ULTRASTRUCTURAL ABNORMALITY IN ALZHEIMER NEOCORTEX

511 " XBD=1011 XBD=1182XHG=719 XBD=335 XBD=407 XBD=710 XBD=960 XHG=124 XHG=345 XHG=417 XHG=970YBD=316 XHG=1020 YBD=317 YBD=316 YBD=317 YHG=294>TREATMENTS YHG=295>FOR YHG=294>CARDIOVASCULAR YHG=294>MANAGEMENT YHG=295>OF YHG=295>SCORPION " XBD=694 XHG=595 YBD=360 YHG=338>STING

" XBD=2225 XBD=2431 XHG=2236 XBD=1419 XBD=1467 XBD=1663 XBD=1829 XBD=1916 XBD=2119 XHG=1300 YBD=330 XHG=1429 XHG=1471 XHG=1675 XHG=1840 XHG=1927 XHG=2132 YBD=326 YHG=293>microscopy YBD=334 YBD=325 YBD=332 YHG=296>history YHG=296>of YHG=296>progressive YHG=296>dementia YHG=296>with YHG=295>myoclonus. YHG=294>Light " XBD=2436 XBD=1441 XHG=2317 XBD=1579 XBD=1653 XBD=1781 XBD=1907 XBD=2165 XBD=2302 XBD=2386 XHG=2398 YBD=365 XHG=1300 XHG=1451 XHG=1592 XHG=1664 XHG=1794 XHG=1919 XHG=2176 YBD=378 YHG=336>of YBD=369 YBD=376 YBD=377 YBD=368 YBD=367 YBD=366 YHG=341>revealed YHG=341>plaques YHG=341>and YHG=340>tangles YHG=340>typical YHG=338>of YHG=338>disease. YHG=337>Part Alzheimer’s " XBD=2430 XBD=1352 XHG=2369 XBD=1522 XBD=1596 XBD=1694 XBD=1747 XBD=1939 XBD=1984 XBD=2092 XBD=2357 XHG=1299 YBD=420 XHG=1365 XHG=1536 XHG=1610 XHG=1706 XHG=1759 XHG=1952 XHG=1997 XHG=2105 YBD=410 YHG=380>and YBD=421 YBD=413 YBD=412 YBD=411 YHG=383>the- 5% YHG=385>specimen YHG=394>was YHG=384>fixed YHG=385>by YHG=384>immersion YHG=384>in YHG=383>2 YHG=381>glutaraldehyde " XBD=1889 XBD=1464 XHG=1686 XBD=1523 XBD=1672 XHG=1299 YBD=465 XHG=1476 XHG=1537 YBD=464 YHG=429>microscopy. YBD=457 YBD=458 YHG=429>processed YHG=428>for YHG=429>electron

" XBD=2428 XBD=1478 XHG=2307 XBD=1695 XBD=1889 XBD=2036 XBD=2119 XBD=2279 XHG=1334 YBD=500 XHG=1500 XHG=1715 XHG=1909 XHG=2058 XHG=2138 YBD=502 YHG=470>Several YBD=510 YBD=509 YBD=501 YBD=508 YHG=470>Electron YHG=473>microscopy YHG=472>confirmed YHG=472>plaques YHG=472>and YHG=464>tangles. " XBD=2284 XBD=2428 XHG=2301 XBD=1444 XBD=1519 XBD=1577 XBD=1682 XBD=1783 XBD=1968 XBD=2143 XHG=1299 YBD=553 XHG=1463 XHG=1536 XHG=1594 XHG=1699 XHG=1802 XHG=1984 XHG=2160 YBD=550 YHG=515>profiles YBD=551 YBD=546 YBD=545 YHG=524>neurons, YHG=516>but YHG=526>no YHG=517>other YHG=517>cells, YHG=517>contained YHG=516>abnormal YHG=516>tubular " XBD=2428 XBD=1488 XHG=2035 XBD=1673 XBD=1763 XBD=1860 XBD=2018 XBD=2247 XHG=2263 YBD=590 XHG=1298 XHG=1504 XHG=1688 XHG=1780 XHG=1876 YBD=589 YHG=560>reticulum YBD=597 YHG=559>specifically YHG=561>associated YHG=561>with YHG=561>their YHG=561>granular YHG=561>endoplasmic " XBD=2428 XBD=1353 XHG=2275 XBD=1413 XBD=1522 XBD=1581 XBD=1679 XBD=1826 XBD=1925 XBD=1977 XBD=2133 XBD=2255 XHG=1297 YBD=634 XHG=1376 XHG=1435 XHG=1543 XHG=1593 XHG=1699 XHG=1846 XHG=1945 XHG=1997 XHG=2152 YBD=640 YHG=605>appeared YBD=632 YBD=641 YBD=633 YHG=602>(fig YHG=603>1). YHG=603>Most YHG=604>of YHG=605>these YHG=605>profiles YHG=614>were YHG=605>in YHG=614>neurons YHG=605>which " XBD=2427 XBD=1427 XHG=2395 XBD=1476 XBD=1571 XBD=1623 XBD=1695 XBD=1832 XBD=1886 XBD=1994 XBD=2148 XBD=2300 XBD=2376 XHG=1297 YBD=678 XHG=1448 XHG=1497 XHG=1591 XHG=1642 XHG=1715 XHG=1852 XHG=1906 XHG=2015 XHG=2167 XHG=2320 YBD=681 YHG=649>in YBD=676 YBD=677 YBD=683 YHG=647>normal, YHG=654>at YHG=648>least YHG=648>in YHG=648>the YHG=649>section YHG=658>or YHG=649>serial YHG=649>sections YHG=649>studied, YHG=649>but

" XBD=1412 XBD=1584 XBD=1652 XBD=1801 XBD=1950 XBD=2030 XBD=2211 XBD=2353 XHG=1297 XHG=1429 XHG=1600 XHG=1668 XHG=1816 XHG=1967 XHG=2046 XHG=2226 XHG=2371 YBD=728 YBD=720 YBD=721 YBD=729 YBD=722 YHG=691>several YHG=691>examples YHG=692>the YHG=691>affected YHG=702>neurons YHG=693>also YHG=693>contained YHG=693>tangles. YHG=693>We *CVS " XBD=2426 XBD=372 XBD=484 XBD=571 XBD=691 XBD=758 XBD=857 XBD=935 XBD=1016 XBD=1078 XBD=1206 XHG=168 XHG=393 XHG=506 XHG=593 XHG=713 XHG=779 XHG=878 XHG=956YBD=731 XHG=1039 XHG=1099 YBD=732 YBD=738 YBD=736 YBD=730 YBD=736 YBD=731 YBD=737 YHG=710>Cardiovascular YHG=715>system; YHG=710>other YHG=714>patients YHG=709>had YHG=715>severe YHG=709>local YHG=710>pain. YHG=710>No YHG=710>systemic " XBD=272 XHG=97 YBD=767 YHG=745>manifestations. " XBD=2427 XBD=1373 XBD=1487 XBD=1593 XBD=1647 XBD=1794 XBD=1942 XBD=1988 XBD=2063 XBD=2214 XBD=2332 XHG=1296 XHG=1388 XHG=1500 XHG=1607 XHG=1662 XHG=1807 XHG=1956 XHG=2001 XHG=2077 XHG=2227 XHG=2346 YBD=764 YBD=765 YBD=774 YBD=766 YBD=767 YHG=736>have YHG=735>found YHG=736>about YHG=736>20 YHG=735>affected YHG=745>neurons YHG=737>in YHG=744>two YHG=744>separate YHG=737>blocks YHG=737>from " XBD=284 XBD=395 XBD=594 XBD=650 XHG=97 XHG=294 XHG=405 XHG=605 YBD=807 YBD=806 YBD=800 YHG=779>tA=frusemide, YHG=779>digoxm, YHG=778>ammophylline, YHG=778>and YHG=778>steroids. " XBD=763 XBD=1358XHG=660 XBD=1552 XBD=1667 XBD=1732 XBD=1837 XBD=1998 XBD=2190 XBD=2426 XHG=1296 XHG=1384 XHG=1580 XHG=1694 XHG=1751 XHG=1863 XHG=2025 XHG=2215 YBD=817 YBD=808 YBD=809 YBD=810 YBD=811 YHG=780>this YHG=780>specimen. YHG=779>Most YHG=779>of YHG=781>these YHG=790>neurons YHG=782>contained YHG=782>considerable " XBD=2426 XBD=1444 XHG=2373 XBD=1498 XBD=1646 XBD=1811 XBD=1866 XBD=1915 XBD=1980 XBD=2036 XBD=2224 XBD=2358 XHG=1296 YBD=855 XHG=1460 XHG=1509 XHG=1663 XHG=1827 XHG=1882 XHG=1933 XHG=2000 XHG=2052 XHG=2240 YBD=861 YBD=862 YBD=852 YBD=853 YBD=854 YHG=825>numbers YHG=824>of YHG=823>profiles, YHG=824>typically YHG=825>20 YHG=831>to YHG=826>50. YHG=825>In YHG=832>transverse YHG=826>section YHG=826>the 41 "" XBD=1207 XBD=124 XBD=291 XBD=376 XBD=570 XBD=798 XBD=900 XBD=1009 XBD=1121 XHG=97 XHG=147 XHG=314 XHG=399 XHG=664 XHG=823 XHG=924 XHG=1035 XHG=1145 YBD=879 YBD=878 YBD=885 YBD=878 YBD=887 YBD=879 YHG=858>as YHG=848>vomiting YHG=848>and YHG=840>sweating. YHG=848>patients YHG=849>aged YHG=849>8-52 YHG=858>years YHG=849>had XBD=1420 XBD=1556 XBD=1722 XBD=1769 XBD=1833 XBD=2020 XBD=2127 XBD=2348 XBD=2425 XHG=1296 XHG=1429 XHG=1566 XHG=1731 XHG=1772 XHG=1843 XHG=2030 XHG=2137 XHG=2357 YBD=906 YBD=897 YBD=898 YBD=907 YBD=899 YHG=869>tubular YHG=868>profiles YHG=868>consisted YHG=868>of YHG=875>two YHG=870>concentric YHG=869>layers YHG=870>of YHG=870>unit trilaminar " XBD=303 XBD=437 XBD=479 XBD=624 XBD=701 XBD=774 XBD=861 XBD=956 XBD=1164 XBD=1212 XHG=97 XHG=312 XHG=447 XHG=490 XHG=636 XHG=710 XHG=783 XHG=871 XHG=966 XHG=1174 YBD=931 YBD=922 YBD=930 YBD=923 YBD=931 YBD=923 YHG=893>hypertension YHG=892>(130/90 YHG=899>to YHG=892>200/110 YHG=902>mm YHG=893>Hg) YHG=892>with YHG=893>sinus YHG=893>bradycardia YHG=894>of " XBD=1474 XBD=1572 XBD=1632 XBD=1769 XBD=1939 XBD=2000 XBD=2109 XBD=2171 XBD=2249 XBD=2332 XBD=2426 XHG=1296 XHG=1496 XHG=1594 XHG=1655 XHG=1792 XHG=1961 XHG=2016 XHG=2133 XHG=2194 XHG=2271 XHG=2352 YBD=941 YBD=942 YBD=943 YBD=952 YHG=914>membrane YHG=913>with YHG=923>an YHG=913>overall YHG=913>diameter YHG=913>of YHG=914>about YHG=914>75 YHG=923>nm YHG=914>and YHG=914>they " XBD=278 XBD=313 XBD=563 XBD=685 XBD=776 XBD=945 XBD=1062 XBD=1205 XHG=97 XHG=298 XHG=332 XHG=583 XHG=703 XHG=796 XHG=964 XHG=1081 YBD=971 YBD=966 YBD=974 YBD=975 YBD=967 YBD=974 YBD=975 YHG=936>38-52/min, YHG=946>a YHG=937>protodiastolic YHG=937>gallop YHG=937>(S3), YHG=937>transient YHG=937>apical YHG=938>systolic " XBD=1449 XBD=1506 XBD=1572 XBD=1708 XBD=1786 XBD=1961 XBD=2025 XBD=2187 XBD=2425 XHG=1296 XHG=1473 XHG=1533 XHG=1597 XHG=1733 XHG=1812 XHG=1987 XHG=2045 XHG=2213 YBD=987 YBD=986 YBD=994 YBD=995 YHG=958>appeared YHG=965>to YHG=957>lie YHG=957>within YHG=957>the YHG=957>cisternae YHG=957>of YHG=958>granular YHG=958>endoplasmic " XBD=232 XBD=426 XBD=558 XBD=623 XBD=695 XBD=1050 XBD=1205 XHG=97 XHG=243 XHG=435 XHG=567 XHG=634 XHG=703 XHG=1059 YBD=1016 YBD=1018 YBD=1019 YBD=1016 YBD=1011 YBD=1018 YBD=1011 YHG=990>murmur, YHG=982>parasternal YHG=981>systolic YHG=981>lift, YHG=981>and YHG=982>evidence " XBD=2424 XBD=1469 XHG=2393 XBD=1593 XBD=1666 XBD=1936 XBD=2010 XBD=2200 XBD=2374 XHG=1296 YBD=1031 XHG=1493 XHG=1614 XHG=1688 XHG=1957 XHG=2032 XHG=2221 YBD=1032YHG=981>electrocardiographic YBD=1030 YBD=1029 YBD=1038 YHG=1002>reticulum. YHG=1002>When YHG=1008>cut YHG=1001>longitudinally, YHG=1001>the YHG=1008>structures YHG=1002>appeared YHG=1011>as " XBD=129 XBD=186 XBD=327 XBD=515 XBD=591 XBD=709 XBD=752 XBD=866 XBD=912 XBD=1097 XBD=1202 XHG=96 XHG=136 XHG=199 XHG=341 XHG=529 XHG=603 XHG=723 XHG=765 XHG=880 XHG=925 XHG=1111 YBD=1056 YBD=1054 YBD=1056 YBD=1055 YBD=1063 YBD=1055 YHG=1025>of YHG=1025>left YHG=1025>anterior YHG=1025>hemiblock YHG=1026>and YHG=1025>tented YHG=1026>T YHG=1035>waves YHG=1026>in YHG=1026>precordial YHG=1025>leads. " XBD=1458 XBD=1568 XBD=1675 XBD=1806 XBD=1880 XBD=2113 XBD=2309 XBD=2387 XBD=2425 XHG=1295 XHG=1478 XHG=1590 XHG=1696 XHG=1827 XHG=1901 XHG=2134 XHG=2331 XHG=2408 YBD=1084 YBD=1076 YBD=1075 YBD=1083 YBD=1080 YBD=1074 YHG=1046>elongated YHG=1046>tubes YHG=1046>lying YHG=1046>within YHG=1046>the YHG=1045>endoplasmic YHG=1045>reticulum, YHG=1045>but YHG=1055>a " XBD=210 XBD=406 XBD=684 XBD=770 XBD=922 XBD=1007 XBD=1121 XBD=1205 XHG=97 XHG=232 XHG=430 XHG=710 XHG=792 XHG=944 XHG=1030 XHG=1144 YBD=1100 YBD=1105 YBD=1108 YBD=1100 YBD=1108 YBD=1108 YBD=1100 YHG=1070>Besides YHG=1070>frusemide, YHG=1070>aminophylline, YHG=1070>and YHG=1070>steroids YHG=1070>(see YHG=1070>table) " XBD=2424 XBD=1427 XHG=2408 XBD=1480 XBD=1565 XBD=1660 XBD=1775 XBD=1892 XBD=1959 XBD=2064 XBD=2257 XBD=2394 XHG=1295 YBD=1118 XHG=1442 XHG=1489 XHG=1580 XHG=1675 XHG=1789 XHG=1906 XHG=1975 XHG=2079 XHG=2273 YBD=1120 YHG=1071>and YBD=1119 YHG=1091>number YHG=1089>of YHG=1091>ends YHG=1100>were YHG=1090>found YHG=1090>where YHG=1090>the YHG=1090>inner YHG=1089>membrane YHG=1089>formed YHG=1099>a " XBD=233 XHG=924 XBD=305 XBD=456 XBD=704 XBD=774 XBD=877 XBD=915 XBD=941 XBD=1048 XBD=1121 XBD=1204 XHG=96 XHG=244 XHG=315 XHG=465 XHG=714 XHG=785 XHG=886 XHG=951 XHG=1058 XHG=1131 YBD=1152 YBD=1151 YBD=1152 YBD=1144 YBD=1143 YBD=1151 YBD=1144 YHG=1115>atropine, YHG=1114>oral YHG=1115>prazosin YHG=1115>hydrochloride YHG=1124>was YHG=1115>given YHG=1121>at YHG=1124>a YHG=1114>single YHG=1115>oral YHG=1115>dose " XBD=2423 XBD=1399 XBD=1501 XBD=1594 XBD=1675 XBD=1794 XBD=2002 XBD=2138 XBD=2243 XBD=2334 XHG=1295 XHG=1428 XHG=1533 XHG=1623 XHG=1705 XHG=1824 XHG=2032 XHG=2166 XHG=2273 XHG=2363 YBD=1164 YBD=1163 YBD=1161 YBD=1162 YHG=1134>closed YHG=1134>tube YHG=1135>and YHG=1135>the YHG=1141>outer YHG=1135>membrane YHG=1133>folded YHG=1133>back YHG=1133>and YHG=1142>was |>" " XBD=128 XBD=198 XBD=312 XBD=472 XBD=556 XBD=638 XBD=754 XBD=887 XBD=1044 XBD=1150 XBD=1211 XBD=260 XHG=96 XHG=146 XHG=281 XHG=334 XHG=495 XHG=578 XHG=723 XHG=776 XHG=911 XHG=1067 XHG=1173 XHG=219 YBD=1189 YBD=1187 YBD=1188 YBD=1189 YBD=1188 YBD=1196 YBD=1195 YBD=1188 YHG=1159>of g YHG=1159>125 YHG=1159>children YHG=1159>and YHG=1160>500 YHG=1159>in YHG=1159>adults. YHG=1158>Clinical YHG=1168>Mg YHG=1159>signs YHG=1159>of " XBD=1202 XBD=322 XHG=891 XBD=546 XBD=725 XBD=839 XBD=877 XBD=968 XBD=1035 XHG=96 XHG=338 XHG=562 XHG=739 XHG=855 XHG=983 XHG=1050 YBD=1234 YBD=1242 YBD=1233 YBD=1232 YBD=1240 YHG=1203>cardiovascular YHG=1203>involvement YHG=1203>improved YHG=1205>21/2-3 YHG=1203>h YHG=1203>after YHG=1203>the YHG=1203>prazosin. " XBD=1204 XBD=209 XHG=822 XBD=376 XBD=540 XBD=602 XBD=682 XBD=805 XBD=925 XBD=1024 XBD=1118 XHG=96 XHG=223 XHG=391 XHG=553 XHG=616 XHG=696 XHG=940 XHG=1038 XHG=1132 YBD=1278 YBD=1277 YBD=1286 YBD=1278 YBD=1278 YBD=1278 YBD=1277 YHG=1249>T-wave YHG=1248>inversion YHG=1248>persisted YHG=1248>for YHG=1250>3-4 YHG=1249>weeks. YHG=1248>These YHG=1258>cases YHG=1257>were YHG=1257>seen " XBD=434 XBD=152 XHG=344 XBD=184 XBD=269 XBD=331 XHG=96 YBD=1323 XHG=164 XHG=196 XHG=281 YBD=1322YHG=1294>3-4 YBD=1321 YBD=1329 YHG=1293>h YHG=1291>after YHG=1292>the YHG=1293>sting. " XBD=1201 XBD=160 XHG=751 XBD=306 XBD=403 XBD=542 XBD=649 XBD=731 XBD=839 XBD=1045 XHG=124 XHG=179 XHG=327 XHG=422 XHG=563 XHG=669 XHG=859YBD=1367 XHG=1065 YBD=1374 YBD=1365 YBD=1375 YBD=1366 YBD=1375 YBD=1371 YHG=1338>24 YHG=1336>patients YHG=1337>aged YHG=1338>21/2-40 YHG=1346>years YHG=1337>had YHG=1343>acute YHG=1337>pulmonary YHG=1337>oedema,

" XBD=1202 XBD=274 XHG=729 XBD=528 XBD=608 XBD=713 XBD=875 XBD=1074 XHG=96 XHG=289 XHG=546 XHG=624 XHG=892YBD=1420 XHG=1090 YBD=1420 YBD=1412 YBD=1420 YBD=1420 YHG=1382>tachycardia YHG=1373>(72-180/min), YHG=1383>and YHG=1382>ECG YHG=1383>evidence YHG=1382>of YHG=1382>injury. hypoxic " XBD=1203 XBD=186 XHG=895 XBD=274 XBD=360 XBD=440 XBD=513 XBD=543 XBD=628 XBD=687 XBD=787 XBD=889 XBD=975 XBD=1074 XHG=95 XHG=195 XHG=282 XHG=369 XHG=447 XHG=521 XHG=550 XHG=636 XHG=696 XHG=797 XHG=983 XHG=1083 YBD=1455 YBD=1454 YBD=1455 YBD=1463 YBD=1464 YBD=1456 YBD=1463 YBD=1463 YHG=1426>These YHG=1435>cases YHG=1435>seen YHG=1426>4-6 YHG=1425>h YHG=1426>after YHG=1426>the YHG=1426>sting. YHG=1426>They YHG=1435>were YHG=1426>given YHG=1435>oxygen

" XBD=1202 XBD=148 XHG=670 XBD=322 XBD=500 XBD=540 XBD=661 XBD=924 XBD=1122 XHG=95 XHG=155 XHG=331 XHG=509 XHG=549 XHG=931 XHG=1133 YBD=1500 YBD=1507 YBD=1499 YBD=1500 YBD=1507 YBD=1499 YHG=1471>and YHG=1470>sublingual YHG=1470>isosorbide YHG=1477>to YHG=1470>reduce YHG=1470>left-ventricular YHG=1471>impedance. YHG=1470>The

" XBD=1201 XBD=265 XHG=857 XBD=403 XBD=490 XBD=569 XBD=605 XBD=652 XBD=837 XBD=869 XBD=1004 XBD=1079 XBD=1108 XHG=95 XHG=278 XHG=417 XHG=505 XHG=584 XHG=619 XHG=666 XHG=887YBD=1552 XHG=1018 XHG=1092 XHG=1122 YBD=1544 YBD=1552 YBD=1543 YBD=1552 YBD=1544 YHG=1514>pulmonary YHG=1515>oedema YHG=1514>took YHG=1509>5-6 YHG=1514>h YHG=1521>to YHG=1515>disappear. YHG=1516>1 YHG=1515>patient YHG=1515>had YHG=1524>a YHG=1515>first" " " " " " " " "

XBD=1202XHG=806 XBD=158 XBD=257 XBD=328 XBD=372 XBD=536 XBD=749 XBD=792 XBD=909 XBD=1129 XHG=95 XHG=170 XHG=270 XHG=340 XHG=385 XHG=550 XHG=761 XHG=921 XHG=1141 YBD=1588 YBD=1589 YBD=1587 YBD=1595 YBD=1588 YBD=1597 YBD=1588 YHG=1559>dose YHG=1558>effect YHG=1558>due YHG=1565>to YHG=1559>prazosin, YHG=1558>manifesting YHG=1568>as YHG=1568>severe YHG=1559>hypotension YHG=1559>and XBD=200 XHG=891 XBD=313 XBD=389 XBD=519 XBD=593 XBD=807 XBD=881 XBD=954 XBD=1148 XBD=1201 XHG=94 XHG=212 XHG=327 XHG=402 XHG=532 XHG=607 XHG=819 XHG=967 XHG=1160 YBD=1632 YBD=1638 YBD=1639 YBD=1632 YBD=1633 YBD=1640 YBD=1632 YHG=1603>cardiac YHG=1609>arrest; YHG=1602>this YHG=1603>patient YHG=1603>resuscitated YHG=1603>and YHG=1612>was YHG=1603>discharged YHG=1612>on XBD=144 XHG=802 XBD=182 XBD=212 XBD=288 XBD=434 XBD=481 XBD=571 XBD=687 XBD=789 XBD=988 XBD=1127 XBD=1202 XHG=94 XHG=156 XHG=201 XHG=229 XHG=301 XHG=448 XHG=494 XHG=583 XHG=700 XHG=1001 XHG=1140 YBD=1685 YBD=1675 YBD=1684 YBD=1677 YBD=1676 YBD=1685 YBD=1677 YBD=1676 YHG=1648>day YHG=1649>7. YHG=1648>1 YHG=1657>was YHG=1646>brought YHG=1647>in YHG=1647>with YHG=1656>severe YHG=1654>acute YHG=1647>pulmonary YHG=1647>oedema YHG=1647>and XBD=150 XHG=785 XBD=385 XBD=525 XBD=614 XBD=721 XBD=772 XBD=950 XBD=1036 XBD=1067 XBD=1101 XBD=1153 XBD=1204 XHG=97 XHG=162 XHG=397 XHG=538 XHG=627 XHG=734 XHG=960 XHG=1047 XHG=1079 XHG=1113 XHG=1165 YBD=1723 YBD=1731 YBD=1730 YBD=1727 YBD=1721 YBD=1722 YBD=1723 YBD=1723 YBD=1724 YBD=1725 YHG=1703>was YHG=1694>expectorating YHG=1694>copious YHG=1693>pink YHG=1693>froth; YHG=1693>he YHG=1693>recovered YHG=1694>with YHG=1695>4 YHG=1695>h YHG=1705>on YHG=1705>an XBD=276 XHG=524 XBD=511 XBD=603 XHG=94 YBD=1766 XHG=289 YBD=1773YHG=1736>intravenous YHG=1733>nitroprusside YHG=1736>drip. XBD=157 XHG=905 XBD=302 XBD=451 XBD=517 XBD=546 XBD=657 XBD=749 XBD=894 XBD=939 XBD=1015 XBD=1048 XBD=1136 XBD=1200 XHG=125 XHG=169 XHG=313 XHG=462 XHG=529 XHG=559 XHG=668 XHG=759 XHG=951YBD=1809 XHG=1027 XHG=1059 XHG=1148 YBD=1817 YBD=1810 YBD=1818 YBD=1809 YBD=1809 YBD=1810 YHG=1781>14 YHG=1780>children YHG=1781>(average YHG=1790>age YHG=1781>5 YHG=1781>years) YHG=1790>were YHG=1780>brought YHG=1781>in YHG=1781>3-4 YHG=1780>h YHG=1780>after YHG=1781>the XBD=164 XHG=827 XBD=293 XBD=525 XBD=768 XBD=946 XBD=1199 XHG=93 XHG=219 XHG=351 XHG=584 XHG=1007 YBD=1862 YBD=1854 YBD=1863 YBD=1860 YBD=1862 YHG=1826>sting YHG=1825>with YHG=1825>peripheral YHG=1824>circulatory YHG=1824>failure, YHG=1825>tachycardia XBD=337 XHG=847 XBD=412 XBD=639 XBD=745 XBD=836 XBD=880 XBD=1084 XBD=1199 XHG=93 XHG=351 XHG=422 XHG=653 XHG=755 XHG=890 XHG=1095 YBD=1907 YBD=1906 YBD=1898 YBD=1905 YBD=1897 YHG=1868>(140-180/min), YHG=1868>and YHG=1868>hypotension. YHG=1868>Some YHG=1878>were YHG=1869>in YHG=1869>cardiogenic YHG=1868>shock. XBD=305 XHG=878 XBD=348 XBD=479 XBD=584 XBD=672 XBD=722 XBD=868 XBD=911 XBD=1016 XBD=1197 XHG=92 XHG=315 XHG=359 XHG=490 XHG=596 XHG=682 XHG=732 XHG=920 XHG=1026 YBD=1951 YBD=1950 YBD=1943 YBD=1942 YBD=1943 YBD=1950 YHG=1914>Improvement YHG=1913>clinical YHG=1914>signs, YHG=1913>with YHG=1923>an YHG=1914>increase YHG=1914>in YHG=1913>tissue YHG=1913>perfusion,

" XBD=977 XBD=1020XHG=937 XBD=144 XBD=224 XBD=342 XBD=373 XBD=417 XBD=520 XBD=665 XBD=881 XBD=924 XHG=91 XHG=156 XHG=235 XHG=356 XHG=387 XHG=431 XHG=531 XHG=677 XHG=892 XHG=990 YBD=1987 YBD=1987 YBD=1993 YBD=1994 YBD=1986 YBD=1986 YHG=1967>was YHG=1967>seen YHG=1957>within YHG=1959>3 YHG=1957>h; YHG=1957>ECG YHG=1958>changes YHG=1957>disappeared YHG=1958>in YHG=1958>24 YHG=1957>h. " XBD=1200 XBD=258 XHG=541 XBD=394 XBD=531 XBD=603 XBD=867 XBD=1058 XHG=613 XHG=123 XHG=269 XHG=405 XHG=878YBD=2033 XHG=1069 YBD=2034 YBD=2041 YBD=2040 YBD=2032 YHG=2003>Prazosin YHG=2004>reduces YHG=2004>preload YHG=2004>and YHG=2004>left-ventricular YHG=2003>impedance YHG=2003>without

"|>"XBD=1198 XBD=192 XBD=259 XBD=360 XBD=640 XBD=771 XBD=814 XBD=849 XBD=974 XBD=466XHG=867 XHG=91 XHG=209 XHG=277 XHG=488 XHG=657 XHG=789 XHG=833 XHG=993 XHG=378 YBD=2083 YBD=2082 YBD=2075 YBD=2083 YBD=2084 YBD=2075 YHG=2047>raising YHG=2047>the YHG=2046>heart YHG=2044>Scorpion YHG=2055>venom YHG=2046>is YHG=2056>a YHG=2052>potent YHG=2046>sympathetic YHG=2044>rate. " XBD=1121 XBD=1199XHG=576 XBD=258 XBD=423 XBD=470 XBD=561 XBD=758 XBD=1013 XHG=91 XHG=275 XHG=437 XHG=485 XHG=772 XHG=1029 XHG=1137 YBD=2125 YBD=2118 YBD=2126 YBD=2119 YBD=2119 YHG=2090>stimulator, YHG=2090>resulting YHG=2091>in YHG=2090>high YHG=2090>circulating YHG=2090>catecholamine YHG=2090>levels YHG=2090>and " XBD=1197 XBD=247 XHG=722 XBD=507 XBD=709 XBD=867 XBD=947 XBD=1032 XBD=1156 XHG=877 XHG=90 XHG=257 XHG=518 XHG=956 XHG=1043 XHG=1165 YBD=2171 YBD=2170 YBD=2163 YBD=2171 YBD=2163 YBD=2170 YBD=2163 YHG=2134>increasing YHG=2134>left-ventricular YHG=2134>impedance. YHG=2134>Prazosin YHG=2143>may YHG=2134>have YHG=2134>helped YHG=2140>to " XBD=1197 XBD=214 XHG=885 XBD=289 XBD=566 XBD=773 XBD=861 XBD=916 XBD=1076 XHG=90 XHG=239 XHG=314 XHG=592 XHG=799 XHG=941 XHG=1102 YBD=2208 YBD=2208 YBD=2215 YBD=2207 YBD=2208 YBD=2208 YHG=2179>alleviate YHG=2178>the YHG=2178>left-ventricular YHG=2178>impedance YHG=2178>and YHG=2185>to YHG=2178>increase YHG=2179>tissue

" XBD=1196 XBD=244 XHG=919 XBD=333 XBD=406 XBD=471 XBD=498 XBD=682 XBD=867 XBD=915 XBD=972 XBD=1071 XBD=1134 XHG=90 XHG=257 XHG=344 XHG=417 XHG=481 XHG=510 XHG=691 XHG=878 XHG=983 XHG=1083 XHG=1144 YBD=2260 YBD=2252 YBD=2251 YBD=2260 YBD=2252 YHG=2223>perfusion. YHG=2223>This YHG=2232>was YHG=2229>not YHG=2233>a YHG=2222>controlled YHG=2222>evaluation YHG=2222>of YHG=2223>the YHG=2223>drug. YHG=2223>All YHG=2222>the

" XBD=1196 XBD=162 XHG=784 XBD=308 XBD=554 XBD=636 XBD=774 XBD=836 XBD=1069 XHG=90 XHG=171 XHG=318 XHG=565 XHG=645 XHG=846YBD=2296 XHG=1078 YBD=2306 YBD=2304 YBD=2296 YBD=2304 YBD=2296 YHG=2277>same YHG=2268>prazosin YHG=2267>hydrochloride YHG=2276>may YHG=2265>counter YHG=2267>the YHG=2266>physiological YHG=2267>actions " XBD=1200 XBD=125 XHG=874 XBD=266 XBD=388 XBD=439 XBD=502 XBD=718 XBD=863 XBD=997 XBD=1072 XBD=1152 XHG=92 XHG=130 XHG=276 XHG=399 XHG=449 XHG=513 XHG=730 XHG=1010 XHG=1082 XHG=1161 YBD=2342 YBD=2342 YBD=2341 YBD=2350 YBD=2349 YBD=2341 YHG=2313>of YHG=2314>scorpion YHG=2322>venom YHG=2322>on YHG=2313>the YHG=2312>sympathetic YHG=2320>nervous YHG=2318>system, YHG=2313>and YHG=2321>may YHG=2312>be

" XBD=1200 XBD=181 XHG=824 XBD=294 XBD=411 XBD=571 XBD=767 XBD=807 XBD=879 XBD=1050 XHG=91 XHG=195 XHG=309 XHG=427 XHG=588 XHG=782 XHG=894YBD=2386 XHG=1068 YBD=2394 YBD=2386 YBD=2393 YBD=2385 YBD=2385 YBD=2385 YHG=2356>worth YHG=2356>trying YHG=2357>where YHG=2356>scorpion YHG=2357>antivenom YHG=2356>is YHG=2362>not YHG=2356>available. YHG=2351>Further " XBD=406 XBD=165 XHG=257 XBD=201 XBD=245 XHG=91 YBD=2438 XHG=177 XHG=213 YBD=2430YHG=2400>work YBD=2429 YBD=2437 YHG=2400>is YHG=2400>in YHG=2409>progress. Rural Hospital,

Poladpur, Maharashtra, India 402

303

H. S. BAWASKAR P. H. BAWASKAR

1 Bawaskar HS. Scorpion sting and cardiovascular complication. Indian Heart J 1977; " XBD=2309 XBD=2428 XBD=1352 XBD=1562 XBD=1773 XBD=1823 XBD=1956 XBD=2095 XBD=2167 XHG=1299 YBD=2651 XHG=1368 XHG=1577 XHG=1788 XHG=1832 XHG=1969 XHG=2109 XHG=2183 YBD=2653 YHG=2626>within YBD=2652 YBD=2660 YBD=2658 YBD=2657 YHG=2626>Fig YHG=2628>I-Electron YHG=2628>micrograph YHG=2628>of YHG=2628>tubular YHG=2628>profiles YHG=2628>(eg, YHG=2627>arrows) 29: 228. XHG=2323 " XBD=2428 XBD=1490 XBD=1561 XBD=1801 XBD=1999 XBD=2068 XBD=2272 XBD=2364 XHG=2397 XHG=1341 XHG=1525 XHG=1590 XHG=1834 XHG=2033 XHG=2097 XHG=2306 YBD=2691 YBD=2692 YBD=2698 YBD=2690 YHG=2666>cisternae YHG=2666>of YHG=2667>endoplasmic YHG=2667>reticulum YHG=2667>of YHG=2666>pyramidal YHG=2666>cell YHG=2665>in 2. Bawaskar HS. Diagnostic cardiac premonitory signs and symptoms of red scorpion " XBD=2428 XBD=1525 XBD=1661 XBD=1844 XBD=1952 XBD=2100 XBD=2198 XHG=1341 XHG=1552 XHG=1688 XHG=1870 XHG=1979 XHG=2127 XHG=2226 YBD=2737 YHG=2704>Alzheimer’s YBD=2730 YBD=2729 YHG=2705>neocortical YHG=2705>biopsy YHG=2706>specimen YHG=2706>from YHG=2713>woman YHG=2705>with 1982; i: 552-54. sting. Lancet

" XBD=1642 XBD=1459 XBD=1553 3. Bawaskar HS. XHG=1341 XHG=1490 XHG=1567 YBD=2769 YBD=2768 YHG=2744>disease YHG=2745>x YHG=2745>000). Trans Roy Soc Trop 414-15. Scorpion sting.YBD=2774 Med Hyg 1984; 78:60 4. Gaitonde BB,

(

Jadhav SS, Bawaskar HS. Pulmonary oedema after scorpion sting. Lancet

1978; i: 445-46. 5. Mundle PM. Scorpion sting. Br Med J 1961; ii: 1042. 6. Gueron M, Yaron R. Cardiovascular manifestation of severe scorpion sting. Chest

1970; 57: 156-62. 7. Gueron M, Stern J, Cohen W. Severe myocardial damage and heart failure in scorpion sting. Am JCardiol 1967; 9: 719-26. 8. Miller R, Avan NA, et al. Mason Sustained reduction of cardiac impedance and preload in congestive heart failure with the N Engl J Med 1977; 297: 303-07.

antihypertensive vasodilatory prazosin

ULTRASTRUCTURAL ABNORMALITY IN ALZHEIMER NEOCORTEX

" XBD=914 XBD=1196XHG=708 XBD=267 XBD=405 XBD=457 XBD=672 XHG=117 XHG=303 XHG=442 XHG=495 XHG=950YBD=3351 YBD=3355 YBD=3357 YBD=3350 YBD=3358 YBD=3352YHG=3322>undescribed YHG=3319>SIR,-We YHG=3327>report YHG=3331>a YHG=3322>previously YHG=3322>ultrastructural " XBD=1196 XBD=279 XHG=679 XBD=324 XBD=357 XBD=537 XBD=663 XBD=837 XBD=892 XBD=1067 XBD=1164 XHG=854 XHG=86 XHG=294 XHG=340 XHG=373 XHG=551 XHG=902 XHG=1083 XHG=1180 YBD=3401 YBD=3393 YBD=3402 YBD=3394 YBD=3395 YBD=3395 YHG=3363>abnormality YHG=3364>in YHG=3374>a YHG=3364>well-fixed YHG=3365>biopsy YHG=3366>specimen YHG=3365>of YHG=3372>neocortex YHG=3366>from YHG=3375>a XBD=194 XHG=503 XBD=280 XBD=490 XBD=629 XHG=86 XHG=206 XHG=291 YBD=3442 YBD=3436 YBD=3437 YHG=3407>patient YHG=3407>with YHG=3407>Alzheimer’s YHG=3408>disease. " XBD=2429 XBD=1352 XBD=1623 XBD=1778 XBD=1997 XBD=2153 XBD=2233 XBD=2289 XHG=1299 XHG=1372 XHG=1644 XHG=1800 XHG=2018 XHG=2173 XHG=2254 XHG=2305 YBD=3446 YBD=3448 YBD=3449 YBD=3442 YBD=3444 YHG=3415>Fig YHG=3416>2-High-power YHG=3417>electron YHG=3417>micrograph YHG=3417>showing YHG=3418>end YHG=3418>of YHG=3419>tubular " XBD=1646 XBD=1556 XHG=1481 XHG=1571 YBD=3479 YBD=3485 YHG=3455>160 YHG=3455>000). XBD=290 XHG=854 XBD=408 XBD=477 XBD=567 XBD=619 XBD=645 XBD=845 XBD=976 XBD=1061 XBD=1088 XBD=1116 XBD=1195 XHG=117 XHG=298 XHG=416 XHG=487 XHG=577 XHG=629 XHG=655 XHG=986YBD=3482 XHG=1071 XHG=1098 XHG=1125 YBD=3487 YBD=3488 YBD=3481 YBD=3480 YBD=3489 YBD=3482 YBD=3482YHG=3461>woman YBD=3481 YBD=3490 YHG=3450>Diagnostic YHG=3451>biopsy YHG=3461>was YHG=3452>done YHG=3461>on YHG=3461>a YHG=3452>62-year-old YHG=3453>with YHG=3462>a YHG=3454>2 YHG=3462>year

profiles(

512

" XBD=2430 XBD=281 XHG=837 XBD=368 XBD=430 XBD=619 XBD=765 XBD=827 XBD=925 XBD=1017 XBD=1066 XBD=1122 XBD=1181 XBD=1230 XBD=1488 XBD=1550 XBD=1660 XBD=1895 XBD=1959 XBD=2034 XBD=2120 XBD=2201 XBD=2244 XHG=94 XHG=292 XHG=377 XHG=440 XHG=630 XHG=774 XHG=936 XHG=1027 XHG=1069 XHG=1132 XHG=1191 XHG=1327 XHG=1497 XHG=1561 XHG=1670 XHG=1906 XHG=1969 XHG=2043 XHG=2129 XHG=2211 XHG=2254 YBD=319 YBD=318 YBD=317 YBD=322 YBD=315 YBD=323 YBD=314 YBD=316 YBD=323 YBD=315 YBD=322 YHG=291>continuous YHG=291>with YHG=290>the YHG=289>membrane YHG=287>forming YHG=287>the YHG=294>outer YHG=286>layer YHG=285>the YHG=294>sac YHG=285>of YHG=285>localising YHG=286>the YHG=286>lesion YHG=286>anatomically; YHG=287>the YHG=287>link YHG=287>with YHG=286>pain YHG=296>or YHG=287>pre-existing " XBD=2429 XBD=1531 XBD=1621 XBD=1695 XBD=1768 XBD=1922 XBD=2082 XBD=2239 XBD=2400 XHG=1326 XHG=1543 XHG=1634 XHG=1706 XHG=1780 XHG=1936 XHG=2094 XHG=2251 XHG=2410 YBD=368 YBD=359 YBD=358 YBD=365 YBD=357 YHG=331>sympathetic YHG=329>fibre YHG=330>loss YHG=338>was YHG=330>variable. YHG=329>Whereas YHG=328>Raeder’s YHG=328>syndrome YHG=329>is XBD=306 XHG=565 XBD=485 XBD=552 XBD=606 XHG=94 XHG=319 XHG=495 YBD=369 YBD=360 YBD=366 YHG=333>endoplasmic YHG=332>reticulum YHG=331>(fig YHG=331>2). " XBD=2430 XBD=1400 XBD=1495 XBD=1670 XBD=1856 XBD=1953 XBD=2229 XHG=1326 XHG=1420 XHG=1518 XHG=1691 XHG=1875 XHG=1972 XHG=2249 YBD=410 YBD=408 YBD=402 YBD=409 YHG=383>very YHG=383>rare, YHG=374>Horner’s YHG=373>syndrome YHG=373>with YHG=373>post-ganglionic YHG=372>sympathetic XBD=288 XHG=900 XBD=426 XBD=498 XBD=552 XBD=717 XBD=794 XBD=879 XBD=969 XBD=1076 XBD=1172 XBD=1225 XHG=129 XHG=309 XHG=448 XHG=519 XHG=573 XHG=738 XHG=816 XHG=990YBD=401 XHG=1097 XHG=1192 YBD=411 YBD=403 YBD=402 YBD=409 YBD=400 YBD=401 YBD=401 YHG=375>Antibody YHG=375>studies YHG=382>are YHG=374>in YHG=381>progress YHG=372>but YHG=373>will YHG=372>take YHG=381>some YHG=372>time YHG=379>to " XBD=2431 XBD=258 XHG=870 XBD=361 XBD=550 XBD=637 XBD=720 XBD=838 XBD=929 XBD=1044 XBD=1113 XBD=1225 XBD=1405 XBD=1492 XBD=1696 XBD=1753 XBD=1829 XBD=1967 XBD=2094 XBD=2221 XBD=2391 XHG=94 XHG=292 XHG=392 XHG=582 XHG=666 XHG=752 XHG=960 XHG=1075 XHG=1138 XHG=1327 XHG=1430 XHG=1515 XHG=1721 XHG=1777 XHG=1854 XHG=1991 XHG=2119 XHG=2245 XHG=2412 YBD=453 YBD=444 YBD=452 YBD=452 YBD=444 YBD=446 YBD=447 YBD=453 YBD=445 YHG=418>complete. YHG=417>The YHG=417>specimen YHG=416>did YHG=422>not YHG=416>show YHG=425>any YHG=416>signs YHG=416>of YHG=423>acute YHG=418>fibre YHG=419>loss YHG=417>(analogous YHG=423>to YHG=416>the YHG=416>animal YHG=416>model YHG=416>Schon YHG=417>proposes) YHG=417>is XBD=326 XHG=847 XBD=456 XBD=620 XBD=717 XBD=835 XBD=908 XBD=1044 XBD=1089 XBD=1126 XBD=1226 XHG=95 XHG=338 XHG=468 XHG=632 XHG=730 XHG=921 XHG=1057 XHG=1101 XHG=1137 YBD=496 YBD=495 YBD=488 YBD=495 YHG=460>inflammatory YHG=460>change YHG=459>although YHG=468>some YHG=459>gliosis YHG=468>was YHG=466>present YHG=469>as YHG=460>is YHG=460>usual " XBD=2432 XBD=1474 XBD=1554 XBD=1776 XBD=1867 XBD=1911 XBD=1983 XBD=2019 XBD=2163 XBD=2251 XBD=2392 XHG=1328 XHG=1492 XHG=1571 XHG=1794 XHG=1886 XHG=1929 XHG=2002 XHG=2036 XHG=2183 XHG=2269 XHG=2407 YBD=490 YBD=497 YBD=488 YBD=489 YHG=469>common YHG=461>and YHG=460>retro-orbital YHG=461>pain YHG=461>is YHG=467>not YHG=470>a YHG=460>feature. YHG=460>The YHG=460>increase YHG=461>in XBD=129 XHG=824 XBD=343 XBD=482 XBD=547 XBD=682 XBD=812 XBD=998 XBD=1048 XBD=1140 XBD=1227 XHG=96 XHG=141 XHG=355 XHG=495 XHG=559 XHG=693 XHG=1009 XHG=1053 XHG=1151 YBD=531 YBD=531 YBD=539 YHG=503>in YHG=502>Alzheimer’s YHG=502>disease. YHG=503>No YHG=502>clinical YHG=502>history YHG=503>suggestive YHG=503>of YHG=510>acute YHG=503>viral " XBD=2434 XBD=1504 XBD=1753 XBD=1835 XBD=1921 XBD=2196 XBD=2256 XBD=2338 XHG=1328 XHG=1513 XHG=1762 XHG=1844 XHG=1929 XHG=2204 XHG=2264 XHG=2346 YBD=541 YBD=532 YBD=531 YBD=533 YHG=505>trigeminal YHG=504>neuropeptides YHG=513>seen YHG=503>after YHG=504>sympathectomy YHG=503>has YHG=503>been YHG=504>linked " XBD=247 XBD=322 XHG=97 XHG=260 YBD=574 YBD=573 YBD=574 YHG=545>infection YHG=554>was YHG=545>obtained. " XBD=490 XBD=1361XHG=334 XBD=1430 XBD=1605 XBD=1851 XBD=2013 XBD=2067 XBD=2129 XBD=2434 XHG=1329 XHG=1377 XHG=1447 XHG=1621 XHG=1866 XHG=2029 XHG=2076 XHG=2145 YBD=577 YBD=575 YBD=576 YBD=584 YHG=555>to YHG=548>increased YHG=548>inflammatory YHG=557>response YHG=547>of YHG=548>the YHG=546>sympathectomised " XBD=236 XBD=416 XBD=465 XBD=530 XBD=654 XBD=696 XBD=784 XBD=873 XBD=1043 XBD=1229 XHG=133 XHG=247 XHG=426 XHG=475 XHG=540 XHG=664 XHG=706 XHG=792 XHG=883 XHG=1051 YBD=625 YBD=617 YBD=618 YBD=619 YBD=626 YHG=588>These YHG=595>structures YHG=588>do YHG=596>not YHG=598>appear YHG=596>to YHG=589>have YHG=589>been YHG=590>described YHG=590>previously |>"XBD=2382 XBD=1386 XBD=1432 XBD=1643 XBD=1682 XBD=1749 XBD=1852 XBD=1945 XBD=2024 XBD=2134 XBD=2202 XBD=1599 XHG=1332 XHG=1400 XHG=1616 XHG=1657 XHG=1695 XHG=1763 XHG=1866 XHG=1958 XHG=2038 XHG=2148 XHG=2215 XHG=1446 YBD=629 YBD=620 YBD=619 YBD=618 YBD=627 YHG=600>eye YHG=598>to YHG=591>It YHG=591>is YHG=597>not YHG=591>made YHG=590>clear YHG=591>that YHG=590>credit YHG=590>lies YHG=583>elsewhere YHG=583>injury.3,4 XBD=131 XHG=919 XBD=199 XBD=380 XBD=431 XBD=614 XBD=758 XBD=807 XBD=905 XBD=976 XBD=1023 XBD=1117 XBD=1168 XBD=1229 XHG=98 XHG=145 XHG=213 XHG=393 XHG=440 XHG=630 XHG=772 XHG=821 XHG=991 XHG=1037 XHG=1130 XHG=1176 YBD=659 YBD=659 YBD=660 YBD=669 YBD=661 YBD=667 YBD=662 YBD=662 YHG=631>in YHG=631>the YHG=639>neocortex YHG=631>of YHG=632>laboratory YHG=633>animals YHG=642>or YHG=642>man, YHG=633>but YHG=634>in YHG=634>view YHG=633>of YHG=634>the " XBD=2435 XBD=1383 XBD=1463 XBD=1563 XBD=1779 XBD=1838 XBD=1947 XBD=2049 XBD=2131 XBD=2235 XBD=2278 XHG=1331 XHG=1395 XHG=1475 XHG=1575 XHG=1791 XHG=1849 XHG=1957 XHG=2060 XHG=2141 XHG=2247 XHG=2289 YBD=664 YBD=663 YBD=671 YBD=662 YBD=661 YBD=670 YHG=635>the YHG=636>idea YHG=635>&dquo;that YHG=634>competition YHG=634>for YHG=641>target YHG=633>NGF YHG=644>may YHG=634>result YHG=634>in YHG=634>reciprocal XBD=222 XHG=790 XBD=374 XBD=432 XBD=508 XBD=709 XBD=771 XBD=806 XBD=1053 XBD=1158 XBD=1230 XHG=98 XHG=248 XHG=400 XHG=455 XHG=533 XHG=734 XHG=830 XHG=1077 XHG=1182 YBD=703 YBD=704 YBD=703 YBD=713 YBD=705 YBD=706 YBD=705 YHG=681>current YHG=675>interest YHG=675>in YHG=675>the YHG=676>possibility YHG=676>of YHG=686>a YHG=677>transmissible YHG=677>basis YHG=676>for " XBD=2344 XBD=1504 XBD=1555 XBD=1614 XBD=1681 XBD=1899 XBD=1973 XBD=2112 XHG=1331 XHG=1517 XHG=1562 XHG=1628 XHG=1694 XHG=1911 XHG=1985 XHG=2125 YBD=714 YBD=707 YBD=715 YBD=706 YHG=678>regulation YHG=677>of YHG=678>the YHG=678>iris YHG=678>sympathetic YHG=678>and YHG=686>sensory YHG=676>innervation&dquo;. XBD=303 XHG=869 XBD=439 XBD=540 XBD=723 XBD=775 XBD=848 XBD=952 XBD=1010 XBD=1076 XBD=1230 XHG=99 XHG=323 XHG=459 XHG=561 XHG=743 XHG=795 XHG=972 XHG=1023 XHG=1095 YBD=747 YBD=747 YBD=756 YBD=748 YBD=749 YBD=749 YHG=717>Alzheimer’s YHG=719>disease YHG=719>their YHG=719>similarity YHG=727>to YHG=720>the YHG=727>coats YHG=720>of YHG=721>the YHG=721>unusual " XBD=2437 XBD=1437 XBD=1539 XBD=1633 XBD=1677 XBD=1768 XBD=1890 XBD=2084 XBD=2230 XBD=2320 XHG=1367 XHG=1454 XHG=1556 XHG=1652 XHG=1695 XHG=1785 XHG=1907 XHG=2103 XHG=2248 XHG=2338 YBD=757 YBD=749 YBD=750 YHG=722>The YHG=721>third YHG=728>state YHG=722>is YHG=722>pain YHG=721>which YHG=721>sometimes YHG=730>appears YHG=719>after YHG=721>lumbar "|>"XBD=1236 XBD=223 XBD=332 XBD=380 XBD=501 XBD=641 XBD=851 XBD=1188 XBD=1149 XHG=99 XHG=235 XHG=341 XHG=385 XHG=511 XHG=653 XHG=1163 XHG=1198 XHG=861 YBD=790 YBD=790 YBD=797 YBD=800 YBD=792 YBD=797 YHG=761>tubular YHG=761>forms YHG=761>of YHG=762>certain YHG=762>viruses, YHG=763>particularly YHG=764>is YHG=763>of YHG=756>rhabdoviruses,2,3 XBD=1584 XBD=1638 XBD=1713 XBD=1815 XBD=2044 XBD=2128 XBD=2173 XBD=2356 XBD=2437 XHG=1332 XHG=1605 XHG=1661 XHG=1736 XHG=1838 XHG=2066 XHG=2149 XHG=2196 XHG=2374 YBD=801 YBD=799 YBD=794 YBD=793 YHG=765>sympathectomy YHG=765>in YHG=765>the YHG=765>Ll,2 YHG=765>dermatomes YHG=764>and YHG=763>associated YHG=765>with XBD=236 XHG=714 XBD=443 XBD=628 XBD=694 XBD=952 XBD=1020 XBD=1147 XBD=1229 XHG=100 XHG=259 XHG=463 XHG=648 XHG=971YBD=836 XHG=1040 XHG=1166 YBD=834 YBD=841 YBD=835 YBD=835 YBD=835 YHG=805>interest. YHG=804>Equivalent YHG=806>diameters YHG=806>for YHG=807>rhabdoviruses YHG=816>are YHG=807>75-80 YHG=816>nm. " XBD=2437 XBD=1492 XBD=1652 XBD=1697 XBD=1761 XBD=1907 XBD=1995 XBD=2147 XBD=2408 XHG=1333 XHG=1503 XHG=1664 XHG=1708 XHG=1773 XHG=1918 XHG=2009 XHG=2158 XHG=2417 YBD=844 YBD=836 YBD=845 YBD=837 YHG=808>increased YHG=808>sweating YHG=809>in YHG=808>the YHG=808>affected YHG=817>area. YHG=807>Lumbar YHG=807>sympathectomy YHG=808>is " XBD=1231 XBD=171 XBD=310 XBD=494 XBD=593 XBD=785 XBD=844 XBD=1072 XBD=1119 XHG=101 XHG=190 XHG=329 XHG=512 XHG=613 XHG=861 XHG=1093 XHG=1138 YBD=885 YBD=886 YBD=878 YBD=879 YBD=887 YBD=879 YBD=879 YHG=848>The YHG=849>longest YHG=849>elongated YHG=849>form YHG=850>illustrated YHG=851>by YHG=843>Matsumoto2 YHG=850>is YHG=850>about XBD=1414XHG=802 XBD=1570 XBD=1617 XBD=1756 XBD=1843 XBD=1906 XBD=1993 XBD=2068 XBD=2232 XBD=2382 XBD=2437 XHG=1334 XHG=1428 XHG=1585 XHG=1630 XHG=1772 XHG=1857 XHG=1920 XHG=2007 XHG=2080 XHG=2246 XHG=2394 YBD=886 YBD=889 YBD=888 YBD=880 YBD=887 YBD=881 YHG=858>most YHG=851>effective YHG=852>in YHG=851>L3-S2; YHG=852>why YHG=861>are YHG=851>pain YHG=852>and YHG=851>excessive YHG=851>sweating YHG=859>not m. XHG=877 XBD=153 XBD=411 XBD=489 XBD=663 XBD=735 XBD=861 XBD=918 XBD=1080 XBD=1134 XBD=1231 XHG=105 XHG=250 XHG=426 XHG=506 XHG=680 XHG=752 XHG=934YBD=923 XHG=1096 XHG=1144 YBD=921 YBD=929 YBD=922 YBD=930 YBD=922 YBD=922 YHG=892>1.2 YHG=892>Although YHG=893>this YHG=894>specimen YHG=894>has YHG=894>shown YHG=903>no YHG=894>evidence YHG=893>of YHG=900>acute " XBD=2439 XBD=1538 XBD=1597 XBD=1709 XBD=1956 XBD=2064 XBD=2197 XBD=2258 XHG=1334 XHG=1564 XHG=1623 XHG=1735 XHG=1983 XHG=2090 XHG=2207 XHG=2283 YBD=931 YBD=924 YBD=923 YBD=930 YHG=895>experienced YHG=895>in YHG=895>these YHG=895>dermatomes? YHG=895>How YHG=894>could YHG=894>the YHG=895>speculated XBD=179 XHG=818 XBD=373 XBD=419 XBD=550 XBD=640 XBD=805 XBD=871 XBD=1059 XBD=1135 XBD=1232 XHG=101 XHG=190 XHG=385 XHG=431 XHG=562 XHG=652 XHG=884YBD=966 XHG=1069 XHG=1146 YBD=965 YBD=967 YBD=974 YBD=974 YBD=965 YHG=936>viral YHG=936>replication YHG=946>or YHG=944>mature YHG=938>viral YHG=938>particles, YHG=937>the YHG=937>possibility YHG=937>that YHG=937>these " XBD=2438 XBD=1471 XBD=1521 XBD=1691 XBD=1726 XBD=1865 XBD=1970 XBD=2119 XBD=2291 XBD=2405 XHG=1335 XHG=1483 XHG=1526 XHG=1702 XHG=1738 XHG=1877 XHG=1983 XHG=2132 XHG=2302 XHG=2415 YBD=966 YBD=975 YBD=974 YBD=973 YBD=967 YBD=968 YHG=938>increase YHG=937>of YHG=938>substance YHG=939>P YHG=947>sensory YHG=938>fibres YHG=938>produce YHG=938>sweating? YHG=938>Raskin YHG=946>et XBD=273 XHG=772 XBD=458 XBD=573 XBD=684 XBD=749 XBD=908 XBD=1011 XBD=1231 XHG=103 XHG=301 XHG=488 XHG=603 XHG=711 XHG=936YBD=1009 XHG=1040 YBD=1017 YBD=1010 YBD=1009 YBD=1016 YHG=987>structures YHG=987>represent YHG=990>some YHG=981>form YHG=980>of YHG=981>abortive YHG=980>viral YHG=980>replication, " XBD=2440 XBD=1376 XBD=1518 XBD=1597 XBD=1962 XBD=2048 XBD=2085 XBD=2197 XBD=2380 XHG=1335 XHG=1393 XHG=1531 XHG=1610 XHG=1974 XHG=2060 XHG=2098 XHG=2208 XHG=2391 YBD=1017 YBD=1018 YBD=1010 YBD=1019 YBD=1012 YHG=975>al6 YHG=988>suggest YHG=981>that YHG=982>post-sympathectomy YHG=982>pain YHG=982>is YHG=981>&dquo;both YHG=981>temporally YHG=985>and XBD=237 XHG=859 XBD=367 XBD=414 XBD=496 XBD=544 XBD=605 XBD=747 XBD=845 XBD=891 XBD=1052 XBD=1234 XHG=104 XHG=252 XHG=381 XHG=427 XHG=507 XHG=551 XHG=619 XHG=760 XHG=905YBD=1052 XHG=1066 YBD=1060 YBD=1053 YBD=1052 YBD=1059 YHG=1024>perhaps YHG=1024>similar YHG=1031>to YHG=1024>that YHG=1024>of YHG=1025>the YHG=1024>measles YHG=1024>virus YHG=1023>in YHG=1023>subacute YHG=1023>sclerosing " XBD=2439 XBD=1603 XBD=1731 XBD=1776 XBD=1935 XBD=1986 XBD=2197 XBD=2346 XBD=2410 XHG=1336 XHG=1616 XHG=1744 XHG=1790 XHG=1948 XHG=1993 XHG=2211 XHG=2358 XHG=2420 YBD=1061 YBD=1053 YBD=1054 YHG=1024>topographically YHG=1024>related YHG=1031>to YHG=1034>recovery YHG=1024>of YHG=1024>sympathetic YHG=1024>function YHG=1026>and YHG=1026>is " XBD=2440 XBD=381 XHG=807 XBD=508 XBD=661 XBD=794 XBD=909 XBD=1506 XBD=1601 XBD=1637 XBD=1803 XBD=1958 XBD=2011 XBD=2234 XBD=2344 XHG=104 XHG=395 XHG=520 XHG=675 XHG=1336 XHG=1525 XHG=1621 XHG=1657 XHG=1822 XHG=1978 XHG=2031 XHG=2252 XHG=2361 YBD=1104 YBD=1105 YBD=1096 YBD=1103 YBD=1097 YBD=1096 YBD=1103 YBD=1105 YHG=1067>panencephalitis, YHG=1067>clearly YHG=1068>deserves YHG=1067>further YHG=1067>study. YHG=1067>associated YHG=1067>with YHG=1077>a YHG=1068>localised YHG=1068>increase YHG=1068>in YHG=1068>sympathetic YHG=1074>target YHG=1077>organ " XHG=1337 YBD=1140 YHG=1111>function&dquo;. " XBD=1513 XBD=277 XHG=825 XBD=371 XBD=550 XBD=638 XBD=680 XBD=735 XBD=817 XBD=904 XBD=1064 XBD=1104 XBD=1128 XBD=1234 XHG=141 XHG=286 XHG=382 XHG=559 XHG=647 XHG=689 XHG=744 XHG=913YBD=1138 XHG=1071 XHG=1112 XHG=1137 YBD=1140 YBD=1139 YBD=1147 YBD=1138 YBD=1138 YBD=1145 YHG=1111>Because YHG=1111>these YHG=1118>structures YHG=1111>have YHG=1120>so YHG=1110>far YHG=1110>only YHG=1110>been YHG=1109>observed YHG=1109>in YHG=1119>a YHG=1109>single XBD=234 XHG=827 XBD=286 XBD=338 XBD=511 XBD=693 XBD=800 XBD=968 XBD=1060 XBD=1160 XBD=1235 XHG=106 XHG=263 XHG=313 XHG=365 XHG=539 XHG=720 XHG=995YBD=1190 XHG=1087 XHG=1187 YBD=1184 YBD=1191 YBD=1183 YBD=1182 YBD=1190 YBD=1182 YHG=1156>patient, YHG=1155>it YHG=1155>is YHG=1155>possible, YHG=1155>whatever YHG=1154>their YHG=1153>identity, YHG=1153>that YHG=1153>they YHG=1162>are " XBD=2441 XBD=1478 XBD=1567 XBD=1666 XBD=1783 XBD=1883 XBD=1935 XBD=2108 XBD=2146 XBD=2258 XBD=2302 XHG=1373 XHG=1493 XHG=1582 XHG=1680 XHG=1798 XHG=1897 XHG=1944 XHG=2123 XHG=2161 XHG=2271 XHG=2316 YBD=1192 YBD=1183 YBD=1184 YBD=1185 YHG=1155>Schon YHG=1155>cites YHG=1164>cases YHG=1155>where YHG=1155>&dquo;loss YHG=1155>of YHG=1156>substance YHG=1156>P YHG=1164>seems YHG=1162>to YHG=1156>correlate XBD=269 XHG=912 XBD=313 XBD=379 XBD=538 XBD=717 XBD=897 XBD=935 XBD=1010 XBD=1157 XBD=1236 XHG=105 XHG=281 XHG=326 XHG=394 XHG=552 XHG=734 XHG=949YBD=1225 XHG=1023 XHG=1170 YBD=1228 YBD=1227 YBD=1235 YBD=1226 YBD=1230 YBD=1225 YBD=1226 YHG=1199>unrelated YHG=1205>to YHG=1198>the YHG=1198>patient’s YHG=1197>dementia. YHG=1197>However, YHG=1198>it YHG=1204>was YHG=1196>thought YHG=1197>that " XBD=2442 XBD=1415 XBD=1496 XBD=1554 XBD=1673 XBD=1732 XBD=1803 XBD=1885 XBD=2059 XBD=2204 XBD=2274 XHG=1338 XHG=1434 XHG=1516 XHG=1567 XHG=1695 XHG=1750 XHG=1822 XHG=1904 XHG=2079 XHG=2224 XHG=2293 YBD=1227 YBD=1235 YBD=1233 YBD=1228 YBD=1237 YHG=1199>with YHG=1199>loss YHG=1199>of YHG=1198>pain&dquo;. YHG=1199>In YHG=1198>the YHG=1205>two YHG=1199>examples YHG=1199>chosen, YHG=1199>the YHG=1199>Riley-Day " XBD=259 XBD=384 XBD=430 XBD=547 XBD=590 XBD=687 XBD=729 XBD=818 XBD=950 XBD=1168 XHG=107 XHG=271 XHG=393 XHG=442 XHG=557 XHG=600 XHG=697 XHG=740 XHG=959 XHG=1177 YBD=1272 YBD=1271 YBD=1270 YBD=1269 YBD=1269 YBD=1269 YHG=1243>attention YHG=1242>should YHG=1243>be YHG=1242>drawn YHG=1248>to YHG=1242>them YHG=1241>in YHG=1241>view YHG=1239>of YHG=1240>well-defined YHG=1240>and their " XBD=1238 XBD=1505XHG=828 XBD=1578 XBD=1640 XBD=1838 XBD=1935 XBD=2004 XBD=2069 XBD=2207 XBD=2292 XBD=2359 XBD=2390 XBD=2442 XHG=1340 XHG=1517 XHG=1588 XHG=1653 XHG=1848 XHG=1949 XHG=2017 XHG=2080 XHG=2217 XHG=2302 XHG=2369 XHG=2399 YBD=1277 YBD=1271 YBD=1280 YBD=1272 YBD=1273 YHG=1243>syndrome YHG=1242>and YHG=1242>the YHG=1242>&dquo;mutilated YHG=1242>foot&dquo; YHG=1249>rat, YHG=1243>the YHG=1252>sensory YHG=1243>fibre YHG=1242>loss YHG=1244>is YHG=1251>not XBD=278 XHG=856 XBD=540 XBD=630 XBD=708 XBD=830 XBD=894 XBD=1101 XBD=1238 XHG=108 XHG=305 XHG=568 XHG=656 XHG=737 XHG=915YBD=1312 XHG=1127 YBD=1315 YBD=1314 YBD=1313 YBD=1320 YBD=1312 YBD=1321 YHG=1286>consistent YHG=1286>ultrastructure YHG=1285>and YHG=1284>the YHG=1284>rarity YHG=1283>of YHG=1283>neocortical YHG=1284>biopsy " XBD=2444 XBD=1488 XBD=1537 XBD=1874 XBD=2047 XBD=2169 XBD=2211 XBD=2267 XHG=1340 XHG=1504 XHG=1554 XHG=1891 XHG=2066 XHG=2186 XHG=2228 XHG=2283 YBD=1323 YBD=1315 YBD=1316 YHG=1286>confined YHG=1293>to YHG=1286>peptide-containing YHG=1286>afferents. YHG=1287>There YHG=1287>is YHG=1296>no YHG=1287>correlation XBD=1481XHG=683 XBD=1654 XBD=1688 XBD=1729 XBD=1865 XBD=1968 XBD=2038 XBD=2290 XBD=2444 XHG=1340 XHG=1490 XHG=1665 XHG=1697 XHG=1738 XHG=1874 XHG=1977 XHG=2046 XHG=2297 YBD=1358 YBD=1359 YBD=1367 YBD=1360 YHG=1331>between YHG=1331>substance YHG=1330>P YHG=1330>in YHG=1339>sensory YHG=1330>fibres YHG=1331>and YHG=1330>self-mutilating YHG=1331>behaviour " XBD=1239 XBD=283 XBD=392 XBD=552 XBD=657 XBD=887 XBD=1031 XBD=1162 XHG=109 XHG=311 XHG=419 XHG=580 XHG=914 XHG=1058 XHG=1190 YBD=1367 YBD=1357 YBD=1365 YBD=1356 YBD=1356 YBD=1357 YBD=1356 YHG=1330>specimens YHG=1328>from YHG=1328>patients YHG=1328>with YHG=1326>Alzheimer’s YHG=1328>disease YHG=1327>which YHG=1337>are -

for

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XBD=240 XHG=608 XBD=301 XBD=446 XBD=595 XBD=812 XHG=109 XHG=254 XHG=314 XHG=458 YBD=1402 YBD=1401 YBD=1400 YHG=1373>suitable YHG=1372>for YHG=1372>detailed YHG=1372>electron " XBD=2445 XBD=1374 XBD=1438 XBD=1651 XBD=1840 XBD=1928 XBD=2018 XBD=2218 XBD=2410 XHG=1342YBD=1407 XHG=1386 XHG=1610 XHG=1663 XHG=1851 XHG=1940 XHG=2030 XHG=2229 XHG=2420 YBD=1403YHG=1371>microscopy. YBD=1410 YBD=1411 YBD=1404 YHG=1375>in capsaicin YHG=1374>the YHG=1383>no YHG=1374>mutilation YHG=1374>after YHG=1374>local YHG=1374>application YHG=1374>of YHG=1382>to " XBD=2445 XBD=1394 XBD=1513 XBD=1630 XBD=1748 XBD=1917 XBD=1969 XBD=2147 XBD=2182 XBD=2255 XHG=1342 XHG=1408 XHG=1527 XHG=1644 XHG=1760 XHG=1931 XHG=1982 XHG=2159 XHG=2195 XHG=2267 XHG=2415 YBD=1453 YBD=1446 YBD=1448 YBD=1447 YHG=1419>the YHG=1418>sciatic YHG=1427>nerve, YHG=1418>which YHG=1418>decreases YHG=1418>its YHG=1419>substance YHG=1418>P YHG=1418>and YHG=1419>increases YHG=1419>its " XBD=2403 XBD=191 XHG=687 XBD=283 XBD=330 XBD=367 XBD=472 XBD=589 XBD=633 XBD=677 XBD=721 XBD=861 XBD=1053 XBD=1242 XHG=731 XHG=142 XHG=199 XHG=291 XHG=338 XHG=377 XHG=481 XHG=598 XHG=643 XHG=869YBD=1467 XHG=1060 YBD=1464 YBD=1469 YBD=1462 YBD=1469 YBD=1471 YHG=1440>We YHG=1439>thank YHG=1438>Dr YHG=1439>P. YHG=1438>Rudge YHG=1438>and YHG=1437>D. YHG=1437>G. YHG=1437>T. YHG=1437>Thomas, YHG=1439>departments YHG=1438>ofMr neurology

" XBD=2446 XBD=1411 XBD=1559 XBD=1779 XBD=1943 XBD=2114 XBD=2162 XBD=2325 XBD=2357 XHG=1342 XHG=1423 XHG=1573 XHG=1791 XHG=1955 XHG=2125 XHG=2167 XHG=2336 XHG=2368 XHG=2404 YBD=1498 YBD=1491 YBD=1490 YHG=1462>VIP YHG=1468>content. YHG=1462>Amputation YHG=1462>produces YHG=1461>depletion YHG=1461>of YHG=1462>substance YHG=1462>P YHG=1463>in YHG=1462>the " XBD=2395 XBD=166 XHG=764 XBD=391 XBD=508 XBD=594 XBD=743 XBD=804 XBD=986 XBD=1035 XBD=1146 XBD=1242 XHG=826 XHG=112 XHG=188 XHG=414 XHG=529 XHG=617 XHG=1007 XHG=1057 XHG=1167 YBD=1503 YBD=1500 YBD=1501 YBD=1502 YBD=1508 YBD=1502 YBD=1509 YBD=1503 YHG=1479>and YHG=1484>neurosurgery, YHG=1476>Maida YHG=1476>Vale YHG=1477>Hospital YHG=1477>for YHG=1477>permission YHG=1484>to YHG=1483>report YHG=1478>these

"" XBD=2369 XBD=2447XHG=112 XBD=1510 XBD=1634 XBD=1749 XBD=1837 XBD=1928 XBD=1988 XBD=2179 XBD=2274 XHG=1344YBD=1546 XHG=1533 XHG=1657 XHG=1776 XHG=1858 XHG=1949 XHG=2010 XHG=2199 XHG=2294 XHG=2390 YBD=1542YHG=1516>findings. YBD=1533 YBD=1541 YBD=1534 YHG=1505>ipsilateral YHG=1505>dorsal YHG=1498>horn8 YHG=1506>and YHG=1514>may YHG=1506>be YHG=1505>associated YHG=1505>with YHG=1506>pain. YHG=1506>The XBD=239 " XBD=2448 XBD=1501 XBD=1668 XBD=1726 XBD=1820 XBD=1901 XBD=2106 XBD=2368 XBD=2406 XHG=2422 XHG=1345 XHG=1521 XHG=1688 XHG=1739 XHG=1840 XHG=1920 XHG=2215 XHG=2386 YBD=1578 YBD=1584 YBD=1577 YHG=1549>extensive YHG=1549>evidence YHG=1548>of YHG=1548>Wall YHG=1549>and YHG=1541>colleagues9 YHG=1549>substance YHG=1549>P YHG=1558>in Human of Department Anatomy,

that

" XBD=2448 XBD=1482 XBD=1642 XBD=1767 XBD=1852 XBD=1900 XBD=1993 XBD=2111 XBD=2215 XBD=2306 XBD=2368 XHG=1345 XHG=1512 XHG=1673 XHG=1798 XHG=1883 XHG=1929 XHG=2023 XHG=2141 XHG=2243 XHG=2334 YBD=1629 YHG=1593>pain YBD=1620 YBD=1621 YBD=1628 YHG=1593>primary YHG=1592>afferent YHG=1592>fibres YHG=1592>has YHG=1601>a YHG=1592>role YHG=1591>other YHG=1592>than YHG=1591>that YHG=1592>of Oxford, University ofXHG=2389 J. J. SLOPER South Parks Road, " XBD=1921 XBD=1561 XBD=1599 XBD=1742 XBD=1795 XHG=1346 YBD=1664 XHG=1575 XHG=1613 XHG=1753 XHG=1808 YBD=1665 YHG=1635>Schon. YBD=1672 YBD=1673 YHG=1636>transmission YHG=1636>is YHG=1636>ignored YHG=1636>by Oxford OX1 3QX T. P. S. POWELL " XBD=2449 XBD=1451 XHG=2328 XBD=1712 XBD=1871 XBD=2009 XBD=2121 XBD=2187 XBD=2318 XHG=1382 YBD=1716 XHG=1465 XHG=1725 XHG=1883 XHG=2021 XHG=2133 XHG=2199 YBD=1717 YHG=1680>peptides YBD=1708 YHG=1679>The YHG=1679>Hammersmith YHG=1679>Hospital YHG=1679>peptide YHG=1688>group YHG=1679>has YHG=1679>studied Department of Neuropathology, " XBD=2365 |>" XBD=1380 XBD=1485 XBD=1557 XBD=1690 XBD=1826 XBD=1929 XBD=1972 XBD=2027 XBD=2142 XBD=2243 XBD=2310 XBD=2450 XHG=1348 XHG=1390 XHG=1496 XHG=1567 XHG=1699 XHG=1835 XHG=1940 XHG=1982 XHG=2038 XHG=2152 XHG=2252 XHG=2318 XHG=2374 YBD=1760 YBD=1761 YBD=1753 YBD=1752 YBD=1752 YHG=1724>intact YHG=1724>injured YHG=1733>sensory YHG=1724>fibres YHG=1724>in YHG=1730>rat YHG=1723>sciatic YHG=1732>nerve YHG=1724>and YHG=1723>the YHG=1723>effect Maida Vale Hospital for Nervous Diseases, " XBD=2451 XBD=1386 XBD=1672 XBD=1739 XBD=1938 XBD=1990 XBD=2050 XBD=2140 XBD=2303 XBD=2352 XHG=1348 YBD=1796 XHG=1394 XHG=1688 XHG=1754 XHG=1952 XHG=1998 XHG=2063 XHG=2151 XHG=2314 XHG=2365 YBD=1803 YHG=1767>Schon YBD=1804 YHG=1768>sympathectomy. YHG=1768>No YHG=1768>correlation YHG=1767>of YHG=1767>the YHG=1767>kind YHG=1768>proposed YHG=1767>by London W9 R. O. BARNARD " XBD=2340 XBD=2451 XHG=2350 XBD=1486 XBD=1577 XBD=1647 XBD=1750 XBD=1926 XBD=1974 XBD=2083 XBD=2217 XBD=2256 XHG=1349 YBD=1839 XHG=1496 XHG=1586 XHG=1657 XHG=1762 XHG=1936 XHG=1984 XHG=2093 XHG=2225 XHG=2268 YBD=1840 YHG=1811>of YBD=1845 YBD=1847 YHG=1820>emerges YHG=1811>from YHG=1811>this YHG=1812>work. YHG=1811>Whatever YHG=1812>its YHG=1811>merit, YHG=1811>writing YHG=1811>in YHG=1812>1983 links Department XHG=2410 of Virology, " XBD=2452 XBD=1489 XBD=1579 XBD=1818 XBD=1965 XBD=2040 XBD=2125 XBD=2229 XBD=2285 XBD=2339 XBD=2399 XHG=1348 XHG=1503 XHG=1592 XHG=1831 XHG=1978 XHG=2052 XHG=2138 XHG=2241 XHG=2298 XHG=2352 YBD=1884 YBD=1891 YBD=1883 YHG=1854>the YHG=1856>between YHG=1855>slow YHG=1855>neuropeptide YHG=1855>changes YHG=1855>and YHG=1855>pain YHG=1861>states YHG=1864>we YHG=1861>set YHG=1862>out Public Health Laboratory, " XBD=2452 XBD=1489 XBD=1685 XBD=1765 XBD=1957 XBD=2033 XBD=2138 XBD=2325 XHG=1350 XHG=1503 XHG=1699 XHG=1779 XHG=1972 XHG=2046 XHG=2151 XHG=2337 YBD=1934 YHG=1906>neurons YBD=1935 YBD=1927 YBD=1933 YBD=1926 YHG=1898>working YHG=1898>hypothesis YHG=1898>that YHG=1898>&dquo;VIP/PHI YHG=1898>and YHG=1898>CCK YHG=1898>containing John Radcliffe Hospital,

Oxford R.role P. EGLIN " XBD=2394 XBD=2453 XBD=1422 XBD=1527 XBD=1573 XBD=1638 XBD=1972 XBD=2119 XBD=2288 XHG=1351 YBD=1970 XHG=1435 XHG=1540 XHG=1586 XHG=1652 XHG=1985 XHG=2132 XHG=2300 XHG=2404 YBD=1979 YHG=1941>and YBD=1977 YBD=1978 YHG=1942>play YHG=1941>a YHG=1942>in YHG=1942>the YHG=1941>pathophysiological YHG=1942>changes YHG=1941>following YHG=1941>injury " XBD=2453 XBD=1478 XHG=2343 XBD=1643 XBD=1782 XBD=1838 XBD=1940 XBD=2209 XBD=2320 XBD=2404 XHG=2423 YBD=2013 XHG=1351 XHG=1505 XHG=1668 XHG=1806 XHG=1863 XHG=1964 XHG=2234 YBD=2019 YHG=1985>be YBD=2014 YBD=2022 YBD=2021 YHG=1986>disease, YHG=1985>possibly YHG=1985>related YHG=1992>to YHG=1985>local YHG=1985>vasodilatation. YHG=1985>They YHG=1994>may " XBD=2454 XBD=1521 XBD=1715 XBD=1872 XBD=1933 XBD=2125 XBD=2237 XBD=2364 XHG=1352 XHG=1543 XHG=1738 XHG=1896 XHG=1949 XHG=2146 XHG=2259 YBD=2066 YBD=2058 YBD=2057 YBD=2065 YHG=2030>important YHG=2030>diagnostic YHG=2030>markers YHG=2029>of YHG=2029>peripheral YHG=2037>nerve YHG=2029>injury; YHG=2036>more 1. Brun A. XHG=2384 An overview of light and electron microscopic changes. In: Reisberg B, ed.

" XBD=2404 XBD=2455 XBD=1564 XBD=1648 XBD=1726 XBD=1862 XBD=1889 XBD=2045 XBD=2112 XBD=2183 XBD=2206 XBD=2361 XHG=1353 XHG=1574 XHG=1656 XHG=1735 XHG=1872 XHG=1898 XHG=2054 XHG=2122 XHG=2190 XHG=2215 XHG=2369 XHG=2413 YBD=2111 YBD=2110 YBD=2102 YBD=2107 YBD=2101 YBD=2109 YBD=2106 YHG=2073>importantly, YHG=2073>they YHG=2082>may YHG=2073>provide YHG=2083>a YHG=2073>rationale YHG=2072>for, YHG=2073>and YHG=2082>a YHG=2072>predictor YHG=2071>of, YHG=2072>the Alzheimer’s disease: theYBD=2100 standard reference. New York: Free Press, 1983: 37-47. 2. Matsumoto, S. Electron microscope Biol studies YHG=2115>including of rabies virus in brain. Cell J " XBD=2456 XBD=1445 XBD=1530 XBD=1839 XBD=1918 XBD=2037 XBD=2272 XHG=2317 XHG=1354 XHG=1493 XHG=1571 XHG=1886 XHG=1964 XHG=2083 YBD=2146 YBD=2155 YBD=2145 YBD=2153 YBD=2151 YHG=2117>effect YHG=2117>of YHG=2117>sympathectomy YHG=2117>in YHG=2117>pain YHG=2117>syndromes, 19: 565-91. mouse

1963;XHG=1354 YBD=2197 YHG=2154>causalgia&dquo;.10 " XBD=1571 3. Matsumoto S. Rabies virus. Adv Virus Res 1970; 16: 257-301.

Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital,

P. ANAND*

London W12

POST-SYMPATHECTOMY PAIN AND SENSORY NEUROPEPTIDES

*Present address:

Department

of Neurology, St Thomas’

Hospital,

London SE1.

" XBD=1259 XBD=313 XHG=773 XBD=435 XBD=537 XBD=604 XBD=645 XBD=755 XBD=922 XBD=1015 XBD=1066 XBD=1168 XHG=164 XHG=330 XHG=451 XHG=554 XHG=624 XHG=665 XHG=939YBD=2612 XHG=1034 XHG=1083 XHG=1186 YBD=2610 YBD=2604 YBD=2611 YBD=2609 YBD=2610 YBD=2603 YBD=2604 YBD=2612 YHG=2575>SiR,―Dr YHG=2574>Schon YHG=2575>(Nov YHG=2575>23, YHG=2584>p YHG=2576>1158) YHG=2584>proposes YHG=2576>that, YHG=2576>in YHG=2576>three YHG=2576>pain " XBD=1058 XBD=1260XHG=887 XBD=220 XBD=401 XBD=487 XBD=703 XBD=792 XBD=875 XBD=939 XBD=1022 XHG=128 XHG=231 XHG=411 XHG=498 XHG=714 XHG=803 XHG=950YBD=2648 XHG=1033 XHG=1069 YBD=2647 YBD=2655 YBD=2653 YBD=2655 YBD=2648 YHG=2626>states YHG=2619>associated YHG=2619>with YHG=2619>sympathetic YHG=2619>fibre YHG=2619>loss, YHG=2619>the YHG=2620>pain YHG=2620>is YHG=2619>&dquo;correlated " XBD=1260 XBD=205 XHG=668 XBD=268 XBD=408 XBD=476 XBD=520 XBD=658 XBD=909 XBD=994 XBD=1036 XBD=1172 XHG=921 XHG=128 XHG=215 XHG=280 XHG=418 XHG=488 XHG=530 XHG=1004 XHG=1047 XHG=1184 YBD=2692 YBD=2700 YBD=2699 YBD=2691 YBD=2691 YBD=2692 YHG=2663>with YHG=2663>the YHG=2663>delayed YHG=2663>rise YHG=2663>in YHG=2671>sensory YHG=2663>neuropeptides YHG=2672>seen YHG=2663>in YHG=2663>rodents YHG=2663>after

" " " " " "

XBD=429 XHG=129 YBD=2745 YHG=2707>sympathectomy&dquo;.1. Ekstrom J, Brodin E, Ekman R, al. VIP and substance P salivary gland of the following denervation duct ligation Reg Pept 1984; 10: 1-10. XBD=269 XHG=737 XBD=379 XBD=462 XBD=642 XBD=721 XBD=894 XBD=1086 XBD=1167 XBD=1260 XHG=165 XHG=287 XHG=397 XHG=480 XHG=659 XHG=912YBD=2778 XHG=1102 XHG=1181 YBD=2780 YBD=2779 YBD=2778 YBD=2778 YBD=2786 YHG=2751>Schon YHG=2757>states YHG=2750>that YHG=2750>Gardener YHG=2750>and YHG=2749>Abdullah YHG=2750>concluded YHG=2750>that YHG=2757>post2. Sharkey KA, Templeton D. Substance P in the parotid gland: evidence for dual XBD=381 XHG=856 XBD=522 XBD=613 XBD=697 XBD=780 XBD=834 XBD=960 XBD=1261 XHG=129 XHG=398 XHG=537 XHG=636 XHG=720 XHG=802 XHG=982YBD=2822 YBD=2832 YBD=2831 YBD=2830 YBD=2830YHG=2802>excess YHG=2795>sympathectomy YHG=2794>parotid YHG=2794>pain YHG=2803>was YHG=2794>due YHG=2800>to YHG=2793>parasympathetic origin from the otic and trigeminal ganglia Brain Res 1984; 304: 392-96 XBD=266 XHG=778 XBD=337 XBD=485 XBD=704 XBD=751 XBD=770 XBD=914 XBD=1096 XBD=1261 XHG=130 XHG=276 XHG=344 XHG=494 XHG=714 XHG=754 XHG=924YBD=2874 XHG=1105 YBD=2876 YBD=2875 YBD=2867 YBD=2866 YBD=2865 YBD=2866 YHG=2839>activity, YHG=2839>and YHG=2845>suggests YHG=2837>involvement YHG=2837>of YHG=2847>a YHG=2837>peptide, YHG=2837>vasoactive YHG=2837>intestinal 3. Unger WG, Terenghi G, Ghatei MA, al. Calcitonin gene-related polypeptide mediator of the neurogenic ocular injury response J Ocular Pharmacal 1985, 1: XBD=257 XHG=668 XBD=359 XBD=463 XBD=513 XBD=656 XBD=838 XBD=1017 XBD=1190 XBD=1263 XHG=131 XHG=268 XHG=370 XHG=474 XHG=525 XHG=853YBD=2909 XHG=1030 XHG=1202 YBD=2918 YBD=2919 YBD=2917 YBD=2910 YBD=2914 YBD=2909 YHG=2883>peptide YHG=2882>(VIP) YHG=2883>being YHG=2891>an YHG=2881>obvious YHG=2881>candidate. YHG=2881>However, YHG=2880>Gardener YHG=2881>and 189-99. XBD=288 XHG=733 XBD=466 XBD=529 XBD=613 XBD=678 XBD=722 XBD=836 XBD=1127 XBD=1263 XHG=130 XHG=298 XHG=476 XHG=540 XHG=625 XHG=689 XHG=847YBD=2953 XHG=1138 YBD=2954 YBD=2961 YBD=2961 YBD=2961 YHG=2925>Abdullah YHG=2925>attributed YHG=2924>the YHG=2925>pain YHG=2931>not YHG=2931>to YHG=2933>excess YHG=2923>parasympathetic YHG=2924>activity 4. Cole DF, Bloom SR, Burnstock G, et al. Increase SP like immunoreactivity et

rat

et

" XBD=1262 XBD=187 XHG=580 XBD=367 XBD=421 XBD=505 XBD=564 XBD=785 XBD=1012 XBD=1134 XHG=131 XHG=208 XHG=389 XHG=443 XHG=526 XHG=807YBD=3005 XHG=1035 XHG=1159 YBD=3007 YBD=2998 YBD=2997 YBD=3005 YBD=3004YHG=2968>antagonistic YBD=2996 YHG=2970>but YHG=2969>primarily YHG=2975>to YHG=2968>loss YHG=2968>of YHG=2967>sympathetic YHG=2967>input. YHG=2967>Schon

" XBD=1214 XBD=1263XHG=634 XBD=234 XBD=290 XBD=444 XBD=490 XBD=535 XBD=620 XBD=761 XBD=1055 XHG=132 XHG=249 XHG=304 XHG=457 XHG=503 XHG=548 XHG=775YBD=3040 XHG=1068 XHG=1229 YBD=3041 YBD=3048 YBD=3047 YBD=3040 YHG=3013>makes YHG=3022>no YHG=3013>mention YHG=3022>as YHG=3019>to YHG=3013>how YHG=3013>&dquo;excess YHG=3012>parasympathetic YHG=3011>activity&dquo; YHG=3021>or " XBD=1263 XBD=200 XHG=617 XBD=308 XBD=355 XBD=494 XBD=602 XBD=745 XBD=911 XBD=1079 XBD=1155 XBD=1196 XHG=760 XHG=131 XHG=216 XHG=324 XHG=371 XHG=508 XHG=928YBD=3091 XHG=1094 XHG=1170 XHG=1211 YBD=3084 YBD=3083 YBD=3092 YBD=3090 YBD=3083 YHG=3056>VIP YHG=3056>relate YHG=3062>to YHG=3055>parotid YHG=3055>gland YHG=3064>sensory YHG=3055>peptides, YHG=3055>although YHG=3054>this YHG=3054>is YHG=3055>the " XBD=1263 XBD=213 XHG=841 XBD=271 XBD=346 XBD=558 XBD=618 XBD=769 XBD=820 XBD=918 XBD=1089 XBD=1160 XHG=132 XHG=233 XHG=286 XHG=366 XHG=580 XHG=640 XHG=788 XHG=938YBD=3126 XHG=1108 XHG=1180 YBD=3127 YBD=3135 YBD=3134 YBD=3127 YBD=3126 YBD=3133 YHG=3099>basis YHG=3098>of YHG=3099>this YHG=3098>hypothesis; YHG=3098>he YHG=3107>appears YHG=3104>to YHG=3098>have YHG=3098>confused YHG=3098>the YHG=3106>para-

"|>" XBD=338 XBD=425 XBD=486 XBD=624 XBD=758 XBD=848 XBD=1060 XBD=1214 XBD=974 XHG=133 XHG=347 XHG=434 XHG=497 XHG=634 XHG=983 XHG=1070 XHG=1223 XHG=858 YBD=3169 YBD=3178 YBD=3170 YBD=3198 YBD=3177 YBD=3169 YHG=3141>sympathetic YHG=3141>with YHG=3141>the YHG=3151>sensory YHG=3148>system. YHG=3142>have YHG=3151>groups YHG=3141>reported YHG=3150>no "|>"XBD=1263 XBD=310 XBD=437 XBD=478 XBD=555 XBD=599 XBD=773 XBD=918 XBD=979 XBD=1033 XBD=1165 XBD=1265 XBD=874XHG=769 XHG=133 XHG=319 XHG=447 XHG=488 XHG=565 XHG=609 XHG=886 XHG=927 XHG=989 XHG=1042 XHG=1172 XHG=782YBD=3170 YBD=3220 YBD=3214 YBD=3212 YBD=3213 YBD=3214 YBD=3218YHG=3141>Two YBD=3221 YHG=3184>significant YHG=3185>change YHG=3185>VIP YHG=3194>or YHG=3186>substance YHG=3185>in YHG=3185>the YHG=3192>rat YHG=3178>p3, I, YHG=3185>parotid YHG=3185>gland " XBD=518 XBD=808 XHG=531 XBD=193 XBD=240 XBD=315 XBD=428 XHG=134 YBD=3263 XHG=206 XHG=253 XHG=327 XHG=441 YBD=3255 YHG=3228>sympathectomy. YBD=3256 YHG=3236>one YHG=3236>or YHG=3234>two YHG=3228>weeks YHG=3227>after " XBD=1265 XBD=217 XHG=672 XBD=376 XBD=649 XBD=827 XBD=957 XBD=1094 XHG=852 XHG=170 XHG=238 XHG=399 XHG=983YBD=3299 XHG=1124 YBD=3298 YBD=3306 YBD=3305 YBD=3300 YBD=3299 YHG=3270>Of YHG=3270>Raeder’s YHG=3271>paratrigeminal YHG=3271>syndrome YHG=3270>Schon YHG=3272>writes: YHG=3271>&dquo;Raeder " XBD=1266 XBD=296 XHG=729 XBD=368 XBD=514 XBD=602 XBD=718 XBD=892 XBD=1109 XBD=1194 XHG=135 XHG=307 XHG=380 XHG=525 XHG=614 XHG=904YBD=3341 XHG=1121 XHG=1206 YBD=3348 YBD=3343 YBD=3350 YBD=3342 YHG=3313>described YHG=3313>five YHG=3313>patients YHG=3313>with YHG=3322>severe YHG=3314>unilateral YHG=3314>retro-orbital YHG=3315>pain YHG=3314>and

" " " "

rat

in

or

XBD=1266XHG=841 XBD=434 XBD=564 XBD=682 XBD=828 XBD=922 XBD=1087 XHG=136 XHG=448 XHG=577 XHG=695 XHG=935YBD=3384 XHG=1101 YBD=3392 YBD=3391 YBD=3385 YBD=3393 YHG=3355>oculosympathetic YHG=3356>paresis YHG=3356>which YHG=3356>differed YHG=3356>from YHG=3357>Horner’s YHG=3358>syndrome XBD=170 XHG=935 XBD=246 XBD=343 XBD=417 XBD=469 XBD=541 XBD=590 XBD=684 XBD=876 XBD=925 XBD=997 XBD=1089 XBD=1196 XBD=1267 XHG=138 XHG=182 XHG=258 XHG=354 XHG=428 XHG=480 XHG=552 XHG=595 XHG=695 XHG=888 XHG=1011 XHG=1100 XHG=1206 YBD=3427 YBD=3428 YBD=3435 YBD=3429 YBD=3429 YBD=3437 YBD=3430 YHG=3399>in YHG=3399>that YHG=3399>there YHG=3408>was YHG=3408>no YHG=3400>loss YHG=3400>of YHG=3399>facial YHG=3400>sweating&dquo;. YHG=3402>In YHG=3401>this YHG=3402>1924 YHG=3410>paper YHG=3408>two XBD=176 XHG=746 XBD=233 XBD=307 XBD=404 XBD=466 XBD=533 XBD=690 XBD=734 XBD=823 XBD=1040 XBD=1135 XBD=1268 XHG=138 XHG=182 XHG=247 XHG=320 XHG=417 XHG=479 XHG=546 XHG=702 XHG=835YBD=3471 XHG=1052 XHG=1149 YBD=3469 YBD=3470 YBD=3478 YBD=3472 YBD=3480 YBD=3472 YHG=3441>of YHG=3442>the YHG=3442>five YHG=3451>cases YHG=3451>are YHG=3449>not YHG=3444>reported YHG=3450>to YHG=3444>have YHG=3445>retro-orbital YHG=3444>pain. YHG=3445>Raeder XBD=199 XHG=754 XBD=323 XBD=421 XBD=574 XBD=661 XBD=734 XBD=919 XBD=1000 XBD=1094 XBD=1216 XBD=1269 XHG=138 XHG=219 XHG=343 XHG=440 XHG=595 XHG=681 XHG=939YBD=3522 XHG=1020 XHG=1113 XHG=1235 YBD=3512 YBD=3513 YBD=3521 YBD=3514 YBD=3515 YBD=3522 YBD=3515 YBD=3514 YHG=3485>and YHG=3485>others YHG=3485>have YHG=3485>thought YHG=3487>that YHG=3486>the YHG=3487>syndrome YHG=3496>was YHG=3487>only YHG=3487>useful YHG=3488>in

a

as a

in

nerve

fibres of rabbit iris and ciliary body one to four months following sympathetic denervation. Expl Eye Res 1983; 37: 191-97. 5. Kessler JA, Bell WO, Black IB. Interaction between the sympathetic and sensory innervation of the iris. J Neurosci 1983; 3: 1301-07. 6. Raskin NH, Levin S, Hoffman P, Pickett JB, Fields L. Post sympathetic neuralgia amelioration with diphenylhydantoin and carbamazepine. Am J Surg 1974, 128: 75-78. 7. Lembeck F, Gamse R. Substance P in peripheral sensory processes. In: Substance P in the nervous system. Ciba Found Symp 1982; no 91: 35-40. 8. Hunt SP, Rosser MN, Emson PC, Clement-Jones V. Substance P and Enkephalin in spinal cord after limb amputation. Lancet 1982; i: 1023 9. Wall PD, Fitzgerald M. If substance P fails to fulfil the criteria as a neurotransmitterin somatosensory afferents, what might be its function? In: Substance P in the nervous system. Ciba Found Symp 1982; no 91: 249-66. 10. Anand P, Gibson SJ, McGregor GP, et al. Peripheral neuronal systems show marked increases in VIP/PHI and CCK content following injury. Regul Pept 1983, 7: 273.