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The monitoring of IgM levels in cerebrospinal fluid
132 The monitoring
Abstracts of IgM
levels in cerehrospinal
fluid
Adam P, Nekola P, Preiningerovk J, CheniekovB M Department of Neurology, Medicine I, Prague, Czech
Charles Republic
University
School
of
Keywords: CSF IgM; IgM in cerebrospinal fluid In a group of 975 patients with neurological disease, IgM levels were measured both in cerebrospinal fluid (CSF) and serum. Another 17 protein fractions were simultaneously measured in CSF and serum: albumin, immunoglobulins (IgG, IgA), acute phase reactants (prealbumin, ec,-antitrypsin, orosomucoid, transferrin, haptoglobin, fibrinogen, CRP, complement components (C3, C4), apolipoproteins (Apo A-I, Apo A-II, Apo B) and other protein fractions (e.g. antithrombinIII, a,-microglobulin). Measurements were performed using laser nephelometry. Basic CSF biochemical and cytological parameters (total protein, element counts, glucose levels) were also evaluated. The group of patients was evaluated as a whole and after division according to the presence of normal or pathological CSF findings (with CSF total protein, glucose levels and element count was used as criteria). Intrathecal
oligoclonal synthesis of IgG, IgA, IgM was also evaluated. All the parameters were mutually correlated using linear regression analysis. In patients with normal CSF findings, only few statistically significant correlations were demonstrated between IgM and other CSF protein fractions while, in the group of patients with pathological CSF findings, significant correlations were found between CSF IgM and other immunoglobulins, complement fractions and the rate of intrathecal synthesis of immunoglobulins. Surprising correlations were found between CSF IgM and CSF antithrombin-III and x,-microglobulin, i.e. protein fractions of unknown significance in CSF. Correlations between CSF IgM and CSF apolipoproteins (Apo A-I, Apo A-II, Apo B) support the theory of the presence of CNS tissue destruction whenever levels of CSF apolipoproteins are elevated. Still, evaluation of CSF protein fractions requires further observations; the data obtained could substantially contribute to establishing the diagnosis in patients with neurological disease; simultaneous measurement of a high number of CSF proteins is becoming inevitable for reasonable assessment of the ‘CSF Proteinic Status’.
Abstracts of IgM
levels in cerehrospinal
fluid
Adam P, Nekola P, Preiningerovk J, CheniekovB M Department of Neurology, Medicine I, Prague, Czech
Charles Republic
University
School
of
Keywords: CSF IgM; IgM in cerebrospinal fluid In a group of 975 patients with neurological disease, IgM levels were measured both in cerebrospinal fluid (CSF) and serum. Another 17 protein fractions were simultaneously measured in CSF and serum: albumin, immunoglobulins (IgG, IgA), acute phase reactants (prealbumin, ec,-antitrypsin, orosomucoid, transferrin, haptoglobin, fibrinogen, CRP, complement components (C3, C4), apolipoproteins (Apo A-I, Apo A-II, Apo B) and other protein fractions (e.g. antithrombinIII, a,-microglobulin). Measurements were performed using laser nephelometry. Basic CSF biochemical and cytological parameters (total protein, element counts, glucose levels) were also evaluated. The group of patients was evaluated as a whole and after division according to the presence of normal or pathological CSF findings (with CSF total protein, glucose levels and element count was used as criteria). Intrathecal
oligoclonal synthesis of IgG, IgA, IgM was also evaluated. All the parameters were mutually correlated using linear regression analysis. In patients with normal CSF findings, only few statistically significant correlations were demonstrated between IgM and other CSF protein fractions while, in the group of patients with pathological CSF findings, significant correlations were found between CSF IgM and other immunoglobulins, complement fractions and the rate of intrathecal synthesis of immunoglobulins. Surprising correlations were found between CSF IgM and CSF antithrombin-III and x,-microglobulin, i.e. protein fractions of unknown significance in CSF. Correlations between CSF IgM and CSF apolipoproteins (Apo A-I, Apo A-II, Apo B) support the theory of the presence of CNS tissue destruction whenever levels of CSF apolipoproteins are elevated. Still, evaluation of CSF protein fractions requires further observations; the data obtained could substantially contribute to establishing the diagnosis in patients with neurological disease; simultaneous measurement of a high number of CSF proteins is becoming inevitable for reasonable assessment of the ‘CSF Proteinic Status’.