The role of substance P in wobbler mouse motoneuron disease

x(;l:i i' [N WO[?,t31.I£[{ >l()i GEl XOTOSE

Y omy,

Uuiv~'rsity

• p~)s:-;,.,ss:ea

,1

n]ototlellFOliS

Jarls

l.]lttt

t'}?tt) ]~2). l)

quant

4n,',

il.at i've

,'~tr'[)'

;ugK,'st

ill

tli4l

r~,t,air

u~rneur<.ns

Sq:,~ ) I t' O' o{ti i i i n g

{7,).

Although ;l[(tJIl°~

,.'~ (~m'.-,id~,,yed \

it!'<.,

(6),

di.-~ea.~,:~

!.

!o('onlol.[C'O ;ts

a

the

by

tc4~e he

subseq uent early SP

Im a y

lllOUS, mouse,

of

the

of

SP

a n td

k i~e

rhizotomy, of

hobbler

llocom~ o c o m o t ion m o t o nme u r o n

a

l_he SP i n c r e a s e

functional must

AChE h y d r o l y z e s motolleurolls

SP.

ill

s p a r t a ± . c oorrdu,

st i ] 1 play

c h o ] ] ,tnnee r ' ~ i c

in.:roase

(c a c

the

Since

fmenomenon.

lhe

IIC L i O l l ~

recover.~

in

5-liT

results

[l]Ot O l l e / l r O H

dorsal

the

t.he $ , o b b l e r

loss

mulaies s', i m ul

1,ro(es's

a 1so .~ SP

in the

d u r i l l gc

,\lLernaLixely,

tile

r e c e F 3tor m e d i a t e d .

bt"

~acea-(:a)

in

he

perl

]n

of

CH a d

res!9OIlSq

increase

i:t(:t>~ase

mmunoassay

k]

thaL

Jn(tuced

t.o m)L

Lopologica[

i,ossibly

i l l C I ' ~ ' ; I S ~ ~ Rt,qy

late

lhe

in

moLou<,uron~.

SP d o e s

~otoneurons

iitn c r e a s e s

su
damage

ng hormone

dege

( 5).

cord.

containing

L h y : ' o t rot: L

SP

[~er'haps

*,as

)i. n a ]

Lh~

-he

i~on

~genera:

(:

b~.~en c o n f i rmeci

t,ro(ess,

t{~ c o n t r i b u t ,

:.4eem,M

(! ~ ~-;ease.

lhe

al'ler

[ ; l i f o r t . ut~;~kely

'i~]iJ by

of

~prout

L,,

:ts

-~rounct

have

occur'~, it

in the

i in

immuno(:2, t , ~ , . ' l m m i s t r y

Origiually

c~.][ul'lr

dala

d}se.ase

t}!t'

sprol-ting

i~'£(mc,r'a~i
rec*~ssixely

a~ ~ , e l ]

i!~c.r<,as, e

lh*?st

Kong,

d e m , , . msst trraat e d

P (SP),

(3-HT),

>](~!'(~ ! ' ( , < : e n l l v ,

H(l'e~,S(t

h,"

studies

sl~bsl,ailc:e

Set'O{OP. Jll

:~.nu

Hens

OC('tIF% ItiOS(, [3Fomillelit [y

immul~ocyLochemi(:a[

nlmltl~,r,~a(:tix(}

a

of

SE

!o~a,,,

!. l_ a n d

Sl.t. i n b e t ' g e r

CC ( 1 9 8 6 ) .

a Neur'oscience

Research,

16:65 7-6 70. 2.

~ : l c c a - ( ~ a 1 [~)w,'l',

LI.,

Steinberger

'fult~ i,i,

i.

Zh:ui'd ~ - 0

5.

T*ossler Brain

6.

Ctmbb

l'an~

\,

and

F a nld d Vacca-Ga[]o!~ay ( aMlI l lIo w a y \ a c :( x: a: -a--(-JM

Glaxer r

Research

E,

Pooie

F

and

Nenon

CD

(11 9c 8 6 ) .

in

)Pegs. Dr(

pp 3 5 9 - 3 6 2 .

SLlb~t/tl/¢e P .~llld_.N(~ucolci -___i us, [~:u r'ol\tn 3.

C,

EL ( 1 9 9 2 ) .

LI_ ( 1 9 9 2 ) .

ArLymyshyn

R,

Brain

Nurray

Neuroscience, Research,

M and

ill p r e'ess ss. •

Goldberger

ME (11980).

459-470.

IW, Hc~dgsoni AJ a n d

~hit.e

GH ( 1 9 8 0 ) .

Neuroscience

5 : 2 0 6 5 - 2 0 ; b72.