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The Xenopus pregnancy test
TREATMENT
4. nancy. 5. One of 6. appears
OF
RH-NEGATIVE
Three out of three untreated
patients
PREGNANT
WOMEN
developed
antibodies
309 during
Two out of three untreated patients delivered erythroblastotic these infants died. In this series the use of anhydro-hydroxy-progesterone and/or to have a definite effect on controlling erythroblastosis fetalis.
The authors realize that this is a relatively small series of are sufficiently suggestive to warrant a preliminary report so that by other observers. Medication used was Pranone (Schering) , part of which was company, and Hykinone (Abbott Laboratories), part of which was 725-4rn
infants. vitamin
I<
cases, but the results
that may
generously supplied
supplied by the by the company.
the results be verified
STREET
Murphy, Douglas P., and Far&, by Rat
preg-
Ovulation
Test,
Edmond J.: Treatment of Sterility: J. A. M. A. 138: 13, Sept. 4, 1948.
Insemination Timed
This test was employed in order to predict the day for the insemination in a series of thirty-two women. Each couple that sought assistance was studied from three points of view: (1) sperm status of the husband, (2) patency of the Fallopian tubes, and (3) character of the wife’s ovulation process. Fifty-seven inseminations were done on thirtytwo women. Ten resulted in conception. Eight of the ten women conceived as a result of the first treatment; the remaining two women conceived on their second insemination. Forty-seven inseminations failed in their objective. Thirty-seven (79 per cent) of the forty-seven failures were charged either to an inadequate number of moving sperm cells or abnormal ovulation. Each of these two categories was predicted before the insemination was performed. Each patient had an insemination only once each month. It is important to note that eight of the ten conceptions followed the first insemination which speaks well for the rat ovulation test as a method for predicting the day when the egg is ready for fertilization. The authors noted a high incidence of low sperm counts and abnormal ovulations in this series. WILLIAM BERMAN.
Polak, Stanley S.:
The
Xenopus
Pregnancy
Test,
Canad.
M. A.
J. 60:
159, 1949.
The Xenopus frog has large ovaries which occupy the greater part of its abdomen and eggs are present in them during the entire year. Eggs are never extruded except through stimulation by the male during the mating season or by injection of hormones. The test is based on the extrusion of eggs from two to twelve hours after the injection of urine concentrates containing gonadotropic hormone into a female Xenopus. If eggs are deposited, the patient is pregnant; if no eggs are extruded, the test is negative. The author found this test positive in 98 per cent plus of his cases. It is important that all drugs, even aspirin and hypodermics, should be avoided for at least two days prior to the test. WILLIAM BERMAN.
4. nancy. 5. One of 6. appears
OF
RH-NEGATIVE
Three out of three untreated
patients
PREGNANT
WOMEN
developed
antibodies
309 during
Two out of three untreated patients delivered erythroblastotic these infants died. In this series the use of anhydro-hydroxy-progesterone and/or to have a definite effect on controlling erythroblastosis fetalis.
The authors realize that this is a relatively small series of are sufficiently suggestive to warrant a preliminary report so that by other observers. Medication used was Pranone (Schering) , part of which was company, and Hykinone (Abbott Laboratories), part of which was 725-4rn
infants. vitamin
I<
cases, but the results
that may
generously supplied
supplied by the by the company.
the results be verified
STREET
Murphy, Douglas P., and Far&, by Rat
preg-
Ovulation
Test,
Edmond J.: Treatment of Sterility: J. A. M. A. 138: 13, Sept. 4, 1948.
Insemination Timed
This test was employed in order to predict the day for the insemination in a series of thirty-two women. Each couple that sought assistance was studied from three points of view: (1) sperm status of the husband, (2) patency of the Fallopian tubes, and (3) character of the wife’s ovulation process. Fifty-seven inseminations were done on thirtytwo women. Ten resulted in conception. Eight of the ten women conceived as a result of the first treatment; the remaining two women conceived on their second insemination. Forty-seven inseminations failed in their objective. Thirty-seven (79 per cent) of the forty-seven failures were charged either to an inadequate number of moving sperm cells or abnormal ovulation. Each of these two categories was predicted before the insemination was performed. Each patient had an insemination only once each month. It is important to note that eight of the ten conceptions followed the first insemination which speaks well for the rat ovulation test as a method for predicting the day when the egg is ready for fertilization. The authors noted a high incidence of low sperm counts and abnormal ovulations in this series. WILLIAM BERMAN.
Polak, Stanley S.:
The
Xenopus
Pregnancy
Test,
Canad.
M. A.
J. 60:
159, 1949.
The Xenopus frog has large ovaries which occupy the greater part of its abdomen and eggs are present in them during the entire year. Eggs are never extruded except through stimulation by the male during the mating season or by injection of hormones. The test is based on the extrusion of eggs from two to twelve hours after the injection of urine concentrates containing gonadotropic hormone into a female Xenopus. If eggs are deposited, the patient is pregnant; if no eggs are extruded, the test is negative. The author found this test positive in 98 per cent plus of his cases. It is important that all drugs, even aspirin and hypodermics, should be avoided for at least two days prior to the test. WILLIAM BERMAN.