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TRANSIENT MYOCARDIAL ISCHEMIA INDUCED LEFT VENTRICULAR MECHANICAL DYSSYNCHRONY IN PATIENTS WITH CORONARY ARTERY DISEASE
E1181 JACC March 27, 2012 Volume 59, Issue 13
Imaging TRANSIENT MYOCARDIAL ISCHEMIA INDUCED LEFT VENTRICULAR MECHANICAL DYSSYNCHRONY IN PATIENTS WITH CORONARY ARTERY DISEASE ACC Moderated Poster Contributions McCormick Place South, Hall A Saturday, March 24, 2012, 9:30 a.m.-10:30 a.m.
Session Title: Evaluation of Left Ventricular Dyssynchrony by Myocardial Perfusion Imaging Abstract Category: 23. Imaging: Nuclear Presentation Number: 1107-359 Authors: Naoto Takahashi, Masahiro Ishikawa, Arifumi Kikuchi, Eisei Yamamoto, Kenichi Amitani, Takahiro Uchida, Naoki Sato, Kazuo Munakata, Kyoichi Mizuno, Nippon Medical School Musashikosugi Hospital, Kawasaki, Japan, Nippon Medical School Hospital, Tokyo, Japan Background: Left ventricular Mechanical dyssynchrony (LVMD) has been demonstrated to be present in patients with severe heart failure including myocardial infarction (MI) and cardiomyopathy. However, the presence and severity of LVMD in stable angina pectoris (AP) has not been fully clarified. Objectives: The aim of this study was to assess the severity of LVMD in stable AP. Methods: A total of 162 patients (age 69 ± 10, 114 men) with suspected coronary artery disease underwent stress/rest gated myocardial perfusion SPECT (GMPS). For the evaluation of LVMD, histogram bandwidth (HBW) and phase standard deviation (PSD) were determined at stress by GMPS using phase analysis. LVMD was compared among three groups: 85 normal control (NCG); [summed stress score (SSS) 1 and summed rest score < 3], and 35 prior MI (pMIG); (SSS ≥ 4 and SDS < 2). Results: There was significant positive correlation between HBW and PSD in all patients (r=0.90, p < 0.0001). The measured LVMD parameters (HBW and PSD) in NCG, IschG, and pMIG are summarized in the figure. Conclusions: LVMD in stable AP was demonstrated to be greater enhancement than those in normal control. LVMD was found to be equivalent severity in patients with stable AP and prior MI.
Imaging TRANSIENT MYOCARDIAL ISCHEMIA INDUCED LEFT VENTRICULAR MECHANICAL DYSSYNCHRONY IN PATIENTS WITH CORONARY ARTERY DISEASE ACC Moderated Poster Contributions McCormick Place South, Hall A Saturday, March 24, 2012, 9:30 a.m.-10:30 a.m.
Session Title: Evaluation of Left Ventricular Dyssynchrony by Myocardial Perfusion Imaging Abstract Category: 23. Imaging: Nuclear Presentation Number: 1107-359 Authors: Naoto Takahashi, Masahiro Ishikawa, Arifumi Kikuchi, Eisei Yamamoto, Kenichi Amitani, Takahiro Uchida, Naoki Sato, Kazuo Munakata, Kyoichi Mizuno, Nippon Medical School Musashikosugi Hospital, Kawasaki, Japan, Nippon Medical School Hospital, Tokyo, Japan Background: Left ventricular Mechanical dyssynchrony (LVMD) has been demonstrated to be present in patients with severe heart failure including myocardial infarction (MI) and cardiomyopathy. However, the presence and severity of LVMD in stable angina pectoris (AP) has not been fully clarified. Objectives: The aim of this study was to assess the severity of LVMD in stable AP. Methods: A total of 162 patients (age 69 ± 10, 114 men) with suspected coronary artery disease underwent stress/rest gated myocardial perfusion SPECT (GMPS). For the evaluation of LVMD, histogram bandwidth (HBW) and phase standard deviation (PSD) were determined at stress by GMPS using phase analysis. LVMD was compared among three groups: 85 normal control (NCG); [summed stress score (SSS) 1 and summed rest score < 3], and 35 prior MI (pMIG); (SSS ≥ 4 and SDS < 2). Results: There was significant positive correlation between HBW and PSD in all patients (r=0.90, p < 0.0001). The measured LVMD parameters (HBW and PSD) in NCG, IschG, and pMIG are summarized in the figure. Conclusions: LVMD in stable AP was demonstrated to be greater enhancement than those in normal control. LVMD was found to be equivalent severity in patients with stable AP and prior MI.