- Email: [email protected]
The malaria genome project: resources for research
6
PATHOGEN
y;z::
ium gordonae.
Cole, S. ‘T., Brosch, R., Parkhill, J., Gamier, T., Churcher, C., Harris, D., Gordon, S. V., Eiglmeier, K., Gas, S., Barry, C. E. III, Tekaia, F., Badcock, K., Basham, D., Brown, D., Chillingworth, T., Connor, R., Davies, R., Devlin, K., Feltwell, T., Gentles, S., Hamlin, N., Holroyd, S., Homsby, T., Jagels, K., Barrel& B. G., et al. (1998). Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature, 393,537-544. Cole, S. T., Eiglmeier, K., Parkhill, J., James, K. D., Thomson, N. R., Wheeler, I’. R., Honore, N., Gamier, T., Churcher, C., Harris, D., Mungall, K., Basham, D., Brown, D., Chillingworth, T., Connor, R., Davies, R. M., Devlin, K., Duthoy, S., Feltwell, T., Fraser, A., Hamlin, N., Holroyd, S., Homsby, T., Jagels, K., Lacroix, C., Maclean, J., Moule, S., Murphy, L., Oliver, K., Quail, M. A., Rajandream, M. A., Rutherford, K. M., Rutter, S., Seeger, K., Simon, S., Simmonds, M., Skelton, J., Squares, R., Squares, S., Stevens, K., Taylor, K., Whitehead, S., Woodward, J. R. & Barrell, B. G. (2001). Massive gene decay in the leprosy bacillus. Nature, 409, 1007- 10 11. Cox, J. S., Chen, B., McNeil, M. & Jacobs, W. R. Jr (1999). Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature, 402, 79-83. Eiglmeier, K., Fsihi, H., Heym, B. & Cole, S. T. (1997). On gene, katG, of Mycobacterium leprae the catalase-peroxidase and the implications for treatment of leprosy with isoniazid. FEMS Microbiological Letters, 149, 273-278. Gordon, S. V., Brosch, R., Billault, A., Gamier, T., Eiglmeier, K. & Cole, S. T. (1999a). Identification of variable regions in the genomes of tubercle bacilli using bacterial artificial chromosome arrays. Molecular Microbiology, 32, 643-655. Gordon, S. V., Heym, B., Parkhill, J., Barrel& B. & Cole, S. T. (1999b). New insertion sequences and a novel repeated sequence in the genome of Mycobacterium tuberculosis H37Rv. Microbiology, 145, 881-892. Gordon, S. V., Eiglmeier, K., Garnier, T., Brosch, R., Parkhill, J., Barrell, B. R., Cole, S. T. & Hewinson, R. G. (2001). Genomics of Mycobacterium bovis. Tuberculosis, 81, 157-163. Hermans, I’. W., van Soolingen, D. & van Embden, J. D. (1992). Characterization of a major polymorphic tandem repeat in Mycobacterium tuberculosis and its potential use in
OF THE ROYAL
Pathogen
genomes
The malaria
genome
Alister
Craig
Liverpool
SOCIETY
OF TROPICAL
HEALTH
of Mycobacterium kansasii and Mycobacterof Bacteriology, 174,4157-4165. Mahairas, G. G., Sabo, I’. J., Hickey, M. J., Singh, D. C. & Stover, C. K. (1996). Molecular analysis of genetic differences between Mycobacterium bovis BCG and virulent M. bovis. Journal ofBacteriology, 178, 127441282. Poulet, S. & Cole, S. T. (1995). Characterization of the highly abundant polymorphic GC-rich-repetitive sequence (PGRS) present in Mycobacterium tuberculosis. Archives of Microbiology, 163, 87-95. Ramakrishnan, L., Federspiel, N. A. & Falkow, S. (2000). Granuloma-specific expression of Mycobacterium virulence proteins from the glycine-rich PE-PGRS family. Science, 288,1436-1439. Skeiky, Y. A., Ovendale, I’. J., Jen, S., Alderson, M. R., Dillon, D. C., Smith, S., Wilson, C. B., Orme, I. M., Reed, S. G. & Campos-Neto, A. (2000). T cell expression cloning of a Mycobacterium tuberculosis gene encoding a protective antigen associated with the early control of infection. Journal ofImmunology, 165,7140-7149. Tekaia, F., Gordon, S. V., Gamier, T., Brosch, R., Barrell, B. G. & Cole, S. T. (1999). Analysis of the proteome of Mycobacterium tuberculosis in silica. Tubercle and Lung Disease, 79,329-342. Triccas, J. A., Berthet, F. X., Pelicic, V. & Gicquel, B. (1999). Use of fluorescence induction and sucrose counterselection to identify Mycobacterium tuberculosis genes expressed within host cells. Microbiology, 145, 2923-2930. Weber, I., Fritz, C., Ruttkowski, S., Kreft, A. & Bange, F. C. (2000). Anaerobic nitrate reductase (narGHJI) activity of Mycobacterium bovis BCG in vitro and its contribution to virulence in immunodeficient mice. Molecular Microbiology, 35, 1017-1025. Wolf, Y. I., Aravind. L., Grishin, N. V. & Koonin, E. V. (1999). Evolution of aminoacyl-&NA synthetases-analysis of unique domain architectures and phylogenetic trees reveals a complex history of horizontal gene transfer events.
of the Mycobacterium tuberculosis complex. In: of the Mycobacteria. Hatfull, G. F. & W. R. (editors). Washington, DC: ASM Press, pp. Genetics
TRANSACTIONS
AND HUMAN
the epidemiology
and evolution Molecular
GENOMES
Journal
Genome Research, 9,689-710.
Zahrt, T. C. & Deretic, V. (2000). An essential two-component signal transduction system in Mycobacterium tuberculo182, 3832-3838. sis. Journal of Bacteriology,
Received 2001
MEDICINE
AND
2 May
HYGIENE
2001;
accepted for publication
14 June
(2002) 96,6
and human health project:
resources
School of Tropical Medicine,
for research
Pembroke Place, Liverpool
L3 SQA, UK
The essence of this presentation has been published (as Horrocks, I?., Bowman, S., Kyes, S., Waters, A. P. & Craig, A. (2000): Entering the post-genomic era of malaria research. Bulletin of the World Health Organization, 78, 14241437) and is available on the WHO website (http:liwww. who.intlbulletinlpdfl20OO/issue12/bu0825.pdj).
PATHOGEN
y;z::
ium gordonae.
Cole, S. ‘T., Brosch, R., Parkhill, J., Gamier, T., Churcher, C., Harris, D., Gordon, S. V., Eiglmeier, K., Gas, S., Barry, C. E. III, Tekaia, F., Badcock, K., Basham, D., Brown, D., Chillingworth, T., Connor, R., Davies, R., Devlin, K., Feltwell, T., Gentles, S., Hamlin, N., Holroyd, S., Homsby, T., Jagels, K., Barrel& B. G., et al. (1998). Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature, 393,537-544. Cole, S. T., Eiglmeier, K., Parkhill, J., James, K. D., Thomson, N. R., Wheeler, I’. R., Honore, N., Gamier, T., Churcher, C., Harris, D., Mungall, K., Basham, D., Brown, D., Chillingworth, T., Connor, R., Davies, R. M., Devlin, K., Duthoy, S., Feltwell, T., Fraser, A., Hamlin, N., Holroyd, S., Homsby, T., Jagels, K., Lacroix, C., Maclean, J., Moule, S., Murphy, L., Oliver, K., Quail, M. A., Rajandream, M. A., Rutherford, K. M., Rutter, S., Seeger, K., Simon, S., Simmonds, M., Skelton, J., Squares, R., Squares, S., Stevens, K., Taylor, K., Whitehead, S., Woodward, J. R. & Barrell, B. G. (2001). Massive gene decay in the leprosy bacillus. Nature, 409, 1007- 10 11. Cox, J. S., Chen, B., McNeil, M. & Jacobs, W. R. Jr (1999). Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature, 402, 79-83. Eiglmeier, K., Fsihi, H., Heym, B. & Cole, S. T. (1997). On gene, katG, of Mycobacterium leprae the catalase-peroxidase and the implications for treatment of leprosy with isoniazid. FEMS Microbiological Letters, 149, 273-278. Gordon, S. V., Brosch, R., Billault, A., Gamier, T., Eiglmeier, K. & Cole, S. T. (1999a). Identification of variable regions in the genomes of tubercle bacilli using bacterial artificial chromosome arrays. Molecular Microbiology, 32, 643-655. Gordon, S. V., Heym, B., Parkhill, J., Barrel& B. & Cole, S. T. (1999b). New insertion sequences and a novel repeated sequence in the genome of Mycobacterium tuberculosis H37Rv. Microbiology, 145, 881-892. Gordon, S. V., Eiglmeier, K., Garnier, T., Brosch, R., Parkhill, J., Barrell, B. R., Cole, S. T. & Hewinson, R. G. (2001). Genomics of Mycobacterium bovis. Tuberculosis, 81, 157-163. Hermans, I’. W., van Soolingen, D. & van Embden, J. D. (1992). Characterization of a major polymorphic tandem repeat in Mycobacterium tuberculosis and its potential use in
OF THE ROYAL
Pathogen
genomes
The malaria
genome
Alister
Craig
Liverpool
SOCIETY
OF TROPICAL
HEALTH
of Mycobacterium kansasii and Mycobacterof Bacteriology, 174,4157-4165. Mahairas, G. G., Sabo, I’. J., Hickey, M. J., Singh, D. C. & Stover, C. K. (1996). Molecular analysis of genetic differences between Mycobacterium bovis BCG and virulent M. bovis. Journal ofBacteriology, 178, 127441282. Poulet, S. & Cole, S. T. (1995). Characterization of the highly abundant polymorphic GC-rich-repetitive sequence (PGRS) present in Mycobacterium tuberculosis. Archives of Microbiology, 163, 87-95. Ramakrishnan, L., Federspiel, N. A. & Falkow, S. (2000). Granuloma-specific expression of Mycobacterium virulence proteins from the glycine-rich PE-PGRS family. Science, 288,1436-1439. Skeiky, Y. A., Ovendale, I’. J., Jen, S., Alderson, M. R., Dillon, D. C., Smith, S., Wilson, C. B., Orme, I. M., Reed, S. G. & Campos-Neto, A. (2000). T cell expression cloning of a Mycobacterium tuberculosis gene encoding a protective antigen associated with the early control of infection. Journal ofImmunology, 165,7140-7149. Tekaia, F., Gordon, S. V., Gamier, T., Brosch, R., Barrell, B. G. & Cole, S. T. (1999). Analysis of the proteome of Mycobacterium tuberculosis in silica. Tubercle and Lung Disease, 79,329-342. Triccas, J. A., Berthet, F. X., Pelicic, V. & Gicquel, B. (1999). Use of fluorescence induction and sucrose counterselection to identify Mycobacterium tuberculosis genes expressed within host cells. Microbiology, 145, 2923-2930. Weber, I., Fritz, C., Ruttkowski, S., Kreft, A. & Bange, F. C. (2000). Anaerobic nitrate reductase (narGHJI) activity of Mycobacterium bovis BCG in vitro and its contribution to virulence in immunodeficient mice. Molecular Microbiology, 35, 1017-1025. Wolf, Y. I., Aravind. L., Grishin, N. V. & Koonin, E. V. (1999). Evolution of aminoacyl-&NA synthetases-analysis of unique domain architectures and phylogenetic trees reveals a complex history of horizontal gene transfer events.
of the Mycobacterium tuberculosis complex. In: of the Mycobacteria. Hatfull, G. F. & W. R. (editors). Washington, DC: ASM Press, pp. Genetics
TRANSACTIONS
AND HUMAN
the epidemiology
and evolution Molecular
GENOMES
Journal
Genome Research, 9,689-710.
Zahrt, T. C. & Deretic, V. (2000). An essential two-component signal transduction system in Mycobacterium tuberculo182, 3832-3838. sis. Journal of Bacteriology,
Received 2001
MEDICINE
AND
2 May
HYGIENE
2001;
accepted for publication
14 June
(2002) 96,6
and human health project:
resources
School of Tropical Medicine,
for research
Pembroke Place, Liverpool
L3 SQA, UK
The essence of this presentation has been published (as Horrocks, I?., Bowman, S., Kyes, S., Waters, A. P. & Craig, A. (2000): Entering the post-genomic era of malaria research. Bulletin of the World Health Organization, 78, 14241437) and is available on the WHO website (http:liwww. who.intlbulletinlpdfl20OO/issue12/bu0825.pdj).