Trabecular Bone Score, Bone Mineral Density and 10-Year Probability of Fracture in Ukrainian Men of Different Ages

Trabecular Bone Score, Bone Mineral Density and 10-Year Probability of Fracture in Ukrainian Men of Different Ages

412 2. Chiu KC, et al. Am J Clin Nutr. 2004;79:820. 3. Greer RM, et al. Med J Aust 2007;187:59. Disclosure of Interest: None Declared P126 TRABECULAR...

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412 2. Chiu KC, et al. Am J Clin Nutr. 2004;79:820. 3. Greer RM, et al. Med J Aust 2007;187:59. Disclosure of Interest: None Declared

P126 TRABECULAR BONE SCORE IN PATIENTS WITH RHEUMATOID ARTHRITIS V. Povoroznyuk1,*, T. Karasevska1, R. Povoroznyuk1, B. Aubry-Rozier2, D. Hans2; 1 Institute of Gerontology AMS Ukraine, Kyiv, Ukraine, 2Center of Bone Diseases, Lausanne University Hospital, Lausanne, Switzerland Aims: To evaluate influence of age, duration of postmenopausal period (PMP) and duration of disease on trabecular bone score (TBS) and BMD of women with rheumatoid arthritis (RA). Methods: 129 women with RA aged 21-83 years were examined (age 52.412.7 yrs; height 162.66.4 cm; weight 68.513.8 kg; duration of disease 9.17.6 years). BMD of lumbar spine, proximal femur and total radius were measured using the DXA method (Prodigy, GEHC Lunar, Madison, WI, USA) and PA spine TBS was assessed by means of TBS iNsightÒ software installed on our DXA machine (Med-Imaps, Pessac, France). Results: We have observed a significant decrease of TBS in 50-year-old women with RA as compared to women aged 30-39 years (1.1560.140 vs. 1.3180.155; p50.001)/ The same was true of BMD of lumbar spine (0.9940.245 vs. 1.1410.161 g/cm2; p50.04), femur neck (0.7160.245 vs. 0.8890.231 g/cm2; p50.02), total radius (0.5850.231 vs. 0.7220.141 g/cm2; p50.04). TBS is significantly lower in patients with a PMP duration of more than 3 years, as compared to women who were still menstruating (1.1740.183vs. 1.3120.129; p50.007). Femoral neck (FN) BMD significantly decreased when PMP duration was 5-10 years, as compared to women without menopause (0.6820.254 vs. 0.9250.211 g/cm2; p50.0004). A similar trend was observed in case of spine BMD (0.9640.262 vs. 1.1330.164 g/cm2; p50.001) and total radius, (0.5260.221 vs. 0.6940.124 g/cm2; p50.001) when the duration of PMP was more than 10 years. Duration of disease did not influence TBS (with duration of the disease up to 3 years TBS was 1.2140.166; 3-5 years e 1.2210.162; 5-10 years e 1.2550.162[D1] ; over 10 years e 1.1730.155; p50.336). However, Total Radius BMD (0.6000.178 vs. 0.6950.213 g/cm2; p50.03) significantly decreased when RA lasted more than 3 years, spine (0.9830.192 vs. 1.1150.181 g/cm2; p50.008) and FN (0.6540.224 vs. 0.7830.245 g/cm2; p50.04) BMD when RA lasted more than 10 years, as compared to patients whose duration of RA did not exceed 3 years. Conclusion: Age influences both TBS and BMD to the same extent; these parameters significantly decrease from 50 years onwards. TBS rapidly reacts to the changing hormonal status which is observed during menopause, and significantly declines after 3 years. Duration of RA influences only BMD, and its significant decrease is observed when the disease lasts for more than 5 years. Disclosure of Interest: None Declared

P127 TRABECULAR BONE SCORE, BONE MINERAL DENSITY AND 10-YEAR PROBABILITY OF FRACTURE IN UKRAINIAN MEN OF DIFFERENT AGES

Abstracts lish FRAXÒ model in comparison with men aged 40-49 yrs. 10-year probability of hip fracture was significantly increased in men aged 70-89 yrs in comparison with men aged 40-69 yrs (p!0.01). It was determined the significant decreasing of TBS (L1-L4) in men according to their age (40-49 yrs e 1.1160.02, 50-59 yrs e 1.1110.02; 60-69 yrs e 1.1180.02; 70-79 yrs - 1.0620.02, 80-89 yrs e 1.0800.05; F52.42, p50.048). The age significantly influenced to the BMD of lumbar spine (F52.84, p50.02) and femoral neck (F54.08, p50.003) in examined patient. TBS in men was significantly higher in subject with normal BMD (1.1210.01) compared with patient who has been diagnosed osteoporosis e 1.0660.03 (p50.04). The significant correlation was observed between TBS and BMD L1-L4 in examined men (r 50.12; p50.03). There was not any observed correlation between TBS and BMD of femoral neck. Conclusion: The 10-year probability of major osteoporotic fracture and hip fracture were significantly increased in men with age. TBS significantly decreased with ageing. Subjects with osteoporosis have significantly lover TBS compared with examined with normal BMD. Also it was found a significant correlation between TBS and BMD of lumbar spine. Disclosure of Interest: None Declared

P128 TEMPORAL TRENDS IN INCREASING HIP BONE MINERAL DENSITY: IS THE PARTY OVER? W. D. Leslie*,1, S. N. Morin2, S. R. Majumdar3; 1University of Manitoba, Winnipeg, 2McGill University, Montreal, 3University of Alberta, Edmonton, Canada Aims: According to US NHANES data, femoral neck BMD increased among white women by 6% from 1988/1994 to 2005/2008 even after adjustment for increasing BMI, osteoporosis treatment, and other covariates (1). Population-based data from Manitoba, Canada over the overlapping period 1996-2006 showed that major osteoporotic fracture rates declined substantially and linearly, and that this decline was explained by improvements in BMD and not greater rates of obesity or osteoporosis treatment (2). The current study aimed to determine whether BMD has continued to increase since 2006. Methods: We studied 50,017 women age 50-years and older in the Manitoba BMD Registry undergoing baseline femoral neck BMD tests from1996 to 2010. Model-based estimates of temporal changes in BMD were adjusted for multiple covariates (osteoporosis treatment, age, BMI, recent prolonged glucocorticoids, prior major fracture, alcohol abuse, rheumatoid arthritis, chronic obstructive pulmonary disease). An interaction term was used to compare changes in BMD for 1996-2006 vs. 2007-2010. Results: Covariate-adjusted femoral neck, total hip and total spine BMD increased 0.3-0.5% per year from 1996-2006 (all p-slope !0.001), similar to the NHANES data. However, from 2007-2010 there was a change in the slope for femoral neck and total hip BMD (p-interaction with time !0.001) such that no further significant BMD increases were seen after 2006 (p-slope O0.3 for 2007-2010 period). In contrast, total spine BMD continued to increase unabated from 1996 through 2010 (p-interaction with time50.9). Generalized additive models (cubic splines with 4 df and 95% CI limits) graphically depict temporal changes in BMD, 1996-2006 vs. 2007-2010, adjusted for multiple covariates (see Figure).

V. Povoroznyuk*, A. Musiienko, N. Dzerovych; Institute Of Gerontology NAMS Ukraine, Kyiv, Ukraine Aims: The aim of the study was to evaluate BMD, trabecular bone score (TBS) and the 10-year probability of major osteoporotic fracture and hip fracture in healthy men of different ages. Methods: We examined 300 men aged 40-89 years (mean age e 50.90.6 yrs; mean height e 1.740.04 m; mean weight e 84.10.9 kg), who were divided into groups depending on their age: 40-49 yrs (n552), 50-59 yrs (n586), 60-69 yrs (n589), 70-79 yrs (n559), 80-89 yrs (n514). The 10-year probability of hip fracture and the 10-year probability of major osteoporotic fracture risk were calculated by Austrian, Polish and Russian FRAXÒ models. BMD of whole body, PA lumbar spine and proximal femur were measured by DXA method (Prodigy, GEHC Lunar, Madison, WI, USA) and PA spine TBS were assessed by TBS iNsightÒ software package installed on the available DXA machine (Med-Imaps, Pessac, France). Results: We have observed a significant increase of 10-year probability of major osteoporotic fracture in men aged 80-89 yrs (p!0.01) using Russian FRAXÒ model, 60-89 yrs (p!0.01) e Austrian FRAXÒ model, 70-89 yrs (p!0.01) e Po-

Conclusion: The still unexplained improvements in hip BMD that occurred from the late 1980s through the mid-2000s appear to have ceased, though spine BMD continues to increase over time. Why this dissociation exists, and how this will affect osteoporotic fracture rates, needs to be determined. References: 1. Looker A et al. Osteoporos Int 2012; 23:771. 2. Leslie WD et al. J Bone Miner Res 2013 [epub], doi: 10.1002/jbmr.2099. Acknowledgement: HIPC File No. HIPC 2011/2012 e 31 Disclosure of Interest: None Declared

Journal of Clinical Densitometry: Assessment & Management of Musculoskeletal Health

Volume 17, 2014