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Thirty years ago
T U B ERC L E
264
October 1954
It shows some slight tendency, greater at least than that of the ox, to develop tubercle in its muscles. Straus reported that a piece o f h a m sent him on suspicion o f trichinosis was found to be sown with little tubercles. N o c a r d and Leclainche say that tuberculosis has been Caseno. 15' 3o" 60" 9o' 12o' x8o' recorded in pig's muscle b y Moule, Strosse, Stockman and Winter. Sir Stewart Stockman x Plasma --0-38 --o'33 indeed reported 2 cases, hut in neither case did Milk ~ o,t2 0.38 o'3~ oq 9 0-37 -'2 Plasma 0. 3 0-47 0"6 he think tile disease was haematogenous. Milk o-~a 0.38 0-47 0.55 0"38 H o w then can we account for this tendency in 3 Plasma o.i2 - o.4 o.58 the pig, slight t h o u g h it is, to develop tubercle in Milk o.xa o.2 0-44 0"68 0"31 4 Plasma o'4~ - 0"68 its muscles, and bring this fact into h a r m o n y Milk -0-38 o-52 0"58 0"48 with the view that tuberculosis attacks hard5 Plasma o. 3 0.48 0"5 worked or highly specialized organs? For the pig Milk o-28 0.55 0"27 o-t (The figures represent concentration of I.N.It. in mg/ is not, like the monkey, noted for its muscular activity, and indeed its life, after the first flush of 1OO C.C.) y o u t h is over, is usually an indolent and sedenAs m a y be seen from the table the m a x i m u m tary one. It is in this very fact, contrar T though it concentrations of I . N . H . excreted in the milk, m a y seem to the doctrine which we are defendone to two hours following the administration o f ing, that we find an explanation of the liability a 2oo mg. dose, ranged between o.38 rag. - o.68 of pig's muscles to develop tubercle. VCe are told, for individual patients. by Ostertag, that hogs when they are being In the samples taken one and two hours after fattened seldom, during the last months of the drug administration, the I . N . H . levels in milk process, get u p o n their legs except to move to the tend to be slightly higher than those in plasma. food trough, a n d that their muscles becoL-ne, from It was found that the levels o f I . N . H . in milk disuse, so altered by fatty metamorphosisas to be begin to decrease two hours after administration incapable of doing their work when callcd upon; of the drug in all b u t o n e case. consequently w h e n these animals, overweighted with fat, are at last driven to the market, they are References liable to rupture some of their m u s c u l a r fibres, Ill Selikoff, I.J., and Robitzek, E. H. (t952) Dis. of Chest, ~pecially those o f the diaphragm, as the result of xxb 385. [-',] Kelly, J. M., and Poet, R. B. (1952) Am. Rer. Tuberc., the unwonted exercise and the dyspnoea which it entails; and that multiple haemorrhages of this LXV, 484kind are c o m m o n in various muscles. Yours faithfidly,
plasma and in milk. T h e levels o f I . N . H . were determined b y the m e / h o d described by Keely and Poet [2]. T h e results are presented in the following table:
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Y. hi. BRO.XtBERO. hi. SALZ~EROER. I. BRUDERMAN.
From the department of Obstetrics and Gynecology, Hebrew University Hadassah Medical Sdwol, Jerusalem, Israel.
CLASSIFIED
ADVERTISEMENTS
F.R.C.$.)
PORTSMOUTH A N D ISLE OF W I G H T A R E A PATHOLOGICAL SERVICE PPLICATIONS are invited for the appointment o f a LABORATORY T E C I I N I C I A N . Senior or Technician grade, for service at the Royal National Hospital for Diseases of the Chest, Vcmnor, Isle o f Wight. but '.he successful applicant may be required to serve in any of the Laboratories in the Area Service. Candidates must be well experienced in general clinical path0losy, and hold the Diploma o f the Institute o f Medical Laboratory Technology in Bacteriological Icchniclue. Salary and conditions of service in accordance with current Whitley Council recommendations. Accommodation may be arranged for the successful appl!cant, if single. Applications, giving full particulars o f qualifications, present appointment, and past experience together with the names of three referees should be sent to the S~cretary of the Area Pathological Board, 35. Grove Road South, Soutb~ea, Hants, as ,soon as possible.
But before we can pursue this part o f the argum e n t we ought to consider for a m o m e n t the case of the pig; for this animal exhibits an exception to the rule which we have attempted to establish, namely that tuberculosis is particularly liable to attack organs which are hard-worked or, at least, from which great results are demanded.
t t U L L (B) H.M.C.--CASTLE t I I L L HOSPITAL, C O T l r l N G I I A M " I U N I O R I t O S P I T A L MEDICAL O F F I C E R (resident), to work ,a in Major Thoracic Surgery Unit. The Unit has 50 beds for all types o f thoracic surgery, including tuberculous and nontuberculous, oesophagcal and cardiac. Applications v,-ilh laamcs o f referees, to Group Secretary, De la Po;e lfospitat, Willerby, E. Yorkshire.
Thirty Years Ago (Extract from ~I'UBEI~.CLE, O c t o b e r I924 Tuberculosis in M a n and Domesticated Animals. T h e Relative Susceptibility to the Disease of Their Various Organs, by Louis Cobbett, M.D.,
A
264
October 1954
It shows some slight tendency, greater at least than that of the ox, to develop tubercle in its muscles. Straus reported that a piece o f h a m sent him on suspicion o f trichinosis was found to be sown with little tubercles. N o c a r d and Leclainche say that tuberculosis has been Caseno. 15' 3o" 60" 9o' 12o' x8o' recorded in pig's muscle b y Moule, Strosse, Stockman and Winter. Sir Stewart Stockman x Plasma --0-38 --o'33 indeed reported 2 cases, hut in neither case did Milk ~ o,t2 0.38 o'3~ oq 9 0-37 -'2 Plasma 0. 3 0-47 0"6 he think tile disease was haematogenous. Milk o-~a 0.38 0-47 0.55 0"38 H o w then can we account for this tendency in 3 Plasma o.i2 - o.4 o.58 the pig, slight t h o u g h it is, to develop tubercle in Milk o.xa o.2 0-44 0"68 0"31 4 Plasma o'4~ - 0"68 its muscles, and bring this fact into h a r m o n y Milk -0-38 o-52 0"58 0"48 with the view that tuberculosis attacks hard5 Plasma o. 3 0.48 0"5 worked or highly specialized organs? For the pig Milk o-28 0.55 0"27 o-t (The figures represent concentration of I.N.It. in mg/ is not, like the monkey, noted for its muscular activity, and indeed its life, after the first flush of 1OO C.C.) y o u t h is over, is usually an indolent and sedenAs m a y be seen from the table the m a x i m u m tary one. It is in this very fact, contrar T though it concentrations of I . N . H . excreted in the milk, m a y seem to the doctrine which we are defendone to two hours following the administration o f ing, that we find an explanation of the liability a 2oo mg. dose, ranged between o.38 rag. - o.68 of pig's muscles to develop tubercle. VCe are told, for individual patients. by Ostertag, that hogs when they are being In the samples taken one and two hours after fattened seldom, during the last months of the drug administration, the I . N . H . levels in milk process, get u p o n their legs except to move to the tend to be slightly higher than those in plasma. food trough, a n d that their muscles becoL-ne, from It was found that the levels o f I . N . H . in milk disuse, so altered by fatty metamorphosisas to be begin to decrease two hours after administration incapable of doing their work when callcd upon; of the drug in all b u t o n e case. consequently w h e n these animals, overweighted with fat, are at last driven to the market, they are References liable to rupture some of their m u s c u l a r fibres, Ill Selikoff, I.J., and Robitzek, E. H. (t952) Dis. of Chest, ~pecially those o f the diaphragm, as the result of xxb 385. [-',] Kelly, J. M., and Poet, R. B. (1952) Am. Rer. Tuberc., the unwonted exercise and the dyspnoea which it entails; and that multiple haemorrhages of this LXV, 484kind are c o m m o n in various muscles. Yours faithfidly,
plasma and in milk. T h e levels o f I . N . H . were determined b y the m e / h o d described by Keely and Poet [2]. T h e results are presented in the following table:
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
Y. hi. BRO.XtBERO. hi. SALZ~EROER. I. BRUDERMAN.
From the department of Obstetrics and Gynecology, Hebrew University Hadassah Medical Sdwol, Jerusalem, Israel.
CLASSIFIED
ADVERTISEMENTS
F.R.C.$.)
PORTSMOUTH A N D ISLE OF W I G H T A R E A PATHOLOGICAL SERVICE PPLICATIONS are invited for the appointment o f a LABORATORY T E C I I N I C I A N . Senior or Technician grade, for service at the Royal National Hospital for Diseases of the Chest, Vcmnor, Isle o f Wight. but '.he successful applicant may be required to serve in any of the Laboratories in the Area Service. Candidates must be well experienced in general clinical path0losy, and hold the Diploma o f the Institute o f Medical Laboratory Technology in Bacteriological Icchniclue. Salary and conditions of service in accordance with current Whitley Council recommendations. Accommodation may be arranged for the successful appl!cant, if single. Applications, giving full particulars o f qualifications, present appointment, and past experience together with the names of three referees should be sent to the S~cretary of the Area Pathological Board, 35. Grove Road South, Soutb~ea, Hants, as ,soon as possible.
But before we can pursue this part o f the argum e n t we ought to consider for a m o m e n t the case of the pig; for this animal exhibits an exception to the rule which we have attempted to establish, namely that tuberculosis is particularly liable to attack organs which are hard-worked or, at least, from which great results are demanded.
t t U L L (B) H.M.C.--CASTLE t I I L L HOSPITAL, C O T l r l N G I I A M " I U N I O R I t O S P I T A L MEDICAL O F F I C E R (resident), to work ,a in Major Thoracic Surgery Unit. The Unit has 50 beds for all types o f thoracic surgery, including tuberculous and nontuberculous, oesophagcal and cardiac. Applications v,-ilh laamcs o f referees, to Group Secretary, De la Po;e lfospitat, Willerby, E. Yorkshire.
Thirty Years Ago (Extract from ~I'UBEI~.CLE, O c t o b e r I924 Tuberculosis in M a n and Domesticated Animals. T h e Relative Susceptibility to the Disease of Their Various Organs, by Louis Cobbett, M.D.,
A