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The muscarinic receptors
Inr. J. Bmhem. Vol. 22, No. 6, pp. 617-679. Printed in Great B&am
1990
BOOK
REVIEWS
9. Cancer Management in Man (detection; diagnosis; chronobiology; endocrine surgery; radiology; therapy)-A. L. Goldson. 10. Cancer Management in Man (biological response modifiers; chemotherapy; antibiotics; hyperthermia; supporting measures)-P. V. Woolley.
Protein Sequencing; a Practical Approach-Edited by J. B. C. FINDLAY and M. J. GEISOW. 199 pp. 1989. IRL Press. Oxford. Hardback $56. Paperback $36. If you want to know how to carry out protein and peptide purification: peptide preparation and characterization; automated solid phase microsequencing; gas or pulsed liquid phase sequence analysis; sequencing by mass spectrometry; manual methods of protein sequencing; or structure prediction, then this book will be very useful. It will get you started within the limits of its 199 pages.
These volumes provide valuable and will be much consulted.
of the subject
Chemical Senses, Vol. 1, Receptor Events, Transduction in Taste and Olfactio+Edited by J. G. BRAND, J. H. TEETER, R. H. CAGAN and M. R. KARE. 529 pp. 1989. Marcel Dekker, New York. U.S.A. & Canada $135. Elsewhere $162.
Advances in Chromatography, Vol. 29-Edited by J. C. GIDDINGS, E. GRUSHKA and P. R. BROWN. 257 pp. 1989. Marcel Dekker, New York. U.S.A. & Canada $125. Elsewhere $150.
The main topics of this book are: transduction of biological signals, focus on phospholipase A2; biochemical events in taste reception and transduction; ionic mechanisms of taste cell activation; biochemical events in olfactory reception and transduction; and ionic mechanisms of olfactory transduction. The main developments over the last five years have been the biochemical analysis of the different stages involved in taste and smell differentiation and membrane transduction. A greater understanding of these stages will lead to great advances in the perfume and food industry.
Five topics are reviewed in this volume. They are: capillary electrophoresis; multidimensional chromatography in biotechnology; high performance immunoaffinity chromatography; protein purification by multidimensional liquid chromatography; and fluorescence derivatization in HPLC. Practical details are given together with the theoretical basis of the techniques. Process Chromatography; a Practical Guide-Edited K. SOFER and L. E. NYSTKOM. 145 pp. 1989. Academic London. E19.95.
summaries
by G. Press,
The Muscarinic Receptors-Edited by J. H. BROWN. 478 pp. 1989. Human Press, New Jersey. $89.50. Elsewhere $94.50.
The staff of Pharmacia have contributed to this account of economic chromatographic purification and separation. The chapters are on: choice of a protein source; isolation steps; initial feed; initial purification steps; optimization; scale up chromatography; equipment; process hygiene; and economics. There are appendices on: chromatographic techniques; product analysis; regulatory considerations; and column packing. The book will be very useful to those who wish to scale up their chromatography.
A simple classification of acetylcholine receptors divides them into nicotinic receptors [Nk] and muscarjnic receptors IMR]. This volume describes the historv of MR: bindine. prop&ties; purification; subtypes; pharmacological properties; structure activity; CAMP: IP3; calcium mobilization; allosteric interaction; GMP; ionic channels; regulation of number of MR: future trends in MR research five MRs have been cloned and sequenced. The MR are members of a superfamily of receptors that interact with and activate one or more G proteins. They have seven transmembrane alpha helix segments, they lack a signal protein but have a heavily glycosylated site close to the NH, terminus. The 5-6 loop shows considerable variability. The purified MRs have allowed specific antibodies to be developed. The molecular analysis of MRs should lead to the development of more specific drugs acting on selected sites.
Cancer Growth and Progression. 10 Volumes-Series Editor H. E. KAISER. 1989. Each volume ca 210 pp. Kluver Academic, Dordecht, The Netherlands. Each volume $99.50; D.FI. 195. This IO volume encyclopedic series has 252 contributors and covers the development of neoplastic progression, spread and metastases. and factors that operate at the secondary level of involvement. from a comparative biological and clinical viewpoint. Each volume has its own editor, and each chauter is complete in itself with a detailed bibliography. The 10 volumes and the volume editors are as follows.
Manual of Toxicologic Emergencies-Edited by E. K. NOJI and G. D. KELEN. 859 pp. 1989. Year Book Medical Publishers, Chicago.
I. Fundamental Aspects of Cancer-R. H. Goldfarb. 2. Mechanisms of Carcinogenesis-E. K. Weisburger. 3. Influence of Tumor Development on the HostL. A. Liotta. 4. Influence of the Host on Tumor DevelopmentR. B. Herbeman. 5. Comparative Aspects of Tumor DevelopmentH. E. Kaiser. 6. Etiology of Cancer in Man-A. S. Levine. 7. Local Invasion and Spread of Cancer-K. W. Brunson. 8. Metastasis/Dissemination-E. Gorelik.
It is very easy to become poisoned by taking an overdose of a medicine by accident. This book gives details of how a physician should treat a patient; the general management of a poisoned patient; what to do for specific poisons and drugs (treatments for more than 60 different drugs and chemicals are given including common chemicals such as sodium chloride, bleach. detergents. soaps; less common substances such as mushrooms, heavy metals, carbon monoxide, formaldehyde, phenols; and drugs from aspirin and alcohol to most generally prescribed medicines). This book will be very useful to have in the laboratory or office just in case something happens. 611
1990
BOOK
REVIEWS
9. Cancer Management in Man (detection; diagnosis; chronobiology; endocrine surgery; radiology; therapy)-A. L. Goldson. 10. Cancer Management in Man (biological response modifiers; chemotherapy; antibiotics; hyperthermia; supporting measures)-P. V. Woolley.
Protein Sequencing; a Practical Approach-Edited by J. B. C. FINDLAY and M. J. GEISOW. 199 pp. 1989. IRL Press. Oxford. Hardback $56. Paperback $36. If you want to know how to carry out protein and peptide purification: peptide preparation and characterization; automated solid phase microsequencing; gas or pulsed liquid phase sequence analysis; sequencing by mass spectrometry; manual methods of protein sequencing; or structure prediction, then this book will be very useful. It will get you started within the limits of its 199 pages.
These volumes provide valuable and will be much consulted.
of the subject
Chemical Senses, Vol. 1, Receptor Events, Transduction in Taste and Olfactio+Edited by J. G. BRAND, J. H. TEETER, R. H. CAGAN and M. R. KARE. 529 pp. 1989. Marcel Dekker, New York. U.S.A. & Canada $135. Elsewhere $162.
Advances in Chromatography, Vol. 29-Edited by J. C. GIDDINGS, E. GRUSHKA and P. R. BROWN. 257 pp. 1989. Marcel Dekker, New York. U.S.A. & Canada $125. Elsewhere $150.
The main topics of this book are: transduction of biological signals, focus on phospholipase A2; biochemical events in taste reception and transduction; ionic mechanisms of taste cell activation; biochemical events in olfactory reception and transduction; and ionic mechanisms of olfactory transduction. The main developments over the last five years have been the biochemical analysis of the different stages involved in taste and smell differentiation and membrane transduction. A greater understanding of these stages will lead to great advances in the perfume and food industry.
Five topics are reviewed in this volume. They are: capillary electrophoresis; multidimensional chromatography in biotechnology; high performance immunoaffinity chromatography; protein purification by multidimensional liquid chromatography; and fluorescence derivatization in HPLC. Practical details are given together with the theoretical basis of the techniques. Process Chromatography; a Practical Guide-Edited K. SOFER and L. E. NYSTKOM. 145 pp. 1989. Academic London. E19.95.
summaries
by G. Press,
The Muscarinic Receptors-Edited by J. H. BROWN. 478 pp. 1989. Human Press, New Jersey. $89.50. Elsewhere $94.50.
The staff of Pharmacia have contributed to this account of economic chromatographic purification and separation. The chapters are on: choice of a protein source; isolation steps; initial feed; initial purification steps; optimization; scale up chromatography; equipment; process hygiene; and economics. There are appendices on: chromatographic techniques; product analysis; regulatory considerations; and column packing. The book will be very useful to those who wish to scale up their chromatography.
A simple classification of acetylcholine receptors divides them into nicotinic receptors [Nk] and muscarjnic receptors IMR]. This volume describes the historv of MR: bindine. prop&ties; purification; subtypes; pharmacological properties; structure activity; CAMP: IP3; calcium mobilization; allosteric interaction; GMP; ionic channels; regulation of number of MR: future trends in MR research five MRs have been cloned and sequenced. The MR are members of a superfamily of receptors that interact with and activate one or more G proteins. They have seven transmembrane alpha helix segments, they lack a signal protein but have a heavily glycosylated site close to the NH, terminus. The 5-6 loop shows considerable variability. The purified MRs have allowed specific antibodies to be developed. The molecular analysis of MRs should lead to the development of more specific drugs acting on selected sites.
Cancer Growth and Progression. 10 Volumes-Series Editor H. E. KAISER. 1989. Each volume ca 210 pp. Kluver Academic, Dordecht, The Netherlands. Each volume $99.50; D.FI. 195. This IO volume encyclopedic series has 252 contributors and covers the development of neoplastic progression, spread and metastases. and factors that operate at the secondary level of involvement. from a comparative biological and clinical viewpoint. Each volume has its own editor, and each chauter is complete in itself with a detailed bibliography. The 10 volumes and the volume editors are as follows.
Manual of Toxicologic Emergencies-Edited by E. K. NOJI and G. D. KELEN. 859 pp. 1989. Year Book Medical Publishers, Chicago.
I. Fundamental Aspects of Cancer-R. H. Goldfarb. 2. Mechanisms of Carcinogenesis-E. K. Weisburger. 3. Influence of Tumor Development on the HostL. A. Liotta. 4. Influence of the Host on Tumor DevelopmentR. B. Herbeman. 5. Comparative Aspects of Tumor DevelopmentH. E. Kaiser. 6. Etiology of Cancer in Man-A. S. Levine. 7. Local Invasion and Spread of Cancer-K. W. Brunson. 8. Metastasis/Dissemination-E. Gorelik.
It is very easy to become poisoned by taking an overdose of a medicine by accident. This book gives details of how a physician should treat a patient; the general management of a poisoned patient; what to do for specific poisons and drugs (treatments for more than 60 different drugs and chemicals are given including common chemicals such as sodium chloride, bleach. detergents. soaps; less common substances such as mushrooms, heavy metals, carbon monoxide, formaldehyde, phenols; and drugs from aspirin and alcohol to most generally prescribed medicines). This book will be very useful to have in the laboratory or office just in case something happens. 611