- Email: [email protected]
Update on drug-related problems in the elderly
The American Journal of Geriatric Pharmacotherapy Updates
Update on Drug-Related Problems in the Elderly Joseph T. H a n l o n , P h a r m D , MS
Division of Geriatric Medicine, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Pharmacy and Therapeutics, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania; and Geriatric Research Education and Clinical Center, and Center for Health Equity Research and Promotion, Veterans Administration Pittsburgh Healthcare System, Pittsburgh, Pennsylvania To keep readers up to date with the latest developments in the field of medication-related problems in older adults, we will be providing occasional bibliographies of newly published articles. Based on the model originally published in this journal in the article "Epidemiology of Medication-Related Adverse Events in Nursing Homes" by Handler, Wright, Ruby, and Hanlon ( A m J Geriatr Pharmacother. 2006:4:264-272), each bibliography will be divided into 2 major areas: medicationrelated adverse patient events and medication errors. The medication-related adverse patient events area will contain 3 subdivisions: adverse drug reactions; adverse drug-withdrawal events; and therapeutic failure. The medication-errors area will have 6 subdivisions: prescribing; order communication; dispensing; adherence; administration; and monitoring. If no relevant publications are identified within a particular section during the relevant period, that section will be omitted.
MEDICATION-RELATED ADVERSE PATIENT EVENTS Adverse Drug Reactions Aronson JK. Adverse drug reactions--no farewell to harms. Br J Clin Phamacol. 2007;63:131-135. Beard K. Drugs in the elderly--more good than harm? Expert Opin Drug Saf. 2007;6:229-231. Poon IO, Lal L, Brown EN, Braun UK. The impact of pharmacist-managed oral anticoagulation therapy in older veterans. J Clin Pharm Ther. 2007;32:21-29. Zhang M, Holman CD, Preen DB, Brameld K. Repeat adverse drug reactions causing hospitalization in older Australians: A population-based longitudinal study 1980-2003. B r J Clin PharmacoL 2007;63:163-170. MEDICATION ERRORS Prescribing Agostini JV, Zhang Y, Inouye SK. Use of a computerbased reminder to improve sedative-hypnotic prescrib-
Accepted for publication December4, 200Z Printed in the USA, Reproduction in whole or part is not permitted,
3"16
December 2007
Volume 5 • Number4
ing in older hospitalized patients. J A m Geriatr Soc. 2007;55:43-48. Barry PJ, O'Keefe N, O'Connor KA, O'Mahony D. Inappropriate prescribing in the elderly: A comparison of the Beers criteria and the Improved Prescribing in the Elderly Tool (IPET) in acutely ill elderly hospitalized patients. J Clin Pharm Ther. 2006;31:617-626. De Wilde S, Carey IM, Harris T, et al. Trends in potentially inappropriate prescribing amongst older UK primary care patients. Pharmacoepidemiol Drug Saf. 2007;16: 658-667. Fu AZ, Jiang JZ, Reeves JH, et al. Potentially inappropriate medication use and healthcare expenditures in the US community-dwelling elderly. Med Care. 2007;45:472476. Gallagher P, Barry P, O'Mahony D. Inappropriate prescribing in the elderly. J Clin Pharm Ther. 2007;32:113-121. Hayes BD, Kelin-Schwartz W, Barrueto F Jr. Polypharmacy and the geriatric patient. Clin Geriatr Med. 2007;23:371390, vii. Jano E, Aparasu RR. Healthcare outcomes associated with Beers' criteria: A systematic review. Ann Pharmacother. 2007;41:438-44Z Landi F, Russo A, Liperoti R, et al. Impact of inappropriate drug use on physical performance among a frail elderly population living in the community. Eur J Clin PharmacoL 2007;63:791-799. Launay-Vacher V, Chatelut E, Lichtman SM, et al. Renal insufficiency in elderly cancer patients: International Society of Geriatric Oncology clinical practice recommendations. Ann Oncol. 2007;18:1314-1321. Mallet L, Spinewine A, Huang A. The challenge of managing drug interactions in elderly people. Lancet. 2007;370:185-191. Pit SW, Byles JE, Cockburn J. Medication review: Patient selection and general practitioner's report of drug-related problems and actions taken in elderly Australians. J A m Geriatr Soc. 2007;55:927-934. doi:10.1016/j.amjopharm.200Z12.010 1543 5946/$32.00
Copyright© 2007 Fo
Updates The AmericanJournal of Geriatric Pharmacotherapy
Pit SW, Byles JE, Henry DA, et al. A Quality Use of Medicines program for general practitioners and older people: A cluster randomised controlled trial. MedJAust. 2007;187:23-30. Pugh MJ, Hanlon JT, Zeber JE, et al. Assessing potentially inappropriate prescribing in the elderly Veterans Affairs population using the HEDIS 2006 quality measure. J Manag Care Pharm. 2006;12:537-545. Raebel MA, Charles J, Dugan J, et al. Randomized trial to improve prescribing safety in ambulatory elderly patients. J A m Geriatr Soc. 2007;55:977-985. Smith KL, Soriano TA, Boal J. Brief communication: National quality-of-care standards in home-based primary care. Ann Intern Med. 2007;146:188-192. Spinewine A, Schmader KE, Barber N, et al. Appropriate prescribing in elderly people: How can it be measured and optimised? Lancet. 2007;370:173-184. Spinewine A, Swine C, Dhillon S, et al. Effect of a collaborative approach on the quality of prescribing for geriatric inpatients: A randomized, controlled trial. J A m Geriatr Soc. 2007;55:658-665. Steinman MA, Rosenthal GE, Landefeld CS, et al. Conflicts and concordance between measures of medication prescribing quality. Med Care. 2007;45:95-99.
Adherence Chia LR, Schlenk EA, Dunbar-Jacob J. Effect of personal and cultural beliefs on medication adherence in the elderly. Drugs Aging. 2006;23:191-202. Elliott RA, Ross-Degnan D, Adams AS, et al. Strategies for coping in a complex world: Adherence behavior among older adults with chronic illness. J Gen Intern Med. 2007;22:805-810. Holland R, Brooksby I, Lenaghan E, et al. Effectiveness of visits from community pharmacists for patients with heart
failure: HeartMed randomised controlled trial. BMJ. 2007;334:1098. Lenaghan E, Holland R, Brooks A. Home-based medication review in a high risk elderly population in primary care-the POLYMED randomised controlled trial. Age Ageing. 2006;36:292-297. Murray MD, Young J, Hoke S, et al. Pharmacist intervention to improve medication adherence in heart failure: A randomized trial. Ann Intern Med. 2007;146:714725. Pacini M, Smith RD, Wilson EC, Holland R. Home-based medication review in older people: Is it cost effective? Pharmacoeconomics. 2007;25:171-180. Russell CL, Conn VS, Jantarakupt P. Older adult medication compliance: Integrated review of randomized controlled trials. Am J Health Behav. 2006;30:636-650. Salter C, Holland R, Harvey I, Henwood K. "I haven't even phoned my doctor yet." The advice giving role of the pharmacist during consultations for medication review with patients aged 80 or more: Qualitative discourse analysis. BM]. 2007;334:1101. Travis SS, McAuley WJ, Dmochowski 1, et al. Factors associated with medication hassles experienced by family caregivers of older adults. Patient Educ Couns. 2007;66:51-57. Vik SA, Hogan DB, Patten SB, et al. Medication nonadherence and subsequent risk of hospitalisation and mortality among older adults. Drugs Aging. 2006;23:345-356.
Monitoring Quartarolo JM, Thoelke M, Schafers SJ. Reporting of estimated glomerular filtration rate: Effect on physician recognition of chronic kidney disease and prescribing practices for elderly hospitalized patients. ] Hosp Med. 2007;2:74-78.
Address c o r r e s p o n d e n c e to: Joseph T. Hanlon, PharmD, MS, Department of Medicine (Geriatrics), University of Pittsburgh, ICaufman Medical Building-Suite 514, 3471 5th Avenue, Pittsburgh, PA 15213. E-mail: hanlonj@ dom.pitt.cdu
377
Update on Drug-Related Problems in the Elderly Joseph T. H a n l o n , P h a r m D , MS
Division of Geriatric Medicine, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Pharmacy and Therapeutics, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania; and Geriatric Research Education and Clinical Center, and Center for Health Equity Research and Promotion, Veterans Administration Pittsburgh Healthcare System, Pittsburgh, Pennsylvania To keep readers up to date with the latest developments in the field of medication-related problems in older adults, we will be providing occasional bibliographies of newly published articles. Based on the model originally published in this journal in the article "Epidemiology of Medication-Related Adverse Events in Nursing Homes" by Handler, Wright, Ruby, and Hanlon ( A m J Geriatr Pharmacother. 2006:4:264-272), each bibliography will be divided into 2 major areas: medicationrelated adverse patient events and medication errors. The medication-related adverse patient events area will contain 3 subdivisions: adverse drug reactions; adverse drug-withdrawal events; and therapeutic failure. The medication-errors area will have 6 subdivisions: prescribing; order communication; dispensing; adherence; administration; and monitoring. If no relevant publications are identified within a particular section during the relevant period, that section will be omitted.
MEDICATION-RELATED ADVERSE PATIENT EVENTS Adverse Drug Reactions Aronson JK. Adverse drug reactions--no farewell to harms. Br J Clin Phamacol. 2007;63:131-135. Beard K. Drugs in the elderly--more good than harm? Expert Opin Drug Saf. 2007;6:229-231. Poon IO, Lal L, Brown EN, Braun UK. The impact of pharmacist-managed oral anticoagulation therapy in older veterans. J Clin Pharm Ther. 2007;32:21-29. Zhang M, Holman CD, Preen DB, Brameld K. Repeat adverse drug reactions causing hospitalization in older Australians: A population-based longitudinal study 1980-2003. B r J Clin PharmacoL 2007;63:163-170. MEDICATION ERRORS Prescribing Agostini JV, Zhang Y, Inouye SK. Use of a computerbased reminder to improve sedative-hypnotic prescrib-
Accepted for publication December4, 200Z Printed in the USA, Reproduction in whole or part is not permitted,
3"16
December 2007
Volume 5 • Number4
ing in older hospitalized patients. J A m Geriatr Soc. 2007;55:43-48. Barry PJ, O'Keefe N, O'Connor KA, O'Mahony D. Inappropriate prescribing in the elderly: A comparison of the Beers criteria and the Improved Prescribing in the Elderly Tool (IPET) in acutely ill elderly hospitalized patients. J Clin Pharm Ther. 2006;31:617-626. De Wilde S, Carey IM, Harris T, et al. Trends in potentially inappropriate prescribing amongst older UK primary care patients. Pharmacoepidemiol Drug Saf. 2007;16: 658-667. Fu AZ, Jiang JZ, Reeves JH, et al. Potentially inappropriate medication use and healthcare expenditures in the US community-dwelling elderly. Med Care. 2007;45:472476. Gallagher P, Barry P, O'Mahony D. Inappropriate prescribing in the elderly. J Clin Pharm Ther. 2007;32:113-121. Hayes BD, Kelin-Schwartz W, Barrueto F Jr. Polypharmacy and the geriatric patient. Clin Geriatr Med. 2007;23:371390, vii. Jano E, Aparasu RR. Healthcare outcomes associated with Beers' criteria: A systematic review. Ann Pharmacother. 2007;41:438-44Z Landi F, Russo A, Liperoti R, et al. Impact of inappropriate drug use on physical performance among a frail elderly population living in the community. Eur J Clin PharmacoL 2007;63:791-799. Launay-Vacher V, Chatelut E, Lichtman SM, et al. Renal insufficiency in elderly cancer patients: International Society of Geriatric Oncology clinical practice recommendations. Ann Oncol. 2007;18:1314-1321. Mallet L, Spinewine A, Huang A. The challenge of managing drug interactions in elderly people. Lancet. 2007;370:185-191. Pit SW, Byles JE, Cockburn J. Medication review: Patient selection and general practitioner's report of drug-related problems and actions taken in elderly Australians. J A m Geriatr Soc. 2007;55:927-934. doi:10.1016/j.amjopharm.200Z12.010 1543 5946/$32.00
Copyright© 2007 Fo
Updates The AmericanJournal of Geriatric Pharmacotherapy
Pit SW, Byles JE, Henry DA, et al. A Quality Use of Medicines program for general practitioners and older people: A cluster randomised controlled trial. MedJAust. 2007;187:23-30. Pugh MJ, Hanlon JT, Zeber JE, et al. Assessing potentially inappropriate prescribing in the elderly Veterans Affairs population using the HEDIS 2006 quality measure. J Manag Care Pharm. 2006;12:537-545. Raebel MA, Charles J, Dugan J, et al. Randomized trial to improve prescribing safety in ambulatory elderly patients. J A m Geriatr Soc. 2007;55:977-985. Smith KL, Soriano TA, Boal J. Brief communication: National quality-of-care standards in home-based primary care. Ann Intern Med. 2007;146:188-192. Spinewine A, Schmader KE, Barber N, et al. Appropriate prescribing in elderly people: How can it be measured and optimised? Lancet. 2007;370:173-184. Spinewine A, Swine C, Dhillon S, et al. Effect of a collaborative approach on the quality of prescribing for geriatric inpatients: A randomized, controlled trial. J A m Geriatr Soc. 2007;55:658-665. Steinman MA, Rosenthal GE, Landefeld CS, et al. Conflicts and concordance between measures of medication prescribing quality. Med Care. 2007;45:95-99.
Adherence Chia LR, Schlenk EA, Dunbar-Jacob J. Effect of personal and cultural beliefs on medication adherence in the elderly. Drugs Aging. 2006;23:191-202. Elliott RA, Ross-Degnan D, Adams AS, et al. Strategies for coping in a complex world: Adherence behavior among older adults with chronic illness. J Gen Intern Med. 2007;22:805-810. Holland R, Brooksby I, Lenaghan E, et al. Effectiveness of visits from community pharmacists for patients with heart
failure: HeartMed randomised controlled trial. BMJ. 2007;334:1098. Lenaghan E, Holland R, Brooks A. Home-based medication review in a high risk elderly population in primary care-the POLYMED randomised controlled trial. Age Ageing. 2006;36:292-297. Murray MD, Young J, Hoke S, et al. Pharmacist intervention to improve medication adherence in heart failure: A randomized trial. Ann Intern Med. 2007;146:714725. Pacini M, Smith RD, Wilson EC, Holland R. Home-based medication review in older people: Is it cost effective? Pharmacoeconomics. 2007;25:171-180. Russell CL, Conn VS, Jantarakupt P. Older adult medication compliance: Integrated review of randomized controlled trials. Am J Health Behav. 2006;30:636-650. Salter C, Holland R, Harvey I, Henwood K. "I haven't even phoned my doctor yet." The advice giving role of the pharmacist during consultations for medication review with patients aged 80 or more: Qualitative discourse analysis. BM]. 2007;334:1101. Travis SS, McAuley WJ, Dmochowski 1, et al. Factors associated with medication hassles experienced by family caregivers of older adults. Patient Educ Couns. 2007;66:51-57. Vik SA, Hogan DB, Patten SB, et al. Medication nonadherence and subsequent risk of hospitalisation and mortality among older adults. Drugs Aging. 2006;23:345-356.
Monitoring Quartarolo JM, Thoelke M, Schafers SJ. Reporting of estimated glomerular filtration rate: Effect on physician recognition of chronic kidney disease and prescribing practices for elderly hospitalized patients. ] Hosp Med. 2007;2:74-78.
Address c o r r e s p o n d e n c e to: Joseph T. Hanlon, PharmD, MS, Department of Medicine (Geriatrics), University of Pittsburgh, ICaufman Medical Building-Suite 514, 3471 5th Avenue, Pittsburgh, PA 15213. E-mail: hanlonj@ dom.pitt.cdu
377