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The treatment of actinomycosis with streptomycin
ABSTRACTS
OF
!)I 1
ClJRRLEST l,ITER.\‘L’VRI~:
ORAL
MEDICINE
Mucocutaneous-Ocular Syndrome: Report of a Case Treated With Aureomycin. M. Nellen and R. Lang. Int. Rec. Med. and Gen. Prart. (‘liuics 164: 469, September. I!)>l. A case is describer1 : producing a rate 112 pclr
of an idiopathic form of erythema multiforme gravis treateri with aureornycin ’ ( The patient, a male, had ulceratetl arks on the lips, gums, palate, and tongue. purulent, bloodstaine~l, watery saliva. Tcrnprratur~~ was 102 F. and the lrr~lsc~ minute.
“Penicillin was administered, 300,000 Cr. daily intr:ttt~u~~~~~larl~ but discontinur~l on 111~ fourth day xntl aureomycin therapy startecl (250 mg. every six hours hy mouth). Four (lays later temperature was 99 F. and pulse rate 100 beats prr minutca. Thrb lesions in theI or:11 cavity and on the skin healed in approximately ten days.” Credit
is given to the aureomycin
therapy
for
tht, ,‘linit31
inll)rovement. T. .I. I-.
The Treatment of Actinomycoeis With Streptomycin. (Traitment de 1’ actinomycose par la Streptomycine.) A. Lambert. Bemaine cl. hAp. Paris 27: 1477, lO51. A 30.year-old patient was seen three months after a lower molar tooth There was an abnormally large tumefartion of the right side of the face. mastication Hut1 some nocturnal pain lyere the patient’s only cornl~laints.
was remove~l. Difficult>- ill
Physical eraminat,ion showed the classical symptoms of ac*tinomgcosis : ii tumor (3vt:rt91 by red, glistening skin which was studded with f&Was. There \vere lines of intluration with intervening zones of softening ant1 fluctuation. The fistulas exuded pus in which yello\v granules were sought for in vein. Cult,ures from the pus were ne&ve. .\ Imllous The patient \vas treated with organic iodine for 1 days with no improvement. one of tilt! :11’1’;,:: eruption appeared in the thorax, the lumbar region, ant1 in the forearm. was incised ant1 an abumlxncae of pus was obtained. h sizable collection of pus beneatlt solution was made in sit,u.
the xygoma
was int&(l
ant1 an injection
of l,ug~~i ‘Y
About twelve days later, pus was again evacuated from l)eneath the zygoma ant1 nly(~elilrnl was found in the pus for the first time. Yruicillin was given in doses of 2 million units tbily for right days and tllc>rl 1 rnillioll units daily for two weeks. Improvement was rapid. Cicatrization of the jaw relaxed. Considerable induration high in the neck was unchanged. Twenty
exposures
to s-rays
of all the Ii~tulaS was complet,c. persistecl in the nrassetcr region
The *tiflnt,ss and a kt,rnal
were given.
Fire months after trextment was begun by the author, the iJat,ient returned, complaining The blood pressure was normal. J)uh of generalized weakness, anorexia, and emaciation. from an incision at the angle of the right jaw was negative on examination. I’onicaillin was again given, 1 million units daily for one week, without effort. Streptomycin in doses of 1 Gm. per day was given for trn days. After .Ul swelling and a11 fistulas hat1 tlisappearell. patient was absolutely curetl. general cBontlition had improved.
this llerio~l tIlti Tltcl patient ‘:.
ln rPsum+, in the treatment of this case iodine heeme:l to have some slight etfec*~ OH Penicillin produced more markell im the disease, but it was not tolerated by the patient. Roentgen t,herapy W&R ineffective. Atreptomypin ln~lr1~~1 provement, but \vas not curative. a cuw in ten days. In treating actinomycosis with streptomycin, the author recommends daily 110~5 of I to 2 Gm. and that this dose be continued until cure is well established. ‘I‘ .I. (‘.
OF
!)I 1
ClJRRLEST l,ITER.\‘L’VRI~:
ORAL
MEDICINE
Mucocutaneous-Ocular Syndrome: Report of a Case Treated With Aureomycin. M. Nellen and R. Lang. Int. Rec. Med. and Gen. Prart. (‘liuics 164: 469, September. I!)>l. A case is describer1 : producing a rate 112 pclr
of an idiopathic form of erythema multiforme gravis treateri with aureornycin ’ ( The patient, a male, had ulceratetl arks on the lips, gums, palate, and tongue. purulent, bloodstaine~l, watery saliva. Tcrnprratur~~ was 102 F. and the lrr~lsc~ minute.
“Penicillin was administered, 300,000 Cr. daily intr:ttt~u~~~~~larl~ but discontinur~l on 111~ fourth day xntl aureomycin therapy startecl (250 mg. every six hours hy mouth). Four (lays later temperature was 99 F. and pulse rate 100 beats prr minutca. Thrb lesions in theI or:11 cavity and on the skin healed in approximately ten days.” Credit
is given to the aureomycin
therapy
for
tht, ,‘linit31
inll)rovement. T. .I. I-.
The Treatment of Actinomycoeis With Streptomycin. (Traitment de 1’ actinomycose par la Streptomycine.) A. Lambert. Bemaine cl. hAp. Paris 27: 1477, lO51. A 30.year-old patient was seen three months after a lower molar tooth There was an abnormally large tumefartion of the right side of the face. mastication Hut1 some nocturnal pain lyere the patient’s only cornl~laints.
was remove~l. Difficult>- ill
Physical eraminat,ion showed the classical symptoms of ac*tinomgcosis : ii tumor (3vt:rt91 by red, glistening skin which was studded with f&Was. There \vere lines of intluration with intervening zones of softening ant1 fluctuation. The fistulas exuded pus in which yello\v granules were sought for in vein. Cult,ures from the pus were ne&ve. .\ Imllous The patient \vas treated with organic iodine for 1 days with no improvement. one of tilt! :11’1’;,:: eruption appeared in the thorax, the lumbar region, ant1 in the forearm. was incised ant1 an abumlxncae of pus was obtained. h sizable collection of pus beneatlt solution was made in sit,u.
the xygoma
was int&(l
ant1 an injection
of l,ug~~i ‘Y
About twelve days later, pus was again evacuated from l)eneath the zygoma ant1 nly(~elilrnl was found in the pus for the first time. Yruicillin was given in doses of 2 million units tbily for right days and tllc>rl 1 rnillioll units daily for two weeks. Improvement was rapid. Cicatrization of the jaw relaxed. Considerable induration high in the neck was unchanged. Twenty
exposures
to s-rays
of all the Ii~tulaS was complet,c. persistecl in the nrassetcr region
The *tiflnt,ss and a kt,rnal
were given.
Fire months after trextment was begun by the author, the iJat,ient returned, complaining The blood pressure was normal. J)uh of generalized weakness, anorexia, and emaciation. from an incision at the angle of the right jaw was negative on examination. I’onicaillin was again given, 1 million units daily for one week, without effort. Streptomycin in doses of 1 Gm. per day was given for trn days. After .Ul swelling and a11 fistulas hat1 tlisappearell. patient was absolutely curetl. general cBontlition had improved.
this llerio~l tIlti Tltcl patient ‘:.
ln rPsum+, in the treatment of this case iodine heeme:l to have some slight etfec*~ OH Penicillin produced more markell im the disease, but it was not tolerated by the patient. Roentgen t,herapy W&R ineffective. Atreptomypin ln~lr1~~1 provement, but \vas not curative. a cuw in ten days. In treating actinomycosis with streptomycin, the author recommends daily 110~5 of I to 2 Gm. and that this dose be continued until cure is well established. ‘I‘ .I. (‘.