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Transfer of 67Ga from the hamster dam to fetus and offspring
42
Audrey T. Schlafke-Stelson
Techniques used to account for all of the administered activity are discussed in detail, and illustrations of pitfalls to avoid and examples to follow are given for presentation of data.
Transfer of ‘j7Ga from the Hamster Dam to Fetus and Offspring R. L. HAYESand B. L. BYRD Medical and Health Sciences Division, Oak Ridge Associated Universities, Oak Ridge, Tennessee, U.S.A. WE HAVE studied
the transfer of 67Ga from the hamster dam to the fetus and also to the postpartum offspring. During gestation the concentration of 67Ga in the mammary glands increased by approximately 20-fold, and 67Ga was transferred across the placenta into the fetus. The concentration of ‘j’Ga in the fetus decreased during the terminal stages of gestation, partly due to a decreased transfer of 67Ga itself and partly as a result of the rapid growth of the fetus. One-day-old offspring were able to absorb from the gastrointestinal tract the 67Ga contained in ingested dam’s milk, whereas 9-day-old offspring excreted essentially all such ingested 67Ga. The 67Ga radiation hazards to the fetus during gestation and that resulting from the transfer of 67Ga to the newborn through ingestion of the mother’s milk should receive further investigation.
Initial Kinetics and Cumulative Biodistribution of [gg”Tc]Diethyl-IDA
in a Mammalian
Model
J. W. DIRKSEN,M. A. QUAIFE,R. H. MCINTIRE, JR and R. F. SCHMELTER Department
of Radiology (Nuclear Medicine), University of Nebraska Omaha, Nebraska, U.S.A.
Medical Center,
THE EARLY (initial 30 min) kinetic behavior and cumulative biodistribution (30, 60, 90, and 180 min and 6, 12, 24, and 36 h time periods) of 99mTc-N-cr-(2,6-diethyl acetanalide) iminodiacetic acid have been described in a mammalian (rabbit) model as a basis for dosimetric consideration of this hepatobiliary agent. These data were obtained from in uivo region of interest time activity curves generated by automated data processing techniques from the initial distribution and localization of the radiopharmaceutical. Subsequently, using classic biodistribution techniques, tissue analysis of the percentage of administered dose per tissue or organ was determined. Results show the time distribution compares favorably with other mammalian species and demonstrated that this iminodiacetic acid derivative was rapidly cleared from the vascular bed, incorporated and excreted by the liver via the hepatobiliary system with minimal renal excretion.
The Distribution of I1 ‘In Labeled Blood Cells in Humans DAVID A. GOODWIN,ROLANDA. FINSTONand SHEILAI. SMITH Veterans Administration
Medical Center and Stanford University, Palo Alto, California, U.S.A.
THE DISTRIBUTION OF ‘“In labeled leukocytes and platelets was studied by whole body y-camera imaging in patients. Images were made 1 and 24 h after IV injection, and stored in digital form in computer memory. Nearly quantitative retention of cell activity was observed with little or no excretion seen in either gut or kidneys. Mixed leukocytes (predominantly neutrophils) were distributed in spleen, liver, and bone marrow in de-
Audrey T. Schlafke-Stelson
Techniques used to account for all of the administered activity are discussed in detail, and illustrations of pitfalls to avoid and examples to follow are given for presentation of data.
Transfer of ‘j7Ga from the Hamster Dam to Fetus and Offspring R. L. HAYESand B. L. BYRD Medical and Health Sciences Division, Oak Ridge Associated Universities, Oak Ridge, Tennessee, U.S.A. WE HAVE studied
the transfer of 67Ga from the hamster dam to the fetus and also to the postpartum offspring. During gestation the concentration of 67Ga in the mammary glands increased by approximately 20-fold, and 67Ga was transferred across the placenta into the fetus. The concentration of ‘j’Ga in the fetus decreased during the terminal stages of gestation, partly due to a decreased transfer of 67Ga itself and partly as a result of the rapid growth of the fetus. One-day-old offspring were able to absorb from the gastrointestinal tract the 67Ga contained in ingested dam’s milk, whereas 9-day-old offspring excreted essentially all such ingested 67Ga. The 67Ga radiation hazards to the fetus during gestation and that resulting from the transfer of 67Ga to the newborn through ingestion of the mother’s milk should receive further investigation.
Initial Kinetics and Cumulative Biodistribution of [gg”Tc]Diethyl-IDA
in a Mammalian
Model
J. W. DIRKSEN,M. A. QUAIFE,R. H. MCINTIRE, JR and R. F. SCHMELTER Department
of Radiology (Nuclear Medicine), University of Nebraska Omaha, Nebraska, U.S.A.
Medical Center,
THE EARLY (initial 30 min) kinetic behavior and cumulative biodistribution (30, 60, 90, and 180 min and 6, 12, 24, and 36 h time periods) of 99mTc-N-cr-(2,6-diethyl acetanalide) iminodiacetic acid have been described in a mammalian (rabbit) model as a basis for dosimetric consideration of this hepatobiliary agent. These data were obtained from in uivo region of interest time activity curves generated by automated data processing techniques from the initial distribution and localization of the radiopharmaceutical. Subsequently, using classic biodistribution techniques, tissue analysis of the percentage of administered dose per tissue or organ was determined. Results show the time distribution compares favorably with other mammalian species and demonstrated that this iminodiacetic acid derivative was rapidly cleared from the vascular bed, incorporated and excreted by the liver via the hepatobiliary system with minimal renal excretion.
The Distribution of I1 ‘In Labeled Blood Cells in Humans DAVID A. GOODWIN,ROLANDA. FINSTONand SHEILAI. SMITH Veterans Administration
Medical Center and Stanford University, Palo Alto, California, U.S.A.
THE DISTRIBUTION OF ‘“In labeled leukocytes and platelets was studied by whole body y-camera imaging in patients. Images were made 1 and 24 h after IV injection, and stored in digital form in computer memory. Nearly quantitative retention of cell activity was observed with little or no excretion seen in either gut or kidneys. Mixed leukocytes (predominantly neutrophils) were distributed in spleen, liver, and bone marrow in de-