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The treatment of rhabdomyosarcoma in a community hospital setting
(99)
INFLUENCE OF POSTOPERATIVE RADIATION THERAPY TIMING AND DOSE FOR WILMS' TUMOR G. J. D'Angio, M.D.*, Melvin Tefft, M.D.**, Norman Breslow, Ph.D.*** * **
***
Children's Cancer Research Center, Children's Hospital of Philadelphia Rhode Island Hospital, Providence, R.I. University of Washington, Seattle, Washington
Prompt postoperative radiation therapy given within hours, and the use of higher doses for older children have been thought important by some therapists for success in the treatment of children with Wilms' tumors. These factors were analyzed in relation to local and distant relapse rates for 242 Wilms' tumor patients given postoperative irradiation. All also received actinomycin-D, vincristine, or both. Patients given less than specified rad doses modulated for age fared as well as those receiving at least the target dose. Sample target doses recommended in the Study were 1800 rads for babies and 4000 rads for children four or more years of age.
Four that tive more
There were five patients who had relapse of tumor in the operative bed. these five relapses were in children with anaplastic tumors, suggesting histologic type is a major factor in this complication. The postoperaRT dose was not a major contributing variable; three cases had 3000 or rads given.
It is concluded that, at least for patients given chemotherapy, good local and systemic control was provided by radiation therapy given in modest doses even when delayed for up to ten days postoperatively.
(100)
THE TREATMENT OF RHABDOMYOSARCOMA
IN A COMMUNITY HOSPITAL SETTING
Cornelia Porter, R.N., P.N.P., A. Robert Kagen, M.D., ASTR, Herman Nussbaum., M.D., Harvey A. Gilbert, M.D., ASTR, Paul Chan, M.D., ASTR, Aroor Rao, M.D. Department of Pediatrics and Radiation Therapy, Southern California Permanente Medical Group, 1510 N. Edgemont St., Los Angeles, Ca. 90027
Twenty-five children with rhabdomyosarcoma were treated with an operative procedure., multi-agent chemotherapy and radiations at the Southern California Permanente Medical Group from 1969 to 1976. Patients were staged by the same criteria as suggested by the IRS (Intergroup Rhabdomyosarcoma Study). Five year survival for Group I was 87%; for Group II was 83%; for Group III was 50%; and for Group IV was 28%. Five year survival for all patients was 64%. Patients were treated at each of our 7 hospitals by a pediatric oncologist. Radiation Therapy was centralized at one hospital. The two year survival rates are similar to those generated by IRS suggesting that quality pediatric oncology can be practiced at a community hospital.
113
INFLUENCE OF POSTOPERATIVE RADIATION THERAPY TIMING AND DOSE FOR WILMS' TUMOR G. J. D'Angio, M.D.*, Melvin Tefft, M.D.**, Norman Breslow, Ph.D.*** * **
***
Children's Cancer Research Center, Children's Hospital of Philadelphia Rhode Island Hospital, Providence, R.I. University of Washington, Seattle, Washington
Prompt postoperative radiation therapy given within hours, and the use of higher doses for older children have been thought important by some therapists for success in the treatment of children with Wilms' tumors. These factors were analyzed in relation to local and distant relapse rates for 242 Wilms' tumor patients given postoperative irradiation. All also received actinomycin-D, vincristine, or both. Patients given less than specified rad doses modulated for age fared as well as those receiving at least the target dose. Sample target doses recommended in the Study were 1800 rads for babies and 4000 rads for children four or more years of age.
Four that tive more
There were five patients who had relapse of tumor in the operative bed. these five relapses were in children with anaplastic tumors, suggesting histologic type is a major factor in this complication. The postoperaRT dose was not a major contributing variable; three cases had 3000 or rads given.
It is concluded that, at least for patients given chemotherapy, good local and systemic control was provided by radiation therapy given in modest doses even when delayed for up to ten days postoperatively.
(100)
THE TREATMENT OF RHABDOMYOSARCOMA
IN A COMMUNITY HOSPITAL SETTING
Cornelia Porter, R.N., P.N.P., A. Robert Kagen, M.D., ASTR, Herman Nussbaum., M.D., Harvey A. Gilbert, M.D., ASTR, Paul Chan, M.D., ASTR, Aroor Rao, M.D. Department of Pediatrics and Radiation Therapy, Southern California Permanente Medical Group, 1510 N. Edgemont St., Los Angeles, Ca. 90027
Twenty-five children with rhabdomyosarcoma were treated with an operative procedure., multi-agent chemotherapy and radiations at the Southern California Permanente Medical Group from 1969 to 1976. Patients were staged by the same criteria as suggested by the IRS (Intergroup Rhabdomyosarcoma Study). Five year survival for Group I was 87%; for Group II was 83%; for Group III was 50%; and for Group IV was 28%. Five year survival for all patients was 64%. Patients were treated at each of our 7 hospitals by a pediatric oncologist. Radiation Therapy was centralized at one hospital. The two year survival rates are similar to those generated by IRS suggesting that quality pediatric oncology can be practiced at a community hospital.
113