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Transgenic knockout animals lacking lgG3
• les derniers brevets d6pos6s : morceaux choisis r6alis6e en collaboration avec I'lnpi
AGRICULTUREAGRO-INDUSTRIE Productions animales > Detection of fish spoilage by colorimetry (P Harewood, CT, USA) Gem Biomedical Inc N° WO 98/37227, PCT.
A rapid, on-site method for indicating the degree of spoilage, if an~; of finfish by the level of bacteria present therein. (...)
Productions vegetales > Method of generating embryogenic cell cultures for the production of bananas (Musa spp) (HM Schoofs et al, BE) KU Leuven Research & Development N° 861589, EP.
The present invention relates to a plant regeneration method, comprising the provision of a starting material for regeneration and the regeneration of plants from the starting material wherein the provision of a starting material comprises proliferating in vitro meristems in the presence of cytokinins in a concentration of at least 50 pm, preferably at least 100 pm to obtain ceils in suspension. (...)
Alimentation > Foam proteins, monoclonal antibodies thereto, and their uses (Y Ishibashi et al, JP) Suntory Ltd N° 863153, EP.
Novel foam proteins, monoclonal antibodies specifically recognizing said proteins, a method for determining foam protein contents in beer samples by an immunoassay using said monoclonal antibodies, a method for determining head retention and head retention stability of beer. (...)
Planles transgeniq.es > Selection method for transgenic plants (I Donaldson et al, DK) 48 BIOFUTUR183 • N0vembre1998
Pioneer Hi-Bred International Inc and the inventors N° WO 98/35052, PCT.
culture of untransformed monocotyledonous plant cells on a medium comprising a plant phenolic compound, for a period of time sufficient to stimulate cell division and enhance competence for integration of foreign DNA ; and contacting the untransformed cellls with the DNA fragment under conditions in which the DNA fragment is taken up by the untransformed cells and is stably integrated in the genome of the mltransformed cells, to generate transformed cells.
> Methods and means for gene silencing in transgenic plants (D Baulcombe and SM Angel, GB)
> Nouvelles utilisations de la st~rilit6 m&le chez les plantes (P Perez et P Flament, FR)
Plant B i o s c i e n c e Ltd and the inventors N° WO 98/36083, PCT.
Biocem et les inventeurs N° WO 98/38323, POT.
Danisco A/S and t h e inventors N° WO 98/35047, PCT.
A selection method for selecting from a population of cells one or more selectable genetically transformed cells is described. (...) > Production of self-compatible Brassica hybrids using a self-incompatible pollination control system (S Rothstein et al, CA)
Disclosed are DNA constructs (amplicons TM) comprising a promoter operably linked to DNA which can be transcribed in a plant cell to an RNA transcript, which RNA transcript includes plant virus sequence (eg derived from polato virus X) which confers on the RNA transcript the ability to replicate in the cytoplasm of the plant cell. (..)
L'invention conceme de nouvelles utilisations de la st&ilit6 m~le pour amdliorer les conditions de cultures des plantes transgdniques pour l'homme et l'environnement. > Insect control with a hypersensitive response elicitor (T Zitter and Z-M Wei, NY, USA) Cornell Research Foundation Inc N° WO 98/37752, PCT.
> Improved transformation method for plants (K D'Halluin, BE)
The present invention relates to a method of controlling insects on plants. This involves applying a hypersensitive response elicitor polypeptide or protein in a non-infectious form to a plant or plant seed under conditions effective to control insects on the plants or plants produced from the plant seed. Ahernatively, transgenic plants or transgenic plant seeds transformed with a DNA molecule encoding a hypersensitive response elicitor polypeptide or protein can be provided and the transgenic plants or plants resulting from the transgenic plant seeds are grown under conditions effective to control insects.
Plant Genetic S y s t e m NV and the inventor N° WO 98/37212, PCT.
Animaux transgeniques
A process for integrating a DNA fragment into the gehome of a cell of a monocowledonous plant, the process comprising the steps of : incubating, prior to comacting with the DNA fragment, a
> Methods and materials for introducing exogenous genes into cultured cells or fertilized eggs (H Yasue et al, JP)
> Genetically transformed pineapple plants and methods for their production (E Firoozabady and N Gutterson, CA, USA) DNA Plant T e c h n o l o g y Corp N° WO 98/36637, POT.
The present invention is directed to methods for the genetic transformation of pineapple plant tissue with Agrobacterium. The present invention also provides for the regeneration of intact pineapple plants for the transformed tissue.
Director General and Na-
•
tional Institute of Animal Industry N° 859059, EP.
There is provided a method of introducing exogenous genes into cultured cells or fertilized eggs, characterized in that each exogenous gene is introduced into chromosome DNA in a cultured cell or fertilized egg under a condition where the exogenous gene is placed between insulators so as to insure and insulated environment, such that the introduced exogenous gene will not be affected by any influence from adjacent genes in the cultured cell or fertilized egg. > Transgenic knockout animals lacking IgG3 (J Schreiber et al, OH, USA) Case Western Reserve University N° WO 98/37174, POT.
The present invention provides non-human transgenic animals in which an antibody subtype is selectively inactivated such that the transgenic animals express a reduced level of IgG3 relative to the level expressed by the corresponding wildtype animal. (...) > Transgenic animals and cell lines for screening drugs effective for the treatment or prevention of Alzheimer's disease (S de la Monte and J Wands, MA, USA) The General Hospital Corp and the inventors N° WO 98/38204. POT.
Disclosed are transgenic animals and tmnsfected cell lines expressing a protein associated with Alzheimer's disease, neuroectodermal tumors, malignant astrocytomas and glioblastomas. Also disclosed is the use of such transgenie animals and transfected cell lines to screen potential drug candidates for treating or preventing Alzheimer's disease. (...)
Proteines et peptides > Structurally modified peptides resistant to pep-
AGRICULTUREAGRO-INDUSTRIE Productions animales > Detection of fish spoilage by colorimetry (P Harewood, CT, USA) Gem Biomedical Inc N° WO 98/37227, PCT.
A rapid, on-site method for indicating the degree of spoilage, if an~; of finfish by the level of bacteria present therein. (...)
Productions vegetales > Method of generating embryogenic cell cultures for the production of bananas (Musa spp) (HM Schoofs et al, BE) KU Leuven Research & Development N° 861589, EP.
The present invention relates to a plant regeneration method, comprising the provision of a starting material for regeneration and the regeneration of plants from the starting material wherein the provision of a starting material comprises proliferating in vitro meristems in the presence of cytokinins in a concentration of at least 50 pm, preferably at least 100 pm to obtain ceils in suspension. (...)
Alimentation > Foam proteins, monoclonal antibodies thereto, and their uses (Y Ishibashi et al, JP) Suntory Ltd N° 863153, EP.
Novel foam proteins, monoclonal antibodies specifically recognizing said proteins, a method for determining foam protein contents in beer samples by an immunoassay using said monoclonal antibodies, a method for determining head retention and head retention stability of beer. (...)
Planles transgeniq.es > Selection method for transgenic plants (I Donaldson et al, DK) 48 BIOFUTUR183 • N0vembre1998
Pioneer Hi-Bred International Inc and the inventors N° WO 98/35052, PCT.
culture of untransformed monocotyledonous plant cells on a medium comprising a plant phenolic compound, for a period of time sufficient to stimulate cell division and enhance competence for integration of foreign DNA ; and contacting the untransformed cellls with the DNA fragment under conditions in which the DNA fragment is taken up by the untransformed cells and is stably integrated in the genome of the mltransformed cells, to generate transformed cells.
> Methods and means for gene silencing in transgenic plants (D Baulcombe and SM Angel, GB)
> Nouvelles utilisations de la st~rilit6 m&le chez les plantes (P Perez et P Flament, FR)
Plant B i o s c i e n c e Ltd and the inventors N° WO 98/36083, PCT.
Biocem et les inventeurs N° WO 98/38323, POT.
Danisco A/S and t h e inventors N° WO 98/35047, PCT.
A selection method for selecting from a population of cells one or more selectable genetically transformed cells is described. (...) > Production of self-compatible Brassica hybrids using a self-incompatible pollination control system (S Rothstein et al, CA)
Disclosed are DNA constructs (amplicons TM) comprising a promoter operably linked to DNA which can be transcribed in a plant cell to an RNA transcript, which RNA transcript includes plant virus sequence (eg derived from polato virus X) which confers on the RNA transcript the ability to replicate in the cytoplasm of the plant cell. (..)
L'invention conceme de nouvelles utilisations de la st&ilit6 m~le pour amdliorer les conditions de cultures des plantes transgdniques pour l'homme et l'environnement. > Insect control with a hypersensitive response elicitor (T Zitter and Z-M Wei, NY, USA) Cornell Research Foundation Inc N° WO 98/37752, PCT.
> Improved transformation method for plants (K D'Halluin, BE)
The present invention relates to a method of controlling insects on plants. This involves applying a hypersensitive response elicitor polypeptide or protein in a non-infectious form to a plant or plant seed under conditions effective to control insects on the plants or plants produced from the plant seed. Ahernatively, transgenic plants or transgenic plant seeds transformed with a DNA molecule encoding a hypersensitive response elicitor polypeptide or protein can be provided and the transgenic plants or plants resulting from the transgenic plant seeds are grown under conditions effective to control insects.
Plant Genetic S y s t e m NV and the inventor N° WO 98/37212, PCT.
Animaux transgeniques
A process for integrating a DNA fragment into the gehome of a cell of a monocowledonous plant, the process comprising the steps of : incubating, prior to comacting with the DNA fragment, a
> Methods and materials for introducing exogenous genes into cultured cells or fertilized eggs (H Yasue et al, JP)
> Genetically transformed pineapple plants and methods for their production (E Firoozabady and N Gutterson, CA, USA) DNA Plant T e c h n o l o g y Corp N° WO 98/36637, POT.
The present invention is directed to methods for the genetic transformation of pineapple plant tissue with Agrobacterium. The present invention also provides for the regeneration of intact pineapple plants for the transformed tissue.
Director General and Na-
•
tional Institute of Animal Industry N° 859059, EP.
There is provided a method of introducing exogenous genes into cultured cells or fertilized eggs, characterized in that each exogenous gene is introduced into chromosome DNA in a cultured cell or fertilized egg under a condition where the exogenous gene is placed between insulators so as to insure and insulated environment, such that the introduced exogenous gene will not be affected by any influence from adjacent genes in the cultured cell or fertilized egg. > Transgenic knockout animals lacking IgG3 (J Schreiber et al, OH, USA) Case Western Reserve University N° WO 98/37174, POT.
The present invention provides non-human transgenic animals in which an antibody subtype is selectively inactivated such that the transgenic animals express a reduced level of IgG3 relative to the level expressed by the corresponding wildtype animal. (...) > Transgenic animals and cell lines for screening drugs effective for the treatment or prevention of Alzheimer's disease (S de la Monte and J Wands, MA, USA) The General Hospital Corp and the inventors N° WO 98/38204. POT.
Disclosed are transgenic animals and tmnsfected cell lines expressing a protein associated with Alzheimer's disease, neuroectodermal tumors, malignant astrocytomas and glioblastomas. Also disclosed is the use of such transgenie animals and transfected cell lines to screen potential drug candidates for treating or preventing Alzheimer's disease. (...)
Proteines et peptides > Structurally modified peptides resistant to pep-