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UP-3.153: Factors Affecting the Outcome of Ureteroscopy in the Management of Ureteric Stones in Children
UNMODERATED POSTER SESSIONS
UP-3.151 Percutaneous Nephrolithotomy in Children Ali B1, Qotb E1, Abbas M2 1 Department of Urology, Al-Abbas Hospital, Taiz, Yemen; 2Cairo University, Cairo, Egypt Introduction and Objectives: Open surgery was the only choice for treatment of pediatric urolithiasis. There is always a need for less invasive procedure. The availability of endourological procedure for adults necessitates this use also for children. We will present our experience with PCNL in children. Materials and Methods: Between March 2006 and January 2008, 24 boys and 16 girls with renal calculi were treated with PCNL. Patient age ranged from 2 years to 12 years (mean 10 year). Excretory urography (IVP) was the primary imaging modality. The method of PCNL in children is the same as used in adults. Percutaneous access was achieved with the patient under general anasthesia. Subcostal puncture was used in all cases. Access was achieved using an 18 gauge needle and guidewire. Dilation of the tract to the minimal size (24ch) necessary for instrumentation and stone removal were then done. For small stones the graspers were used for mechanical stone extraction but for larger calculi lithotripsy was used for fragmentation. At the end of the procedure a nephrostomy tube was left in the kidney for 2-3 days. Success was defined as complete removal of the stones. The patients were followed after one month by KUB. Results: For the 24 kidneys with stones in the renal pelvis, only percutaneous access was achieved through the lower calyx. Stones in the pelvis and upper calix were removed through a lower caliceal puncture in 7 cases and an upper caliceal puncture in 1 case. One of cases was converted to ESWL because of difficult puncture. Significant intraoperative bleeding that required blood transfusion developed in 4 cases, renal pelvis perforation in 1 case which necessitated prolonged nephrostomy drainage for one week. Postoperatively, 4 patients had transient fever for 24 to 48 hours but none had urosepsis. Mean hospital stay was 3 days, antegrade pyelography was done for patient with pelvic perforation and revealed healing and nephrostomy was removed after one week. A total of 30 cases (75%) were stone-free at hospital discharge, 4 cases had residual stones treated with ESWL and the remaining 6 had insignificant peripheral caliceal stones that spontaneously
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passed at 3-months follow up. Therefore, the stone-free rate at 3 months was 100%. Conclusion: PCNL is a suitable and safe procedure for the treatment of children with renal calculi. The procedure has the advantages of small skin incision, short hospital stay and low complication rate. The minimally invasive nature of PCNL is of great value in this age group because there is always a risk of stone recurrence that may necessitate repeated intervention.
boys) without any history of UTI and normal urinalysis we observed febrile infection managed by antibiotics within short course.Two boys needed open surgery. ESWL procedures were well tolerated in all patients, without major complications. Conclusion: ESWL is safe and highly effective treatment method of kidney and ureteral stones in children and it should be regarded as the first line option in pediatric patients with nephrolithiasis.
UP-3.152 Efficacy of Extracorporeal Shock Wave Lithotripsy in Pediatric Patients Managadze G, Varshanidze L, Begashvili M, Silagava D, Tchanturaia Z National Center of Urology, Tbilisi, Georgia
UP-3.153 Factors Affecting the Outcome of Ureteroscopy in the Management of Ureteric Stones in Children Hidoussi A, Jaidane M, Hamida W, Kallel Y, Salama A, Ben Sorba N, Mosbah A Department of Urology, Sahloul Hospital, Sousse, Tunisia
Introduction and Objective: We analyzed efficacy of Extracorporeal Shock Wave Lithotripsy (ESWL) for treatment of kidney and ureteral stones in children. Materials and Methods: During 2003008 we treated 74 pediatric patients: age 1-14 years, 31 girls, 43 boys. ESWL was performed under general or i.v. sedoanalgesia. None of them underwent ureteral stenting or percutaneous nephrostomy. We used Dornier Compact Delta II. Stones were located in kidneys in 41 patients; in upper, mid and lower ureter, respectively in 8, 9 and 15 patients; in urinary bladder in one boy; 12 patients had more than one stone, 7 of them bilateral disease. 43 stones were ⬍10 mm in size, 55 between 10 mm and 20 mm, and ⬎20mm 3 (none were staghorn). Sessions were carried out mainly at level 2 (11.5 kV) and in others at level 3 – 12.75 kV (23 cases), but in two patients stones were fragmented at level 1 (10 kV). Number of shock waves used was 1500-3000. Results: Total number of ESWL session was 134: average 1.65 per patient and 1.3 per stone. Mean number of sessions for the stone ⬍10 mm and 10-20 mm were same (1.3 vs. 1.34) and patients with ⬎ 20 mm stones needed 2 sessions. Three sessions were needed in patients with multiple and bilateral stones. Patients needed analgesia by Voltaren 25 mg suppositorium (2 - 5 days). Repeat sessions were performed 7-10 days later. 89 % of patients were stone free within one week of the last session of ESWL. In girl with cerebral palsy clearance process took 5 weeks. Three patients developed Steintraße successfully managed by repeat ESWL session. In 4 patients (2 girls, 2
Introduction and Objective: To identify the factors involved in failure and postoperative complications of retrograde rigid ureteroscopy (URS) in the treatment of ureteric stones in children. Materials and Methods: This is a retrospective study, including 30 children who underwent 31 rigid URS (one case bilateral) for obstructive ureteric stones over a period of 10 years (1996 to 2006). We made an analytical study to identify the variables related to the incidence of postoperative complications and failure of URS. Results: There were 30 children (20 girls and 10 boys) with a mean age of 8 years (range, 4 to 14 years).The site of stones were pelvic in 21 cases (67.7%), iliac in 2 cases (6.4%) and lumbar in 8 cases (25%). The mean size of stones was 10.5 mm (5 to 22mm). The success rate by renal unit was 90.3%. Univariate Analysis revealed that the variables related to the failure of URS were: the size of stone (p ⫽ 0.052), stone site (p ⫽ 0.054) and the renal parenchymal thickness (p ⫽ 0.021). There was no intraoperative complication from the ureteroscopic procedure. Postoperative complication rate was 22% (4 cases of renal colic and 3 cases of urinary tract infection). The variables in relation with postoperative complications were: the size of stone (p ⫽ 0.044), parenchymal thickness (0.034) and duration of the procedure (p ⫽ 0.001). Conclusion: The rigid URS in children is a reliable and effective treatment option in the management of ureteric stones. According to our study, the favorable factors for success of URS are: stone iliac or pelvic ureter, stones less than 10 mm and
UROLOGY 74 (Supplment 4A), October 2009
UNMODERATED POSTER SESSIONS
ureteric stones with a preserved renal parenchyma. The variables involved in postoperative complications are: stones above 10 mm, a thinned renal parenchyma and long operative duration.
UP-3.154 Optimizing Retrograde Flexible Ureteroscopy for Upper Urinary Tract Pathology Georgescu D, Multescu R, Geavlete B, Geavlete P Department of Urology, “Saint John” Emergency Clinical Hospital, Bucharest, Romania Introduction and Objective: The development of retrograde flexible ureteroscopy significantly modified the diagnosis and treatment of upper urinary tract pathology. This study aimed to identify solutions to optimize this endoscopic procedure. Matrerials and Methods: Between 2002 and 2008, 173 patients underwent retrograde flexible ureteroscopy in our department. We evaluated the variables influencing method’s performances, as well as solutions to solve these problems. Results: The visibility, reduced due to the technical particularities of flexible ureteroscopes, may be supplementary diminished by the presence of hematuria/pyuria or the insertion of accessory instruments through the working channel. By avoiding iatrogenic lesions of the urothelium, using pressure irrigation or inserting small calibre accessory instruments through the working channel (eventually unsheathed baskets), visibility may be improved. The access to the entire pyelocaliceal system (especially the lower pole) may be limited by the renal anatomy, presence of hydronephrosis or ureteroscope’s maximal deflection. In cases with the infundibulopyelic angle lower than 30o, or between 30o -90o associated with an inferior calyx infundibular length shorter than 3 cm, the success rates of the lower pole access were 0% and 61.1%, by comparison to 88% in other patients. Massive hydronephrosis imposes ureteral stenting followed by flexible ureteroscopy in a secondary setting. Maintaining an acute deflection for a long time must be avoided by calculus displacement into the renal pelvis. Conclusion: Specific limitations of the method must be taken into consideration when indicating this procedure. Each problem has a specific solution, however applicable only in selected cases.
UP-3.155 Fourth-Generation Lithotripter in Treatment of Lower Calyceal Stones Hejj R, Chow W North Manchester General Hospital, Pennine Acute Hospitals NHS Trust, Manchester, UK Introduction and Objective: Treatment of lower calyceal stones has been controversial since the introduction of minimally invasive treatment options. EAU guidelines recommend ESWL as first line treatment for renal stones ⬍20 mm. On the other hand, the Lower Pole Study Group recommended that lower calyceal stones, especially those ⬎10 mm in diameter, should be better managed initially with percutaneous removal rather than ESWL. Some recent publications reported very good results achieved by fourth-generation, electroconductive lithotripter. This might be due to fragmentation characteristics of this technology, which produces smaller fragments than those achieved with an electromagnetic generator. Materials and Methods: From our prospectively maintained database of over 400 ESWL treatments with the Sonolith Vision (Technomed Medical Systems, Vaulx-en-Velin, France) lithotripter between September 2007 and January 2009 we evaluated the patients with lower calyceal stones who completed follow-up. ESWL was considered to have failed when there were residual stone fragments of ⬎4 mm, or an additional procedure was required to render the patient stone free. Results: 63 patients completed followup. Average stone size was 9,7 mm (range 4-20). Overall stone free rate (SFR) was 68 % (43/63). 40 patients had stones with maximum diameter ⬍10 mm. SFR for this group was 77% (31/ 40). 23 patients had stones of 11-20mm. SFR was 52% (12/23). Retreatment rate for a group of successfully treated patients (43 patients, average stone size⫽8,8mm) was 30%. 30 patients (48%) were stone-free after 1 treatment session, 13 patients (20%) needed 2nd session. 6 patients had clinically insignificant residual fragments (⬍4mm, asymptomatic). Average number of sessions for 20 patients who weren’t stone free was 3 (with average stone size of 11,7 mm). There were no serious complications. Conclusions: Our results confirm good efficacy of the Sonolith Vision lithotripter for treatment of lower calyceal stones ⬍10 mm in diameter. For stones
UROLOGY 74 (Supplment 4A), October 2009
between 11-20 mm, question of the best treatment option remains controversial and it’s important to involve patient in decision making process by explaining pros and cons of all available treatment options (ESWL, PCNL, Flexible ureterorenoscopy). UP-3.156 Preparation and Characterization of Phosphomycin Loaded Double-J Stents Cirak T1, Yildiz M2, Vural T3, Aslan B3, ¨ ner G5 Akin A4, Denkbas E3, O 1 Dept. of Bioengineering, Institute for Graduate Studies in Science and Engineering, Hacettepe University, Beytepe, Ankara, Turkey; 2Dept. of Urology, Ozel Lokman Hekim Hospital, Ankara, Turkey; 3Dept. of Nanotechnology and Nanomedicine, Institute for Graduate Studies in Science and Engineering, Hacettepe University, Beytepe, Ankara, Turkey; 4 Dept. of Pharmaceutical Microbiology, Ankara University Faculty of Pharmacy, Ankara, Turkey; 5Dept. of Fundamental and Industrial Microbiology, Dept. of Biology, Ege University, Izmir, Turkey Introduction and Objective: Urethral stents are frequently used in the urinary tract disorders. Encrustation, bacterial adhesion and catheter associated urinary tract infections (CAUTI) are the potential complications of long term usage of urethral stents.Aim of the presented study was the modification of double-J stent surfaces for the inhibition of bacterial adhesion and encrustation. Materials and Methods: Surface modification of stents were performed by Radio Frequency Glow Discharge (RFGD) plasma polymerization technique using poly(ethylene glycol). Furthermore double-J stents were coated with fosfomycin by using poly(DL-lactide-co-glycolide) polymer with solvent evaporation technique. Encrustation tests, contact angle measurements and drug release studies were performed for the characterization of double-J stents. Morphological evaluations of the modified stent surfaces were carried out by using scanning electron microscope (SEM). Poly(DL-lactideco-glycolide) concentration, fosfomycin concentration, plasma exposure time and plasma frequency were selected as effective parameters in these studies. Results: The results showed that phosphomycin-loaded double-J stents prepared were able to provide controlled release of phosphomycin in parallel with the degradation of PEG and poly(DL-lactide-co-glycolide). A decrease in porosity of the
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UP-3.151 Percutaneous Nephrolithotomy in Children Ali B1, Qotb E1, Abbas M2 1 Department of Urology, Al-Abbas Hospital, Taiz, Yemen; 2Cairo University, Cairo, Egypt Introduction and Objectives: Open surgery was the only choice for treatment of pediatric urolithiasis. There is always a need for less invasive procedure. The availability of endourological procedure for adults necessitates this use also for children. We will present our experience with PCNL in children. Materials and Methods: Between March 2006 and January 2008, 24 boys and 16 girls with renal calculi were treated with PCNL. Patient age ranged from 2 years to 12 years (mean 10 year). Excretory urography (IVP) was the primary imaging modality. The method of PCNL in children is the same as used in adults. Percutaneous access was achieved with the patient under general anasthesia. Subcostal puncture was used in all cases. Access was achieved using an 18 gauge needle and guidewire. Dilation of the tract to the minimal size (24ch) necessary for instrumentation and stone removal were then done. For small stones the graspers were used for mechanical stone extraction but for larger calculi lithotripsy was used for fragmentation. At the end of the procedure a nephrostomy tube was left in the kidney for 2-3 days. Success was defined as complete removal of the stones. The patients were followed after one month by KUB. Results: For the 24 kidneys with stones in the renal pelvis, only percutaneous access was achieved through the lower calyx. Stones in the pelvis and upper calix were removed through a lower caliceal puncture in 7 cases and an upper caliceal puncture in 1 case. One of cases was converted to ESWL because of difficult puncture. Significant intraoperative bleeding that required blood transfusion developed in 4 cases, renal pelvis perforation in 1 case which necessitated prolonged nephrostomy drainage for one week. Postoperatively, 4 patients had transient fever for 24 to 48 hours but none had urosepsis. Mean hospital stay was 3 days, antegrade pyelography was done for patient with pelvic perforation and revealed healing and nephrostomy was removed after one week. A total of 30 cases (75%) were stone-free at hospital discharge, 4 cases had residual stones treated with ESWL and the remaining 6 had insignificant peripheral caliceal stones that spontaneously
S342
passed at 3-months follow up. Therefore, the stone-free rate at 3 months was 100%. Conclusion: PCNL is a suitable and safe procedure for the treatment of children with renal calculi. The procedure has the advantages of small skin incision, short hospital stay and low complication rate. The minimally invasive nature of PCNL is of great value in this age group because there is always a risk of stone recurrence that may necessitate repeated intervention.
boys) without any history of UTI and normal urinalysis we observed febrile infection managed by antibiotics within short course.Two boys needed open surgery. ESWL procedures were well tolerated in all patients, without major complications. Conclusion: ESWL is safe and highly effective treatment method of kidney and ureteral stones in children and it should be regarded as the first line option in pediatric patients with nephrolithiasis.
UP-3.152 Efficacy of Extracorporeal Shock Wave Lithotripsy in Pediatric Patients Managadze G, Varshanidze L, Begashvili M, Silagava D, Tchanturaia Z National Center of Urology, Tbilisi, Georgia
UP-3.153 Factors Affecting the Outcome of Ureteroscopy in the Management of Ureteric Stones in Children Hidoussi A, Jaidane M, Hamida W, Kallel Y, Salama A, Ben Sorba N, Mosbah A Department of Urology, Sahloul Hospital, Sousse, Tunisia
Introduction and Objective: We analyzed efficacy of Extracorporeal Shock Wave Lithotripsy (ESWL) for treatment of kidney and ureteral stones in children. Materials and Methods: During 2003008 we treated 74 pediatric patients: age 1-14 years, 31 girls, 43 boys. ESWL was performed under general or i.v. sedoanalgesia. None of them underwent ureteral stenting or percutaneous nephrostomy. We used Dornier Compact Delta II. Stones were located in kidneys in 41 patients; in upper, mid and lower ureter, respectively in 8, 9 and 15 patients; in urinary bladder in one boy; 12 patients had more than one stone, 7 of them bilateral disease. 43 stones were ⬍10 mm in size, 55 between 10 mm and 20 mm, and ⬎20mm 3 (none were staghorn). Sessions were carried out mainly at level 2 (11.5 kV) and in others at level 3 – 12.75 kV (23 cases), but in two patients stones were fragmented at level 1 (10 kV). Number of shock waves used was 1500-3000. Results: Total number of ESWL session was 134: average 1.65 per patient and 1.3 per stone. Mean number of sessions for the stone ⬍10 mm and 10-20 mm were same (1.3 vs. 1.34) and patients with ⬎ 20 mm stones needed 2 sessions. Three sessions were needed in patients with multiple and bilateral stones. Patients needed analgesia by Voltaren 25 mg suppositorium (2 - 5 days). Repeat sessions were performed 7-10 days later. 89 % of patients were stone free within one week of the last session of ESWL. In girl with cerebral palsy clearance process took 5 weeks. Three patients developed Steintraße successfully managed by repeat ESWL session. In 4 patients (2 girls, 2
Introduction and Objective: To identify the factors involved in failure and postoperative complications of retrograde rigid ureteroscopy (URS) in the treatment of ureteric stones in children. Materials and Methods: This is a retrospective study, including 30 children who underwent 31 rigid URS (one case bilateral) for obstructive ureteric stones over a period of 10 years (1996 to 2006). We made an analytical study to identify the variables related to the incidence of postoperative complications and failure of URS. Results: There were 30 children (20 girls and 10 boys) with a mean age of 8 years (range, 4 to 14 years).The site of stones were pelvic in 21 cases (67.7%), iliac in 2 cases (6.4%) and lumbar in 8 cases (25%). The mean size of stones was 10.5 mm (5 to 22mm). The success rate by renal unit was 90.3%. Univariate Analysis revealed that the variables related to the failure of URS were: the size of stone (p ⫽ 0.052), stone site (p ⫽ 0.054) and the renal parenchymal thickness (p ⫽ 0.021). There was no intraoperative complication from the ureteroscopic procedure. Postoperative complication rate was 22% (4 cases of renal colic and 3 cases of urinary tract infection). The variables in relation with postoperative complications were: the size of stone (p ⫽ 0.044), parenchymal thickness (0.034) and duration of the procedure (p ⫽ 0.001). Conclusion: The rigid URS in children is a reliable and effective treatment option in the management of ureteric stones. According to our study, the favorable factors for success of URS are: stone iliac or pelvic ureter, stones less than 10 mm and
UROLOGY 74 (Supplment 4A), October 2009
UNMODERATED POSTER SESSIONS
ureteric stones with a preserved renal parenchyma. The variables involved in postoperative complications are: stones above 10 mm, a thinned renal parenchyma and long operative duration.
UP-3.154 Optimizing Retrograde Flexible Ureteroscopy for Upper Urinary Tract Pathology Georgescu D, Multescu R, Geavlete B, Geavlete P Department of Urology, “Saint John” Emergency Clinical Hospital, Bucharest, Romania Introduction and Objective: The development of retrograde flexible ureteroscopy significantly modified the diagnosis and treatment of upper urinary tract pathology. This study aimed to identify solutions to optimize this endoscopic procedure. Matrerials and Methods: Between 2002 and 2008, 173 patients underwent retrograde flexible ureteroscopy in our department. We evaluated the variables influencing method’s performances, as well as solutions to solve these problems. Results: The visibility, reduced due to the technical particularities of flexible ureteroscopes, may be supplementary diminished by the presence of hematuria/pyuria or the insertion of accessory instruments through the working channel. By avoiding iatrogenic lesions of the urothelium, using pressure irrigation or inserting small calibre accessory instruments through the working channel (eventually unsheathed baskets), visibility may be improved. The access to the entire pyelocaliceal system (especially the lower pole) may be limited by the renal anatomy, presence of hydronephrosis or ureteroscope’s maximal deflection. In cases with the infundibulopyelic angle lower than 30o, or between 30o -90o associated with an inferior calyx infundibular length shorter than 3 cm, the success rates of the lower pole access were 0% and 61.1%, by comparison to 88% in other patients. Massive hydronephrosis imposes ureteral stenting followed by flexible ureteroscopy in a secondary setting. Maintaining an acute deflection for a long time must be avoided by calculus displacement into the renal pelvis. Conclusion: Specific limitations of the method must be taken into consideration when indicating this procedure. Each problem has a specific solution, however applicable only in selected cases.
UP-3.155 Fourth-Generation Lithotripter in Treatment of Lower Calyceal Stones Hejj R, Chow W North Manchester General Hospital, Pennine Acute Hospitals NHS Trust, Manchester, UK Introduction and Objective: Treatment of lower calyceal stones has been controversial since the introduction of minimally invasive treatment options. EAU guidelines recommend ESWL as first line treatment for renal stones ⬍20 mm. On the other hand, the Lower Pole Study Group recommended that lower calyceal stones, especially those ⬎10 mm in diameter, should be better managed initially with percutaneous removal rather than ESWL. Some recent publications reported very good results achieved by fourth-generation, electroconductive lithotripter. This might be due to fragmentation characteristics of this technology, which produces smaller fragments than those achieved with an electromagnetic generator. Materials and Methods: From our prospectively maintained database of over 400 ESWL treatments with the Sonolith Vision (Technomed Medical Systems, Vaulx-en-Velin, France) lithotripter between September 2007 and January 2009 we evaluated the patients with lower calyceal stones who completed follow-up. ESWL was considered to have failed when there were residual stone fragments of ⬎4 mm, or an additional procedure was required to render the patient stone free. Results: 63 patients completed followup. Average stone size was 9,7 mm (range 4-20). Overall stone free rate (SFR) was 68 % (43/63). 40 patients had stones with maximum diameter ⬍10 mm. SFR for this group was 77% (31/ 40). 23 patients had stones of 11-20mm. SFR was 52% (12/23). Retreatment rate for a group of successfully treated patients (43 patients, average stone size⫽8,8mm) was 30%. 30 patients (48%) were stone-free after 1 treatment session, 13 patients (20%) needed 2nd session. 6 patients had clinically insignificant residual fragments (⬍4mm, asymptomatic). Average number of sessions for 20 patients who weren’t stone free was 3 (with average stone size of 11,7 mm). There were no serious complications. Conclusions: Our results confirm good efficacy of the Sonolith Vision lithotripter for treatment of lower calyceal stones ⬍10 mm in diameter. For stones
UROLOGY 74 (Supplment 4A), October 2009
between 11-20 mm, question of the best treatment option remains controversial and it’s important to involve patient in decision making process by explaining pros and cons of all available treatment options (ESWL, PCNL, Flexible ureterorenoscopy). UP-3.156 Preparation and Characterization of Phosphomycin Loaded Double-J Stents Cirak T1, Yildiz M2, Vural T3, Aslan B3, ¨ ner G5 Akin A4, Denkbas E3, O 1 Dept. of Bioengineering, Institute for Graduate Studies in Science and Engineering, Hacettepe University, Beytepe, Ankara, Turkey; 2Dept. of Urology, Ozel Lokman Hekim Hospital, Ankara, Turkey; 3Dept. of Nanotechnology and Nanomedicine, Institute for Graduate Studies in Science and Engineering, Hacettepe University, Beytepe, Ankara, Turkey; 4 Dept. of Pharmaceutical Microbiology, Ankara University Faculty of Pharmacy, Ankara, Turkey; 5Dept. of Fundamental and Industrial Microbiology, Dept. of Biology, Ege University, Izmir, Turkey Introduction and Objective: Urethral stents are frequently used in the urinary tract disorders. Encrustation, bacterial adhesion and catheter associated urinary tract infections (CAUTI) are the potential complications of long term usage of urethral stents.Aim of the presented study was the modification of double-J stent surfaces for the inhibition of bacterial adhesion and encrustation. Materials and Methods: Surface modification of stents were performed by Radio Frequency Glow Discharge (RFGD) plasma polymerization technique using poly(ethylene glycol). Furthermore double-J stents were coated with fosfomycin by using poly(DL-lactide-co-glycolide) polymer with solvent evaporation technique. Encrustation tests, contact angle measurements and drug release studies were performed for the characterization of double-J stents. Morphological evaluations of the modified stent surfaces were carried out by using scanning electron microscope (SEM). Poly(DL-lactideco-glycolide) concentration, fosfomycin concentration, plasma exposure time and plasma frequency were selected as effective parameters in these studies. Results: The results showed that phosphomycin-loaded double-J stents prepared were able to provide controlled release of phosphomycin in parallel with the degradation of PEG and poly(DL-lactide-co-glycolide). A decrease in porosity of the
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