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This abstract has been withdrawn
Abstracts
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Figure 1
http://dx.doi.org/10.1016/j.hlc.2016.06.111 111 This abstract has been withdrawn 112 Lack of Association Between LDL-cholesterol, Plaque Burden and Lipid-Rich Plaque in Coronary Lesions Requiring PCI: The Color Registry N. Schwarz 1,∗ , J. A. Andrews 1 , T. Nguyen 1 , A. Janssan 1 , A. Vidanapathirana 1 , B. Pullen 1 , A. Maehara 3 , M. Matsumura 3 , M. Yamamoto 3 , A. S. Kini 3 , P. Shah 2 , J. E. Muller 2 , G. W. Stone 3 , G. S. Mintz 3 , G. Weisz 3 , S. J. Nicholls 1 1 South
Australian Health and Medical Research Institute, Adelaide, South Australia, Australia 2 Infra Re Dx Inc, Burlington, Massachusetts, USA 3 Columbia University Medical Centre, New York, USA Background: Prior community-based studies have demonstrated a direct association between systemic levels of low-density lipoprotein cholesterol (LDL-C) and both the progression of coronary atherosclerosis and incidence of adverse cardiovascular events. The relationship between plasma LDLC levels and coronary lipid-rich plaques (LRPs) in patients undergoing percutaneous coronary intervention (PCI) has not been studied. Methods: Simultaneous near-infrared spectroscopy (NIRS) and intravascular ultrasound (IVUS) coronary imaging were performed during PCI in the prospective, multicentre COLOR registry. Plaque burden (PB) was determined by
.. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. ..
IVUS and plaque lipid composition by NIRS, which quantified LRP as the total lesion lipid core burden index (LCBI) and the maximum LCBI over any 4-mm lesion segment (maxLCBI4mm ). We examined predictors of plaque burden and lipid composition in 584 patients stratified according to LDL-C tertiles. Results: Patients with higher LDL-C levels were less likely to be male and treated with a statin. No statistically significant correlation was found between LDL-C tertiles with regard to measurements of plaque burden or lipid composition at either the minimum lumen area site or elsewhere within the PCI lesion (Table). Conclusion: In patients with a coronary lesion requiring PCI, plasma LDL-C levels are not correlated with LRP, suggesting a more complex relationship between circulating atherogenic lipoproteins and the composition of coronary atherosclerosis. TABLE
LDL-C <67 mg/dL (n=197)
LDL-C 67-95 mg/dL (n=169)
LDL-C >95 mg/dL (n=188)
65 (59, 72) 85.8% 91.3% 77 (68, 83) 21(0, 39)
63 (57, 70) 79.3% 78.4% 77(70, 81) 27 (0, 41)
63 (55, 72) 72.3% 56.5% 76 (69, 83) 25(0, 48)
0.19 0.006 <0.0001 0.99 0.89
93 (34, 176)
106 (45, 162)
108 (40, 190)
0.46
P Value
............................................. Age (yrs) Male Statin use PB at MLA site (%) LRP burden at MLA (%) Lesion LCBI
http://dx.doi.org/10.1016/j.hlc.2016.06.113 113 Long-Term Postoperative Patency of Radial Artery is Superior to Saphenous Vein Graft A. Royse 1,2,∗ , P. Zulfayandi 1 , O. Jared 1 , E. David 1,2 , A. Andrew 1,2 , W. William 1,2 , R. Colin 1,2 1 The 2 The
University of Melbourne, Australia Royal Melbourne Hospital, Australia
Introduction: Late patency of coronary bypass grafts can be compared, when all the conduit types are present in each patient so all are exposed to the same patient and environmental factors. Methods: A unique cohort of patients where each patient had at least one of an internal mammary artery (IMA), radial artery (RA) and saphenous vein graft (SVG) were identified and volunteered for angiography at least 10 years postoperative. Overall patency and angiographic irregularity of the conduit lumen, indicative of conduit atherosclerosis, and perfect patency when the conduit lumen appeared normal. Results: 49 non randomised patients, 47 male, underwent elective research coronary angiography at 13.5±2.8 (10-19) yr postoperative. Age at surgery was 77.1±7.9 yr, and at angiogram was 74.2±7.4 yr. Symptoms of any kind were infrequent; CCS 0/I in 98% and NYHA I/II in 98%. 189 grafts were analysed by distal anastomosis; IMA 60, RA 74, SVG 55. Patency was IMA 96.7% (58/60) was not different to RA 93.2% (69/74) (p=0.459). SVG patency was 76.4%
S50
Figure 1
http://dx.doi.org/10.1016/j.hlc.2016.06.111 111 This abstract has been withdrawn 112 Lack of Association Between LDL-cholesterol, Plaque Burden and Lipid-Rich Plaque in Coronary Lesions Requiring PCI: The Color Registry N. Schwarz 1,∗ , J. A. Andrews 1 , T. Nguyen 1 , A. Janssan 1 , A. Vidanapathirana 1 , B. Pullen 1 , A. Maehara 3 , M. Matsumura 3 , M. Yamamoto 3 , A. S. Kini 3 , P. Shah 2 , J. E. Muller 2 , G. W. Stone 3 , G. S. Mintz 3 , G. Weisz 3 , S. J. Nicholls 1 1 South
Australian Health and Medical Research Institute, Adelaide, South Australia, Australia 2 Infra Re Dx Inc, Burlington, Massachusetts, USA 3 Columbia University Medical Centre, New York, USA Background: Prior community-based studies have demonstrated a direct association between systemic levels of low-density lipoprotein cholesterol (LDL-C) and both the progression of coronary atherosclerosis and incidence of adverse cardiovascular events. The relationship between plasma LDLC levels and coronary lipid-rich plaques (LRPs) in patients undergoing percutaneous coronary intervention (PCI) has not been studied. Methods: Simultaneous near-infrared spectroscopy (NIRS) and intravascular ultrasound (IVUS) coronary imaging were performed during PCI in the prospective, multicentre COLOR registry. Plaque burden (PB) was determined by
.. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. ..
IVUS and plaque lipid composition by NIRS, which quantified LRP as the total lesion lipid core burden index (LCBI) and the maximum LCBI over any 4-mm lesion segment (maxLCBI4mm ). We examined predictors of plaque burden and lipid composition in 584 patients stratified according to LDL-C tertiles. Results: Patients with higher LDL-C levels were less likely to be male and treated with a statin. No statistically significant correlation was found between LDL-C tertiles with regard to measurements of plaque burden or lipid composition at either the minimum lumen area site or elsewhere within the PCI lesion (Table). Conclusion: In patients with a coronary lesion requiring PCI, plasma LDL-C levels are not correlated with LRP, suggesting a more complex relationship between circulating atherogenic lipoproteins and the composition of coronary atherosclerosis. TABLE
LDL-C <67 mg/dL (n=197)
LDL-C 67-95 mg/dL (n=169)
LDL-C >95 mg/dL (n=188)
65 (59, 72) 85.8% 91.3% 77 (68, 83) 21(0, 39)
63 (57, 70) 79.3% 78.4% 77(70, 81) 27 (0, 41)
63 (55, 72) 72.3% 56.5% 76 (69, 83) 25(0, 48)
0.19 0.006 <0.0001 0.99 0.89
93 (34, 176)
106 (45, 162)
108 (40, 190)
0.46
P Value
............................................. Age (yrs) Male Statin use PB at MLA site (%) LRP burden at MLA (%) Lesion LCBI
http://dx.doi.org/10.1016/j.hlc.2016.06.113 113 Long-Term Postoperative Patency of Radial Artery is Superior to Saphenous Vein Graft A. Royse 1,2,∗ , P. Zulfayandi 1 , O. Jared 1 , E. David 1,2 , A. Andrew 1,2 , W. William 1,2 , R. Colin 1,2 1 The 2 The
University of Melbourne, Australia Royal Melbourne Hospital, Australia
Introduction: Late patency of coronary bypass grafts can be compared, when all the conduit types are present in each patient so all are exposed to the same patient and environmental factors. Methods: A unique cohort of patients where each patient had at least one of an internal mammary artery (IMA), radial artery (RA) and saphenous vein graft (SVG) were identified and volunteered for angiography at least 10 years postoperative. Overall patency and angiographic irregularity of the conduit lumen, indicative of conduit atherosclerosis, and perfect patency when the conduit lumen appeared normal. Results: 49 non randomised patients, 47 male, underwent elective research coronary angiography at 13.5±2.8 (10-19) yr postoperative. Age at surgery was 77.1±7.9 yr, and at angiogram was 74.2±7.4 yr. Symptoms of any kind were infrequent; CCS 0/I in 98% and NYHA I/II in 98%. 189 grafts were analysed by distal anastomosis; IMA 60, RA 74, SVG 55. Patency was IMA 96.7% (58/60) was not different to RA 93.2% (69/74) (p=0.459). SVG patency was 76.4%