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Transcortin: A corticosteroid-binding protein of plasma
SELECTED ABSTRACTS
68.t-
Am.
J. Ob,l.
& Gynec. September. l9~ll
delivery. The slow clearance in pregnant women is accompanieu by subnormal eonren trations of 17-0H-corticosteroid glucuronides in the blood. The pregnant women showed an "apparently exaggerated response" to injections of ACTH, in that the pln,;ma •·oncentrations of free 17-0H-eorticosteroid Vlere above norrnal before arHl after tlH~ injertion. It seems improbable that the rlelayeu clea1·ance of steroirl can be the sole rea~ll!l for tlw elevaten plasma levels found in pregnaney, for a coinparabJ,,- low clearance ratp i,.: found in cirrhosis, \vhere the plasma levels and respon~e to AC'reH are nornu11. LBON !'. CHEBLEY
Slaunwhite and Sandberg: p. 384.
Transcortin:
A Corticosteroid-Billding Protein of Plasma,
The pla,.:ma contains a protein calle
The Lancet Vol. 2, Dec. 6, 1958. *Marshall, John, and Thomas, P. K.: Myotonica, p. 1209. -l<·Giles, C., and Shuttle,vorth, E. 1v1.:
Nuclear
~ex-Chromatin
Pattern in Dystrophia
N1ega1ohlastic _._.\..nemia of Prcgnaney and tlte
Puerperium, p. 1341.
Marshall and Thomas:
The Nuclear Sex-Chromatin Pattern in Dystrophia Myotonica,
p. 1209. Both buccal smears and polymorphonuclear leukocyte smears were studied in 1!1 instance,: of rl~·strophia myotonica (14 males anrl f:i temaies). In all, the nuciPar ,;exchromatin pattern, h~· whichever technirtue, was appropriate to the phenot~·pic sex. Reversal of nuclear sex in males with dystrophia myotonica, therefore, appears to be uncommon although Grumbaeh, Engle, anrl Blanc (.J'. Ciin. l~noiocrinol. lti: D:J3, 1D5t)) have observed such a phenomenon in one instance. l>AVTil M. KYJHJ
Giles and Shuttleworth:
Megaloblastic Anemia of Pregnancy and the Puerperium, p.
1341. In a period of .15 months 3,199
patient~
were delivered in 2 hospitals which contain In all patients who were found to have a hemoglobin of 65 per cent or less after the twenty-fourth week of pregnancy and who did not improve following the administration of iron by the thirty-second week and in all patients who were first seen after the thirty-sixth wPek of pregnancy with a hemoglobin of 65 per cent or less, or in all puerperal patients whose anemia could not be explained by hemorrhage alone, a bone marrow aspiration was performed and the concentration of serum iron determined. In all, 47 4 sternal aspirations were examined. Of these, 90 proved to be megaloblastic in type (li2 during pregnancy and 38 rluring puerperium), 372 were normoblastic, ann 12 were questionably megaloblastic. A normoblastic marrow was obtained between the twenty-ninth and thirty-third week of pregnancy from 6 patients who failed to respond to iron. Some weeks later the marr·ow waR re-examined and by that time a megaloblastic marrow had developed in :1. 'l'his ~ug gested megaloblasts may not appear until near term. Of the 65 patients whose hemo· globins were 45 per cent or less, 35 had megaloblastic anemia, and 7 of the .'l ratient.H
711
of all the obstetrical beds serving a population of .!liO,OOO.
68.t-
Am.
J. Ob,l.
& Gynec. September. l9~ll
delivery. The slow clearance in pregnant women is accompanieu by subnormal eonren trations of 17-0H-corticosteroid glucuronides in the blood. The pregnant women showed an "apparently exaggerated response" to injections of ACTH, in that the pln,;ma •·oncentrations of free 17-0H-eorticosteroid Vlere above norrnal before arHl after tlH~ injertion. It seems improbable that the rlelayeu clea1·ance of steroirl can be the sole rea~ll!l for tlw elevaten plasma levels found in pregnaney, for a coinparabJ,,- low clearance ratp i,.: found in cirrhosis, \vhere the plasma levels and respon~e to AC'reH are nornu11. LBON !'. CHEBLEY
Slaunwhite and Sandberg: p. 384.
Transcortin:
A Corticosteroid-Billding Protein of Plasma,
The pla,.:ma contains a protein calle
The Lancet Vol. 2, Dec. 6, 1958. *Marshall, John, and Thomas, P. K.: Myotonica, p. 1209. -l<·Giles, C., and Shuttle,vorth, E. 1v1.:
Nuclear
~ex-Chromatin
Pattern in Dystrophia
N1ega1ohlastic _._.\..nemia of Prcgnaney and tlte
Puerperium, p. 1341.
Marshall and Thomas:
The Nuclear Sex-Chromatin Pattern in Dystrophia Myotonica,
p. 1209. Both buccal smears and polymorphonuclear leukocyte smears were studied in 1!1 instance,: of rl~·strophia myotonica (14 males anrl f:i temaies). In all, the nuciPar ,;exchromatin pattern, h~· whichever technirtue, was appropriate to the phenot~·pic sex. Reversal of nuclear sex in males with dystrophia myotonica, therefore, appears to be uncommon although Grumbaeh, Engle, anrl Blanc (.J'. Ciin. l~noiocrinol. lti: D:J3, 1D5t)) have observed such a phenomenon in one instance. l>AVTil M. KYJHJ
Giles and Shuttleworth:
Megaloblastic Anemia of Pregnancy and the Puerperium, p.
1341. In a period of .15 months 3,199
patient~
were delivered in 2 hospitals which contain In all patients who were found to have a hemoglobin of 65 per cent or less after the twenty-fourth week of pregnancy and who did not improve following the administration of iron by the thirty-second week and in all patients who were first seen after the thirty-sixth wPek of pregnancy with a hemoglobin of 65 per cent or less, or in all puerperal patients whose anemia could not be explained by hemorrhage alone, a bone marrow aspiration was performed and the concentration of serum iron determined. In all, 47 4 sternal aspirations were examined. Of these, 90 proved to be megaloblastic in type (li2 during pregnancy and 38 rluring puerperium), 372 were normoblastic, ann 12 were questionably megaloblastic. A normoblastic marrow was obtained between the twenty-ninth and thirty-third week of pregnancy from 6 patients who failed to respond to iron. Some weeks later the marr·ow waR re-examined and by that time a megaloblastic marrow had developed in :1. 'l'his ~ug gested megaloblasts may not appear until near term. Of the 65 patients whose hemo· globins were 45 per cent or less, 35 had megaloblastic anemia, and 7 of the .'l ratient.H
711
of all the obstetrical beds serving a population of .!liO,OOO.