115 Proteins of Excitable Membranes, by B. Hille and D.M. Fambrough (eds.), WileyInterscience, New York, Chichester, Brisbane, Toronto, Singapore, 1987 This physiology volume is based on a symposium in which physiologists and protein chemists focussed their attention on membrane proteins subserving the voltage-gated Na+/Ca 2+ channels, the nicotinic ACh receptor, Na +/K + -ATPase and Ca 2 + -ATPase. The sequences of these proteins having provided a detailed structure chart, analyses of the structure-function relationship became feasible. The ACh receptor site, function, regulation, and transient state are dealt with in 5 chapters. The same features of the Na + -channels and Ca 2 + -channels, and the ATPases in sarcoplasmic reticulum are the subject of 17 expert review chapters and provide a wealth of molecular biological detail with well-selected bibliographies. Although progress in these fields is so rapid as to render this monograph already behind the current state of knowledge, it constitutes a solid landmark of scientific development. G.W. BRUYN
Brain Systems, Disorders, and Psychotropic Drugs, by H. Ashton (ed.), Oxford University Press, Oxford, New York, Toronto, 1987 This text, aimed at a sound way of conveying the principles of psychopharmacology, provides in lucid fashion, the necessary substrate of the discipline, viz. the brain systems subserving and controlling disorders of cognition, volition, emotion and behaviour that bridges the gap between the basic scientist and the clinician in a successful and brave fashion. It is the first book of its kind the present reviewer has come across that does not loose its reader within a short time, either because of abstruse esotericism or hyperspecialist limitations, or over-referenced non-readibility. Unreservedly recommended to psychiatrists and neurologists, both clinical and experimental. G.W. BRUVN
The Neural and Molecular Bases of Learning, by J. P. Changeux and M. Knoshi (eds.), John Wiley & Sons, Chichester, New York, Brisbane, Toronto, Singapore, 1987 This research report on the Dahlem Workshop of December 1985 ranges, in 23 chapters and 550 pages, over nearly all aspects of information representation, processing and storage, and organisation. Gene expression, the role of nerve growth factor, regulatory mechanisms of gene transcription and synaptic transmission long-term potentiation, neuronal assemblies, synaptic plasticity, and circuit modification, are the subjects of chapters written in detail. The text is rewarding reading for the neuropsychologist and molecular biologist. G.W. BRUYN
Trends in Cluster Headache, by F. Sicuteri, L. Vecchiet and M. Fanciullacci (eds.), Excerpta Medica, International Congress Series 731, Elsevier Science Publishers B.V., Amsterdam, 1987. This monograph contains the proceedings of the international workshop on cluster headache held in Montesilvano in 1986. The formal presentations are grouped under headings "Nature of pain", ~Pharmacotherapy of pain', "Neuropeptides in cluster headache and other pain states", "The eye in cluster headache", "Autonomic aspects", "Genetics", and "Chronopathology".