The modifying effect of the BDNF Val66Met polymorphism on the neurophysiological characteristics of verbal information processing

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the physical and neurological test help to assess the presence of variables. Statistics methods where used. Principal Results: Our findings were consistent across different countries. The main NM in decreasing frequency order were apraxia with imitation gestures, the non fluent anomic aphasia, the urinary incontinency, the extrapiramidal signs, the problems at walking and the focal neurological sings. Associated with cognitive declining were the neuropsychiatric symptoms. Conclusions. As the disease shows different stages, NM reflects a pattern of progression among cognitive impairment. The main NM is apraxia. doi:10.1016/j.ijpsycho.2016.07.371

529 Group cognitive therapy in patients with mild cognitive impairment and Alzheimer’s disease Nelky Urrutia Amable Servicio Provincial de Atención Integral Comunitario a los trastornos de la memoria, Hospital GD Ivan Portuondo, Havana, Cuba Introduction. Normal aging causes a variety of changes associated with a general declension of the physiological functions. As a consequence, a group of behavioral, cognitive, and emotionaldeficits comes up.Talking about forgetfulness, loss of memory, or difficulty to learn new things was, until recently, a synonym of old age.However, the long-term memory loss is nowadays known as a damaged cognitive process provoked by the most common form of dementia: Alzheimer Disease (AD). This project deals with various fundamentals and methodological strategies as part of a Group Cognitive Therapy to train the mental capacities of patients with Mild Cognitive Impairment (MCI) and Alzheimer ’s disease. Besides, the paper contrasts those fundamentals with a control group to reveal convincing results as a non-pharmacological alternative. Objectives. To evaluate the effectiveness of the Group Cognitive Therapy for the training of the mental capacities in previously diagnosed patients with Mild Cognitive Impairment and Alzheimer´s disease. To describe the behavior of the different studied groups based on the training of the mental capacities. Methodology. Research Classification: A quasi-experimental descriptive investigation of community intervention. Methodological Design: A quasi-experimental analysis was made, including 200 subjects between the ages of 50 and 88. These subjects were previously evaluated in the multidisciplinary consultation of the Provincial Department of Communal Comprehensive Service to Mental Disorders in San Antonio de los Baños, Artemisa. A group of 100 subjects wasanalyzed in the Group Cognitive Therapy, resulting in 30 patients with Normal Cognition, 40 with MCI and 30 with AD. They were applied a pre-test and a post-test to compare results and evaluate the effectiveness of the Therapy as a training of the mental capacities.Besides, we contrasted those results with a control group constituted by 100 subjects who did not receive therapy. Main Results. Throughout the comparison between the pre-test results and the post-test results, we could notice that the 100% of the subjects who took the Cognitive Therapy had an important advance regarding the training of the mental capacities. Contrasting such progress with the post-test results of the control group, we could describe the significant advance of the group who took the Therapy. Conclusions. It was determined the success and effectiveness of the Group Cognitive Therapy as a suitable non-pharmacological alternative for patients with MCI and AD. Moreover, the Therapy

reaffirmed its effectiveness to promote and favor an appropriate general cognitive maintenance. doi:10.1016/j.ijpsycho.2016.07.372

530 Physiological repercussion of depressive symptoms in patients with Alzheimer’s disease Naybí Prendes Rivero, Denise Alvarez Sam, Tamara Cervantes Villareal Polyclinic No.2 “Felipe Ismael Rodríguez Ramos”, MINSAP SONECUB SCUAL, Artemisa Province, Cuba Introduction. Alzheimer’s disease (AD) is a degenerative disease with three main symptomatic domains: neurological, cognitive and neuropsychiatric, is the most common cause of dementia in the elderly (70%). The geriatric’s depression with prevalence of 0.6% to 29.7% can be a risk factor for the development of dementia. The relationship between AD and depression is a complex field of investigation, they can be together or in an independent way, or just closely. Over 50% of patients with dementing illnesses, such as Alzheimer’s disease, may also have depressive symptoms, with 20% meeting criteria for a major depressive episode. They are associated with declining cognitive and functional ability, decreased quality of life and increased institutionalization and care cost. Goal. To describe a disorder: depression, with its physiological manifestations in patients with Alzheimer’s disease. Identified the possible correlation with global cognitive impairment in patients of the Psychogeriatric Consult, Polyclinic No.2 “Felipe Ismael Rodríguez Ramos”. Mental Health Department: September 2014January 2016. Methodology. We support a correlational, descriptive, transversal investigation, on 60 AD patients with depressive symptoms; Mild AD 46.7%, Moderate AD 30% and Severe AD 23%. Cognitive and behavioral tests (MMSE and Cornell scale for depression in dementia) help to assess the presence of variables. Statistics analyzes were used to determine the different types of depressive symptoms, setting the degree of cognitive impairment as scores achieved by the patient in the MMSE. Explore the relationship between depressive somatic symptoms and manifestations or MMSE results, we used the Pearson correlation coefficient with a significance level (p b0.05) (Vilalta J et al, 1999). Statistical analysis of data was performed using STATISTICA software, version 7 (StatSoft, Inc. 2004). Results. Our findings were consistent across different countries and suggested a significant incidence of sings related to humor in mild and moderate stages; the behavior and cyclic function disorders in the severe stage were found. Conclusions: As the disease shows different stages, depression reflects a pattern of progression among cognitive impairment. doi:10.1016/j.ijpsycho.2016.07.373

63 Seesion 4 The modifying effect of the BDNF Val66Met polymorphism on the neurophysiological characteristics of verbal information processing Vera Golimbeta, Zhanna Garakhb, Galina Korovaitsevaa, Tatyana Lezheikoa, Yulia Zaytsevac, Valeria Streletsb

IOP 2016 a

Mental Health Research Center, Moscow, Russia Institute of Higher Nervous Activity and Neurophysiology of RAS, Moscow, Russia c Moscow Research Institute of Psychiatry – Branch of Federal Medical Research Centre of Psychiatry and Narcology named after V.P.Serbsky, Moscow, Russia b

The mechanisms of visual word recognition have been studied using psychological, neurophysiological and neuroimaging approaches. However, no studies on the molecular-genetic correlates of the visual word recognition have been conducted so far though the recent twin study has demonstrated that genetic factors may contribute to the brain activation evoked by written words (Pinel et al.2015). An aim of the study was to search for the association between the components of the early stages of verbal information processing in the brain during the passive reading of single words and the gene coding for brain-derived neurotrophic factor (BDNF). BDNF plays an important role in the brain promoting the development and function of serotonin and dopamine neurons. The functional polymorphism Val66Met produces the aminoacid substitution valine for methionine, with a Met allele activity being less sensitive to stimuli by inducing BDNF secretion compared to the Val/ Val genotype. The BDNF Val66Met polymorphism has been reportedly shown to be associated with neuroimaging and neuropsychological measures. Carriers of a Met allele perform worse on neurocognitive tests. We explored the association of the BDNF gene with neurophysiological characteristics of the early stages of verbal information processing in the brain in the groups of patients with schizophrenia and schizophrenia spectrum disorders and healthy people. A sample consisted of 93 patients, 48 (51.6%) men, 45 (48.4%) women, mean age 27.3 (7.9) years, and 96 healthy people, 51 (53.1%) men and 45 (46.9%) women, mean age 27.3 (7.9) years. 19 channel-EEG was recorded during visual presentation of a random sequence of words written in Russian and presented with different occurrence frequency. It has been shown that the BDNF Val66Met polymorphism is associated with P100 and N170 latencies in the left parietal-temporal area during the passive reading of single words. The latencies of P3 and T5 were lower in the Met-allele carriers compared to the ValVal genotype carriers (p=0.02). The association was found in healthy people but not in the patients with schizophrenia. Thus, the Met allele carriers performed the task worse compared to the ValVal carriers. This finding is in line with the previous literature results on the role of the BDNF Val66Met in cognitive performance. The work was supported by the Russian Foundation for Humanities grant № 15-06-10047. References: Pinel P, Lalanne C, Bourgeron T, Fauchereau F, Poupon C, Artiges E, Le Bihan D, Dehaene-Lambertz G, Dehaene S. Genetic and Environmental Influences on the Visual Word Form and Fusiform Face Areas. Cereb Cortex. 2015 Sep; 25(9):2478-93. doi:10.1016/j.ijpsycho.2016.07.374

89 Creutzfeldt-jacob disease; a case report with radiological and cerebrospinal fluid findings Orhan Yilmaz Marmara Universty Department of Neurology, Istanbul, Turkey Introduction. Crutzfeld-Jacob disease, a rare but fatal disease is a progressive neurological disruptıon. Methods and materıals. 52 years old man apply us with right hand tremor and speech disorder 1, 5 months ago started. We found

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in his neurological examination cognıtıve loss, pyramidal and exstrapyramidal signs. We were excluded metabolıc and paraneoplastıc disorders. In MRI hyperintense cortical ribbon marker in frontal area and head of caudate nucleus and anterıor of basal ganglia in T2 and flair sequences. Diffusıon and ADC sequences show us hyperintense cortical ribbon marker in frontal area and head of caudate nucleus and anterıor of basal ganglia. Radıological findings were significant for this disease. Three months later myoclonic seizures began. Clinical and radıological findings were consistent with sporadic Crutzfeld-Jacob disease. We worked 14-3-3 protein in cerebrospinal fluid. İt was negative. However, neuron specific enolase was hıgher it is supported CJD. Discussıon. Defınıtıve diagnosıs of CJD is possible with tissue analysis. Some types of CJD in cerebrospinal fluid 14.3.3.protein can be negative but tau and neuron specific enolase can be hıgher it is supported CJD. İn CJD clinical and radiological findings should be considered together. doi:10.1016/j.ijpsycho.2016.07.375

92 Ways to improve ecological validity of biofeedback and improving operator’s attentiveness Anna Vinkova International Organization of Psychophysiology, Milan, Italy Scientific interest in adult’s Attention Deficit Disorder (ADD) has increased significantly since the late 90s. Despite the fact that the validity of ADD as not only children’s but also adults’ disease, is shown by many researches, still too little attention is paid to problems of attention deficit of people whose daily work involves interaction with program’s interfaces and requires increased concentration on working task. Assuming that inattentive adults experience low arousal, the subjects trained to increase the ratio of faster activity to slow activity using special stimuli and without using medications. We have developed a new training technique using EEG biofeedback to form directed attention to special stimuli, being real tasks of subjects’ working process, causing attention deficit and boredom in working conditions. There were 10 subjects aged 27-34 years, 7 of which were males, with symptoms of inattention, disorganization and inability to complete the started task. The subjects received EEG biofeedback from two active electrodes Fz and Pz using 10-20 International System. Each subject participated in about 20 trainings to increase beta activity according to the Othmer’s protocol (Othmer & Othmer (1992)), who considered an increase of beta brain activity by subjects of any age a sufficient condition for successful training, and postulated a concomitant decrease in low-frequency rhythms as a natural consequence. Real adult subjects’ working tasks were used as stimuli during training session. Before and after the series of trainings the subjects were tested by working task for searching mistakes and errors in programs. The results were processed statistically using Wilcoxon test. After the trainings with biofeedback the results of testing the subjects with working tasks showed statistically significant increase in beta capacity during the search of errors against the level before training (pb0.033); increase in beta/ alpha ratio (pb0.034) and improvement in psychological tests for attention (pb0.034). The subjects learned to increase their functional state activity level when solving working task and to reduce the number of errors to an acceptable minimum (pb0.014), which is a significant result for increasing ecological validity of biofeedback. The experiment shows the importance of the choice of stimulus material for biofeedback depending on the task, requiring maximum operator’s