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Treatment of liver cirrhosis with colchicine
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D~-I'~]IATI~N OF ZINC A~D CO~P~9 IN T ~ SER'.M C~ P A ~
WITH C~DNIC ~PATITIS AM] LIVER C ~ I S .
J.E. Ac~ami, E. Boletini University of Tir~m, Albania. To study the char~es ur~rzone by zinc in the body of patients with liver cirrhosis or d-~unlic hepatitis and the need of its use f~- their treab~ent its se_~m concentrations ~ atomic abeo~b~nt.
determined by the spectro~not(~etFic method with
For the purpose the V~ian-Techtron spectrophot~metar with ~etylere-a/r flame with a 213.85 rm
~ v e l e ~ h t ~ s used. The examinatinn was performed on 19 patients with liver clrnhosis ccnfirmed by lapar~scopy, Z3 patients widn chronic hepatitis and a contr~ol ~
of 20 students of the Faculty of Medicine. The f i n ~
titis, as c(~)sr~d to the eontrol @~oup, serum zinc u m ~ fall ~ s
a si~ificant fall (P
showed d~at in chronic hepa0.01); in liver cirrhosis the
more marked (P 0.0005). A certain parallelism existed between the de~ree of destruction of the liver par~n-
chyma and the fall of seman zinc. Thus the mean values of serum zinc in liver cirrhosis wer~ lowe~ ~%m~ dnose in chro:]ic hepatitis (P
0.001). The treab,ent with zinc sulphate helped to improve some of hhe s ~ p t o ~
of the patients,
a~ticul~ly the disbxbances of the senses of taste and smell. As re~srds ~he levels of c~pper, no difference ~ s
found between the patients with chrmnic hepatitis and those with
liver ci_~osis, but in both groups the levels of serum copper ~
hi~her than in the control ~roup (P 0.0005). In
~ne case with liver cirrhosis and low serum zinc concentration with o~mplete icss of the sense of taste and sm~ll, [hese disturbances, and later hemer~lopia disappeared under the treatment with zinc sulphate 660 m~ daily. Conclusion: In c~ntrast with the control ~ ,
the patients with chronic he~a~xlDathy presented lower levels of se-
rum zinc, more pron~_mced in cirmho~is than in chronic hepatitis. In addition a fall is noted of serzm copper but without si~nificsnt differences between cirrhosis and chronic hepatitis. The use of zinc sulphate as an im~unoreK~latot ma~v be halpful in the treatment of these patients.
2
TREAT~ZNT OF LIVER C ~ I S
WITH OOLOHICINE
J.E. Achani, B. Resuli t/niversity of Tirana, Albania. The object of this work was to study the effect of colchicine in cirrhotic patients and the biological cha~es occurrir~ d ~ i r ~ its use. In 1980-83 a series of 98 cases of liver cirrhosis received treatment with colchicine; 57 had ascites and 41 were c~pensated; 80 ~ere men and 18 women. In 82 cases the dia~x)sis was confirmed by laparoscopy; 51.55~ were ~sAg-9~sitive; of these, 8 were negative by ~ l e c t r D p h o r e s i s ,
but resulted anti-4~-positive by the
ELISA method. C~lehicine was administered orally, in daily doses of 1 mg by day, over periods of 5 days with intervals or rest of 2 days. In ii, or 19.30Z of the 57 decompensated cases, the ascites disappeared within two months and the ~se of diLa'etics was suspended definitely. The follow-up period without ascites was betwe~1 4 and 30 months, 13.9 T~TndlS in aversge. In 19 others, or 33.3.T~ the 8scites receded and ~J~at condition was maintained with smaller and less f~-~uent doses of diuretics. In 15 cases, or 26.32~ the ascites remained ~mcha~ed and they continued to take diure,.ics as before. The period of observation of the remainir~ 12 cases w~s too short. In the c~urse, of the treatment with colchicine, the serum billrubin fell more in decc,~ensated than in co~ensated cirrhosis, with a p1~gbability of error of P 0.005 and P 0.05. It was the same with Mac ~=an, but in d ~ r s a t e d cirrhosis P 0.01, in the o0mperr~ted cases the fall w~s statistically insignificant. The ~ - s a m i n a s e activity fell more pronouncedly in the ccmpersated cases r~ather ~/nan in those with 8scites, in pal~ticular S(~T (P 0.01); SGOT was P
0.05 in the ozmpensated cases, but
in both deco~pensated cases the fall was statistically insignificant. Side effects: diannhea in 4 patients (4.(]5~), thrrmbocyt~penia in 5 (5.1%), but only one of them had epistaxis, and leukopenia in 4 (~.05~). In ~ other cases, originally with leukopenia, the number of leukmcytes not only did not fall, but actually rose afte~ the treatment with cold~icine. This s u ~ s t s
that colchieine m~tv have a positive effect on the manifestations of hypersplenism. D~-ir~
these 4 years 8 patients died (8.1(~). Conclusion: L] parL of the patients with cirrhosis, treahment with colchicine, e]iminates ascites; the use of diuretics is suspended o," reduced. The biological tests are improved.
S1
D~-I'~]IATI~N OF ZINC A~D CO~P~9 IN T ~ SER'.M C~ P A ~
WITH C~DNIC ~PATITIS AM] LIVER C ~ I S .
J.E. Ac~ami, E. Boletini University of Tir~m, Albania. To study the char~es ur~rzone by zinc in the body of patients with liver cirrhosis or d-~unlic hepatitis and the need of its use f~- their treab~ent its se_~m concentrations ~ atomic abeo~b~nt.
determined by the spectro~not(~etFic method with
For the purpose the V~ian-Techtron spectrophot~metar with ~etylere-a/r flame with a 213.85 rm
~ v e l e ~ h t ~ s used. The examinatinn was performed on 19 patients with liver clrnhosis ccnfirmed by lapar~scopy, Z3 patients widn chronic hepatitis and a contr~ol ~
of 20 students of the Faculty of Medicine. The f i n ~
titis, as c(~)sr~d to the eontrol @~oup, serum zinc u m ~ fall ~ s
a si~ificant fall (P
showed d~at in chronic hepa0.01); in liver cirrhosis the
more marked (P 0.0005). A certain parallelism existed between the de~ree of destruction of the liver par~n-
chyma and the fall of seman zinc. Thus the mean values of serum zinc in liver cirrhosis wer~ lowe~ ~%m~ dnose in chro:]ic hepatitis (P
0.001). The treab,ent with zinc sulphate helped to improve some of hhe s ~ p t o ~
of the patients,
a~ticul~ly the disbxbances of the senses of taste and smell. As re~srds ~he levels of c~pper, no difference ~ s
found between the patients with chrmnic hepatitis and those with
liver ci_~osis, but in both groups the levels of serum copper ~
hi~her than in the control ~roup (P 0.0005). In
~ne case with liver cirrhosis and low serum zinc concentration with o~mplete icss of the sense of taste and sm~ll, [hese disturbances, and later hemer~lopia disappeared under the treatment with zinc sulphate 660 m~ daily. Conclusion: In c~ntrast with the control ~ ,
the patients with chronic he~a~xlDathy presented lower levels of se-
rum zinc, more pron~_mced in cirmho~is than in chronic hepatitis. In addition a fall is noted of serzm copper but without si~nificsnt differences between cirrhosis and chronic hepatitis. The use of zinc sulphate as an im~unoreK~latot ma~v be halpful in the treatment of these patients.
2
TREAT~ZNT OF LIVER C ~ I S
WITH OOLOHICINE
J.E. Achani, B. Resuli t/niversity of Tirana, Albania. The object of this work was to study the effect of colchicine in cirrhotic patients and the biological cha~es occurrir~ d ~ i r ~ its use. In 1980-83 a series of 98 cases of liver cirrhosis received treatment with colchicine; 57 had ascites and 41 were c~pensated; 80 ~ere men and 18 women. In 82 cases the dia~x)sis was confirmed by laparoscopy; 51.55~ were ~sAg-9~sitive; of these, 8 were negative by ~ l e c t r D p h o r e s i s ,
but resulted anti-4~-positive by the
ELISA method. C~lehicine was administered orally, in daily doses of 1 mg by day, over periods of 5 days with intervals or rest of 2 days. In ii, or 19.30Z of the 57 decompensated cases, the ascites disappeared within two months and the ~se of diLa'etics was suspended definitely. The follow-up period without ascites was betwe~1 4 and 30 months, 13.9 T~TndlS in aversge. In 19 others, or 33.3.T~ the 8scites receded and ~J~at condition was maintained with smaller and less f~-~uent doses of diuretics. In 15 cases, or 26.32~ the ascites remained ~mcha~ed and they continued to take diure,.ics as before. The period of observation of the remainir~ 12 cases w~s too short. In the c~urse, of the treatment with colchicine, the serum billrubin fell more in decc,~ensated than in co~ensated cirrhosis, with a p1~gbability of error of P 0.005 and P 0.05. It was the same with Mac ~=an, but in d ~ r s a t e d cirrhosis P 0.01, in the o0mperr~ted cases the fall w~s statistically insignificant. The ~ - s a m i n a s e activity fell more pronouncedly in the ccmpersated cases r~ather ~/nan in those with 8scites, in pal~ticular S(~T (P 0.01); SGOT was P
0.05 in the ozmpensated cases, but
in both deco~pensated cases the fall was statistically insignificant. Side effects: diannhea in 4 patients (4.(]5~), thrrmbocyt~penia in 5 (5.1%), but only one of them had epistaxis, and leukopenia in 4 (~.05~). In ~ other cases, originally with leukopenia, the number of leukmcytes not only did not fall, but actually rose afte~ the treatment with cold~icine. This s u ~ s t s
that colchieine m~tv have a positive effect on the manifestations of hypersplenism. D~-ir~
these 4 years 8 patients died (8.1(~). Conclusion: L] parL of the patients with cirrhosis, treahment with colchicine, e]iminates ascites; the use of diuretics is suspended o," reduced. The biological tests are improved.
S1