perhaps intervention in newborns with high concentration of Apo B ( > 0 . 4 7 g/L for male and female neonates). "Partially supported by Behring Institute.
Conclusion: Asymptomatic atherosclerosis occurs in one third of uuselected HIV-positive patients. Those patients with plaques have larger tobacco consumption and lower HDLcholesterol. HIV infection is characterized by an atherogenic lipidic profile. HIV might accelerate the development of atherosclerosis.
454
456
THE LIPID PROFILE IN AIDS PATIENTS Sp. Paximadas, St. Pagoni, El. Vervesou, A. Armenaka, E. Chatzikonstantinos, S. Giannakidis Unit Lipid and 1st Dept Internal Medicin, General Hospital of Athens "ELPIS", Greece
ANTHROPOMETRY AND LIPOPROTEINS-RELATED CHARACTERISTICS OF YOUNG ADULT MALES IN TAIWAN Yu-An Ding, Nain-Feng Chu Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, R.O.C.
Purpose: To study the lipid profile in AIDS patients and a possible role in diagnosis. Material-Methods: 32 AIDS patients (25 males and 7 females), aged 20-68 years (mean age 34+:8 years) were studied (Group A). Serum lipid levels of Group A were compared to those of 80 randomly selected controls that came to the outpatient clinic for a checkup (Group B), aged 17-66 years (mean age 484-12 years). Results: Group A Group B TC(mg/dl) 158+38 229+424 TG(mg/dl) 178+:98 120+603 HDL(mg/dl) 32+: 12 44 4-113 LDL(mg/dl) 764-28 163+:374 Chylom(%) 11.74-11.3 0.74-1.54 g(%) 47.04-17.7 54.3_+9.42 pre-I~(%) 15.94-19.3 19.0+7.7 ~ ~(%) 25.44-14.0 26.0_+6.0NS apoAI(mg/dl) 83 5=45 134 +: 254 apoB(mg/dl) 56-+32 140-+324 (*p< .02, Zp< .03, 3p< .001, 4p< .00001, NS=Not Significant Conclusion: HIV infected patients have abnormal lipid metabolism. These lipidaemic parameters should be taken into consideration when evaluating these patients.
To investigate the prevalence of obesity and the lipoprotein-related characteristics among young male adults in Taiwan area. A crosssectional survey with total 936 males (mean age 20, 18-24) were enrolled. The prevalence of obesity was 9.6% by the criterion of body weight greater than 20% of ideal body weight, or 12.6% by the criterion of body mass index (BMI) greater than 25. The obese subjects had significantly higher serum total cholesterol (CHOL), triglyceride (TG) and apo-lipoprotein B (apo B) and lower high density lipoprotein-cholesterol (HDL-C) levels than the non-obese. Whereas, apo-A1 and the lipoprotein[a] (Lp[a]) levels were no difference between two groups. Pearson correlation coefficient of body weight, body height, BMI, waist circumference, hip circumference and waist-hip ratio (WHR) to lipoproteins variables showed that both BMI and WHR are positively correlated with CHOL, TG and apo B, but negatively correlated with HDL-C. Furthermore the lipoproteins variables seem to be more correlated with BMI than WHR in lean subjects (BMI < 25). However, this phenomena was quite different in obese (BM1 > 25) subjects, that the WHR is more correlated with lipoprotein variables than BMI does.