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The results of treating 1178 patients with breast cancer by radical mastectomy
increasing experience in many centers with the primary management of such lesions with radiation therapy. This has usually been combined with such minor surgical procedures as incisional biopsy, ranging through segmental The Radiation Therapy Oncology Group consisting of 32 partimastectomy. cipating institutions have combined to pool their experience in the primary management of adenocarcinoma with megavoltage irradiation. -All cases submitted must meet defined criteria of histology, staging, operative procedure and are reviewed by the Study Chairman with reference to the irradiEndpoints of the study include the overall local control ation delivered. of the malignancy, the systemic control and the asthetic effect in the breast. Results of such treatment in these patients will be discussed and comparisons drawn from other modern radiotherapeutic series.
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THE RESULTS OF TREATING 1178 PATIENTS WITH BREAST CANCER BY RADICAL MASTECTOMY Irving M. Ariel, M.D., F.A.C.S. Clinical Professor of Surgery, New York Medical College, New York, New York Vice President, Pack Medical Foundation
This study details the accoqplishments of treating breast cancer by radical mastectomy. The data are unique in that all patients were treated by four well-trained senior cancer surgeons who have spent their entire professional life in the treatment of cancer. The same techniques and principles of therapy were utilized. (i.e. If no metastases were present no postoperative irradiation was given. If metastases in the lymph nodes, were present, irradiation was given to the local region). The patients were followed from 5 to 30 years and a 96.5% followup was obtained. The absolute 5-year survival rate was 64%, the absolute lo-year survival rate was 55%, the absolute 15-year survival rate was 45% and the absolute 30-year survival rate was 38%. The relative lo-year survival rate was 73%, that is, deleting 458 of the 1178 patients who are considered indeterminate for the following reasons: 200 were treated before the ten year period, 168 died from other causes, 31 died from another cancer and 59 were lost to followup. The local recurrence rate of all these patients was 4.5%. The data are further analyzed according to different parameters including the location and size of the cancer, the delay before therapy, the histologic type of cancer and the influence of metastases to axillary nodes upon the survival rate. 46
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THE RESULTS OF TREATING 1178 PATIENTS WITH BREAST CANCER BY RADICAL MASTECTOMY Irving M. Ariel, M.D., F.A.C.S. Clinical Professor of Surgery, New York Medical College, New York, New York Vice President, Pack Medical Foundation
This study details the accoqplishments of treating breast cancer by radical mastectomy. The data are unique in that all patients were treated by four well-trained senior cancer surgeons who have spent their entire professional life in the treatment of cancer. The same techniques and principles of therapy were utilized. (i.e. If no metastases were present no postoperative irradiation was given. If metastases in the lymph nodes, were present, irradiation was given to the local region). The patients were followed from 5 to 30 years and a 96.5% followup was obtained. The absolute 5-year survival rate was 64%, the absolute lo-year survival rate was 55%, the absolute 15-year survival rate was 45% and the absolute 30-year survival rate was 38%. The relative lo-year survival rate was 73%, that is, deleting 458 of the 1178 patients who are considered indeterminate for the following reasons: 200 were treated before the ten year period, 168 died from other causes, 31 died from another cancer and 59 were lost to followup. The local recurrence rate of all these patients was 4.5%. The data are further analyzed according to different parameters including the location and size of the cancer, the delay before therapy, the histologic type of cancer and the influence of metastases to axillary nodes upon the survival rate. 46