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Toxemia superimposed upon prepregnant hypertension treated by splanchnicectomy
SELECTED
did occur, it did so within of 6-propylthiouracil were toxicity with 6-propylthiouracil,
ABSTRACTS
‘U.5
eight weeks of beginning treatment. The observed, a tendency to water retention and intermittent in doses up to 200 mg. a day, was observed.
untoward claudication.
e8ecls ?VO
\VI
D. A.: Peripheral Vascular J. A. M. A. 137584 (June
Disease in 12), 1948.
the
Lungs:
Hoe.11 I -
The authors review the various disorders which affect the peripheral pulmonary vessels and which may produce roentgenographic changes. The diseases are classified under three catcgorics: (1) Intrinsic disease of the vessel wall (arteriosclerosis and arteriolosclerosis) or obstructi~~n of the vascular lumen (embolism by clot, neoplastic cells, and parasites, and thrombosis, as sww in the leucemias and polycythemia Vera). The close association between obliterative vascular changes and pulmonary hypertension, and between obliterative vascular disease and pulmonar)~ emphysema is pointed out. (2) V ascular change secondary to disease of the adjacent parenchyma (acute and chronic pulmonary inflammatory disorders, and neoplasms of the lung). (3j Toxic and hypersensitivity states (sulfonamide poisoning, serum sickness, acute rheumatic fever, lupus erythematosus, periarteritis nodosa, glomerulonephritis, hypoproteinemia, beriberi). These consequent
disorders all bring patchy or massive
about edema
increased permeability and present the same
of the pulmonary type of roentgenologic
capillaries picture.
with H.~\uso.
Peet,
M. M., Isberg, E. M., pregnant Hypertension’Treated (June), 1948.
and
Bassett, R. C.: Toxemia by Splanchnicectomy.
Superimposed Surg., Gynec.
Upon Pre& Ohst. 86:67,7
The authors point out that about 50 per cent of prepregnant hypertensive women can be expected to develop a superimposed toxemia and that one-fourth of these patients are left with higher blood pressure levels and more extensive disease as a result of a toxemic pregnancy. The authors report five patients with hypertension who developed a toxemia during pregnancy. Each of these patients was submitted to bilateral supradiaphragmatic splanchnicectom>aith excellent results, including return to normal levels of the blood pressure and relief of the toxemia in two patients. These two patients also continued to do well as long as four years and IWO years, respectively, after operation. Of the three remaining patients, two were helped moderalel:J and one was a failure. The failure occurred in a patient who exhibited extremely poor renal func:tion and who subsequently died fifteen months after operation. In the discussion, the authors point out that splanchnicectomy should be performed within the first three weeks of the toxemia in this group of patients. Further, if spianchnicectomy has not relieved the toxemia within three weeks, then the pregnancy should be terminaled. The third point made by the authors is that splanchnicectomy should not be employed in patic.nt5 whose toxemia of pregnancy is associated with marked renal datnage. I.1 *1(1b. An Experimental hiesewetter, W. B., and Schmacker, H. B., Jr.: parative Efficacy of Heparin and Dicumarol in the Prevention Thrombosis. Surg., Gynec. & Obst. 86:687 (June), 1948.
Study of Arterial
of the 4 :on~and Ver~~ur>~
In an extensive series of experiments carried out on dogs, the authors developed of effecting thromboses in veins and arteries with great consistency. Approximately cent of the veins (jugular and femoral), 80 per cent of the small arteries (femoral), and of the large arteries (carotid) were thrombosed by the seventh day following trauma animals. In the group treated with heparin a significant reduction in the incidence of was noted: 56 per cent of the veins, 6.7 per cent of the small arteries, and 9.5 per large arteries. In the Dicumarol-treated animals, the incidence of thromboses was of the veins, 50 per cent of the small arteries, and 15.8 per cent of the large arteries.
a techniclue 90 pet70 per ten c in control thrombosis cent of the 41 per c.ent
did occur, it did so within of 6-propylthiouracil were toxicity with 6-propylthiouracil,
ABSTRACTS
‘U.5
eight weeks of beginning treatment. The observed, a tendency to water retention and intermittent in doses up to 200 mg. a day, was observed.
untoward claudication.
e8ecls ?VO
\VI
D. A.: Peripheral Vascular J. A. M. A. 137584 (June
Disease in 12), 1948.
the
Lungs:
Hoe.11 I -
The authors review the various disorders which affect the peripheral pulmonary vessels and which may produce roentgenographic changes. The diseases are classified under three catcgorics: (1) Intrinsic disease of the vessel wall (arteriosclerosis and arteriolosclerosis) or obstructi~~n of the vascular lumen (embolism by clot, neoplastic cells, and parasites, and thrombosis, as sww in the leucemias and polycythemia Vera). The close association between obliterative vascular changes and pulmonary hypertension, and between obliterative vascular disease and pulmonar)~ emphysema is pointed out. (2) V ascular change secondary to disease of the adjacent parenchyma (acute and chronic pulmonary inflammatory disorders, and neoplasms of the lung). (3j Toxic and hypersensitivity states (sulfonamide poisoning, serum sickness, acute rheumatic fever, lupus erythematosus, periarteritis nodosa, glomerulonephritis, hypoproteinemia, beriberi). These consequent
disorders all bring patchy or massive
about edema
increased permeability and present the same
of the pulmonary type of roentgenologic
capillaries picture.
with H.~\uso.
Peet,
M. M., Isberg, E. M., pregnant Hypertension’Treated (June), 1948.
and
Bassett, R. C.: Toxemia by Splanchnicectomy.
Superimposed Surg., Gynec.
Upon Pre& Ohst. 86:67,7
The authors point out that about 50 per cent of prepregnant hypertensive women can be expected to develop a superimposed toxemia and that one-fourth of these patients are left with higher blood pressure levels and more extensive disease as a result of a toxemic pregnancy. The authors report five patients with hypertension who developed a toxemia during pregnancy. Each of these patients was submitted to bilateral supradiaphragmatic splanchnicectom>aith excellent results, including return to normal levels of the blood pressure and relief of the toxemia in two patients. These two patients also continued to do well as long as four years and IWO years, respectively, after operation. Of the three remaining patients, two were helped moderalel:J and one was a failure. The failure occurred in a patient who exhibited extremely poor renal func:tion and who subsequently died fifteen months after operation. In the discussion, the authors point out that splanchnicectomy should be performed within the first three weeks of the toxemia in this group of patients. Further, if spianchnicectomy has not relieved the toxemia within three weeks, then the pregnancy should be terminaled. The third point made by the authors is that splanchnicectomy should not be employed in patic.nt5 whose toxemia of pregnancy is associated with marked renal datnage. I.1 *1(1b. An Experimental hiesewetter, W. B., and Schmacker, H. B., Jr.: parative Efficacy of Heparin and Dicumarol in the Prevention Thrombosis. Surg., Gynec. & Obst. 86:687 (June), 1948.
Study of Arterial
of the 4 :on~and Ver~~ur>~
In an extensive series of experiments carried out on dogs, the authors developed of effecting thromboses in veins and arteries with great consistency. Approximately cent of the veins (jugular and femoral), 80 per cent of the small arteries (femoral), and of the large arteries (carotid) were thrombosed by the seventh day following trauma animals. In the group treated with heparin a significant reduction in the incidence of was noted: 56 per cent of the veins, 6.7 per cent of the small arteries, and 9.5 per large arteries. In the Dicumarol-treated animals, the incidence of thromboses was of the veins, 50 per cent of the small arteries, and 15.8 per cent of the large arteries.
a techniclue 90 pet70 per ten c in control thrombosis cent of the 41 per c.ent