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Tuberculosis lymphadenitis in a south-eastern region in Tunisia: Epidemiology, clinical features, diagnosis and treatment
IJMYCO 192
No. of Pages 1, Model 7
20 November 2014 International Journal of Mycobacteriology
H O S T E D BY
x x x ( 2 0 1 4 ) x x x –x x x
Available at www.sciencedirect.com
ScienceDirect journal homepage: www.elsevier.com/locate/IJMYCO 6 7 3 4 5
8 Q1 9 10 11 12 13 14 15
Tuberculosis lymphadenitis in a south-eastern region in Tunisia: Epidemiology, clinical features, diagnosis and treatment S. Smaoui a,b,*, M.A. Mezghanni a, B. Hammami c, N. Zalila d, C. Marouane S. Kammoun a,b, A. Ghorbel e, M. Ben Jemaa c, F. Messadi-Akrout a,b
a,b
,
a
Regional Laboratory of Hygiene, Tunisia Faculty of Pharmacy Monastir, Tunisia c Department of Infectious Diseases CHU Hedi Chaker Sfax, Tunisia d Department of Care and Basic Health Sfax, Tunisia e Department Oto-Rhino-Laryngology CHU Habib Bourguiba Sfax, Tunisia b
16 1 8
A R T I C L E I N F O
A B S T R A C T
19 20 21 22
Article history:
Aim: To evaluate patients’ profiles, demographics, clinical and therapeutic approaches and
23 24 25 26 27 28 29
Keywords:
female/male ratio was 1.78 to 1. Raw milk consumption was noted in 1/3 of patients. Most
Tuberculous lymphadenitis
cases involved the head and neck region (83.4%), nodes involvement, including axillary (12
Epidemiology
cases), and mediastinal (9 cases). Clinical symptoms were present in only 55.2%. TST was
Microbiology
conducted with 82.6% positive responses. Diagnostics confirmation was done with anatom-
Treatment
ical pathology in most of the patients; only 56 of them had any microbiology analysis done.
Tunisia
Demonstration of acid-fast bacilli in microscopy from either fine-needle aspirates or biop-
Received 20 October 2014
strategies in patients with tuberculous lymphadenitis (TBG).
Accepted 21 October 2014
Patients and methods: A retrospective study of all TBG-confirmed cases admitted in a tuber-
Available online xxxx
culosis specific health care facility between 1 January 2009 and 16 June 2013. Results: A total of 181 clinical files were examined. Mean age was 32 years old; the
sies was done in 17.5%, and cultures yielded positive results in 27%. Treatment duration was varied. Paradoxical reactions were noted in 12% and persistent lymphadenopathy after treatment completion was noted in 10% of cases. Conclusions: TBG remains a disease of interest. Today, its diagnosis and management is still a problem despite its increasing worldwide incidence, and especially in this study area. Disease control should be strengthened in this country. Ó 2014 Published by Elsevier Ltd. on behalf of Asian-African Society for Mycobacteriology.
49 50
* Corresponding author. http://dx.doi.org/10.1016/j.ijmyco.2014.10.022 2212-5531/Ó 2014 Published by Elsevier Ltd. on behalf of Asian-African Society for Mycobacteriology.
Please cite this article in press as: S Smaoui et al. Tuberculosis lymphadenitis in a south-eastern region in Tunisia: Epidemiology, clinical features, diagnosis and treatment. Int. J. Mycobacteriol. (2014), http://dx.doi.org/10.1016/j.ijmyco.2014.10.022
No. of Pages 1, Model 7
20 November 2014 International Journal of Mycobacteriology
H O S T E D BY
x x x ( 2 0 1 4 ) x x x –x x x
Available at www.sciencedirect.com
ScienceDirect journal homepage: www.elsevier.com/locate/IJMYCO 6 7 3 4 5
8 Q1 9 10 11 12 13 14 15
Tuberculosis lymphadenitis in a south-eastern region in Tunisia: Epidemiology, clinical features, diagnosis and treatment S. Smaoui a,b,*, M.A. Mezghanni a, B. Hammami c, N. Zalila d, C. Marouane S. Kammoun a,b, A. Ghorbel e, M. Ben Jemaa c, F. Messadi-Akrout a,b
a,b
,
a
Regional Laboratory of Hygiene, Tunisia Faculty of Pharmacy Monastir, Tunisia c Department of Infectious Diseases CHU Hedi Chaker Sfax, Tunisia d Department of Care and Basic Health Sfax, Tunisia e Department Oto-Rhino-Laryngology CHU Habib Bourguiba Sfax, Tunisia b
16 1 8
A R T I C L E I N F O
A B S T R A C T
19 20 21 22
Article history:
Aim: To evaluate patients’ profiles, demographics, clinical and therapeutic approaches and
23 24 25 26 27 28 29
Keywords:
female/male ratio was 1.78 to 1. Raw milk consumption was noted in 1/3 of patients. Most
Tuberculous lymphadenitis
cases involved the head and neck region (83.4%), nodes involvement, including axillary (12
Epidemiology
cases), and mediastinal (9 cases). Clinical symptoms were present in only 55.2%. TST was
Microbiology
conducted with 82.6% positive responses. Diagnostics confirmation was done with anatom-
Treatment
ical pathology in most of the patients; only 56 of them had any microbiology analysis done.
Tunisia
Demonstration of acid-fast bacilli in microscopy from either fine-needle aspirates or biop-
Received 20 October 2014
strategies in patients with tuberculous lymphadenitis (TBG).
Accepted 21 October 2014
Patients and methods: A retrospective study of all TBG-confirmed cases admitted in a tuber-
Available online xxxx
culosis specific health care facility between 1 January 2009 and 16 June 2013. Results: A total of 181 clinical files were examined. Mean age was 32 years old; the
sies was done in 17.5%, and cultures yielded positive results in 27%. Treatment duration was varied. Paradoxical reactions were noted in 12% and persistent lymphadenopathy after treatment completion was noted in 10% of cases. Conclusions: TBG remains a disease of interest. Today, its diagnosis and management is still a problem despite its increasing worldwide incidence, and especially in this study area. Disease control should be strengthened in this country. Ó 2014 Published by Elsevier Ltd. on behalf of Asian-African Society for Mycobacteriology.
49 50
* Corresponding author. http://dx.doi.org/10.1016/j.ijmyco.2014.10.022 2212-5531/Ó 2014 Published by Elsevier Ltd. on behalf of Asian-African Society for Mycobacteriology.
Please cite this article in press as: S Smaoui et al. Tuberculosis lymphadenitis in a south-eastern region in Tunisia: Epidemiology, clinical features, diagnosis and treatment. Int. J. Mycobacteriol. (2014), http://dx.doi.org/10.1016/j.ijmyco.2014.10.022