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The Role of TB in COPD
Obstructive Lung Diseases SESSION TITLE: Airways 3 SESSION TYPE: Original Investigation Poster PRESENTED ON: Wednesday, October 26, 2016 at 01:30 PM - 02:30 PM
The Role of TB in COPD Hakan Gunen PhD*; and Halil Yakar PhD Sureyyapasa, Istanbul, Turkey PURPOSE: Recent studies emphasize that past tuberculosis (TB) infection is an important risk factor for development of COPD. In this study, we analyzed the patients who were hospitalized due to exacerbation of COPD with and without TB scars for epidemiological and clinical characteristics.
OBSTRUCTIVE LUNG DISEASES
METHODS: All COPD patients admitted to hospital with an exacerbation were included in the study consecutively. After obtaining detailed demographical and clinical characteristics, the patients were divided into 2 groups as 1) with and 2) without old TB scars. Patients groups were compared regarding the multiple characteristics and, were followed-up for 1 year to 3 years after discharge for mortality. RESULTS: 598 COPD patients were included in the study.93 patients had old TB scars on their chest X-rays (15.5%). The mean age of the patients with and without TB scars were 66.3 11.3 and 70.1 10.4 years respectively (p¼0.002). There were no differences between the groups regarding age, sex distribution, blood count and length of hospital stay (Table 1). In arterial blood gases PC02 was higher in TB scar group (p¼0.008). Exacerbation rates during the last 12 months higher in TB scar group (2.46/ year versus 1.56/year; p <0.001). Any significant difference between mortality rates after discharge was not detected (Kaplan Meier test, p ¼ 0.08). However, it was found that first COPD diagnosis was made 5 years earlier in COPD patients with old TB scars compared to the patients without TB scars (58.6 12.3 years versus 63.2 11.2 years; p <0.001) and in mortality age 5 years earlier in TB scar group (68,3 11,4 years versus 73,4 9,8; p ¼ 0,001). CONCLUSIONS: The mean age of onset of COPD symptoms were found significantly earlier in COPD patients with old TB scars. Although the patients with TB scars were significantly younger, their mortality rates were comparable to the patients without TB scars. Past TB infection leaving scars were found as an important risk factor for earlier development and faster progression of COPD in our study. CLINICAL IMPLICATIONS: The mean age of onset of COPD symptoms were found significantly earlier in COPD patients with old TB scars. Although the patients with TB scars were significantly younger, their mortality rates were comparable to the patients without TB scars. Past TB infection leaving scars were found as an important risk factor for earlier development and faster progression of COPD in our study. DISCLOSURE: The following authors have nothing to disclose: Hakan Gunen, Halil Yakar No Product/Research Disclosure Information DOI:
http://dx.doi.org/10.1016/j.chest.2016.08.956
Copyright ª 2016 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.
856A
[
150#4S CHEST OCTOBER 2016
]
The Role of TB in COPD Hakan Gunen PhD*; and Halil Yakar PhD Sureyyapasa, Istanbul, Turkey PURPOSE: Recent studies emphasize that past tuberculosis (TB) infection is an important risk factor for development of COPD. In this study, we analyzed the patients who were hospitalized due to exacerbation of COPD with and without TB scars for epidemiological and clinical characteristics.
OBSTRUCTIVE LUNG DISEASES
METHODS: All COPD patients admitted to hospital with an exacerbation were included in the study consecutively. After obtaining detailed demographical and clinical characteristics, the patients were divided into 2 groups as 1) with and 2) without old TB scars. Patients groups were compared regarding the multiple characteristics and, were followed-up for 1 year to 3 years after discharge for mortality. RESULTS: 598 COPD patients were included in the study.93 patients had old TB scars on their chest X-rays (15.5%). The mean age of the patients with and without TB scars were 66.3 11.3 and 70.1 10.4 years respectively (p¼0.002). There were no differences between the groups regarding age, sex distribution, blood count and length of hospital stay (Table 1). In arterial blood gases PC02 was higher in TB scar group (p¼0.008). Exacerbation rates during the last 12 months higher in TB scar group (2.46/ year versus 1.56/year; p <0.001). Any significant difference between mortality rates after discharge was not detected (Kaplan Meier test, p ¼ 0.08). However, it was found that first COPD diagnosis was made 5 years earlier in COPD patients with old TB scars compared to the patients without TB scars (58.6 12.3 years versus 63.2 11.2 years; p <0.001) and in mortality age 5 years earlier in TB scar group (68,3 11,4 years versus 73,4 9,8; p ¼ 0,001). CONCLUSIONS: The mean age of onset of COPD symptoms were found significantly earlier in COPD patients with old TB scars. Although the patients with TB scars were significantly younger, their mortality rates were comparable to the patients without TB scars. Past TB infection leaving scars were found as an important risk factor for earlier development and faster progression of COPD in our study. CLINICAL IMPLICATIONS: The mean age of onset of COPD symptoms were found significantly earlier in COPD patients with old TB scars. Although the patients with TB scars were significantly younger, their mortality rates were comparable to the patients without TB scars. Past TB infection leaving scars were found as an important risk factor for earlier development and faster progression of COPD in our study. DISCLOSURE: The following authors have nothing to disclose: Hakan Gunen, Halil Yakar No Product/Research Disclosure Information DOI:
http://dx.doi.org/10.1016/j.chest.2016.08.956
Copyright ª 2016 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.
856A
[
150#4S CHEST OCTOBER 2016
]