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Thiouracil in the treatment of hyperthyroidism complicating pregnancy and its effect on the human fetal thyroid
Volume 58 Number I
SELECTED
199
ABSTRACTS
The then followed congenital heart disease, mental deficiency, and finally cataracts. authors conclude that despite the lack of experimental evidence, there is sufficient clinica evidence in this and other reports to show the grave risk of exposure of the pregnant woman to rubella. Certain preventive measures are outlined to prevent these abnormalities. The treatment and education of the handicapped are also outlined. WILLIAM BERMAN.
Pregnancy,
Complications
O’Hanlon, R. H., and Stewart, F. S.: Maternal Disease Due to Rh Sensitization, Irish J. M.
Jaundice
in Association
With Remolytic
SC., 1948.
Two cases of coincidental maternal jaundice in Rh sensitization are presented. In one, the mother gave birth to an infant with relatively mild hemolytic disease. In the other, the infant was hydropic. The authors do not establish any causal relationship between the maternal jaundice and hemolytic disease. L. M. HELLMAN.
Whitelaw, M. James: Thiouracil in the Treatment of Hyperthyroidism Complicating Pregnancy and Its Effect on the Human Fetal Thyroid, J. Clin. Endocrinol., November,
1947.
The literature to date of cases of hyperthyroidism, complicated by pregnancy and treated with thiouracil, is reviewed. A case is then reported of a patient exhibiting marked thyro.toxicosis (basal metabolism rate plus 65 per cent) who was hospitalized in her twenty-sixth Thiouracil treatment was instituted and continued until the fortyweek of pregnancy. first week of her pregnancy when she delivered an encephalic male monster. The infant survived six hours and ten minutes. After death the thyroid gland was removed. The gland was found to be slightly smaller than the reported normal, there was no diminution of the iodine content, and the histologic appearance was normal. Thus, it would appear, (o a hyperthyroid pregnant
based female
on a single case, has no demonstrable
that
the administration of thiouracil injurious effect on the newborn. HERBERT
J. SIMON.
Radiation Borell,
U., Westmann, A., and Orstrom, A.: Studies on the Functions of the HypophysealDiencephalic System and of the Ovaries by Means of Radioactive Phosphorus, Gynaecologia
123:
186-200,
March,
1947.
The authors, reporting from the Gynecology Clinic at Caroline Hospital, Stockholm, determined to find a way to demonstrate the possible role that the nervous centers in the hypothalamus might play in ovarian function beyond the known hypophyseal factors. They selected the rabbit as the best suited experimental animal because the maturation and rupture of the follicles occur only after intercourse or strong sexual stimulus. Radioactive phosphorus as free phosphorus, Psz, in 5 per cent glucose solution, was iujected intravenously into anestrus and estrus females at predetermined intervals before and after coitus. Castrate animals were also examined three to five weeks after oophorectomy. Each animal received 0.1 mc. in 1.0 c.e. Thirty minutes after injection the animals were killed by decapitation to remove all possible blood from organs. The blood, cerebellum, tuber cinereum, pars glandularis of the hypophysis, and the ovaries were examined for total radioactivity and total phosphate. For the tuber cinereum, adenohypophysis, and ovaries the authors found no difference in phosphate turnover between the a.nestrus and estrus female rabbits. In castrate animals they found an appreciable increase in the phosphate turnover in the adenohypophysis and no increase in the tuber einereum.
SELECTED
199
ABSTRACTS
The then followed congenital heart disease, mental deficiency, and finally cataracts. authors conclude that despite the lack of experimental evidence, there is sufficient clinica evidence in this and other reports to show the grave risk of exposure of the pregnant woman to rubella. Certain preventive measures are outlined to prevent these abnormalities. The treatment and education of the handicapped are also outlined. WILLIAM BERMAN.
Pregnancy,
Complications
O’Hanlon, R. H., and Stewart, F. S.: Maternal Disease Due to Rh Sensitization, Irish J. M.
Jaundice
in Association
With Remolytic
SC., 1948.
Two cases of coincidental maternal jaundice in Rh sensitization are presented. In one, the mother gave birth to an infant with relatively mild hemolytic disease. In the other, the infant was hydropic. The authors do not establish any causal relationship between the maternal jaundice and hemolytic disease. L. M. HELLMAN.
Whitelaw, M. James: Thiouracil in the Treatment of Hyperthyroidism Complicating Pregnancy and Its Effect on the Human Fetal Thyroid, J. Clin. Endocrinol., November,
1947.
The literature to date of cases of hyperthyroidism, complicated by pregnancy and treated with thiouracil, is reviewed. A case is then reported of a patient exhibiting marked thyro.toxicosis (basal metabolism rate plus 65 per cent) who was hospitalized in her twenty-sixth Thiouracil treatment was instituted and continued until the fortyweek of pregnancy. first week of her pregnancy when she delivered an encephalic male monster. The infant survived six hours and ten minutes. After death the thyroid gland was removed. The gland was found to be slightly smaller than the reported normal, there was no diminution of the iodine content, and the histologic appearance was normal. Thus, it would appear, (o a hyperthyroid pregnant
based female
on a single case, has no demonstrable
that
the administration of thiouracil injurious effect on the newborn. HERBERT
J. SIMON.
Radiation Borell,
U., Westmann, A., and Orstrom, A.: Studies on the Functions of the HypophysealDiencephalic System and of the Ovaries by Means of Radioactive Phosphorus, Gynaecologia
123:
186-200,
March,
1947.
The authors, reporting from the Gynecology Clinic at Caroline Hospital, Stockholm, determined to find a way to demonstrate the possible role that the nervous centers in the hypothalamus might play in ovarian function beyond the known hypophyseal factors. They selected the rabbit as the best suited experimental animal because the maturation and rupture of the follicles occur only after intercourse or strong sexual stimulus. Radioactive phosphorus as free phosphorus, Psz, in 5 per cent glucose solution, was iujected intravenously into anestrus and estrus females at predetermined intervals before and after coitus. Castrate animals were also examined three to five weeks after oophorectomy. Each animal received 0.1 mc. in 1.0 c.e. Thirty minutes after injection the animals were killed by decapitation to remove all possible blood from organs. The blood, cerebellum, tuber cinereum, pars glandularis of the hypophysis, and the ovaries were examined for total radioactivity and total phosphate. For the tuber cinereum, adenohypophysis, and ovaries the authors found no difference in phosphate turnover between the a.nestrus and estrus female rabbits. In castrate animals they found an appreciable increase in the phosphate turnover in the adenohypophysis and no increase in the tuber einereum.