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The prognostic utility of uric acid: An inadvertent confession
e18
Abstracts
the main, and conscription of child-bearing age. Objective: To investigate the prevalence of PMK, clinical features, to identify the most frequent electrocardiographic phenomena and rhythm disorders and examine the status of intracardiac hemodynamics in patients with PMC, depending on the degree of mitral valve prolapse and the presence of regurgitation. Practical significance: This study will help in the diagnosis of the disease, prognosis and assessment of the course and in patients with MVP. The study involved 62 patients 2 RCH cardiology department with mitral valve prolapse. Of these, 56 were men (90.3%), 6 women (9.6%). The average age of the patients was 22.8 years. Besides general clinical methods we used noninvasive methods of investigation of the cardiovascular system, which included electrocardiography (ECG) and echocardiography (M-mode). Hemodynamically significant mitral valve prolapse with regurgitation was detected in 41 men. In evaluating the data of electrocardiography in 56.1% of the surveyed group they had identified a variety of cardiac arrhythmias. PMK is often accompanied by the following electrocardiographic phenomena: blockade of the right and left bundle-branch block (41.1%), syndrome W-P-W (14.7%), sinus tachycardia (11.7%), sinus bradycardia (26.4%), supraventricular and ventricular ectopic beats (14.7%), left ventricular hypertrophy (29.4%), paroxysmal supraventricular tachycardia (2.4%), and complete AV-block (2.4%). Conclusions: PMK is quite frequent pathologies among young people and is not echo phenomenon. The average age of the patients was 22.8 years. Patients diagnosed with MVP regardless of the degree of regurgitation are recommended with ECG monitoring and exercise testing (bicycle ergometry) to identify LDCs. The combination of PMC with myxomatous degeneration of the valves worsens prognosis, intracardiac hemodynamics and is a predictor of arrhythmias. This revealed the greatest changes in intracardiac hemodynamics in patients with PMC registered with LDCs. The most pronounced hemodynamic changes are marked by complications PMK II–III degree of regurgitation with various LDCs. The presence of cardiac arrhythmias in patients with mitral valve prolapse is associated with an increase in end-diastolic volume of the left ventricle and the volume of the left atrium, the mitral regurgitate volume as compared with the healthy subjects. By echocardiography in patients with MVP is marked diastolic dysfunction. The increase in severity over time, IBC and the degree of mitral valve regurgitation can lead to a progressive disruption of intracardiac hemodynamics.
Results: On the basic science goal, the silent adverse effects of UA thrive on undesirable and unattainable source of excess oxidative stress causing endothelial dysfunction. It is hugely important to rely on the willingness of HT and DL in consent with UA to boost risk of atherosclerosis development. Hence, in contrast with primary link between BP and lipids in Pearson correlation represented in previous work, in partial correlation analyses with UA inclusion we defined weaker mischievous interaction between BP and lipid constituents. First of all, we brought to light positive correlation of TC with CSBP (r = 0.364, P b 0.001), CDiBP (r = 0.282, P b 0.001), HSBP (r = 0.271, P b 0.001), HDiBP (r = 0.207, P b 0.001), 24-hSBP (r = 0.243, P b 0.001), 24-hDiBP (r = 0.250, P b 0.001), DSBP (r = 0.216, P b 0.001), DDiBP (r = 0.207, P b 0.001), NSBP (r = 0.204, P b 0.001), and NDiBP (r = 0.218, P b 0.001). The second delicate hint was that TG was associated with CSBP (r = 0.285, P b 0.001), CDiBP (r = 0.283, P b 0.001), HSBP (r = 0.262, P b 0.001), HDiBP (r = 0.199, P = 0.001), 24-hSBP (r = 0.280, P b 0.001), 24-hDiBP (r = 0.269, P b 0.001), DSBP (r = 0.236, P b 0.001), DDiBP (r = 0.212, P b 0.001), NSBP (r = 0.293, P b 0.001), and NDiBP (r = 0.282, P b 0.001). The third subtle point was the positive integration of LDL-C with CSBP (r = 0.364, P b 0.001), CDiBP (r = 0.287, P b 0.001), HSBP (r = 0.285, P b 0.001), HDiBP (r = 0.236, P b 0.001), 24-hSBP (r = 0.273, p b 0.001), 24-hDiBP (r = 0.282, P b 0.001), DSBP (r = 0.248, P b 0.001), DDiBP (r = 0.237, P b 0.001), NSBP (r = 0.224, P b 0.001), and NDiBP (r = 0.243, P b 0.001). Interestingly, HDL-C was negatively related with CDiBP (r = −0.123, P = 0.035), HSBP (r = −0.142, P = 0.015), HDiBP (r = −0.176, P = 0.002), 24-hSBP (r = −0.229, P b 0.001), 24-hDiBP (r = −0.224, P b 0.001), DSBP (r = −0.209, P b 0.001), DDiBP (r = −0.188, p b 0.001), NSBP (r = −0.215, P b 0.001), and NDiBP (r = −0.220, P b 0.001). Again, in a majority of cases clinic BP was strongly correlated with lipids than with ambulatory BP; TG and HDL-C were tightly associated with NS/DiBP than with DS/DiBP; integration of LDL-C with DS/DiBP was dominated in comparison with all lipids; interrelations between TG and 24-hSBP, LDL-C and 24-hDiBP were more prominent. Approximately, just as sumptuously as the arts, the pivotal motives have remained. Conclusions: As far as we may judge, doctrines and findings do precisely correspond to each other. Attention is mutually converged on what exists: the impact of UA alone and in conjunction with several risk factors unleashes exaggeration of worse influences in contemplation of CVD and acute disorders evolvement.
doi:10.1016/j.ejim.2013.08.039 doi:10.1016/j.ejim.2013.08.040 ID: 384 The prognostic utility of uric acid: An inadvertent confession E. Pello, S. Malyutina, G. Simonova, Y. Nikitin Department of Internal Medicine, Institute of Internal Medicine, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, Russian Federation
ID: 442 Lung ultrasound performed at discharge: A prognostic tool to predict 90-day death and readmission in patients hospitalised for heart failure I. Bossi, D. Torzillo, G. Costantino, G. Casazza, S. Furlotti, C. Cogliati Internal Medicine, Sacco Hospital, Milan, Italy
Objectives: Overall, the soaring rates of cardiovascular morbidity and mortality became perceptible. So, researchers have reported that hyperuricemia is an independent predictor of poor outcome in general population, but in broader context of whole spectrum of acute coronary syndromes the opinions have devoted to controversial dissonance. Hypertension (HT) and dyslipidemia (DL) are the main risk factors for a range of cardiovascular events and criteria of metabolic syndrome. Alternatively, we sought the trigger activities of uric acid (UA) provoking cardiovascular disease (CVD) and acute conditions. Methods: Participants were ardently supported (EPOGH, n = 300); lipids, clinic (C), home (H), and ambulatory (24-h, D, N) systolic (S)\diastolic (Di) blood pressure (BP) were evaluated.
Background Heart failure (HF) is one of the most important causes of morbidity and mortality in the industrialized world, representing the leading cause of hospitalisation for patients older than 65 years, with a combined mortality and readmission rate of 30% within 90 days post-discharge. Several factors have been evaluated to stratify prognosis, such as ejection fraction (EF), NYHA class and nt-proBNP; however timing of discharge is mostly based on medical judgement that considers patient's symptoms and physical examination. Lung ultrasound (LUS) has been demonstrated to be a valid tool for the assessment of pulmonary congestion: the detection
Abstracts
the main, and conscription of child-bearing age. Objective: To investigate the prevalence of PMK, clinical features, to identify the most frequent electrocardiographic phenomena and rhythm disorders and examine the status of intracardiac hemodynamics in patients with PMC, depending on the degree of mitral valve prolapse and the presence of regurgitation. Practical significance: This study will help in the diagnosis of the disease, prognosis and assessment of the course and in patients with MVP. The study involved 62 patients 2 RCH cardiology department with mitral valve prolapse. Of these, 56 were men (90.3%), 6 women (9.6%). The average age of the patients was 22.8 years. Besides general clinical methods we used noninvasive methods of investigation of the cardiovascular system, which included electrocardiography (ECG) and echocardiography (M-mode). Hemodynamically significant mitral valve prolapse with regurgitation was detected in 41 men. In evaluating the data of electrocardiography in 56.1% of the surveyed group they had identified a variety of cardiac arrhythmias. PMK is often accompanied by the following electrocardiographic phenomena: blockade of the right and left bundle-branch block (41.1%), syndrome W-P-W (14.7%), sinus tachycardia (11.7%), sinus bradycardia (26.4%), supraventricular and ventricular ectopic beats (14.7%), left ventricular hypertrophy (29.4%), paroxysmal supraventricular tachycardia (2.4%), and complete AV-block (2.4%). Conclusions: PMK is quite frequent pathologies among young people and is not echo phenomenon. The average age of the patients was 22.8 years. Patients diagnosed with MVP regardless of the degree of regurgitation are recommended with ECG monitoring and exercise testing (bicycle ergometry) to identify LDCs. The combination of PMC with myxomatous degeneration of the valves worsens prognosis, intracardiac hemodynamics and is a predictor of arrhythmias. This revealed the greatest changes in intracardiac hemodynamics in patients with PMC registered with LDCs. The most pronounced hemodynamic changes are marked by complications PMK II–III degree of regurgitation with various LDCs. The presence of cardiac arrhythmias in patients with mitral valve prolapse is associated with an increase in end-diastolic volume of the left ventricle and the volume of the left atrium, the mitral regurgitate volume as compared with the healthy subjects. By echocardiography in patients with MVP is marked diastolic dysfunction. The increase in severity over time, IBC and the degree of mitral valve regurgitation can lead to a progressive disruption of intracardiac hemodynamics.
Results: On the basic science goal, the silent adverse effects of UA thrive on undesirable and unattainable source of excess oxidative stress causing endothelial dysfunction. It is hugely important to rely on the willingness of HT and DL in consent with UA to boost risk of atherosclerosis development. Hence, in contrast with primary link between BP and lipids in Pearson correlation represented in previous work, in partial correlation analyses with UA inclusion we defined weaker mischievous interaction between BP and lipid constituents. First of all, we brought to light positive correlation of TC with CSBP (r = 0.364, P b 0.001), CDiBP (r = 0.282, P b 0.001), HSBP (r = 0.271, P b 0.001), HDiBP (r = 0.207, P b 0.001), 24-hSBP (r = 0.243, P b 0.001), 24-hDiBP (r = 0.250, P b 0.001), DSBP (r = 0.216, P b 0.001), DDiBP (r = 0.207, P b 0.001), NSBP (r = 0.204, P b 0.001), and NDiBP (r = 0.218, P b 0.001). The second delicate hint was that TG was associated with CSBP (r = 0.285, P b 0.001), CDiBP (r = 0.283, P b 0.001), HSBP (r = 0.262, P b 0.001), HDiBP (r = 0.199, P = 0.001), 24-hSBP (r = 0.280, P b 0.001), 24-hDiBP (r = 0.269, P b 0.001), DSBP (r = 0.236, P b 0.001), DDiBP (r = 0.212, P b 0.001), NSBP (r = 0.293, P b 0.001), and NDiBP (r = 0.282, P b 0.001). The third subtle point was the positive integration of LDL-C with CSBP (r = 0.364, P b 0.001), CDiBP (r = 0.287, P b 0.001), HSBP (r = 0.285, P b 0.001), HDiBP (r = 0.236, P b 0.001), 24-hSBP (r = 0.273, p b 0.001), 24-hDiBP (r = 0.282, P b 0.001), DSBP (r = 0.248, P b 0.001), DDiBP (r = 0.237, P b 0.001), NSBP (r = 0.224, P b 0.001), and NDiBP (r = 0.243, P b 0.001). Interestingly, HDL-C was negatively related with CDiBP (r = −0.123, P = 0.035), HSBP (r = −0.142, P = 0.015), HDiBP (r = −0.176, P = 0.002), 24-hSBP (r = −0.229, P b 0.001), 24-hDiBP (r = −0.224, P b 0.001), DSBP (r = −0.209, P b 0.001), DDiBP (r = −0.188, p b 0.001), NSBP (r = −0.215, P b 0.001), and NDiBP (r = −0.220, P b 0.001). Again, in a majority of cases clinic BP was strongly correlated with lipids than with ambulatory BP; TG and HDL-C were tightly associated with NS/DiBP than with DS/DiBP; integration of LDL-C with DS/DiBP was dominated in comparison with all lipids; interrelations between TG and 24-hSBP, LDL-C and 24-hDiBP were more prominent. Approximately, just as sumptuously as the arts, the pivotal motives have remained. Conclusions: As far as we may judge, doctrines and findings do precisely correspond to each other. Attention is mutually converged on what exists: the impact of UA alone and in conjunction with several risk factors unleashes exaggeration of worse influences in contemplation of CVD and acute disorders evolvement.
doi:10.1016/j.ejim.2013.08.039 doi:10.1016/j.ejim.2013.08.040 ID: 384 The prognostic utility of uric acid: An inadvertent confession E. Pello, S. Malyutina, G. Simonova, Y. Nikitin Department of Internal Medicine, Institute of Internal Medicine, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, Russian Federation
ID: 442 Lung ultrasound performed at discharge: A prognostic tool to predict 90-day death and readmission in patients hospitalised for heart failure I. Bossi, D. Torzillo, G. Costantino, G. Casazza, S. Furlotti, C. Cogliati Internal Medicine, Sacco Hospital, Milan, Italy
Objectives: Overall, the soaring rates of cardiovascular morbidity and mortality became perceptible. So, researchers have reported that hyperuricemia is an independent predictor of poor outcome in general population, but in broader context of whole spectrum of acute coronary syndromes the opinions have devoted to controversial dissonance. Hypertension (HT) and dyslipidemia (DL) are the main risk factors for a range of cardiovascular events and criteria of metabolic syndrome. Alternatively, we sought the trigger activities of uric acid (UA) provoking cardiovascular disease (CVD) and acute conditions. Methods: Participants were ardently supported (EPOGH, n = 300); lipids, clinic (C), home (H), and ambulatory (24-h, D, N) systolic (S)\diastolic (Di) blood pressure (BP) were evaluated.
Background Heart failure (HF) is one of the most important causes of morbidity and mortality in the industrialized world, representing the leading cause of hospitalisation for patients older than 65 years, with a combined mortality and readmission rate of 30% within 90 days post-discharge. Several factors have been evaluated to stratify prognosis, such as ejection fraction (EF), NYHA class and nt-proBNP; however timing of discharge is mostly based on medical judgement that considers patient's symptoms and physical examination. Lung ultrasound (LUS) has been demonstrated to be a valid tool for the assessment of pulmonary congestion: the detection