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The Relationships Between Visual Disability and Visual Scores in Patients With Retinitis Pigmentosa
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ABSTRACTS
Jun Kozaki, Hiroshi Kozaki*† and Ryo Kozaki‡ *Kozaki Eye Clinic (†Deceased); ‡Department of Ophthalmology, Osaka University School of Medicine PII S0021-5155(99)00046-5
Suppression of Experimental Autoimmune Uveoretinitis With a Combination of Cyclosporin and Alloprinol Purpose: We assessed the suppressive effect of a combination of cyclosporin (an immunosuppressive agent) and allopurinol (a xanthine oxidase inhibitor and radical scavenger) on experimental autoimmune uveoretinitis (EAU) in Lewis rats, induced by interphotoreceptor retinoid-binding protein (IRBP). Methods: After the immunization of Lewis rats with 30 mg of IRBP. We administrated cyclosporin and/or allopurinol to the IRBP-immunized Lewis rats. We observed the incidence and the severity of EAU. Histological, immunological, and biochemical examinations were performal 13 days after the immunization. The suppressive effect of these drugs in vitro on the production of free radicals derived from polymorphonuclear leukocytes. Results: The incidence of EAU was suppressed by 50% at 13 days after immunization, and in terms of clinical and histological findings, inflammatory reaction was more inhibited by the combination of these drugs than by either cyclosporin or allopurinol alone. Lymphocyte proliferation assay against IRBP was significantly inhibited by the combination of drugs. No adverse systemic effects were identified. Cyclosporin and allopurinol inhibited radical production both separately and in combination. Conclusion: This suggests that suppression of EAU is based not only on inhibited cell-mediated immunity but also on inhibited production of free radicals derived from polymorphonuclear leukocytes. (J Jpn Ophthalmol Soc 103:26–33, 1999) Gakushi Matuura, Hiroshi Goto, Takeshi Kezuka, Naoyuki Yamakawa and Masahiko Usui Department of Ophthalmology, Tokyo Medical College PII S0021-5155(99)00047-7
The Relationships Between Visual Disability and Visual Scores in Patients With Retinitis Pigmentosa Purpose: To evaluate the relationship between visual disability and visual scores in patients with retinitis pigmentosa.
Methods: The relationship between visual disability and visual scores (visual acuity and visual field) were investigated in 93 patients with retinitis pigmentosa. The visual disability of each patient was evaluated using a questionnaire (a total of 35 questions in 7 sections regarding daily life). Reproducibility and validity of the questionnaire had been established by an investigation in glaucoma patients. The mean (6standard deviation) age of patients was 52.6 6 15.1 years, the mean visual acuity (log10 MAR) was 0.6 6 0.4, and the mean deviation of visual field with Humphrey program 30-2 was 221.1 6 10.0 dB. Results: The visual acuity in the better eye (r 5 0.66–0.81) and the mean sensitivity within the central 10 degrees of the visual field (r 5 20.76–20.62) had a definite relationship to the visual disability index of each section (section DI) and their sum (total DI) (P , .0001). This relationship was also confirmed in stepwise multiple linear regression analysis, which showed a high correlation coefficient (R2 5 0.57– 0.77, P , .0001). Conclusions: Besides the visual acuity, the mean sensitivity within the central 10 degrees of the visual field is important in evaluating the visual disability of patients with retinitis pigmentosa. (J Jpn Ophthalmol Soc 103:34–39, 1999) Izumi Sumi,* Osamu Okajima† and Shiroaki Shirato‡ *Department of Ophthalmology, Tokyo Teishin Hospital; † Department of Ophthalmology, Sanraku Hospital; ‡ Department of Ophthalmology, The University of Tokyo, School of Medicine PII S0021-5155(99)00048-9
Multicenter Retrospective Study of Retinal Detachment Associated With Atopic Dermatitis Purpose: Epidemiological and clinical study of retinal detachment associated with atopic dermatitis. Methods: A multicenter retrospective study. Results: We analyzed 417 eyes of 348 patients operated on during the 5 years from 1989 to 1993 and follow up for more than 6 months by vitreo-retina specialists in 33 hospitals throughout Japan. The number of eyes operated increased yearly from 42 in 1989 to 132 in 1993. These were 2.3% of the average number of the eyes operated on for rhegmatogenous retinal detachment during the same period, but when restricted to the Kanto area or further to Tokyo only, the percentage was as high as 3.8% and 4.7%, respectively. Clinical characteristics of retinal detachment previously reported, such as traumatic
ABSTRACTS
Jun Kozaki, Hiroshi Kozaki*† and Ryo Kozaki‡ *Kozaki Eye Clinic (†Deceased); ‡Department of Ophthalmology, Osaka University School of Medicine PII S0021-5155(99)00046-5
Suppression of Experimental Autoimmune Uveoretinitis With a Combination of Cyclosporin and Alloprinol Purpose: We assessed the suppressive effect of a combination of cyclosporin (an immunosuppressive agent) and allopurinol (a xanthine oxidase inhibitor and radical scavenger) on experimental autoimmune uveoretinitis (EAU) in Lewis rats, induced by interphotoreceptor retinoid-binding protein (IRBP). Methods: After the immunization of Lewis rats with 30 mg of IRBP. We administrated cyclosporin and/or allopurinol to the IRBP-immunized Lewis rats. We observed the incidence and the severity of EAU. Histological, immunological, and biochemical examinations were performal 13 days after the immunization. The suppressive effect of these drugs in vitro on the production of free radicals derived from polymorphonuclear leukocytes. Results: The incidence of EAU was suppressed by 50% at 13 days after immunization, and in terms of clinical and histological findings, inflammatory reaction was more inhibited by the combination of these drugs than by either cyclosporin or allopurinol alone. Lymphocyte proliferation assay against IRBP was significantly inhibited by the combination of drugs. No adverse systemic effects were identified. Cyclosporin and allopurinol inhibited radical production both separately and in combination. Conclusion: This suggests that suppression of EAU is based not only on inhibited cell-mediated immunity but also on inhibited production of free radicals derived from polymorphonuclear leukocytes. (J Jpn Ophthalmol Soc 103:26–33, 1999) Gakushi Matuura, Hiroshi Goto, Takeshi Kezuka, Naoyuki Yamakawa and Masahiko Usui Department of Ophthalmology, Tokyo Medical College PII S0021-5155(99)00047-7
The Relationships Between Visual Disability and Visual Scores in Patients With Retinitis Pigmentosa Purpose: To evaluate the relationship between visual disability and visual scores in patients with retinitis pigmentosa.
Methods: The relationship between visual disability and visual scores (visual acuity and visual field) were investigated in 93 patients with retinitis pigmentosa. The visual disability of each patient was evaluated using a questionnaire (a total of 35 questions in 7 sections regarding daily life). Reproducibility and validity of the questionnaire had been established by an investigation in glaucoma patients. The mean (6standard deviation) age of patients was 52.6 6 15.1 years, the mean visual acuity (log10 MAR) was 0.6 6 0.4, and the mean deviation of visual field with Humphrey program 30-2 was 221.1 6 10.0 dB. Results: The visual acuity in the better eye (r 5 0.66–0.81) and the mean sensitivity within the central 10 degrees of the visual field (r 5 20.76–20.62) had a definite relationship to the visual disability index of each section (section DI) and their sum (total DI) (P , .0001). This relationship was also confirmed in stepwise multiple linear regression analysis, which showed a high correlation coefficient (R2 5 0.57– 0.77, P , .0001). Conclusions: Besides the visual acuity, the mean sensitivity within the central 10 degrees of the visual field is important in evaluating the visual disability of patients with retinitis pigmentosa. (J Jpn Ophthalmol Soc 103:34–39, 1999) Izumi Sumi,* Osamu Okajima† and Shiroaki Shirato‡ *Department of Ophthalmology, Tokyo Teishin Hospital; † Department of Ophthalmology, Sanraku Hospital; ‡ Department of Ophthalmology, The University of Tokyo, School of Medicine PII S0021-5155(99)00048-9
Multicenter Retrospective Study of Retinal Detachment Associated With Atopic Dermatitis Purpose: Epidemiological and clinical study of retinal detachment associated with atopic dermatitis. Methods: A multicenter retrospective study. Results: We analyzed 417 eyes of 348 patients operated on during the 5 years from 1989 to 1993 and follow up for more than 6 months by vitreo-retina specialists in 33 hospitals throughout Japan. The number of eyes operated increased yearly from 42 in 1989 to 132 in 1993. These were 2.3% of the average number of the eyes operated on for rhegmatogenous retinal detachment during the same period, but when restricted to the Kanto area or further to Tokyo only, the percentage was as high as 3.8% and 4.7%, respectively. Clinical characteristics of retinal detachment previously reported, such as traumatic