Unusual reactions of patients with hypertension to glyceryl trinitrate

640

THE

AMERICAN

Holman, Russell L., and Self, Viability in “Devascularized”

HEART

Edward Lymph

JOURNAL

B.: The Nodes.

Ability of Lymph to Maintain Am. J. Path. 14: 463, 1938.

Studies were made on the ability of lymph per se to keep tissues alive. The vascular and lymphatic connections of popliteal nodes in dogs were completely severed and the nodes replaced in the popliteal space. All the nodes underwent massive necrosis. When the authors severed all blood vascular connections but left one or more afferent and one or more efYerent lymphatics intact, the nodes remained viable. The observations imply a nutritive function on the part of lymph. NAIDE. Veal, James Radiology

Ross: Direct 31: 183, 193s.

Visualization

of

the

Axillary

and

A method of directly visualizing the axillary and subclavian trast is presented. A number of normal and abnormal venograms are included. The value and limitations of this method are discussed.

Subclavian

veins

Veins.

by use of thoro-

NAIDE. Bowesman, Charles: Intra-Arterial Surg. 26: 86, 1938.

Glycerin

Treatment

of Elephantiasis.

Brit.

J.

When glycerin is placed in contact with living tissue, it causes a movement of tissue fluid from the tissue spaces tomard the vessels or region in which the glycerin is placed. Injection of 2 to 3 CC. of sterile 10 per cent glycerin into the femoral artery, repeated at weekly intervals, affords a simple and safe method of alleviating to some extent elephantiasis of the leg due to filaria. Intravenous injections produce an effect en the limb, though less marked. Early cases showed marked reduction in the size of the limb. Late cases showed some improvement. The dull aching discomfort is in all cases much lessened. Five months after treatment patients showed limbs which either had the same size as at the end of the treatment or remained smaller than before the commencement of treatment. NAIDE. Lueth, Harold pertension

C., and Hanks, Thrift to Glyceryl Trinitrate.

G.: Unusual Reactions of Patients Arch. Int. Med. 62: 97, 1938.

With

Hy-

Severe reactions not infrequently follow the administration of glyceryl trinitrate to patients with hypertension. The nature and frequency of these reactions were studied. Fifty patients with essential hypertension or hypertensive heart disease were selected from the outpatient dispensary. A chemically assayed solution of glyceryl trinitrate was carefully administered directly under the patient ‘a tongue with an accurately graduated pipette. All tests were made under standard basal conditions, and frequent blood pressure readings were made. Nine patients (18 per cent) showed reactions, i.e., nausea, vomiting, syucope, collapse, and involuntary passage These followed doses as low as 0.24 mg. (+&,o grain) and were of urine and feces. more severe when the patient was sitting up than when he was recumbent. All the patients recovered completely within an hour. Four well-known clinical procedures were applied in these cases in the hope of determining unusual vasomotor lability. The Hines-Brown test, the histamine flare test, and changes in the pulse volume and observations of the capillaries of the skin were of no assistance in predicting these reactions. AUTHOR.