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Translocation t(7;11)(p13;p15) in acute nonlymphocytic leukemia
LETTER TO THE EDITOR Translocation t(7;11)(p13;p15) in Acute Nonlymphocytic Leukemia
The d e v e l o p m e n t of chromosome b a n d i n g techniques has enabled cytogeneticists to find specific chromosome translocation8 in various h u m a n leukemias and related disorders. Recently, some of these specific translocations have been revealed to be related to oncogenes. With further progress in chromosome analysis, there remains a possibility of finding new types of specific chromosome translocations. We have been carrying out chromosome studies in h u m a n leukemias and related disorders, and have found a n e w chromosome translocation in an 18-year-old female patient with acute m y e l o m o n o c y t i c l e u k e m i a belonging to M4 in the FAB classification. As seen in Figure 1, the new translocation involves the short arm of chromosome # 7 and the short arm of #11, and is designated as t(7;11)(p13;p15). This translocation deserves special attention because breakpoint p13 in the short arm of # 7 involved in the translocation is i n c l u d e d in the region in w h i c h the oncogene c-erb B is s u p p o s e d to be located [1, 2], and breakpoint p15 in the short arm of #11 is the portion in w h i c h the oncogene c-H-ras 1 has been m a p p e d [3]. It is not k n o w n what relationship exists between these oncogenes and the chromosome translocation described. However, if the translocation is a specific one to a subgroup of the disease, it will be of importance to search for a relationship between these oncogenes and chromosome translocation to the genesis of the leukemia. Two more cases of acute n o n l y m p h o c y t i c leukemia (ANLL) with the same translocation as this one have been found in different institutions in Japan. Further investigations seem necessary to find out if the translocation reported here is specific to one type of ANLL. Supported in part by a Grant-in-Aid for Cancer Research from the Ministry of Education, Science and Culture, Japan. TAKAAKI ISHIHARA MASAKO MINAMIHISAMATSU YASUNOBU YOKOYAMA
National Institute of RadiologicaI Sciences Chiba, Japan Special Reference Laboratory Co., Inc. Hachioji, Japan
Address requests for reprints to Dr. Takaaki Ishihara, Division of Radiation Hazards, National Institute of Radiological Sciences, 9-1, Anagawa-4-chome, Chiba 260, Japan. Received May 24, 1985; accepted June 4, 1985.
363 © 1986 Elsevier Science Publishing Co., Inc. 52 Vanderbilt Ave., New York, NY 10017
Cancer Genet Cytogenet 19:383-364(1986} 0165-4608/86/$03.50
364
T. Ishih.r.
el ~II.
F i g u r e 1 Q-5~mded kary{%,pe i)I a bonl~ m~lrrow ~:~11 Irom (i [)~lfienl with ANI,I,-NI4 ~md th~ [ranslocation [{7:11](p13;[)15). (;-bande(I partial karyot?+p(! of the (:hromo,;oem i)airs # 7 and #11 is s h o w n in the inset.
REFERENCES 1. S p u r r NK, S o [ o m o n E, Jansson M, Sheer D, Goodfellow PN. B o d m e r WE, V e n n s t r o m B (1984): C h r o m o s o m a l localization of the h u m a n h o m o l o g u e s to t h e o n c o g e n e s erbA ~md B. EMBO J 3:159-164. 2. K o n d o 1, S h i m i z u N {1983): M a p p i n g of t h e h u m a n gene for e p i d e r m a l g r o w t h factor receptor {EGFR) on t h e p13-->q22 region of c h r o m o s o m e 7. Cytogenet Cell Genet 35:9-14. 3. J h a n w a r SC, Neel BG, H a y w a r d WS, Chaganti RSK (1983): Localization of c-ras o n c o g e n e family on h u m a n g e r m - l i n e c h r o m o s o m e s . Proc Natl Acad Sci, USA 80:4794 4797.
The d e v e l o p m e n t of chromosome b a n d i n g techniques has enabled cytogeneticists to find specific chromosome translocation8 in various h u m a n leukemias and related disorders. Recently, some of these specific translocations have been revealed to be related to oncogenes. With further progress in chromosome analysis, there remains a possibility of finding new types of specific chromosome translocations. We have been carrying out chromosome studies in h u m a n leukemias and related disorders, and have found a n e w chromosome translocation in an 18-year-old female patient with acute m y e l o m o n o c y t i c l e u k e m i a belonging to M4 in the FAB classification. As seen in Figure 1, the new translocation involves the short arm of chromosome # 7 and the short arm of #11, and is designated as t(7;11)(p13;p15). This translocation deserves special attention because breakpoint p13 in the short arm of # 7 involved in the translocation is i n c l u d e d in the region in w h i c h the oncogene c-erb B is s u p p o s e d to be located [1, 2], and breakpoint p15 in the short arm of #11 is the portion in w h i c h the oncogene c-H-ras 1 has been m a p p e d [3]. It is not k n o w n what relationship exists between these oncogenes and the chromosome translocation described. However, if the translocation is a specific one to a subgroup of the disease, it will be of importance to search for a relationship between these oncogenes and chromosome translocation to the genesis of the leukemia. Two more cases of acute n o n l y m p h o c y t i c leukemia (ANLL) with the same translocation as this one have been found in different institutions in Japan. Further investigations seem necessary to find out if the translocation reported here is specific to one type of ANLL. Supported in part by a Grant-in-Aid for Cancer Research from the Ministry of Education, Science and Culture, Japan. TAKAAKI ISHIHARA MASAKO MINAMIHISAMATSU YASUNOBU YOKOYAMA
National Institute of RadiologicaI Sciences Chiba, Japan Special Reference Laboratory Co., Inc. Hachioji, Japan
Address requests for reprints to Dr. Takaaki Ishihara, Division of Radiation Hazards, National Institute of Radiological Sciences, 9-1, Anagawa-4-chome, Chiba 260, Japan. Received May 24, 1985; accepted June 4, 1985.
363 © 1986 Elsevier Science Publishing Co., Inc. 52 Vanderbilt Ave., New York, NY 10017
Cancer Genet Cytogenet 19:383-364(1986} 0165-4608/86/$03.50
364
T. Ishih.r.
el ~II.
F i g u r e 1 Q-5~mded kary{%,pe i)I a bonl~ m~lrrow ~:~11 Irom (i [)~lfienl with ANI,I,-NI4 ~md th~ [ranslocation [{7:11](p13;[)15). (;-bande(I partial karyot?+p(! of the (:hromo,;oem i)airs # 7 and #11 is s h o w n in the inset.
REFERENCES 1. S p u r r NK, S o [ o m o n E, Jansson M, Sheer D, Goodfellow PN. B o d m e r WE, V e n n s t r o m B (1984): C h r o m o s o m a l localization of the h u m a n h o m o l o g u e s to t h e o n c o g e n e s erbA ~md B. EMBO J 3:159-164. 2. K o n d o 1, S h i m i z u N {1983): M a p p i n g of t h e h u m a n gene for e p i d e r m a l g r o w t h factor receptor {EGFR) on t h e p13-->q22 region of c h r o m o s o m e 7. Cytogenet Cell Genet 35:9-14. 3. J h a n w a r SC, Neel BG, H a y w a r d WS, Chaganti RSK (1983): Localization of c-ras o n c o g e n e family on h u m a n g e r m - l i n e c h r o m o s o m e s . Proc Natl Acad Sci, USA 80:4794 4797.