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Time-release silica encapsulation in antiacne treatments
P718 Time-release silica encapsulation in antiacne treatments Avner Shemer, MD, Laniado Hospital, Netanya, Central, Israel; Daniela Mavor, MBA, Sol Gel Technologies, Ness Ziona, Central, Israel; Eli Drori, MBBS, Sol Gel Technologies, Ness Ziona, Central, Israel; Haim Barsimantov, Sol Gel Technologies, Ness Ziona, Central, Israel; Ofer Toledano, PhD, Sol Gel Technologies, Ness Ziona, Central, Israel
P720
The efficacy of benzoyl peroxide (BPO) for eradication of P acnes is well established. Time-release encapsulation technologies in silica have been developed in order to improve the efficacy, safety, and tolerability of BPO-based treatments. Objective: This study compared efficacy, tolerability, and patients experience of two antiacne treatment regimens (Kits) comparing Kits based on silica-encapsulated BPO (Sol Gel Technologies [SGT], Israel) to commercially available Kits based on nonencapsulated BPO (Guthy-Renker, Palm Desert, CA) (PRO) in mild to moderate acne vulgaris patients. Methods: The study was double-blind, controlled and randomized, 4-week, 4-arm parallel groups. Seventy-eight eligible patients 16 to 35 years of age were randomized to receive one of the following Kits: SGT-7%BPO, SGT-4%BPO, PRO-7%BPO, or PRO-2.5%BPO. Efficacy endpoints included nominal and percent reduction in lesion counts (inflammatory, noninflammatory and total lesions, open and closed comedones) and dichotomized global severity assessment. Evaluation included both superiority and noninferiority testing and analyzed in both intent-to-treat and perprotocol populations. Local tolerability and safety were assessed. Patients were asked to complete a questionnaire after 1 and 4 weeks of treatment and indicate their rating of treatment efficacy, tolerability and overall satisfaction. Evaluation was based on a prospective cross-sectional survey. Results: The group treated by SGT-7%BPO proved to be superior to PRO-7%BPO and PRO-2.5%BPO by all efficacy parameters throughout the study (P ¼.047, P ¼.030). Overall improvement by SGT-7%BPO reached 74.9% after 4 weeks. Tolerability assessment indicated very high tolerability by all parameters for SGT-4%BPO followed by SGT-7%BPO. Patient evaluations of efficacy and tolerability matched closely those of the Principle Investigator. Satisfaction rates averaged 70.8% with SGT-7%BPO and 76.5% with SGT-4%BPO after 1 week. At the end of treatment these rates increased to an average 77.6% and 86.1%, respectively. The comparable average satisfaction rates were 61.3% with PRO-7%BPO and 64.3% with PRO2.5%BPO, which decreased to an average 50.0% and 62.5% respectively. Conclusions: Silica-encapsulated BPO-based treatment Kits tested in this study improved their clinical outcome, tolerability, and patients’ satisfaction. Commercial support: 100% is sponsored by Sol Gel Technologies.
AGING/GERIATRICS P800 P719 Acneiform eruption in a newborn after steroid intravenous treatment Ana Maria Mo´sca de Cerqueira, MD, Hospital Municipal Jesus, Rio de Janeiro, Brazil; Ericka Andrade de Aguiar, MD, Policlinica Geral do Rio de Janeiro, Rio de Janeiro, Brazil; Larissa Fernanda Campos Moreira, MD, Hospital Municipal Jesus, Rio de Janeiro, Brazil; Soraya de S. Chantre Oliveira, MD, Hospital Municipal Jesus, Rio de Janeiro, Brazil Background: Acneiform eruption is much less common on young pediatric patients, especially between 6 and 16 months of age; therefore, our knowledge about its pathogenesis is limited, making it easy to diagnose but difficult to manage. The patient’s age, the morphology of the injury, its distribution, and the presence of itching are important factors for the differential diagnosis. Methods: We present a 7-month-old male admitted with a case of pneumonia and bronchiolitis showing no response with antibiotics and steroids intravenous treatment. The patient was admitted on the Municipal Jesus Hospital and after the third day, grouped vesicles on an erythematous base were disseminated throughout the body. After examination, the conclusive diagnosis disseminated herpes simplex infection. Systemic hypertension caused by acute adrenal insufficiency also occurred. Fifteen days after the beginning of the treatment, he developed small erythematous and itching folliculocentric papules on the cheeks and forehead, some of then covered with hematic crusts; these also involved erythematous closed comedones on the cheeks. Results: The patient is being treated with benzoyl peroxide 2.5%, 2 hours a day, showing satisfactory results.
Skin elasticity: Influence of age and regional body site Stefanie Luebberding, University of Hamburg, Hamburg, Germany; Mareike Oltmer, University of Hamburg, Hamburg, Germany; Martina Kerscher, MD, PhD, University of Hamburg, Hamburg, Germany; Nils Krueger, MS, University of Hamburg, Hamburg, Germany Background: Skin elasticity is a very important function to protect skin against mechanical effects and for the youthful appearance of the skin. The aim of this study was to evaluate the influence of age and body site onto the biomechanical properties of the skin in vivo. Methods: One hundred twenty female subjects evenly distributed to four age groups (I ¼ 18-29; II ¼ 30-39; III ¼ 40-49; and IV ¼ 50-65) were evaluated in vivo by suction method (Cutometer MPA 580 with a 2-mm probe) on the cheeks, neck, cleavage, volar forearm, and dorsal surfaces of the hands. While women in the age groups I to III had to be in the follicular phase of their menstrual cycle, woman in age group IV had to be postmenopausal. Hormone replacement therapies, treatments with phytohormones, strong smoking habits, or extensive sun exposition were exclusion criteria. All measurements were performed under standardized conditions at 20 8C (688F) and 50% relative humidity. Results: The data of 119 women aged 20 to 65 (Ø 39.6 6 12.4) were statistically analyzed. The mean age in the four groups was 24.7 (group I), 33.1 (group II), 43.7 (group III), and 56.7 (group IV). The highest skin distensibility (Uf) was measured at the neck. It showed a clear decrease at all sites from age group I to IV. While gross elasticity (Ua/Uf) was high at neck, cleavage and forearm, pure elasticity (Ur/Ue) was significant higher (P \ 0.001) at the neck than at all other sites. The loss in gross and pure elasticity clearly correlated with age (r [ 0.4; P \.001).
Conclusions: The acneiform eruption is a side effect, widely known for the use of corticosteroids, since the 1950s, but its occurrence in infants is rare. Discontinuing the causative medication is the better therapy, if is possible. Treatment with benzoyl peroxide 2.5% was effective in this case.
Conclusion: The results show a distinct influence of age and regional body site onto the biomechanical properties of the skin in vivo. At all evaluated body sites skin distensibility as well as gross and pure elasticity decreased significantly with age. These data could be helpful to objectively show the effects of minimal invasive procedures or cosmeceuticals influencing skin elasticity.
Commercial support: None identified.
Commercial support: None identified.
AB18
J AM ACAD DERMATOL
MARCH 2010
P720
The efficacy of benzoyl peroxide (BPO) for eradication of P acnes is well established. Time-release encapsulation technologies in silica have been developed in order to improve the efficacy, safety, and tolerability of BPO-based treatments. Objective: This study compared efficacy, tolerability, and patients experience of two antiacne treatment regimens (Kits) comparing Kits based on silica-encapsulated BPO (Sol Gel Technologies [SGT], Israel) to commercially available Kits based on nonencapsulated BPO (Guthy-Renker, Palm Desert, CA) (PRO) in mild to moderate acne vulgaris patients. Methods: The study was double-blind, controlled and randomized, 4-week, 4-arm parallel groups. Seventy-eight eligible patients 16 to 35 years of age were randomized to receive one of the following Kits: SGT-7%BPO, SGT-4%BPO, PRO-7%BPO, or PRO-2.5%BPO. Efficacy endpoints included nominal and percent reduction in lesion counts (inflammatory, noninflammatory and total lesions, open and closed comedones) and dichotomized global severity assessment. Evaluation included both superiority and noninferiority testing and analyzed in both intent-to-treat and perprotocol populations. Local tolerability and safety were assessed. Patients were asked to complete a questionnaire after 1 and 4 weeks of treatment and indicate their rating of treatment efficacy, tolerability and overall satisfaction. Evaluation was based on a prospective cross-sectional survey. Results: The group treated by SGT-7%BPO proved to be superior to PRO-7%BPO and PRO-2.5%BPO by all efficacy parameters throughout the study (P ¼.047, P ¼.030). Overall improvement by SGT-7%BPO reached 74.9% after 4 weeks. Tolerability assessment indicated very high tolerability by all parameters for SGT-4%BPO followed by SGT-7%BPO. Patient evaluations of efficacy and tolerability matched closely those of the Principle Investigator. Satisfaction rates averaged 70.8% with SGT-7%BPO and 76.5% with SGT-4%BPO after 1 week. At the end of treatment these rates increased to an average 77.6% and 86.1%, respectively. The comparable average satisfaction rates were 61.3% with PRO-7%BPO and 64.3% with PRO2.5%BPO, which decreased to an average 50.0% and 62.5% respectively. Conclusions: Silica-encapsulated BPO-based treatment Kits tested in this study improved their clinical outcome, tolerability, and patients’ satisfaction. Commercial support: 100% is sponsored by Sol Gel Technologies.
AGING/GERIATRICS P800 P719 Acneiform eruption in a newborn after steroid intravenous treatment Ana Maria Mo´sca de Cerqueira, MD, Hospital Municipal Jesus, Rio de Janeiro, Brazil; Ericka Andrade de Aguiar, MD, Policlinica Geral do Rio de Janeiro, Rio de Janeiro, Brazil; Larissa Fernanda Campos Moreira, MD, Hospital Municipal Jesus, Rio de Janeiro, Brazil; Soraya de S. Chantre Oliveira, MD, Hospital Municipal Jesus, Rio de Janeiro, Brazil Background: Acneiform eruption is much less common on young pediatric patients, especially between 6 and 16 months of age; therefore, our knowledge about its pathogenesis is limited, making it easy to diagnose but difficult to manage. The patient’s age, the morphology of the injury, its distribution, and the presence of itching are important factors for the differential diagnosis. Methods: We present a 7-month-old male admitted with a case of pneumonia and bronchiolitis showing no response with antibiotics and steroids intravenous treatment. The patient was admitted on the Municipal Jesus Hospital and after the third day, grouped vesicles on an erythematous base were disseminated throughout the body. After examination, the conclusive diagnosis disseminated herpes simplex infection. Systemic hypertension caused by acute adrenal insufficiency also occurred. Fifteen days after the beginning of the treatment, he developed small erythematous and itching folliculocentric papules on the cheeks and forehead, some of then covered with hematic crusts; these also involved erythematous closed comedones on the cheeks. Results: The patient is being treated with benzoyl peroxide 2.5%, 2 hours a day, showing satisfactory results.
Skin elasticity: Influence of age and regional body site Stefanie Luebberding, University of Hamburg, Hamburg, Germany; Mareike Oltmer, University of Hamburg, Hamburg, Germany; Martina Kerscher, MD, PhD, University of Hamburg, Hamburg, Germany; Nils Krueger, MS, University of Hamburg, Hamburg, Germany Background: Skin elasticity is a very important function to protect skin against mechanical effects and for the youthful appearance of the skin. The aim of this study was to evaluate the influence of age and body site onto the biomechanical properties of the skin in vivo. Methods: One hundred twenty female subjects evenly distributed to four age groups (I ¼ 18-29; II ¼ 30-39; III ¼ 40-49; and IV ¼ 50-65) were evaluated in vivo by suction method (Cutometer MPA 580 with a 2-mm probe) on the cheeks, neck, cleavage, volar forearm, and dorsal surfaces of the hands. While women in the age groups I to III had to be in the follicular phase of their menstrual cycle, woman in age group IV had to be postmenopausal. Hormone replacement therapies, treatments with phytohormones, strong smoking habits, or extensive sun exposition were exclusion criteria. All measurements were performed under standardized conditions at 20 8C (688F) and 50% relative humidity. Results: The data of 119 women aged 20 to 65 (Ø 39.6 6 12.4) were statistically analyzed. The mean age in the four groups was 24.7 (group I), 33.1 (group II), 43.7 (group III), and 56.7 (group IV). The highest skin distensibility (Uf) was measured at the neck. It showed a clear decrease at all sites from age group I to IV. While gross elasticity (Ua/Uf) was high at neck, cleavage and forearm, pure elasticity (Ur/Ue) was significant higher (P \ 0.001) at the neck than at all other sites. The loss in gross and pure elasticity clearly correlated with age (r [ 0.4; P \.001).
Conclusions: The acneiform eruption is a side effect, widely known for the use of corticosteroids, since the 1950s, but its occurrence in infants is rare. Discontinuing the causative medication is the better therapy, if is possible. Treatment with benzoyl peroxide 2.5% was effective in this case.
Conclusion: The results show a distinct influence of age and regional body site onto the biomechanical properties of the skin in vivo. At all evaluated body sites skin distensibility as well as gross and pure elasticity decreased significantly with age. These data could be helpful to objectively show the effects of minimal invasive procedures or cosmeceuticals influencing skin elasticity.
Commercial support: None identified.
Commercial support: None identified.
AB18
J AM ACAD DERMATOL
MARCH 2010