Treatment of female menopause with methyl testosterone and stilbestrol

Alvarez, C., G-eary, E., and Belizan, L.: Basal Metabolism An. Catedra de clin. girlec. 2: ~94-830, 1913.

in the Menopause,

The authors studied the ba~;rl rate in a group of 41) wlert4 owes. Clinical and gynecologica investigations were carried out, as mcall as metabolism The patests. tients all had a natural menopause, and all the patients had menopausal symptoms It was thought that if the severe enough to cause them to seek medical attention. climacteric has an influence on basal metabolism, it would he most apparent in the group with symptoms. The symptoms for which the patients sought relief were the usual ones: dyspnea, palpitation, hypertensicn, I~eetla~l~r~, neuralgia, increased weight, psychic disturbances, etc. Nine of the 40 patients had metabolic rat,ex of more than plus 10; five, of less than minus IO; and 26 had normal rates, i.e., between minus IO and plus 10. Clinical analysis of the nine patients with high metabolic rat,es showed that except for one patient. with definite hyperthyroidism, all the others had hypertension, which is known to be accompanied frequently with increased ba8aI met.abolism. Only one of the patients with a low metabolic rate had an exceedingly low rate, and her menopausal symptoms did not differ from those of patients with normal rates. An additional statistical study was made to determine the incidence of hyperthyroidism in different age groups of women. In a series of 193 cases, the incidence in patients 46 to 50 was higher than in those from 41 to 45, but not so high as in any of the groups representing five-year age periods from 21 to -10. The authors conclude that their evidence indicates that alterations in the basal rnetxbolism are not directly attributable to the menopause, hut rather to disturbancaes ant1 diseases that are roincidmtal. J. P. GREEPITHILI,

Kurzrok, L., and Rothbart, H.: Treatment Testosterone and Stilbestrol, Am. J. Burg.

of Female Menopause 56:

636,

With

Methyl

19-4-P.

The authors treated 16 menopause cases both natural and surgical with methyl testosterone and stilbestrol, administered orally. In addition to the flushes, headaches, and sweats present, 3 of the patients complained of arthralgias, and 3 of pruritus vulvae. Dosage of the preparations varied; from 5 to 25~ mg. of methyl testosterone was administered daily together with 2 to 3 mg. of stilbestrol. The duration of t,reatment was from I to 6 months. Improvement or complete relief of the menopause symptoms was obtained in all cases. Two of the 3 patients complaining of pruritus vulvae were relieved and 1 was unimproved. The 3 cases of arthralgia were improved in varying degrees. One patient showed transient lowering of the voice during therapy. No other evidence O-F masculinization was noted. FRAKK

SPIELNAN

Menstruation Mackey, R.:

Anovulatory

Menstruation,

N. J. Australia

1: 305. 19-U.

The theories of anovulatory menstruation are reviewed. The author goes into detail in his description of the pathologic picture of t.he premenstrual or secretory endomet.rium, the presence of which is essential for the diagnosis of ovulation. The anovulatory endometrium has its own characteristic pathologic picture. Clinically, anovulatory woman. The irregularity indication of early and diagnosis of anovulation

cycles occur at either end of the menstrual history of of the cycles at the menarcha and menopause may be an late anovular phases. The author stresses the fact that the cannot be made on result of one biopsy. Treatment has not