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Treatment of panic disorder in insulin dependent diabetes mellitus
Poster A. Clinical
(blood donors) as controls. All patients and controls were Greeks, unrelated among them and were personally examined by the use of a structured psychiatric questionnaire (Schedules for Clinical Assessment in Nemopsychiatry-SCAN). For the genotyping of the DRD2 gene a dinuclentide repeat marker was analysed by polymerase chain reaction (PCR) and electrophoresis after end-labeling with Y-~*P. For the genotyping of the DRD3 gene, a restrictive enzyme digestion was used for the Bali polymorphism. The results of genotyping were read by investigators blind to clinical diagnosis. Regarding the DRD2 gene, no differences were observed in allelic frequencies between the groups of patients and controls (p=O.223). For the DRD3 gene, however, a statistically significant association was found with the patients allelic and genotypic frequencies differing from those of controls (p=O.O14 and p=O.O19 respectively). This association was more prominent among female subjects. The results of the present study suggest that polymorphisms of the DA receptor D3, but not D2, may be implicated in the pathogenesis of affective disorder.
Manki H, Kanba S, Muramatsu T et al, 1996. Dopamine D2, D3 and D4 receptor and transporter gene polymorphisms and mood disorders. J Affect Disord 40:7-13. Souery D, Lipp 0, Mahieu et al, 1996. Association study of bipolar disorder with candidate genes involved in catecholamine neurotransmission: DRD2, DRD3, DATl, and TH genes. Am J Med Genet (Neuropsychiat Genet) 67:55!-555.
Treatment of panic disorder betes mellitus
DrDragih
in insulin dependent
Persky, H. (1974). Reproductive hormones, moods. and the menstrual cycle. In R.G. Friedman, R.M. Richard and R.L.. Vande Wiele (Eds.), Sex Differences in Behaviour. New York: Wiley. Parke, R.D. and Slaby, R.G. (1983). The development of aggression. In E.M. Hetherington (Ed.), Carmicael’s Manual of Child Psychology, Vol. IV, New York: Wiley, p. 561. Scamarella, T.C., and Brown, W.A. (1978). Serum testosterone and aggressiveness in hockey players, Psychosomatic Medicine, 40, pp. 262-265.
dia-
D. KostiC. Department of Psychiatry, KBC” MiSoviC, 11000 Beograd, N.H. Milana TepiCa 1, Yugoslavia
V Diligenski,
Humans who have the rates of these neurochemical substances in low levels present overexcitation because suspension of the action of the monoaminoxidase (MAO) has as result the increase of the activation of neurotransmitters substances i.e. dopamine (DA). Dogmatyl neutralizes dopamine restraining hormone of pro&tin (PRL). This entails increase of the paragon for the release of prolactin (PRF) because prolactin is excreted as connection with paragon of the release of the prolactin from hypothalamus. Prolactin acts on the breast glands putting the production of the milk. Prolactin (it does not clear scientifically) causes rousing of the globus pallidus and excretion of progesterone, sometimes in notable quantities (gonadotrope action). But, by our intervention (dogmatyl), this does not happen, as it turns out of the release of the caused menstruation. This entails (indirect evidence) decrease of the aggressiveness against others. But subjects do not avoid the aggressiveness against theirself because the aggressiveness does not vanish but this is oppressed producing undesirable effects (side effects) which evidently are due to the uncontrolled action of the ascending testosterone. References
References
I A-8
V Adamovic,
El
A-l 0
AZ. In the group of patients of insulin dependent diabetes (58 patients) we found that 28% meet criteria of DSM IV classification for partial or complete panic disorder. From 13 classified possible symptoms for panic disorder, this group had at least 4 symptoms, or one or more symptoms with anticipatory anxiety in the last one month. So high percentage of panic disorder is surprising because in general population it is up to 3%. It is result of the bad regulated diabetes, hereditary hypersensibility disposition, often hypoglycaemic crisis, which all contribute to the high neurotic degrees of these patients, particularly high anxiety. We used to regulate panic attacks Clonazepam in dosage of 0,5 up to 4 mg per day, for at least 6 months, in the combination with cognitive-behaviour therapy. The results were very quick, and with the glycaemia regulation, the treatment was effective. Diabetic hypoglycaemia highly overlapped panic attacks in their symptoms. Sometimes it was necessary to add TCA or SSRI antidepressants in small dosage.
A-9 El
Neuropsychopharmaceutical control of the correlation between testosterone and aggressiveness
C.V. Dimoulas. Health Services
Sll
Department of Medical Laboratory Technology, and Welfare, T.E.I. of Larissa, Greece.
School of
Purpose of this study is to prove neuropsychopharmaceutically the correlation among aggressiveness and level of testosterone in the blood. Against contradictory picture whom data of researches with human subjects offer in this matter, in some forms of aggressive behaviour the influence of androgenes hormones has more general empirical support. But data of researches with human as subjects report lower - comparatively to their sample - correlations between level of testosterone and aggressiveness. Such higher correlations are remarked during some phases of the periodical circle, especially at the phase of excretion of the progesterone. Notable is ascertainment that while the level of the testosterone presented fluctuations during the several phases of the periodical circle, the measurements of the aggressive behaviour remained firm. Parallelly, there are indications of increased aggressive behaviour at the phase that precedes the menstruation. Periodical circle before women present notable emotional instability (others of them subside into depressiveness and others present overexcitation). This behaviour, depends on the rate of the harmonic substances which affect the hypothalamus and limbic system (tonsil and diaphragm). These feminine hormones (progesterone and oestrogones) wane the rates of stoppers of monoaminoxidase.
Peculiarities of blood serotonin system in psychogenic depressive disorders
Drozdov,
B.M.
National Research Russ&
Kogan,
T.S. Filatova,
IV. Mankovsky.
Centre for Social and Forensic
Psychiatry,
Serbsky Moscow,
Despite of large number of studies there are some contradictory opinions about the state of platelet indoleamine uptake system in affective disorders up to now. 66 males in the age of 18-51 years with psychogenic depressive disorders correspondingly subdivided into three groups with hysterical, anxiety and asthenic syndromes were examined. There were two comparative groups composed of (1) 20 psychopathic persons without depression and (2) 15 healthy subjects. A serotonin content in the blood plasma and platelets by means of HPLC-EC methods were determined. Parameters of the ‘H-serotonin platelet uptake (V,,, and K,) were also measured. V“lax of the serotonin uptake by platelets in patients with depressive disorder exceeds control figures only in persons with anxious-depressive manifestations (606252 pmol/ lO”/min, p
Ultrastructural immunocytochemical localization of noradrenaline in locus coeruleus neurons of control and suicide brains M.R. Issidorides”.“, M. Chrysanthou-Piterou”, S. Havaki”,V. Krihoh, G.D. Pappass. aDepartment of Psychiatry, University of Athens, Eginition Hospital, Greece, bDepartment of Anatomy and Cell Biology, Medicine, University of Illinois at Chicago, (ISA
College
qf
Extensive studies have shown that a large fall in noradrenaline (NA) concentration in the locus coeruleus (LC) is critically involved in
(blood donors) as controls. All patients and controls were Greeks, unrelated among them and were personally examined by the use of a structured psychiatric questionnaire (Schedules for Clinical Assessment in Nemopsychiatry-SCAN). For the genotyping of the DRD2 gene a dinuclentide repeat marker was analysed by polymerase chain reaction (PCR) and electrophoresis after end-labeling with Y-~*P. For the genotyping of the DRD3 gene, a restrictive enzyme digestion was used for the Bali polymorphism. The results of genotyping were read by investigators blind to clinical diagnosis. Regarding the DRD2 gene, no differences were observed in allelic frequencies between the groups of patients and controls (p=O.223). For the DRD3 gene, however, a statistically significant association was found with the patients allelic and genotypic frequencies differing from those of controls (p=O.O14 and p=O.O19 respectively). This association was more prominent among female subjects. The results of the present study suggest that polymorphisms of the DA receptor D3, but not D2, may be implicated in the pathogenesis of affective disorder.
Manki H, Kanba S, Muramatsu T et al, 1996. Dopamine D2, D3 and D4 receptor and transporter gene polymorphisms and mood disorders. J Affect Disord 40:7-13. Souery D, Lipp 0, Mahieu et al, 1996. Association study of bipolar disorder with candidate genes involved in catecholamine neurotransmission: DRD2, DRD3, DATl, and TH genes. Am J Med Genet (Neuropsychiat Genet) 67:55!-555.
Treatment of panic disorder betes mellitus
DrDragih
in insulin dependent
Persky, H. (1974). Reproductive hormones, moods. and the menstrual cycle. In R.G. Friedman, R.M. Richard and R.L.. Vande Wiele (Eds.), Sex Differences in Behaviour. New York: Wiley. Parke, R.D. and Slaby, R.G. (1983). The development of aggression. In E.M. Hetherington (Ed.), Carmicael’s Manual of Child Psychology, Vol. IV, New York: Wiley, p. 561. Scamarella, T.C., and Brown, W.A. (1978). Serum testosterone and aggressiveness in hockey players, Psychosomatic Medicine, 40, pp. 262-265.
dia-
D. KostiC. Department of Psychiatry, KBC” MiSoviC, 11000 Beograd, N.H. Milana TepiCa 1, Yugoslavia
V Diligenski,
Humans who have the rates of these neurochemical substances in low levels present overexcitation because suspension of the action of the monoaminoxidase (MAO) has as result the increase of the activation of neurotransmitters substances i.e. dopamine (DA). Dogmatyl neutralizes dopamine restraining hormone of pro&tin (PRL). This entails increase of the paragon for the release of prolactin (PRF) because prolactin is excreted as connection with paragon of the release of the prolactin from hypothalamus. Prolactin acts on the breast glands putting the production of the milk. Prolactin (it does not clear scientifically) causes rousing of the globus pallidus and excretion of progesterone, sometimes in notable quantities (gonadotrope action). But, by our intervention (dogmatyl), this does not happen, as it turns out of the release of the caused menstruation. This entails (indirect evidence) decrease of the aggressiveness against others. But subjects do not avoid the aggressiveness against theirself because the aggressiveness does not vanish but this is oppressed producing undesirable effects (side effects) which evidently are due to the uncontrolled action of the ascending testosterone. References
References
I A-8
V Adamovic,
El
A-l 0
AZ. In the group of patients of insulin dependent diabetes (58 patients) we found that 28% meet criteria of DSM IV classification for partial or complete panic disorder. From 13 classified possible symptoms for panic disorder, this group had at least 4 symptoms, or one or more symptoms with anticipatory anxiety in the last one month. So high percentage of panic disorder is surprising because in general population it is up to 3%. It is result of the bad regulated diabetes, hereditary hypersensibility disposition, often hypoglycaemic crisis, which all contribute to the high neurotic degrees of these patients, particularly high anxiety. We used to regulate panic attacks Clonazepam in dosage of 0,5 up to 4 mg per day, for at least 6 months, in the combination with cognitive-behaviour therapy. The results were very quick, and with the glycaemia regulation, the treatment was effective. Diabetic hypoglycaemia highly overlapped panic attacks in their symptoms. Sometimes it was necessary to add TCA or SSRI antidepressants in small dosage.
A-9 El
Neuropsychopharmaceutical control of the correlation between testosterone and aggressiveness
C.V. Dimoulas. Health Services
Sll
Department of Medical Laboratory Technology, and Welfare, T.E.I. of Larissa, Greece.
School of
Purpose of this study is to prove neuropsychopharmaceutically the correlation among aggressiveness and level of testosterone in the blood. Against contradictory picture whom data of researches with human subjects offer in this matter, in some forms of aggressive behaviour the influence of androgenes hormones has more general empirical support. But data of researches with human as subjects report lower - comparatively to their sample - correlations between level of testosterone and aggressiveness. Such higher correlations are remarked during some phases of the periodical circle, especially at the phase of excretion of the progesterone. Notable is ascertainment that while the level of the testosterone presented fluctuations during the several phases of the periodical circle, the measurements of the aggressive behaviour remained firm. Parallelly, there are indications of increased aggressive behaviour at the phase that precedes the menstruation. Periodical circle before women present notable emotional instability (others of them subside into depressiveness and others present overexcitation). This behaviour, depends on the rate of the harmonic substances which affect the hypothalamus and limbic system (tonsil and diaphragm). These feminine hormones (progesterone and oestrogones) wane the rates of stoppers of monoaminoxidase.
Peculiarities of blood serotonin system in psychogenic depressive disorders
Drozdov,
B.M.
National Research Russ&
Kogan,
T.S. Filatova,
IV. Mankovsky.
Centre for Social and Forensic
Psychiatry,
Serbsky Moscow,
Despite of large number of studies there are some contradictory opinions about the state of platelet indoleamine uptake system in affective disorders up to now. 66 males in the age of 18-51 years with psychogenic depressive disorders correspondingly subdivided into three groups with hysterical, anxiety and asthenic syndromes were examined. There were two comparative groups composed of (1) 20 psychopathic persons without depression and (2) 15 healthy subjects. A serotonin content in the blood plasma and platelets by means of HPLC-EC methods were determined. Parameters of the ‘H-serotonin platelet uptake (V,,, and K,) were also measured. V“lax of the serotonin uptake by platelets in patients with depressive disorder exceeds control figures only in persons with anxious-depressive manifestations (606252 pmol/ lO”/min, p
Ultrastructural immunocytochemical localization of noradrenaline in locus coeruleus neurons of control and suicide brains M.R. Issidorides”.“, M. Chrysanthou-Piterou”, S. Havaki”,V. Krihoh, G.D. Pappass. aDepartment of Psychiatry, University of Athens, Eginition Hospital, Greece, bDepartment of Anatomy and Cell Biology, Medicine, University of Illinois at Chicago, (ISA
College
qf
Extensive studies have shown that a large fall in noradrenaline (NA) concentration in the locus coeruleus (LC) is critically involved in