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This month's theme
Contents
T HE J OURNAL OF
Allergy Clinical Immunology AND
VOLUME 119 NUMBER 6 d
OFFICIAL JOURNAL OF THE AMERICAN ACADEMY OF ALLERGY, ASTHMA
Y
& IMMUNOLOGY
This month’s theme: Eosinophil-mediated disease
About the cover The cover image shows an eosinophilic microabscess located in the esophageal epithelium of a patient with eosinophilic esophagitis. Note the surrounding tissue damage. Several articles in this month’s issue examine the important role of eosinophils. A good place to start would be the Editorial by Rothenberg (p 1321), which provides an overview of the latest concepts about eosinophils as summarized in this issue of the Journal. In the Current Reviews article, Dagmar and Hans-Uwe Simon (p 1291) present a clinically relevant classification of eosinophilic disorders based on new understandings of the disease mechanism. The Molecular Mechanisms review by Rosenberg et al (p 1303) summarizes recent advances in understanding eosinophil development and accumulation in inflamed tissues. In a Current Perspectives review, Jacobsen et al (p 1313) propose that eosinophils are critical immunoregulatory cells with pleotropic capabilities that affect diverse immune responses. In an Update Review, Munitz and Levi-Schaffer (p 1382) review the biology and therapeutic significance of a new set of inhibitory receptors expressed by eosinophils. Finally, in the Images in Allergy and Immunology feature, Foley and colleagues (p 1563) review the role of eosinophils in diverse tissue remodeling responses. Overall, we are now in a very strong position to design ways to modulate the activity of eosinophils in a variety of immune responses, opening the door to new approaches for therapeutic intervention in allergic disease. Articles relevant to the theme of ‘‘Eosinophil-mediated disease’’ are noted in the Table of Contents by a red starburst next to their titles. Original image supplied by Dr Margaret Collins, Cincinnati Children’s Hospital Medical Center. Adapted for the cover by JDI, LLC. This month in Beyond Our Pages Two reports deal with the beneficial effects of different pharmacotherapeutic agents in chronic obstructive pulmonary disease. d The effects of the blockade of TNF activity in asthma have been described. d A study has further defined the characteristics of memory TH2 lymphocytes. d Another study has explored the function of IL-31, a cytokine that is expressed by TH2 lymphocytes; its function has been unclear. d The role of IL-15 in breaking the homeostasis in the intestinal tract has been explored as a possible underlying mechanism in celiac disease. d Investigators have uncovered evidence that the etiology of idiopathic pulmonary fibrosis is related to abnormal chromosomal telomere formation. Ó 2007 American Academy of Allergy, Asthma & Immunology The Journal of Allergy and Clinical Immunology (ISSN: 0091-6749) is published monthly by Elsevier Inc., 360 Park Avenue South, New York, NY 100101710. Business Office: 1600 John F. Kennedy Boulevard, Suite 1800, Philadelphia, PA 19103-2899. Editorial Office: 11830 Westline Industrial Drive, St Louis, MO 63146-3318. Customer Service Office: 6277 Sea Harbor Drive, Orlando, FL 32887-4800. Periodicals postage paid at New York, NY and additional mailing offices. POSTMASTER: Send address changes to The Journal of Allergy and Clinical Immunology, Elsevier Periodicals Customer Service, 6277 Sea Harbor Drive, Orlando, FL 32887-4800.
6A June 2007
J ALLERGY CLIN IMMUNOL
T HE J OURNAL OF
Allergy Clinical Immunology AND
VOLUME 119 NUMBER 6 d
OFFICIAL JOURNAL OF THE AMERICAN ACADEMY OF ALLERGY, ASTHMA
Y
& IMMUNOLOGY
This month’s theme: Eosinophil-mediated disease
About the cover The cover image shows an eosinophilic microabscess located in the esophageal epithelium of a patient with eosinophilic esophagitis. Note the surrounding tissue damage. Several articles in this month’s issue examine the important role of eosinophils. A good place to start would be the Editorial by Rothenberg (p 1321), which provides an overview of the latest concepts about eosinophils as summarized in this issue of the Journal. In the Current Reviews article, Dagmar and Hans-Uwe Simon (p 1291) present a clinically relevant classification of eosinophilic disorders based on new understandings of the disease mechanism. The Molecular Mechanisms review by Rosenberg et al (p 1303) summarizes recent advances in understanding eosinophil development and accumulation in inflamed tissues. In a Current Perspectives review, Jacobsen et al (p 1313) propose that eosinophils are critical immunoregulatory cells with pleotropic capabilities that affect diverse immune responses. In an Update Review, Munitz and Levi-Schaffer (p 1382) review the biology and therapeutic significance of a new set of inhibitory receptors expressed by eosinophils. Finally, in the Images in Allergy and Immunology feature, Foley and colleagues (p 1563) review the role of eosinophils in diverse tissue remodeling responses. Overall, we are now in a very strong position to design ways to modulate the activity of eosinophils in a variety of immune responses, opening the door to new approaches for therapeutic intervention in allergic disease. Articles relevant to the theme of ‘‘Eosinophil-mediated disease’’ are noted in the Table of Contents by a red starburst next to their titles. Original image supplied by Dr Margaret Collins, Cincinnati Children’s Hospital Medical Center. Adapted for the cover by JDI, LLC. This month in Beyond Our Pages Two reports deal with the beneficial effects of different pharmacotherapeutic agents in chronic obstructive pulmonary disease. d The effects of the blockade of TNF activity in asthma have been described. d A study has further defined the characteristics of memory TH2 lymphocytes. d Another study has explored the function of IL-31, a cytokine that is expressed by TH2 lymphocytes; its function has been unclear. d The role of IL-15 in breaking the homeostasis in the intestinal tract has been explored as a possible underlying mechanism in celiac disease. d Investigators have uncovered evidence that the etiology of idiopathic pulmonary fibrosis is related to abnormal chromosomal telomere formation. Ó 2007 American Academy of Allergy, Asthma & Immunology The Journal of Allergy and Clinical Immunology (ISSN: 0091-6749) is published monthly by Elsevier Inc., 360 Park Avenue South, New York, NY 100101710. Business Office: 1600 John F. Kennedy Boulevard, Suite 1800, Philadelphia, PA 19103-2899. Editorial Office: 11830 Westline Industrial Drive, St Louis, MO 63146-3318. Customer Service Office: 6277 Sea Harbor Drive, Orlando, FL 32887-4800. Periodicals postage paid at New York, NY and additional mailing offices. POSTMASTER: Send address changes to The Journal of Allergy and Clinical Immunology, Elsevier Periodicals Customer Service, 6277 Sea Harbor Drive, Orlando, FL 32887-4800.
6A June 2007
J ALLERGY CLIN IMMUNOL