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Treatment problems of cancer in the head and neck region preceded by cancer in other organs
International Congress Series 1240 (2003) 1019 – 1021
Treatment problems of cancer in the head and neck region preceded by cancer in other organs Madoka K. Furukawa a,*, Masaki Furukawa b a
Department of Head and Neck Surgery, Kanagawa Cancer Center. 1-1-2 Nakao, Asahi-ku, Yokohama, 241-0815, Japan b Division of Medical Informatics, Yokohama City University, Medical Center. 4-57 Urafune-cho, Minami-ku, Yokohama, 232-0024, Japan
Abstract We evaluated patients who developed cancer in the head and neck region after radical treatment of cancer in other organs. As the preceding cancer, esophageal cancer most markedly affected the selection of treatment principles because the area of radical operation and radiotherapy for this cancer overlaps with that for cancer in the head and neck region as the second cancer. D 2003 International Federation of Otorhinolaryngological Societies (IFOS). All rights reserved. Keywords: Head and neck; Double cancer; Other organ; Esophagus
1. Introduction Due to improvement in the diagnostic techniques and treatment results of cancer and the prolongation of survival, the incidence of metachronous double cancer has been annually increasing. In the treatment of cancer in the head and neck region, problems sometimes arise when there is preceding cancer in other organs. We evaluated patients who developed cancer in the head and neck region after radical treatment of cancer in other organs.
2. Material and methods The subjects were 35 patients who developed cancer in the head and neck region as the second cancer more than 1 year after radical treatment of cancer in other organs. As the * Corresponding author. Tel.: +81-45-391-5761; fax: +81-45-361-4692. E-mail addresses: [email protected] (M.K. Furukawa), [email protected] (M. Furukawa). 0531-5131/ D 2003 International Federation of Otorhinolaryngological Societies (IFOS). All rights reserved. doi:10.1016/S0531-5131(03)00734-9
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M.K. Furukawa, M. Furukawa / International Congress Series 1240 (2003) 1019–1021
Fig. 1. The survival curve of patients with double cancers. The survival period included the day when the diagnosis of head and neck cancers was established. The 5-year survival rate in patients with metachronous cancers was approximately 60%.
preceding cancer, esophageal cancer was observed in 10 patients, gastric cancer in 10, breast cancer in 4, lung cancer, large intestinal cancer, and bladder cancer each in 3 subjects, and liver cancer in 2. Cancer in the head and neck originated from the hypopharynx in 10 patients, oral cavity in 10, larynx in 9, mesopharynx in 4, and others in 2.
3. Results The 5-year survival rate in patients with metachronous cancers due to carcinomas of other organs was significantly more satisfactory compared to that in patients with simultaneous double cancer (Fig. 1). However, when the survival rate in patients with metachronous cancers in which esophageal cancer preceded the secondary cancer was evaluated, the 5-year survival rate in such patients was as low as that in patients with simultaneous double cancers.
4. Discussion Due to improvement in diagnostic techniques and the results of cancer treatment, as well as a prolonged mean life, the incidence of metachronous double cancers has been increasing every year [1,2]. There is no past report describing the treatment of cancer in the head and neck region preceded by cancer in other organs. It was considered that early detection of the secondary cancer was important in patients with metachronous cancers. However, when the preceding cancer was esophageal cancer,
M.K. Furukawa, M. Furukawa / International Congress Series 1240 (2003) 1019–1021
1021
the general condition of patients was often poor, and the outcome was poor compared with cancer in other organs. In the treatment of cancer in the head and neck region preceded by esophageal cancer, treatment principles should be established with consideration of the influence of the treatment of the preceding cancer and patient’s general condition so as not to impair the QOL.
References [1] J.A. Logemann, Manual for the Videofluorographic Study of Swallowing, 2nd ed., PRO-ED, Texas, 1993. [2] J.L. Miller, K.L. Watkin, Lateral pharyngeal wall motion during swallowing using real time ultrasound, Dysphagia 12 (3) (1997) 125 – 132.
Treatment problems of cancer in the head and neck region preceded by cancer in other organs Madoka K. Furukawa a,*, Masaki Furukawa b a
Department of Head and Neck Surgery, Kanagawa Cancer Center. 1-1-2 Nakao, Asahi-ku, Yokohama, 241-0815, Japan b Division of Medical Informatics, Yokohama City University, Medical Center. 4-57 Urafune-cho, Minami-ku, Yokohama, 232-0024, Japan
Abstract We evaluated patients who developed cancer in the head and neck region after radical treatment of cancer in other organs. As the preceding cancer, esophageal cancer most markedly affected the selection of treatment principles because the area of radical operation and radiotherapy for this cancer overlaps with that for cancer in the head and neck region as the second cancer. D 2003 International Federation of Otorhinolaryngological Societies (IFOS). All rights reserved. Keywords: Head and neck; Double cancer; Other organ; Esophagus
1. Introduction Due to improvement in the diagnostic techniques and treatment results of cancer and the prolongation of survival, the incidence of metachronous double cancer has been annually increasing. In the treatment of cancer in the head and neck region, problems sometimes arise when there is preceding cancer in other organs. We evaluated patients who developed cancer in the head and neck region after radical treatment of cancer in other organs.
2. Material and methods The subjects were 35 patients who developed cancer in the head and neck region as the second cancer more than 1 year after radical treatment of cancer in other organs. As the * Corresponding author. Tel.: +81-45-391-5761; fax: +81-45-361-4692. E-mail addresses: [email protected] (M.K. Furukawa), [email protected] (M. Furukawa). 0531-5131/ D 2003 International Federation of Otorhinolaryngological Societies (IFOS). All rights reserved. doi:10.1016/S0531-5131(03)00734-9
1020
M.K. Furukawa, M. Furukawa / International Congress Series 1240 (2003) 1019–1021
Fig. 1. The survival curve of patients with double cancers. The survival period included the day when the diagnosis of head and neck cancers was established. The 5-year survival rate in patients with metachronous cancers was approximately 60%.
preceding cancer, esophageal cancer was observed in 10 patients, gastric cancer in 10, breast cancer in 4, lung cancer, large intestinal cancer, and bladder cancer each in 3 subjects, and liver cancer in 2. Cancer in the head and neck originated from the hypopharynx in 10 patients, oral cavity in 10, larynx in 9, mesopharynx in 4, and others in 2.
3. Results The 5-year survival rate in patients with metachronous cancers due to carcinomas of other organs was significantly more satisfactory compared to that in patients with simultaneous double cancer (Fig. 1). However, when the survival rate in patients with metachronous cancers in which esophageal cancer preceded the secondary cancer was evaluated, the 5-year survival rate in such patients was as low as that in patients with simultaneous double cancers.
4. Discussion Due to improvement in diagnostic techniques and the results of cancer treatment, as well as a prolonged mean life, the incidence of metachronous double cancers has been increasing every year [1,2]. There is no past report describing the treatment of cancer in the head and neck region preceded by cancer in other organs. It was considered that early detection of the secondary cancer was important in patients with metachronous cancers. However, when the preceding cancer was esophageal cancer,
M.K. Furukawa, M. Furukawa / International Congress Series 1240 (2003) 1019–1021
1021
the general condition of patients was often poor, and the outcome was poor compared with cancer in other organs. In the treatment of cancer in the head and neck region preceded by esophageal cancer, treatment principles should be established with consideration of the influence of the treatment of the preceding cancer and patient’s general condition so as not to impair the QOL.
References [1] J.A. Logemann, Manual for the Videofluorographic Study of Swallowing, 2nd ed., PRO-ED, Texas, 1993. [2] J.L. Miller, K.L. Watkin, Lateral pharyngeal wall motion during swallowing using real time ultrasound, Dysphagia 12 (3) (1997) 125 – 132.