- Email: [email protected]
The presumed neurotoxic effects of Catha edulis — an exotic plant now available in the United Kingdom
Journal of Ethnophatmacology, 19 (1987) Elsevier Scientific Publishers Ireland Ltd.
335-342
335
Abstract Section*
The presumed neurotoxic effects of Catha edulis - an exotic plant now available in the United Kingdom Roper JP BR. J. OPH~ALMOL.; 70/10 (779-781)/1986/ Bilateral optic atrophy is reported in two patients who, although they were long-standing users of the leaves of Catha edulis, had chewed larger quantities than usual. Since the leaves of this plant are used widely throughout its native area as the source of a mildly stimulant narcotic, the effect in these cascts may be an idiosyncratic reaction to an unusually large dose. A double-band, multicenter immunotherapy trial in children, using a purified and standardized Cladoaporium herbarum preparation. I. Clinical results Dreborg S; Agrell B; Fougard T; et al ALLERGY; 4112 (131-140)/1986,’ A double-blind histamine placebo controlled immunotherapy trial was performed to investigate the clinical effect of a purified and standardized Cladosporium herbarum allergen preparation, Thirty children with a clinical history suggesting mould-induced asthma andjor rhinoconjunctivitis were included. The diagnosis was confirmed by positive skin prick test and Phadebas RAST (Reg. trademark) as well as positive bronchial and/or conjunctival provocation test to Cladosporium herbarum. Immuno~erapy was given for 10 months in a double-blind manner to randomized groups with either Pharrnalgen (Reg. trademark)/Clado sporium herbarum preparation or histamine placebo. Allergic side effects to injections were common, especially during the peak of the mould season (JulySeptember in Scandinavia). In the active group, 13/16 patients experienced general reactions during the first 10 months of treatment. After 6 months of treatment, eye, nose and bronchial symptom scores and peak expiratory flow rates were similar for the groups, maybe because most of the children were also sensitive to many other allergens, including Alternaria alternata. However, medication scores were significantly lower in the treated group (P < 0.001). Bronchial (P < 0.01) and conjunctival sensitivity (P = 0.01) were significantly reduced in the Cladospo~um-t~ated group but not in the placebo group after 10 months of treatment. T&s is the first double-blind clinical trial showing the clinical efficacy of immunotherapy in children with mould-induced asthma. The assessment of chemotherapeutic effects of vinca alkaloids by hnmunofluorescence and flow cytometry Gratzner HG; Fountzilas G; Stein JH; Yunis AA ANN. N.Y. ACAD. SCI.; VOL. 468 (67-79)/1986/ The effects of the vinca alkaloids on the rates of DNA synthesis in the human pancreatic carcinoma line, MIA Pa Ca-2 have been studied by a new technique for measuring cell kinetics and DNA synthesis by flow cytometry and immunofiuorescence. The method employs a monoclonal antibody that is highly specific for bromodeoxyuridine or iodo*Generated from the Excerpta Medica Database, EMBASE.
335-342
335
Abstract Section*
The presumed neurotoxic effects of Catha edulis - an exotic plant now available in the United Kingdom Roper JP BR. J. OPH~ALMOL.; 70/10 (779-781)/1986/ Bilateral optic atrophy is reported in two patients who, although they were long-standing users of the leaves of Catha edulis, had chewed larger quantities than usual. Since the leaves of this plant are used widely throughout its native area as the source of a mildly stimulant narcotic, the effect in these cascts may be an idiosyncratic reaction to an unusually large dose. A double-band, multicenter immunotherapy trial in children, using a purified and standardized Cladoaporium herbarum preparation. I. Clinical results Dreborg S; Agrell B; Fougard T; et al ALLERGY; 4112 (131-140)/1986,’ A double-blind histamine placebo controlled immunotherapy trial was performed to investigate the clinical effect of a purified and standardized Cladosporium herbarum allergen preparation, Thirty children with a clinical history suggesting mould-induced asthma andjor rhinoconjunctivitis were included. The diagnosis was confirmed by positive skin prick test and Phadebas RAST (Reg. trademark) as well as positive bronchial and/or conjunctival provocation test to Cladosporium herbarum. Immuno~erapy was given for 10 months in a double-blind manner to randomized groups with either Pharrnalgen (Reg. trademark)/Clado sporium herbarum preparation or histamine placebo. Allergic side effects to injections were common, especially during the peak of the mould season (JulySeptember in Scandinavia). In the active group, 13/16 patients experienced general reactions during the first 10 months of treatment. After 6 months of treatment, eye, nose and bronchial symptom scores and peak expiratory flow rates were similar for the groups, maybe because most of the children were also sensitive to many other allergens, including Alternaria alternata. However, medication scores were significantly lower in the treated group (P < 0.001). Bronchial (P < 0.01) and conjunctival sensitivity (P = 0.01) were significantly reduced in the Cladospo~um-t~ated group but not in the placebo group after 10 months of treatment. T&s is the first double-blind clinical trial showing the clinical efficacy of immunotherapy in children with mould-induced asthma. The assessment of chemotherapeutic effects of vinca alkaloids by hnmunofluorescence and flow cytometry Gratzner HG; Fountzilas G; Stein JH; Yunis AA ANN. N.Y. ACAD. SCI.; VOL. 468 (67-79)/1986/ The effects of the vinca alkaloids on the rates of DNA synthesis in the human pancreatic carcinoma line, MIA Pa Ca-2 have been studied by a new technique for measuring cell kinetics and DNA synthesis by flow cytometry and immunofiuorescence. The method employs a monoclonal antibody that is highly specific for bromodeoxyuridine or iodo*Generated from the Excerpta Medica Database, EMBASE.