Timeline: Mitochondria

1985

1995

Chaperone-mediated protein folding in mitochondria is demonstrated

1990–1991

19 8 9

DOI http://dx.doi.org/10.1016/j.molcel.2016.02.015

1 9 9 7 –2 0 0 4

NRF-1 is found to regulate nuclear-encoded mitochondrial genes, and the mitochondrial transcription factor TFAM/mtTF1 is characterized.

Mitochondrial gene expression

Mitochondrial derived cytochrome c is shown to trigger apoptosis.

Mitochondria and cell death

A physiological role for mitochondrial ROS is identified

2015

Pyruvate transporter is identified

Mitophagy is observed, and Pink1 and Parkin are shown to regulate it

Mitochondrial calcium uniporter is identified

ER tubules are observed to play an active role in defining the position of mitochondrial division sites.

Mitochondrial-organellar contacts

Widespread acetylation is demonstrated and shown to be important for metabolism and disease.

Mitochondrial protein acetylation

The mtDNA mutator mouse is created, suggesting a role for mitochondria in aging.

2005

20 0 4 –2 0 0 5 PGC-1 is shown to control mitochondrial biogenesis and respiration

The biological relevance of fission is demonstrated, and studies uncover regulators of fission and fusion.

Mitochondrial fission and fusion

1998

Mitochondrial DNA mutations are linked to human disease

1999

Mitochondria and aging

2 0 0 6 –2 0 1 3

1 9 8 8 –1 9 8 9

Allyson Evans1 1 Senior Editor, Molecular Cell

2007–2010

Timeline: Mitochondria

2011

Molecular Cell 61, March 3, 2016 ©2016 Elsevier Inc.

1996

20 1 2

790